专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5945105A Peptides of the antigen Sm-D and their use, in particular for the diagnostics of systemic lupus erythematosus (SLE) 失效
标题翻译：抗原Sm-D的肽及其用途，特别是用于诊断系统性红斑狼疮（SLE）
公开(公告)号：US5945105A
公开(公告)日：1999-08-31
申请号：US733982
申请日：1996-10-18
申请人： Falk Hiepe , Gabriele Riemekasten , Jeannette Marell , Gerd-Rudiger Burmester
发明人： Falk Hiepe , Gabriele Riemekasten , Jeannette Marell , Gerd-Rudiger Burmester
IPC分类号： G01N33/564 , A61K38/00 , A61K39/00 , A61K39/395 , A61P37/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/42
CPC分类号： C07K14/4713
摘要： Peptides of the antigen Sm-D and their use, in particular for the diagnostics of the SLE. The invention relates to peptides of the antigen Sm-D, comprised of 35 to 45 amino acids, which form a conformation epitope and which are capable of binding autoantibodies, such as they occur in connection with systemic lupus erythematosus (SLE). Particularly preferred is the peptide of 37 amino acids with the structure VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR (SEQ ID NO:3) and its mutants and variants, respectively.
摘要翻译：抗原Sm-D的肽及其用途，特别是SLE的诊断。本发明涉及抗原Sm-D的肽，其由35至45个氨基酸组成，其形成构象表位并且能够结合自身抗体，例如它们与系统性红斑狼疮（SLE）有关。特别优选分别具有结构VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR（SEQ ID NO：3）的37个氨基酸的肽及其突变体和变体。

2. 发明申请

US20080108509A1 Process for Recognizing Signatures in Complex Gene Expression Profiles 审中-公开
标题翻译：识别复杂基因表达谱中的特征的过程
公开(公告)号：US20080108509A1
公开(公告)日：2008-05-08
申请号：US11547040
申请日：2005-04-04
申请人： Thomas Haupl , Joachim Grun , Andreas Radbruch , Gerd-Rudiger Burmester , Christian Kaps , Andreas Grutzkau
发明人： Thomas Haupl , Joachim Grun , Andreas Radbruch , Gerd-Rudiger Burmester , Christian Kaps , Andreas Grutzkau
IPC分类号： C40B30/02 , G06G7/48 , C40B60/12
CPC分类号： C12Q1/6809
摘要： This invention relates to a process for recognizing signatures in complex gene expression profiles that comprises the steps of: a) making available a biological sample that is to be examined, b) making available at least one suitable expression profile, whereby at least one expression profile comprises one or more markers that are typical exclusively of the expression profile, c) determining the complex expression profile of the biological sample, d) determining the quantitative cellular composition of the biological sample by means of the expression profiles determined in steps b) and c). In addition, the process according to the invention can comprise the steps of e) calculating a virtual signal that is expected based on the specific composition of the expression profile, f) calculation of the difference from the actually measured complex expression profile and the virtual signal, and g) determination of the quantitative composition of the complex expression profile based on the determined differences. In addition, this invention relates to the application of the process according to the invention in the diagnosis, prognosis and/or tracking of a disease. Finally, corresponding computer systems, computer programs, computer-readable data media and laboratory robots or evaluating devices for molecular detection methods are disclosed.
摘要翻译：本发明涉及用于识别复合基因表达谱中的特征的方法，其包括以下步骤：a）提供待检查的生物样品，b）提供至少一种合适的表达谱，其中至少一个表达谱包括一个或多个仅表达谱的典型的标记，c）确定生物样品的复合物表达谱，d）通过步骤b）和c中确定的表达谱确定生物样品的定量细胞组成）。此外，根据本发明的过程可以包括以下步骤：e）基于表达简档的特定组合来计算期望的虚拟信号，f）与实际测量的复合表达谱和虚拟信号的差的计算，以及g）基于确定的差异确定复合体表达谱的定量组成。此外，本发明涉及根据本发明的方法在疾病的诊断，预后和/或跟踪中的应用。最后，公开了相应的计算机系统，计算机程序，计算机可读数据介质和实验室机器人或用于分子检测方法的评估装置。

3. 发明申请

US20060216707A1 Nucleic acid array consisting of selective monocyte macrophage genes 审中-公开
标题翻译：由选择性单核细胞巨噬细胞基因组成的核酸阵列
公开(公告)号：US20060216707A1
公开(公告)日：2006-09-28
申请号：US10521935
申请日：2003-05-28
申请人： Bruno Stuhlmuller , Thomas Haeupl , Olaf Kiesslich , Gerd-Rudiger Burmester
发明人： Bruno Stuhlmuller , Thomas Haeupl , Olaf Kiesslich , Gerd-Rudiger Burmester
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The invention relates to an array comprising oligo- or poly-nucleotide probes, immobilized on a solid support. The array is characterized in that, sequences of a selection or all of the selective monocytic macrophagic genes given in Tables 1-6 are bonded on the surface. The array permits the diagnosis of rheumatoid arthritis and other chronic inflammatory diseases, a corresponding analysis of the efficacy of treatment and the monitoring of side-effects with the anti-tumor necrosis factor (TNF) therapy and thus permits the selection of the most effective therapy for each patient with rheumatoid arthritis. The invention further relates to a nucleic acid array for the prognosis and development of novel anti-TNF type medicaments and such medicaments with a mode of action in said regulatory circuit.
摘要翻译：本发明涉及一种固定在固体支持物上的包含寡聚核苷酸或多核苷酸探针的阵列。该阵列的特征在于，表1-6中给出的选择或所有选择性单核细胞巨噬细胞基因的序列结合在表面上。该阵列允许诊断类风湿性关节炎和其他慢性炎性疾病，相应地分析治疗的功效和用抗肿瘤坏死因子（TNF）治疗的副作用的监测，从而允许选择最有效的治疗对于每个患有类风湿性关节炎的患者。本发明还涉及用于预防和发展新型抗TNF型药物的核酸阵列，以及在所述调节电路中具有作用模式的这种药物。

4. 发明授权

US06602294B1 Implantable substrates for the healing and protection of connecting tissue, preferably cartilage 失效
标题翻译：用于愈合和保护连接组织的植入物，优选软骨
公开(公告)号：US06602294B1
公开(公告)日：2003-08-05
申请号：US09718801
申请日：2000-11-22
申请人： Michael Sittinger , Olaf Schultz , Gerd-Rudiger Burmester
发明人： Michael Sittinger , Olaf Schultz , Gerd-Rudiger Burmester
IPC分类号： A61F228
CPC分类号： A61L27/227 , A61B17/00491 , A61F2/30756 , A61F2002/2817 , A61F2002/30677 , A61F2002/30678 , A61F2002/30929 , A61F2310/00377 , A61K38/00
摘要： Implantable substrate for the healing and/or protection of connecting tissue, preferably cartilage, comprising at least one composition for the activation of locally present cells for tissue regeneration and at least one structure for cell invasion in vivo and/or for the formation of cell matrix and/or for the release of constituents of the employed composition.
摘要翻译：用于愈合和/或保护连接组织（优选软骨）的可植入底物，其包含用于激活局部存在的细胞用于组织再生的至少一种组合物和用于体内细胞侵入和/或形成细胞基质的至少一种结构和/或用于释放所用组合物的组分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式