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1. 发明授权

US06576455B1 Structure-based designed herbicide resistant products 失效
标题翻译：基于结构设计的除草剂抗性产品
公开(公告)号：US06576455B1
公开(公告)日：2003-06-10
申请号：US09367512
申请日：2000-08-17
申请人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
发明人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
IPC分类号： C12N988
CPC分类号： C12N9/88 , C12N15/8278 , G06F19/16
摘要： Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.
摘要翻译：本文公开了用于制备乙酰羟酸合酶（AHAS）变体的基于结构的建模方法，包括对除草剂如咪唑啉除草剂和AHAS抑制性除草剂显示选择性增加的抗性的那些。本发明包括编码这种变体的分离的DNA，包括DNA的载体，以及用于产生含有特异性AHAS基因突变的变体多肽和除草剂抗性植物的方法。还提供了作物杂草防治方法。

2. 发明授权

US4686365A Fourier transform ion cyclothon resonance mass spectrometer with spatially separated sources and detector 失效
标题翻译：具有空间分离源和检测器的傅里叶变换离子环共振质谱仪
公开(公告)号：US4686365A
公开(公告)日：1987-08-11
申请号：US685811
申请日：1984-12-24
申请人： John T. Meek , Gerald W. Stockton
发明人： John T. Meek , Gerald W. Stockton
IPC分类号： G01N27/62 , H01J49/38 , B01D59/44
CPC分类号： H01J49/38
摘要： A Fourier transform ion cyclotron resonance (ICR) mass spectrometer, with a vacuum housing comprising three differentially pumped regions allows spatial separation of the processes for generation, translocation, and detection of the ionic species. The ion source provides inlets for solid, liquid, and gaseous samples from direct injection or chromatographic interfaces. Provision is made for ionization by electron impact, chemical ionization, fast atom bombardment, and laser ionization. A system of electrostatic lenses accelerates, focusses, and decelerates the ions for transmission to the ion detector. The mass analyzer includes an ion cyclotron resonance cell in which the ionic motions are detected by amplification of a small "image" current induced in the walls of the cell and made to flow through external detection circuitry. The characteristic frequencies of the ionic motions are revealed by Fourier transformation of the digitized image current, and related to the ionic masses by a simple algebraic calibration function. High resolution and accuracy in the measured masses are achieved through the ultra high vacuum in the analyzer region, and the use of very large data tables for the digital representation of the image current. Such large data arrays (typically 512K words) require the use of a high speed array processor for the Fourier transformation and other mathematical processing, and high capacity magnetic storage media for the mass spectral data arrays. Electronic circuitry achieves an extremely large dynamic range in the ICR mass measurement.
摘要翻译：具有包括三个差分泵浦区域的真空壳体的傅立叶变换离子回旋共振（ICR）质谱仪允许用于离子物质的产生，易位和检测的过程的空间分离。离子源为直接注入或色谱界面的固体，液体和气体样品提供入口。通过电子冲击，化学电离，快速原子轰击和激光电离进行电离。静电透镜系统加速，聚焦和减速离子以传输到离子检测器。质量分析器包括离子回旋共振电池，其中通过放大在电池壁中感应的小的“图像”电流并使其流过外部检测电路来检测离子运动。通过数字化图像电流的傅里叶变换揭示离子运动的特征频率，并通过简单的代数校准函数与离子质量相关。测量质量的高分辨率和精度通过分析仪区域中的超高真空实现，并且使用非常大的数据表来进行图像电流的数字表示。这种大数据阵列（通常为512K字）需要使用用于傅里叶变换和其他数学处理的高速阵列处理器和用于质谱数据阵列的高容量磁存储介质。电子电路在ICR质量测量中实现了极大的动态范围。

3. 发明授权

US06855533B2 Structure-based designed herbicide resistant products 失效
标题翻译：基于结构设计的除草剂抗性产品
公开(公告)号：US06855533B2
公开(公告)日：2005-02-15
申请号：US10407339
申请日：2003-04-04
申请人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
发明人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
IPC分类号： A01H5/00 , C07K14/415 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/82 , C12P21/02 , C12R1/19
CPC分类号： C12N9/88 , C12N15/8278 , G06F19/16
摘要： Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.
摘要翻译：本文公开了用于制备乙酰羟酸合酶（AHAS）变体的基于结构的建模方法，包括对除草剂如咪唑啉除草剂和AHAS抑制性除草剂显示选择性增加的抗性的那些。本发明包括编码这种变体的分离的DNA，包括DNA的载体，以及用于产生含有特异性AHAS基因突变的变体多肽和除草剂抗性植物的方法。还提供了作物杂草防治方法。

4. 发明授权

US4892707A Apparatus for the calorimetry of chemical processes 失效
标题翻译：用于化学过程量热法的装置
公开(公告)号：US4892707A
公开(公告)日：1990-01-09
申请号：US517189
申请日：1983-07-25
申请人： Gerald W. Stockton , Dale H. Chidester , Susan J. Ehrlich
发明人： Gerald W. Stockton , Dale H. Chidester , Susan J. Ehrlich
IPC分类号： B01J19/00 , G01N25/48
CPC分类号： G01N25/4846 , B01J19/0006
摘要： A calorimeter for measuring the thermodynamic and kinetic characteristics of chemical reactions, microbial fermentations, and other processes of industrial importance is described. The present invention also relates to a method of operation of this apparatus.
摘要翻译：描述了用于测量化学反应，微生物发酵和工业重要性的其它工艺的热力学和动力学特性的量热计。本发明还涉及该装置的操作方法。

5. 发明授权

US5928937A Structure-based designed herbicide resistant products 失效
公开(公告)号：US5928937A
公开(公告)日：1999-07-27
申请号：US455355
申请日：1995-05-31
申请人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
发明人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
IPC分类号： A01H5/00 , C07K14/415 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/29 , C12N15/82 , C12P21/02 , C12R1/19 , A01H4/00
CPC分类号： C12N15/8278 , C12N9/88
摘要： Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.

6. 发明授权

US5853973A Structure based designed herbicide resistant products 失效
标题翻译：基于结构设计的除草剂抗性产品
公开(公告)号：US5853973A
公开(公告)日：1998-12-29
申请号：US426125
申请日：1995-04-20
申请人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
发明人： Genichi Kakefuda , Karl-Heinz Ott , Jae-Gyu Kwagh , Gerald W. Stockton
IPC分类号： A01H5/00 , C07K14/415 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/29 , C12N15/82 , C12P21/02 , C12R1/19 , C12Q1/00
CPC分类号： C12N15/8278 , C12N9/88
摘要： Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.
摘要翻译：本文公开了用于制备乙酰羟酸合酶（AHAS）变体的基于结构的建模方法，包括对除草剂如咪唑啉除草剂和AHAS抑制性除草剂显示选择性增加的抗性的那些。本发明包括编码这种变体的分离的DNA，包括DNA的载体，以及用于产生含有特异性AHAS基因突变的变体多肽和除草剂抗性植物的方法。还提供了作物杂草防治方法。

7. 发明授权

US4963499A Method for the calorimetry of chemical processes 失效
标题翻译：化学过程量热法的方法
公开(公告)号：US4963499A
公开(公告)日：1990-10-16
申请号：US315363
申请日：1989-02-24
申请人： Gerald W. Stockton , Dale H. Chidester , Susan J. Ehrlich
发明人： Gerald W. Stockton , Dale H. Chidester , Susan J. Ehrlich
IPC分类号： B01J19/00 , G01N25/48
CPC分类号： G01N25/4846 , B01J19/0006
摘要： A calorimeter for measuring the thermodynamic and kinetic characteristics of chemical reactions, microbial fermentations, and other processes of industrial importance is described. The present invention also relates to a method of operation of this apparatus.
摘要翻译：描述了用于测量化学反应，微生物发酵和工业重要性的其它工艺的热力学和动力学特性的量热计。本发明还涉及该装置的操作方法。

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