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1. 发明申请

US20140206898A1 PROCESS FOR THE ISOMERISATION OF SUBSTITUTED ALKENES 有权
标题翻译：取代替代碱基的方法
公开(公告)号：US20140206898A1
公开(公告)日：2014-07-24
申请号：US14129201
申请日：2012-07-12
申请人： Natascha Sereinig , Michèle Catherine Christianne Janssen , Johannes Gerardus De Vries
发明人： Natascha Sereinig , Michèle Catherine Christianne Janssen , Johannes Gerardus De Vries
IPC分类号： C07C67/333 , B01J31/24
CPC分类号： C07C67/333 , B01J31/24 , C07C69/58 , C07C69/587 , C07C69/716 , C07C69/732
摘要： The invention relates to a process for the isomerization of unsaturated fatty acids or esters or amides thereof, said process comprising reacting: (a) an unsaturated fatty acid or ester or amide thereof; (b) a source of Pd; (c) a bidentate diphosphine of formula I, R1R2>P1-R-P2
摘要翻译：本发明涉及不饱和脂肪酸或其酯或酰胺异构化的方法，所述方法包括使（a）不饱和脂肪酸或其酯或酰胺反应; （b）Pd源; （c）式I的二齿二膦，R1R2> P1-R-P2

2. 发明申请

US20140172459A1 CLINICAL SUPPORT SYSTEM AND METHOD 审中-公开
标题翻译：临床支持系统与方法
公开(公告)号：US20140172459A1
公开(公告)日：2014-06-19
申请号：US14105633
申请日：2013-12-13
申请人： Jan Johannes Gerardus De Vries , Aleksandra Tesanovic , Gijs Geleijnse
发明人： Jan Johannes Gerardus De Vries , Aleksandra Tesanovic , Gijs Geleijnse
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06Q50/24 , G16H50/30
摘要： The present invention relates to a clinical support system and a corresponding clinical support method. The system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining a health score curve over time of a patient, for whom a recommendation for a moment of discharge from a medical facility shall be provided, obtaining a reference curve to the health score curve, wherein said reference curve indicates a patient stabilization over time, computing a difference between the health score curve and said reference curve, and computing a recommended moment of discharge from the medical facility based on the difference between said health score curve and said reference curve. Further, the present invention relates to a computer-readable non-transitory storage medium and a computer program.
摘要翻译：本发明涉及临床支持系统和相应的临床支持方法。所述系统包括处理器和计算机可读存储介质，其中所述计算机可读存储介质包含由所述处理器执行的指令，其中所述指令使所述处理器执行以下步骤：随着患者的时间获得健康评分曲线，应向其提供从医疗设施排出一刻的建议，获得健康评分曲线的参考曲线，其中所述参考曲线表示患者随时间的稳定，计算健康评分曲线与所述参考曲线之间的差异并且基于所述健康评分曲线和所述参考曲线之间的差异来计算来自所述医疗设施的推荐排放时刻。此外，本发明涉及计算机可读的非暂时性存储介质和计算机程序。

3. 发明申请

US20090043112A1 Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid 有权
标题翻译：对映体富集的二氢吲哚-2-羧酸的制备方法
公开(公告)号：US20090043112A1
公开(公告)日：2009-02-12
申请号：US11794246
申请日：2005-12-22
申请人： Andreas Hendrikus Maria De Vries , Johannes Gerardus De Vries , Friso Bernard Jan Van Assema , Ben De Lange , Daniel Mink , David John Hyett , Peter Johannes Maas
发明人： Andreas Hendrikus Maria De Vries , Johannes Gerardus De Vries , Friso Bernard Jan Van Assema , Ben De Lange , Daniel Mink , David John Hyett , Peter Johannes Maas
IPC分类号： C07D209/42
CPC分类号： C07D209/42
摘要： The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound.
摘要翻译：本发明涉及一种制备对映体富集的任选取代的二氢吲哚-2-羧酸或其盐的方法，其中将对映异构体富集的手性邻-X取代的苯丙氨酸化合物（其中X为离去基团）在形成对映体富集的二氢吲哚-2-羧酸化合物时，优选在低于约140℃的温度下进行环化。

4. 发明授权

US08527041B2 System, method and computer program product for indicating stimulation signals to a user 有权
标题翻译：用于向用户指示刺激信号的系统，方法和计算机程序产品
公开(公告)号：US08527041B2
公开(公告)日：2013-09-03
申请号：US13203984
申请日：2010-02-26
申请人： Floris Maria Hermansz Crompvoets , Jan Johannes Gerardus De Vries , Dirk Brokken , Jacobus Maria Antonius Van Den Eerenbeemd , Paul Marcel Carl Lemmens
发明人： Floris Maria Hermansz Crompvoets , Jan Johannes Gerardus De Vries , Dirk Brokken , Jacobus Maria Antonius Van Den Eerenbeemd , Paul Marcel Carl Lemmens
IPC分类号： A61N1/00
CPC分类号： A61M21/00 , A61B5/02438 , A61B5/0245 , A61B5/1455 , A61B5/486 , A61B5/6805 , A61B5/7475 , A61M21/02 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0061 , A61M2209/088 , A61M2230/04 , A63B23/185
摘要： Stimulation system for indicating stimulation signals to a user, provided with at least one heart beat sensor for converting measured heart beats into a signal, a processing circuit configured to process the measured heart beat signals, a user interface configured to indicate stimulation signals to a user, wherein the processing circuit is configured to calculate intervals between the detected heart beats and register a predetermined number of successive intervals, predict a time interval between a detected heart beat and a predicted future heart beat based on the registered intervals, and instruct the user interface to indicate a stimulation signal to a user non-simultaneously with the predicted heart beat at the end of the predicted time interval so as to change the heart rate and/or heart coherence of the user.
摘要翻译：用于向用户指示刺激信号的刺激系统，设置有至少一个用于将测量的心跳转换为信号的心跳传感器，被配置为处理所测量的心跳信号的处理电路，被配置为向用户指示刺激信号的用户界面其中，所述处理电路被配置为计算检测到的心跳之间的间隔并且登记预定数量的连续间隔，基于所述注册间隔预测检测到的心跳和预测的未来心跳之间的时间间隔，并且指示用户界面以在预测时间间隔结束时与预测的心跳不同时地向用户指示刺激信号，以便改变用户的心率和/或心脏的一致性。

5. 发明申请

US20100069684A1 ASSYMMETRIC HYDROGENERATION OF PROCHIRAL COMPOUNDS 审中-公开
标题翻译：化合物的相对氢化
公开(公告)号：US20100069684A1
公开(公告)日：2010-03-18
申请号：US12520681
申请日：2007-12-21
申请人： Johannes Gerardus De Vries , Bart Stegink
发明人： Johannes Gerardus De Vries , Bart Stegink
IPC分类号： C07C29/143
CPC分类号： C07B53/00 , B01J31/1845 , B01J31/186 , B01J2231/643 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C29/145 , C07C33/22 , C07C33/18 , C07C33/46
摘要： The invention relates to the asymmetric (transfer) hydrogenation of a prochiral keton, prochiral imine, oxime, oxime derivative, hydrazone or hydrazone derivative, using a transition metal catalyst, characterized in that as a catalyst is used a transition metal complex of the general formula [I]: MaL1bL2c(N)dXe wherein a, b, c, d and e are integers; a, b and d can have a value of 1-6; c and e can have a value of 0-6; M is transition metal selected from the group consisting of Ru1 Rh and Ir; L1 is an enantiomerically enriched chiral monodentate phosphor-containing ligand of the general formula [II] or of the general formula [III]; L2 is any monodentate or bidentate neutral or monoanionic ligand, which may be chiral; N is a compound containing at least one primary or secondary amine group; X is a anion.
摘要翻译：本发明涉及使用过渡金属催化剂的前手性酮，前手性亚胺，肟，肟衍生物，腙或腙衍生物的不对称（转移）氢化，其特征在于，作为催化剂，使用通式 [I]：MaL1bL2c（N）dXe其中a，b，c，d和e是整数; a，b和d的值可以是1-6; c和e可以是0-6的值; M是选自Ru1 Rh和Ir的过渡金属; L1是通式[II]或通式[III]的对映异构体富集的手性单齿磷光体配体。 L2是任何单齿或二齿中性或单阴离子配体，其可以是手性的; N是含有至少一个伯或仲胺基的化合物; X是阴离子。

6. 发明申请

US20090298141A1 Continuous Chemical Proceses in Centrifugal Contact Separators 审中-公开
标题翻译：离心式接触分离器的连续化学处理
公开(公告)号：US20090298141A1
公开(公告)日：2009-12-03
申请号：US11991912
申请日：2006-09-15
申请人： Johannes Gerardus De Vries , Gerald Jan Kwant , Hero Jan Heeres
发明人： Johannes Gerardus De Vries , Gerald Jan Kwant , Hero Jan Heeres
IPC分类号： C12P7/64 , C12M1/00
CPC分类号： B01D17/0217 , B01F3/0807 , B01F7/008 , B01J14/00 , B01J19/1806 , C12P7/18 , C12P7/62 , C12P41/005 , Y02P20/582
摘要： The invention relates to the use of a centrifugal contact-separator for carrying out a non-radioactive reaction in a liquid-liquid emulsion formed from two immiscible liquids. The invention also relates to a process for carrying out a reaction in a centrifugal contact-separator, and to a process for carrying out a catalytic reaction in a centrifugal contact-separator. An example of a process for carrying out a reaction, comprising the following steps: i) continuously introducing a liquid phase A and a liquid phase B into at least one first centrifugal contact separator, where in liquid phases A and B are immiscible and wherein phase A and/or phase B comprise at least one reactant ii) mixing phase A and phase B thereby allowing an emulsion to be formed iii) applying a centrifugal force that allows phase separation of the emulsion, such that phases A′ and B′ are obtained; iv) optionally, recovering a reaction product from at least one or the phases A′ and B′.
摘要翻译：本发明涉及离心接触分离器在由两种不混溶液体形成的液 - 液乳液中进行非放射性反应的用途。本发明还涉及在离心式接触分离器中进行反应的方法以及在离心式分离器中进行催化反应的方法。一种进行反应的方法的实例包括以下步骤：i）将液相A和液相B连续引入到至少一个第一离心接触分离器中，其中液相A和B是不混溶的，其中相 A和/或B相包含至少一种反应物ii）混合A相和B相从而允许形成乳液iii）施加允许乳液相分离的离心力，从而获得相A'和B' ; iv）任选地，从至少一个或相A'和B'回收反应产物。

7. 发明授权

US6149311A Rolling element bearing having at least one rolling element which is harder than the other rolling elements and harder than the races 失效
标题翻译：具有至少一个滚动元件的滚动元件轴承比其它滚动元件更坚硬并且比比赛更硬
公开(公告)号：US6149311A
公开(公告)日：2000-11-21
申请号：US974807
申请日：1997-11-20
申请人： Antonio Gabelli , Piter Abraham Veenhuizen , Gerardus De Vries
发明人： Antonio Gabelli , Piter Abraham Veenhuizen , Gerardus De Vries
IPC分类号： F16C19/00 , F16C33/30 , F16C33/32 , F16C33/34 , F16C33/62
CPC分类号： F16C33/303 , F16C33/32 , F16C33/34 , F16C33/6651 , F16C2202/04 , F16C2202/06
摘要： A rolling element bearing having inner and outer rings and a plurality of rolling elements where one, two or at least one but not all of the rolling elements of the plurality of rolling elements is harder than the other of the plurality of rolling elements and harder than the rings.
摘要翻译：具有内圈和外圈的滚动元件轴承和多个滚动元件的多个滚动元件中的一个，两个或至少一个但不是全部的滚动元件比多个滚动元件中的另一个更硬，并且比第戒指。

8. 发明授权

US5492416A Rolling element bearing system with a filtering seal 失效
标题翻译：滚动轴承系统带过滤密封
公开(公告)号：US5492416A
公开(公告)日：1996-02-20
申请号：US159686
申请日：1993-11-30
申请人： Antonio Gabelli , Gerardus De Vries , Gerhard Poll
发明人： Antonio Gabelli , Gerardus De Vries , Gerhard Poll
IPC分类号： F16C23/08 , F16C33/66 , F16C33/78 , F16C33/72
CPC分类号： F16C33/7889 , F16C33/6666 , F16C33/667 , F16C33/78 , F16C33/7816 , F16C19/06 , F16C23/086 , Y10S277/918
摘要： A rolling element bearing system comprises at least one rolling element bearing with an outer race and an inner race which enclose a space containing rolling elements, which space is confined to the outside by sealing rings. At least one of the sealing rings and/or one of the races is provided with flow generating structure for feeding a lubricant into the space, as well as a filter for preventing the ingress of contaminations into the space with the lubricant. Preferably at least one of the sealing rings at its edge which slidably contacts one of the races has a shape which promotes the outflow out of the space towards the outside of the sealing ring during relative movement of the sealing ring and race.
摘要翻译：滚动体轴承系统包括至少一个滚动体轴承，其具有外圈和内圈，该内圈围绕包含滚动体的空间，所述空间通过密封圈限制在外部。密封环和/或其中一个座圈中的至少一个设置有用于将润滑剂供给到该空间中的流动产生结构，以及用于防止污染物通过润滑剂进入空间的过滤器。优选地，其边缘处的至少一个可滑动地接触其中一个座圈的密封环具有在密封圈和座圈的相对移动期间促进从密封环向密封环外部流出的形状。

9. 发明授权

US09962104B2 Stress-measuring device and method 有权
公开(公告)号：US09962104B2
公开(公告)日：2018-05-08
申请号：US14110454
申请日：2012-04-02
申请人： Jan Johannes Gerardus De Vries , Martin Ouwerkerk
发明人： Jan Johannes Gerardus De Vries , Martin Ouwerkerk
IPC分类号： A61B5/053 , A61B5/16 , A61B5/00 , A61B5/021 , A61B5/0205 , A61B5/024
CPC分类号： A61B5/0531 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/0533 , A61B5/165 , A61B5/6802 , A61B5/681 , A61B5/6831 , A61B5/72 , A61B5/7235
摘要： A stress-measuring device (10) and method determines a level (15) of stress of a user (1), in particular long-term stress. The stress-measuring device (10) includes an input interface (12) for receiving a skin conductance signal (11) indicating the skin conductance of the user (1), the skin conductance signal (11) over time forming skin conductance trace data (13). The stress-measuring device (10) further includes a processing unit (14) for processing the skin conductance trace data (13). The processing unit (14) determines, over at least a portion of the skin conductance trace data (13), values of a rise time (tr) between at least two different points of the skin conductance trace data (13), a frequency distribution of the rise time (tr) values, and the level (15) of stress of the user (1) based on the determined frequency distribution.

10. 发明授权

US08712948B2 Methods and systems for adapting a user environment 有权
标题翻译：适应用户环境的方法和系统
公开(公告)号：US08712948B2
公开(公告)日：2014-04-29
申请号：US13264058
申请日：2010-04-08
申请人： Philip Steven Newton , Henricus Fransiscus Petrus Maria Van Doveren , Dirk Brokken , Jacobus Maria Antonius Van Den Eerenbeemd , Floris Maria Hermansz Crompvoets , Paul Marcel Carl Lemmens , Jan Johannes Gerardus De Vries
发明人： Philip Steven Newton , Henricus Fransiscus Petrus Maria Van Doveren , Dirk Brokken , Jacobus Maria Antonius Van Den Eerenbeemd , Floris Maria Hermansz Crompvoets , Paul Marcel Carl Lemmens , Jan Johannes Gerardus De Vries
IPC分类号： G06F17/00
CPC分类号： H04N21/42201 , A63F13/02 , A63F13/06 , A63F13/10 , A63F13/12 , A63F2300/1012 , A63F2300/302 , A63F2300/409 , A63F2300/69 , A63F2300/8082 , H04N7/16 , H04N21/4131 , H04N21/42202 , H04N21/43615 , H04N21/6543 , H04N21/8352
摘要： A method of adapting an environment of a terminal (2) includes: —receiving data (27) from an external source at the terminal (2); —receiving monitoring data from a system for monitoring at least one user in the environment; and —controlling at least one output device for providing an output perceptible in the environment, the output being adjusted in dependence on the monitoring data. At least one segment including data pertaining to at least one mental state is retrieved from the data (27) from the external source, and the adjustment in dependence on the monitoring data is effected at least partly on the basis of the data pertaining to the at least one mental state.
摘要翻译：适应终端（2）的环境的方法包括：从终端（2）的外部源接收数据（27）; - 从用于监视环境中的至少一个用户的系统接收监视数据; 并且控制至少一个输出设备以提供在环境中可感知的输出，该输出根据监视数据进行调整。从外部来源从数据（27）检索至少包括与至少一个精神状态有关的数据的段，并且根据监视数据进行的调整至少部分地基于与at 至少一个精神状态。

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