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1. 发明申请

US20050154536A1 Two-part drug discovery system 审中-公开
标题翻译：两部分药物发现系统
公开(公告)号：US20050154536A1
公开(公告)日：2005-07-14
申请号：US10925862
申请日：2004-08-25
申请人： Carson Chow , Yoram Vodovotz , Gilles Clermont , Mitchell Fink , John Bartels , Steven Chang
发明人： Carson Chow , Yoram Vodovotz , Gilles Clermont , Mitchell Fink , John Bartels , Steven Chang
IPC分类号： A61B20060101 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5091 , G16B5/00 , G16C20/30
摘要： A mathematical prognostic in which changes in a number of physiologically significant factors are measured and interpolated to determine a “damage fluction” incident to bacterial infection or other serious inflammation, followed by either or both of in vitro or in vivo investigations of a particular active agent (drug) and adjustment of the model so as better to evaluate the particular active agent. By measuring a large number of physiologically significant factors including, but not limited to, Interleukin 6 (IL-6), Interleukin 10 (IL-10), Nitric Oxide (NO), and others, it is possible to predict life versus death by the damage function, dD/dt. To evaluate one or more drug candidates against inflammation, the mathematical model is applied first, followed by in vivo and/or in vitro investigations, and the in vivo and/or in vitro investigations are in turn used to adjust or to enhance, if applicable, the mathematical model as it is applied to the particular drug candidate.
摘要翻译：一种数学预测，其中测量和内插多个生理学重要因素的变化以确定对细菌感染或其他严重炎症的“损伤流感”事件，随后是特定活性剂的体外或体内研究中的任一个或两者（药物）和模型的调整，以便更好地评估特定的活性剂。通过测量大量的生理学显着因子，包括但不限于白细胞介素6（IL-6），白细胞介素10（IL-10），一氧化氮（NO）等），可以预测寿命与死亡损伤函数dD / dt。为了评估一种或多种抗炎症候选药物，首先应用数学模型，然后进行体内和/或体外研究，并且如果适用，体内和/或体外研究又被用于调节或增强，它被应用于特定药物候选人的数学模型。

2. 发明申请

US20120271611A1 Modeling Wound Healing 有权
标题翻译：造型伤口愈合
公开(公告)号：US20120271611A1
公开(公告)日：2012-10-25
申请号：US13423714
申请日：2012-03-19
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
IPC分类号： G06G7/60
CPC分类号： G16H50/50 , G06F19/00 , Y02A90/26
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译：提供了模拟组织愈合的方法。该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。还提供了在计算设备上实现这些方法。根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。

3. 发明授权

US08165819B2 Modeling wound healing 有权
标题翻译：建模伤口愈合
公开(公告)号：US08165819B2
公开(公告)日：2012-04-24
申请号：US11869852
申请日：2007-10-10
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
IPC分类号： G06F19/10 , G01N33/50 , G06G7/58 , A61K38/00 , A61K38/18 , A61P17/02
CPC分类号： G16H50/50 , G06F19/00 , Y02A90/26
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译：提供了模拟组织愈合的方法。该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。还提供了在计算设备上实现这些方法。根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。

4. 发明申请

US20080228456A1 MODELING WOUND HEALING 有权
标题翻译：建模治疗
公开(公告)号：US20080228456A1
公开(公告)日：2008-09-18
申请号：US11869852
申请日：2007-10-10
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
IPC分类号： G06G7/60 , G06F17/00
CPC分类号： G16H50/50 , G06F19/00 , Y02A90/26
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译：提供了模拟组织愈合的方法。该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。还提供了在计算设备上实现这些方法。根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。

5. 发明授权

US08630810B2 Modeling wound healing 有权
标题翻译：建模伤口愈合
公开(公告)号：US08630810B2
公开(公告)日：2014-01-14
申请号：US13423714
申请日：2012-03-19
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
IPC分类号： G06F19/00 , G01N33/50 , G06G7/58 , A61K38/00 , A61K38/18 , A61P17/02
CPC分类号： G16H50/50 , G06F19/00 , Y02A90/26
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译：提供了模拟组织愈合的方法。该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。还提供了在计算设备上实现这些方法。根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。

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