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1. 发明授权

US08802815B2 Peptides and uses thereof to modulate IGF-1 synthesis and IGF-1 receptor expression 有权
标题翻译：肽及其用途来调节IGF-1合成和IGF-1受体表达
公开(公告)号：US08802815B2
公开(公告)日：2014-08-12
申请号：US13257332
申请日：2010-03-18
申请人： Claude Carelli , Zvi Laron , Gila Maor
发明人： Claude Carelli , Zvi Laron , Gila Maor
IPC分类号： A61K38/00 , A61K38/04 , A61K38/31 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C09D5/02 , A61K38/00 , B32B27/00 , C07K14/65 , C07K14/655 , C09D147/00
摘要： The invention relates to peptides for modulate IGF-1 activity, a pharmaceutical composition comprising them as well as their applications as medicinal products and cell proliferation modulating agents in vitro.
摘要翻译：本发明涉及用于调节IGF-1活性的肽，包含它们的药物组合物以及它们在体外作为药物产品和细胞增殖调节剂的应用。

2. 发明申请

US20120135926A1 PEPTIDES FOR INHIBITING IGF-1 有权
标题翻译：抑制IGF-1的肽
公开(公告)号：US20120135926A1
公开(公告)日：2012-05-31
申请号：US13257347
申请日：2009-03-19
申请人： Claude Carelli , Zvi Laron , Gila Maor
发明人： Claude Carelli , Zvi Laron , Gila Maor
IPC分类号： A61K38/22 , A61P35/04 , A61P35/00 , C12N5/071 , A61P25/24
CPC分类号： C07K14/61 , A61K38/00 , C07K14/65 , C07K14/77 , C07K2319/00 , C07K2319/74
摘要： The invention relates to peptides useful for inhibiting IGF-1 activity and their use as agents for inhibition of in vitrocell proliferation and for treatment of various diseases.
摘要翻译：本发明涉及可用于抑制IGF-1活性的肽及其作为抑制体外细胞增殖和治疗各种疾病的药剂的用途。

3. 发明授权

US07642092B2 Cultured cartilage/bone cells/tissue, method of generating same and uses thereof 失效
标题翻译：培养软骨/骨细胞/组织，生成方法及其用途
公开(公告)号：US07642092B2
公开(公告)日：2010-01-05
申请号：US10627739
申请日：2003-07-28
申请人： Gila Maor
发明人： Gila Maor
IPC分类号： C12N5/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N2500/38 , C12N2501/105
摘要： A method of generating cultured chondrocytes/endochondral bone cells is provided. The method comprising isolating chondrocytes from mandibular condyle tissue, and culturing the isolated chondrocytes. A method of isolating chondrocytes from mandibular condyle tissue is further provided. The method comprises isolating mandibular condyle tissue from a mammal and treating the mandibular condyle tissue so as to selectively remove fibroblast-like cells and/or myocytes therefrom, the modified mandibular condyle tissue including chondrocytes, and selectively collecting the chondrocytes from the modified mandibular condyle tissue.
摘要翻译：提供产生培养的软骨细胞/软骨内骨细胞的方法。该方法包括从下颌骨组织中分离软骨细胞，并培养分离的软骨细胞。进一步提供从下颌骨髁组织分离软骨细胞的方法。该方法包括从哺乳动物中分离下颌骨髁组织并治疗下颌骨髁组织，以从其中选择性地去除成纤维细胞样细胞和/或肌细胞，修饰的下颌骨髁组织包括软骨细胞，并从修复的下颌骨组织中选择性收集软骨细胞。

4. 发明授权

US08975225B2 Method for inhibiting growth of chondrocytes in a subject by inhibiting IGF-1 有权
标题翻译：通过抑制IGF-1抑制受试者中软骨细胞生长的方法
公开(公告)号：US08975225B2
公开(公告)日：2015-03-10
申请号：US13257347
申请日：2009-03-19
申请人： Claude Carelli , Zvi Laron , Gila Maor
发明人： Claude Carelli , Zvi Laron , Gila Maor
IPC分类号： A61K38/30 , C07K14/65 , A61K38/00 , A61P19/02 , A61K38/10 , A61K38/16 , C07K14/61 , C07K14/77
CPC分类号： C07K14/61 , A61K38/00 , C07K14/65 , C07K14/77 , C07K2319/00 , C07K2319/74
摘要： The invention relates to peptides useful for inhibiting IGF-1 activity and their use as agents for inhibition of in vitrocell proliferation and for treatment of various diseases.
摘要翻译：本发明涉及可用于抑制IGF-1活性的肽及其作为抑制体外细胞增殖和治疗各种疾病的药剂的用途。

5. 发明申请

US20120149640A1 PEPTIDES MODULATING THE ACTIVITY OF IGF-1 AND THE APPLICATIONS OF SAID PEPTIDES 有权
标题翻译：调节IGF-1的活性的肽和应用的肽
公开(公告)号：US20120149640A1
公开(公告)日：2012-06-14
申请号：US13257332
申请日：2010-03-18
申请人： Claude Carelli , Zvi Laron , Gila Maor
发明人： Claude Carelli , Zvi Laron , Gila Maor
IPC分类号： A61K38/16 , C07K14/00 , C12N5/071 , A61K38/10 , A61P35/04 , A61P3/00 , A61P25/00 , A61P25/28 , A61P35/00 , C07K7/08 , A61P13/12
CPC分类号： C09D5/02 , A61K38/00 , B32B27/00 , C07K14/65 , C07K14/655 , C09D147/00
摘要： The invention relates to peptides for modulate IGF-1 activity, a pharmaceutical composition comprising them as well as their applications as medicinal products and cell proliferation modulating agents in vitro.
摘要翻译：本发明涉及用于调节IGF-1活性的肽，包含它们的药物组合物以及它们在体外作为药物产品和细胞增殖调节剂的应用。

6. 发明申请

US20100209397A1 METHOD FOR NON-AUTOLOGOUS CARTILAGE REGENERATION 审中-公开
标题翻译：非自动化手段再生方法
公开(公告)号：US20100209397A1
公开(公告)日：2010-08-19
申请号：US12093323
申请日：2006-11-12
申请人： Gila Maor
发明人： Gila Maor
IPC分类号： A61K35/32 , C12N5/077 , A61P19/02
CPC分类号： C12N5/0655 , A61L27/24 , A61L27/3817 , A61L27/3843 , A61L27/3895 , C12N2533/54
摘要： The present invention relates in general to the field of tissue engineering, and in particular to methods for repair and regeneration of diseased and injured bone and cartilage tissue by allotransplantation or xenotransplantation of neonatal mandibular condyle-derived chondrocytes. The composition may comprise mandibular condyle-derived chondrocytes in the form of a chondrocyte film, per se, or in combination with a scaffold.
摘要翻译：本发明一般涉及组织工程领域，特别涉及通过新生儿下颌骨髁衍生软骨细胞的异种移植或异种移植来修复和再生患病和受损的骨和软骨组织的方法。组合物可以包括软骨细胞膜形式的下颌骨髁衍生的软骨细胞本身或与支架组合。

7. 发明申请

US20100135967A1 CULTURED CARTILAGE/BONE CELLS/TISSUE, METHOD OF GENERATING SAME AND USES THEREOF 审中-公开
标题翻译：培养的培养物/骨细胞/组织，其产生方法及其用途
公开(公告)号：US20100135967A1
公开(公告)日：2010-06-03
申请号：US12631963
申请日：2009-12-07
申请人： Gila Maor
发明人： Gila Maor
IPC分类号： A61K35/32 , C12N5/077 , A61P19/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N2500/38 , C12N2501/105
摘要： A method of generating cultured chondrocytes/endochondral bone cells is provided. The method comprising isolating chondrocytes from mandibular condyle tissue, and culturing the isolated chondrocytes. A method of isolating chondrocytes from mandibular condyle tissue is further provided. The method comprises isolating mandibular condyle tissue from a mammal and treating the mandibular condyle tissue so as to selectively remove fibroblast-like cells and/or myocytes therefrom, the modified mandibular condyle tissue including chondrocytes, and selectively collecting the chondrocytes from the modified mandibular condyle tissue.
摘要翻译：提供产生培养的软骨细胞/软骨内骨细胞的方法。该方法包括从下颌骨组织中分离软骨细胞，并培养分离的软骨细胞。进一步提供从下颌骨髁组织分离软骨细胞的方法。该方法包括从哺乳动物中分离下颌骨髁组织并治疗下颌骨髁组织，以从其中选择性地去除成纤维细胞样细胞和/或肌细胞，修饰的下颌骨髁组织包括软骨细胞，并从修复的下颌骨组织中选择性收集软骨细胞。

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