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1. 发明申请

US20060216730A1 Novel human protein kinases and protein kinase-like enzymes 审中-公开
公开(公告)号：US20060216730A1
公开(公告)日：2006-09-28
申请号：US11320072
申请日：2005-12-29
申请人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez , Peter Flanagan , Douglas Clary
发明人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez , Peter Flanagan , Douglas Clary
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： G01N33/6896 , C12Q1/485 , G01N33/57407 , G01N33/6893
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.

2. 发明申请

US20060140954A1 Novel human protein kinases and protein kinase-like enzymes 审中-公开
公开(公告)号：US20060140954A1
公开(公告)日：2006-06-29
申请号：US11299791
申请日：2005-12-13
申请人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez
发明人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez
IPC分类号： A61K39/395 , C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/12 , C07K16/40
CPC分类号： C07K16/40 , C12N9/1205 , C12Q1/485 , G01N2500/00
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.

3. 发明申请

US20050054070A1 Mammalian protein phosphatases 审中-公开
标题翻译：哺乳动物蛋白磷酸酶
公开(公告)号：US20050054070A1
公开(公告)日：2005-03-10
申请号：US10716442
申请日：2003-11-20
申请人： Gregory Plowman , David Whyte , Gerard Manning
发明人： Gregory Plowman , David Whyte , Gerard Manning
IPC分类号： A61K38/00 , C12N9/16 , C07H21/04
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.
摘要翻译：本发明涉及磷酸酶多肽，编码磷酸酶多肽的核苷酸序列，以及可用于诊断和治疗各种磷酸酶相关疾病和病症的各种产品和方法。通过使用生物信息学策略，已经鉴定了MAP激酶磷酸酶PTP和STP的哺乳动物成员，并预测了其蛋白质结构。

4. 发明申请

US20060204994A1 Novel human protein kinases and protein kinase-like enzymes 审中-公开
公开(公告)号：US20060204994A1
公开(公告)日：2006-09-14
申请号：US11367775
申请日：2006-03-06
申请人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez , Sean Caenepeel
发明人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez , Sean Caenepeel
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.

5. 发明申请

US20060234344A1 Protein kinases 审中-公开
标题翻译：蛋白激酶
公开(公告)号：US20060234344A1
公开(公告)日：2006-10-19
申请号：US11377316
申请日：2006-03-17
申请人： Gregory Plowman , Ricardo Martinez , David Whyte , Sucha Sudarsanam , Gerard Manning
发明人： Gregory Plowman , Ricardo Martinez , David Whyte , Sucha Sudarsanam , Gerard Manning
IPC分类号： C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to novel kinase polypetides, nucleotide sequences encoding the novel kinase polypetides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related disease and conditions.
摘要翻译：本发明涉及新型激酶多肽，编码新型激酶多肽的核苷酸序列，以及可用于诊断和治疗各种激酶相关疾病和病症的各种产物和方法。

6. 发明申请

US20070202107A1 Novel kinases 审中-公开
标题翻译：新型激酶
公开(公告)号：US20070202107A1
公开(公告)日：2007-08-30
申请号：US11407888
申请日：2006-04-21
申请人： David Whyte , Gerard Manning , Sean Caenepeel
发明人： David Whyte , Gerard Manning , Sean Caenepeel
IPC分类号： A61K38/55 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C12N9/12
CPC分类号： C12N9/12
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.
摘要翻译：本发明涉及激酶多肽，编码激酶多肽的核苷酸序列，以及可用于诊断和治疗各种激酶相关疾病和病症的各种产物和方法。通过使用生物信息学策略，确定了PTK和STK的哺乳动物成员，并预测了其蛋白质结构。

7. 发明申请

US20050084877A1 Mammalian protein phosphatases 审中-公开
标题翻译：哺乳动物蛋白磷酸酶
公开(公告)号：US20050084877A1
公开(公告)日：2005-04-21
申请号：US10838181
申请日：2004-05-04
申请人： Gregory Plowman , Ricardo Martinez , David Whyte , Gerard Manning , Sucha Sudarsanam , Ronald Hill , Peter Flanagan
发明人： Gregory Plowman , Ricardo Martinez , David Whyte , Gerard Manning , Sucha Sudarsanam , Ronald Hill , Peter Flanagan
IPC分类号： C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/68
CPC分类号： C07H21/04 , C07K16/40 , C12N9/16 , G01N2800/042
摘要： The present invention relates to phosphatase polypeptides having the amino acid sequence of SEQ ID NO:23 or SEQ ID NO:24, disclosed herein. The invention also relates to nucleotide sequences encoding the phosphatase polypeptides, vectors and recombinant cells comprising such sequences, antibodies having binding affinity to the phosphatase polypeptides, and other products. Included in the invention are methods for identifying modulators of the phosphatase polypeptides, as well as methods for diagnosing and treating various conditions related to the phosphatase polypeptides.
摘要翻译：本发明涉及具有本文公开的SEQ ID NO：23或SEQ ID NO：24的氨基酸序列的磷酸酶多肽。本发明还涉及编码磷酸酶多肽的核苷酸序列，载体和包含此类序列的重组细胞，对磷酸酶多肽具有结合亲和力的抗体，以及其它产物。本发明包括用于鉴定磷酸酶多肽的调节剂的方法，以及用于诊断和治疗与磷酸酶多肽相关的各种病症的方法。

8. 发明申请

US20060188974A1 Human protein kinases and protein kinase-like enzymes 审中-公开
公开(公告)号：US20060188974A1
公开(公告)日：2006-08-24
申请号：US11375615
申请日：2006-03-15
申请人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez
发明人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez
IPC分类号： C12N9/12 , C07H21/04 , C12P21/06
CPC分类号： C12N9/1205 , C07H21/04 , G01N2333/948
摘要： The present invention relates to kinase polypeptides, nucleotides sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment jof various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted. >SGK177 (SEQ ID NO: 1) GCGGAGACGCCCGCTGGCAAGCAGATCCTGCCTCCTTCCCTGGCCAAGGA GCCGCCCCTCCGGGGTAGCTGTGCGCTGGGCGGCGCTCGGACCCCTTGGC AGCCGCAGGTGCCTCCCCAGCCCAGCCCAGCTCAGTCCAGCGCAGCCCAG CCCAGCCCAGCCCGGCGCTCGCAGCCTCCGCCGCTTCCGGGCAGATAGGT GCCTTTTCTTGCTCCTTGCTCTTGGAGTTCTTCTCTTAGTCCCTGTTCCC TGGATGAAAGCATCGCTCCGAGCCTCATGGGAGGAATGAAGGAAGAATCG AGACTAGATATCCAACTAAGGCTTCGGGACATGTTTTGAGCGAAGATGGG TGTTTCTGCCCGGATAGTATAAATCGAGGATCCAGGTCTGGGCAGATTCA ACCATGGGAGCCAACACTTCAAGAAAACCACCAGTGTTTGATGAAAATGA AGATGTCAACTTTGACCACTTTGAAATTTTGCGAGCCATTGGGAAAGGCA GTTTTGGGAAGGTCTGCATTGTACAGAAGAATGATACCAAGAAGATGTAC GCAATGAAGTACATGAATAAACAAAAGTGCGTGGAGCGCAATGAAGTGAG AAATGTCTTCAAGGAACTCCAGATCATGCAGGGTCTGGAGCACCCTTTCC TGGTTAATTTGTGGTATTCCTTCCAAGATGAGGAAGACATGTTCATGGTG GTGGACCTCCTGCTGGGTGGAGACCTGCGTTATCACCTGCAACAGAACGT CCACTTCAAGGAAGAAACAGTGAAGCTCTTCATCTGTGAGCTGGTCATGG CCCTGGACTACCTGCAGAACCAGCGCATCATTCACAGGGATATGAAGCCT GACAATATTTTACTTGACGAACATGGGCACGTGCACATCACAGATTTCAA CATTGCTGCGATGCTGCCCAGGGAGACACAGATTACCACCATGGCTGGCA CCAAGCCTTACATGGCACCTGAGATGTTCAGCTCCAGAAAAGGAGCAGGC TATTCCTTTGCTGTTGACTGGTGGTCCCTGGGAGTGACGGCATATGAACT GCTGAGAGGCCGGAGACCGTATCATATTCGCTCCAGTACTTCCAGCAAGG AAATTGTACACACGTTTGAGACGACTGTTGTAACTTACCCTTCTGCCTGG TCACAGGAAATGGTGTCACTTCTTAAAAAGCTACTCGAACCTAATCCAGA CCAACGATTTTCTCAGTTATCTGATGTCCAGAACTTCCCGTATATGAATG ATATAAACTGGGATGCAGTTTTTCAGAAGAGGCTCATTCCAGGTTTCATT CCTAATAAAGGCAGGCTGAATTGTGATCCTACCTTTGAACTTGAGGAAAT GATTTTGGAGTCCAAACCTCTACATAAGAAAAAAAAGCGTCTGGCAAAGA AGGAGAAGGATATGAGGAAATGCGATTCTTCTCAGACATGTCTTCTTCAA GAGCACCTTGACTCTGTCCAGAAGGAGTTCATAATTTTCAACAGAGAAAA AGTAAACAGGGACTTTAACAAAAGACAACCAAATCTAGCCTTGGAACAAA CCAAAGACCCACAAGGTGAGGATGGTCAGAATAACAACTTGTAA >SGK172 (SEQ ID NO: 2) TCCTCTCCAAACCCATCACCCCTGTCAAGCCATGAGGAAAACATCAGACA AATCCCAGTGGAAGACATTCTACAAAACACCGGATCAGTACAACTCAC >SGK159 (SEQ ID NO: 3) ATGCCCGCCCACTCCCTGGTGGCAGGTGAGGCGGAGCGGGGCGCTCGGCG CGCGGGGCGGGGCGCGCCGGGGGGAAGGGCGCGGGCTGCGCGCGCCGCTA TTGTGTGCGGGGCTCCTCCGCACGGCGAGGCGCGGGCGCTGCTCTCCGCT CCGCCAGGCCGCCGCCAGACTCTGGCCACGGCCCGCGCGCTCCTCGCCTC TCGCTTCCGCACCGCCCCACAGCCCCGCCGCCGCCGTGCCGCCGCCGCCG CCGCCGCCTCCTCGGACGCTAAGCTCAGCCAGCCGGCTCTCGCCGCACTC CCGCCCGGCCCGCACTCTGCGCCGCAGGAAGGGGAGGGCCGGGGGGAGTG CCATAAGCGTCACCGGCACTGCCCAGTCGTCGTGTCAGAGGCCACCATCG TGGGCATCTGCAAGACCAGGCAGATCTGGCCCAACGATGCGGAGGGCACC TTCCATGGAGACGCAGTTTCCTTGAAGTGA >SGK165 (SEQ ID NO: 4) CCCATGGGAAGGTGCTGTTTGGGTATGAAGCGCTGGACTGACAGATCAAG TGGGCTGGCATTTGGTGGGGGCCCGATGCAGGCCCCACAGAGGCTCCCGA GCCCTTTTGGATCTTCCCCGTTTCCAGCCCATTTTCCAGAACAGAACCTC CAAGGCCCCAGGCTTCTCTCCGGGTGGGAGGGTAACACCCTGGCAGCCTG GATTCCATCTCACCAGCCCCGCAGAACACTCTCCCCCATGCCCCCGGGAC TGGGAGCCCCTGGGTTGGGGAGTTCCTCTGCCTGCCACCTCCCTCTCGCC TCCCCATCCCCCCACCCCACTAAGAAATTCCACGGAGGCCGCTTCCTTCC TGCTTTTAGGAAAAAACACTTTGTCTTAAGCTTCCGCTCCTCCGAGAGAC GGGGGATCTCTGTTTCCTCCGATTGCGCTGTCCTGGGGCCT

9. 发明申请

US20050287546A1 Novel proteases 审中-公开
标题翻译：新型蛋白酶
公开(公告)号：US20050287546A1
公开(公告)日：2005-12-29
申请号：US11037243
申请日：2005-01-19
申请人： Gregory Plowman , David Whyte , Sean Caenepeel , Glen Charydczak , Gerard Manning , Sucha Sudarsanam
发明人： Gregory Plowman , David Whyte , Sean Caenepeel , Glen Charydczak , Gerard Manning , Sucha Sudarsanam
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/02 , A61P11/06 , A61P15/10 , A61P17/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/566 , C07H21/04 , C12N9/48 , C12P21/06
CPC分类号： C12N9/6421 , A61K38/00 , C07K2319/00
摘要： The present invention relates to protease polypeptides, nucleotide sequences encoding the protease polypeptides, as well as various products and methods useful for the diagnosis and treatment of various protease-related diseases and conditions.
摘要翻译：本发明涉及蛋白酶多肽，编码蛋白酶多肽的核苷酸序列，以及可用于诊断和治疗各种蛋白酶相关疾病和病症的各种产物和方法。

10. 发明申请

US20050125852A1 Novel kinases 审中-公开
标题翻译：新型激酶
公开(公告)号：US20050125852A1
公开(公告)日：2005-06-09
申请号：US10840512
申请日：2004-05-07
申请人： Sean Caenepeel , Gerard Manning , Glen Charydczak , Igor Grigoriev
发明人： Sean Caenepeel , Gerard Manning , Glen Charydczak , Igor Grigoriev
IPC分类号： A01K67/027 , A61K20060101 , C07H21/04 , C12N9/12 , C12N15/58 , C12Q1/68
CPC分类号： C12N9/1205
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of protein and lipid kinase families have been identified and their protein structure predicted.
摘要翻译：本发明涉及激酶多肽，编码激酶多肽的核苷酸序列，以及可用于诊断和治疗各种激酶相关疾病和病症的各种产物和方法。通过使用生物信息学策略，已经鉴定了蛋白质和脂质激酶家族的哺乳动物成员，并预测了其蛋白质结构。

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