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1. 发明授权

US6139877A Spheroids containing tiagabine, preparation process and pharmaceutical compositions 有权
标题翻译：含有噻加滨的球体，制备方法和药物组合物
公开(公告)号：US6139877A
公开(公告)日：2000-10-31
申请号：US198564
申请日：1998-11-23
申请人： Patrice Debregeas , Gerard Leduc , Pascal Oury , Pascal Suplie
发明人： Patrice Debregeas , Gerard Leduc , Pascal Oury , Pascal Suplie
IPC分类号： A61K9/20 , A61K9/26 , A61K9/50 , A61K31/4535 , A61K47/12 , A61K47/14 , A61K47/34 , A61K47/44 , A61P25/08 , A61K9/16 , A61K9/48 , A61K31/445
CPC分类号： A61K9/5078 , A61K31/4535
摘要： The present invention relates to a novel pharmaceutical form, in the form of spheroids, containing tiagabine as active principle. The invention also covers the process for the preparation of such spheroids and multiparticulate pharmaceutical preparations, such as tablets, containing these spheroids. These pharmaceutical preparations are intended for the delivery of the spheroids they contain, and are characterized by the absence of an adverse effect on the release profile of the tiagabine contained in the spheroids following a possible compression step.
摘要翻译：本发明涉及一种新颖的药物形式，以球状蛋白的形式含有噻加宾作为活性成分。本发明还涵盖了制备包含这些球体的这种球状体和多颗粒药物制剂例如片剂的方法。这些药物制剂用于递送其所含的球体，其特征在于在可能的压缩步骤之后，对包含在球体中的替加滨的释放曲线没有不利影响。

2. 发明授权

US6077544A Spheroids, preparation process and pharmaceutical compositions 有权
标题翻译：球状体，制备方法和药物组合物
公开(公告)号：US6077544A
公开(公告)日：2000-06-20
申请号：US197466
申请日：1998-11-23
申请人： Patrice Debregeas , Gerard Leduc , Pascal Oury , Pascal Suplie
发明人： Patrice Debregeas , Gerard Leduc , Pascal Oury , Pascal Suplie
IPC分类号： A61K9/20 , A61K9/26 , A61K9/50 , A61K31/34 , A61K31/485 , A61K9/16
CPC分类号： A61K31/485 , A61K31/34 , A61K9/2095 , A61K9/5078
摘要： The present invention relates to a novel pharmaceutical form, in the form of spheroids, containing one or more active principles, which the exception of tiagabine.The invention also covers the process for the preparation of such spheroids and multiparticulate pharmaceutical preparations, such as tablets, containing these spheroids.These pharmaceutical preparations are intended for the delivery of the spheroids they contain, and are characterized by the absence of an adverse effect on the release profile of the active principle(s) following a possible compression step.
摘要翻译：本发明涉及一种包含一种或多种活性成分的球状体形式的新型药物形式，除了替加宾之外。本发明还涵盖了制备包含这些球体的这种球状体和多颗粒药物制剂例如片剂的方法。这些药物制剂用于递送其包含的球体，其特征在于在可能的压缩步骤之后对活性成分的释放曲线没有不利影响。

3. 发明授权

US4960596A Slow-release preparation of diltiazem, and a medicine provided thereby 失效
标题翻译：缓释地尔硫卓制剂及其提供的药物
公开(公告)号：US4960596A
公开(公告)日：1990-10-02
申请号：US275354
申请日：1988-11-23
申请人： Patrice Debregeas , Gerard Leduc , Jean-Francois Boyer
发明人： Patrice Debregeas , Gerard Leduc , Jean-Francois Boyer
IPC分类号： A61K9/16 , A61K9/22 , A61K9/48 , A61K9/50 , A61K9/54 , A61K9/56 , A61K31/55 , A61K47/32 , A61K47/38 , A61P9/08 , A61P9/10 , A61P9/12
CPC分类号： A61K31/55 , A61K9/5078
摘要： The slow release preparation obtained by the method of the invention reduces the number of times the medicine needs to be taken per day, and also provides lower peaks of concentration in the blood after the medicine has been taken while simultaneously ensuring that the lowest concentration in the blood remains higher over a period of time.
摘要翻译：通过本发明的方法获得的缓释制剂每天减少药物需要摄取的次数，并且在药物被摄取之后还在血液中提供较低的浓度峰值，同时确保在药物中最低浓度血液在一段时间内仍然较高。

4. 发明授权

US3376822A Variable-delivery hydraulic pump 失效
标题翻译：变送液压泵
公开(公告)号：US3376822A
公开(公告)日：1968-04-09
申请号：US60718867
申请日：1967-01-04
申请人： RENE LEDUC , GERARD LEDUC
发明人： RENE LEDUC , GERARD LEDUC
IPC分类号： F04B1/14 , F04B1/29
CPC分类号： F04B1/146 , F04B1/295

5. 发明授权

US5385739A Stable compositions of gastroprotected omerprazole microgranules and process for the production thereof 失效
标题翻译：胃保护性奥美拉唑微粒的稳定组合物及其生产方法
公开(公告)号：US5385739A
公开(公告)日：1995-01-31
申请号：US78548
申请日：1993-06-16
申请人： Patrice Debregeas , Gerard Leduc
发明人： Patrice Debregeas , Gerard Leduc
IPC分类号： A61K9/52 , A61K9/16 , A61K9/50 , A61K31/44 , A61K47/02 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/38 , A61K9/54 , A61K9/62
CPC分类号： A61K9/1676 , A61K31/44 , A61K9/5078
摘要： The present invention relates to a stable formulation of omeprazole microgranules containing a neutral core consisting of sugar and starch, characterized in that it contains an active layer consisting of a dilution of omeprazole in mannitol in substantially equal amounts. It also relates to a process for producing such formulations.
摘要翻译：本发明涉及含有由糖和淀粉组成的中性核心的奥美拉唑微粒的稳定制剂，其特征在于其含有基本上相等量的甘露醇中的奥美拉唑稀释液的活性层。它还涉及制备这种制剂的方法。

6. 再颁专利

USRE35903E Slow-release preparation of diltiazem, and a medicine provided thereby 失效
公开(公告)号：USRE35903E
公开(公告)日：1998-09-22
申请号：US903247
申请日：1992-06-23
申请人： Patrice Debregeas , Gerard Leduc , Jean-Francois Boyer
发明人： Patrice Debregeas , Gerard Leduc , Jean-Francois Boyer
IPC分类号： A61K9/16 , A61K9/22 , A61K9/48 , A61K9/50 , A61K9/54 , A61K9/56 , A61K31/55 , A61K47/32 , A61K47/38 , A61P9/08 , A61P9/10 , A61P9/12
CPC分类号： A61K31/55 , A61K9/5078
摘要： The slow release preparation obtained by the method of the invention reduces the number of times the medicine needs to be taken per day, and also provides lower peaks of concentration in the blood after the medicine has been taken while simultaneously ensuring that the lowest concentration in the blood remains higher over a period of time.

7. 发明授权

US5549911A Galenic form of 5-nitromidazole derivatives which is effective for the treatment of parasitoses and infections of the entire gastrointestinal tract 失效
标题翻译： 5-硝唑唑衍生物的Galenic形式，其对于治疗寄生虫和整个胃肠道感染是有效的
公开(公告)号：US5549911A
公开(公告)日：1996-08-27
申请号：US371520
申请日：1995-01-11
申请人： Gerard Leduc , Patrice Debregeas
发明人： Gerard Leduc , Patrice Debregeas
IPC分类号： A61K9/26 , A61K9/50 , A61K31/415 , A61K9/22 , A61K9/52 , A61K9/54
CPC分类号： A61K9/5084 , A61K31/415
摘要： The present invention relates to a galenic form of 5-nitroimidazole derivatives which is characterized in that it comprises a combination of microgranules of 5-nitroimidazole derivatives consisting, on the one hand, of gastroresistant microgranules and, on the other hand, of prolonged-release microgranules, the pharmaceutical compositions comprising them and the microgranules as intermediates in the preparation of the form according to the invention.
摘要翻译：本发明涉及5-硝基咪唑衍生物的galenic形式，其特征在于其包含5-硝基咪唑衍生物的微粒的组合，一方面由胃阻的微粒组成，另一方面由长时间释放微粒，包含它们的药物组合物和微粒作为制备本发明形式的中间体。

8. 发明授权

US3981630A Hydraulic swash plate pumps 失效
标题翻译：液压斜盘泵
公开(公告)号：US3981630A
公开(公告)日：1976-09-21
申请号：US580973
申请日：1975-05-27
申请人： Gerard Leduc , Michel Leduc
发明人： Gerard Leduc , Michel Leduc
IPC分类号： F04B1/14 , F04B1/18 , F04B1/12
CPC分类号： F04B1/148 , F04B1/146 , F04B1/184
摘要： A swash plate pump of the type wherein a plurality of pistons bear against the swash plate and are given a reciprocating movement when the plate is rotated by a drive shaft. The drive shaft comprises a solid portion and a hollow portion which latter constitutes a central admission conduit for the liquid to be pumped. The swash plate is mounted at the junction between the solid and hollow portions of the shaft, and the plate has an aperture which communicates with the central conduit and a crescent-shaped port for liquid distribution to the pistons. These pistons are arranged in a circle concentric with the solid shaft portion. A taper roller bearing is mounted on the hollow shaft portion and the front face of the swash plate bears against the roller bearing. The discharge flow of liquid can be divided for distribution into several separate flows by a cylindrical sleeve located on the solid shaft portion.
摘要翻译：这种类型的旋转斜盘泵，其中多个活塞抵靠斜盘，并且当板被驱动轴旋转时给予往复运动。驱动轴包括固体部分和中空部分，后者构成用于待泵送的液体的中心进入管道。旋转斜盘安装在轴的实心部分和中空部分之间的连接处，并且板具有与中心管道连通的孔口和用于液体分配到活塞的月牙形端口。这些活塞与实心轴部分同心地设置。圆锥滚子轴承安装在空心轴部分上，斜盘的前表面抵靠滚子轴承。可以通过位于实心轴部分上的圆柱形套筒来分配液体的排出流分配成几个分开的流。

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