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1. 发明授权

US5993786A Anti-carious chewing gums, candies, gels, toothpastes and dentifrices 失效
标题翻译：抗龋齿的口香糖，糖果，凝胶，牙膏和牙粉
公开(公告)号：US5993786A
公开(公告)日：1999-11-30
申请号：US88869
申请日：1998-06-02
申请人： Laurence C. Chow , Shozo Takagi , Gerald L. Vogel
发明人： Laurence C. Chow , Shozo Takagi , Gerald L. Vogel
IPC分类号： A23G3/00 , A23G3/34 , A23G3/36 , A23G4/00 , A23G4/06 , A61K8/00 , A61K8/19 , A61K8/20 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K9/68 , A61K33/42 , A61P19/00 , A61Q11/00 , A61K7/16
CPC分类号： A61Q11/00 , A23G3/362 , A23G4/064 , A61K8/19 , A61K8/24 , A61K9/0058
摘要： The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride. In addition, the formulations of the invention can be used to desensitize hypersensitive teeth.
摘要翻译：本发明涉及抗转运载体，特别是口香糖，糖果，糖果，牙膏，洁齿剂和凝胶。本发明专门提供口香糖，糖果，糖果，牙膏，洁牙剂和含有无毒性微溶钙和磷酸盐化合物作为添加剂的凝胶，导致钙和磷酸根离子逐渐持续持续一段时间不间断 5分钟。本发明提供了释放的磷酸钙离子，其扩散到部分去矿物质的牙釉质或牙本质中，导致龋齿病变，牙斑，开口牙质小管和暴露牙本质的再矿化和修复。因此，本发明提供了用于牙齿再矿化的药剂和方法，并且用于在蔗糖摄入之后减少或消除斑块中的致龋性攻击。因此，本发明的制剂可以在不使用氟化物的情况下产生有效的防龋作用。此外，本发明的制剂可用于使过敏性牙齿脱敏。

2. 发明授权

US5833954A Anti-carious chewing gums, candies, gels, toothpastes and dentifrices 失效
公开(公告)号：US5833954A
公开(公告)日：1998-11-10
申请号：US704420
申请日：1996-08-20
申请人： Laurence C. Chow , Shozo Takagi , Gerald L. Vogel
发明人： Laurence C. Chow , Shozo Takagi , Gerald L. Vogel
IPC分类号： A23G3/00 , A23G3/34 , A23G3/36 , A23G4/00 , A23G4/06 , A61K8/00 , A61K8/19 , A61K8/20 , A61K8/24 , A61K8/36 , A61K8/362 , A61K8/365 , A61K9/68 , A61K33/42 , A61P19/00 , A61Q11/00 , A61K7/16
CPC分类号： A61Q11/00 , A23G3/362 , A23G4/064 , A61K8/19 , A61K8/24 , A61K9/0058
摘要： The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride. In addition, the formulations of the invention can be used to desensitize hypersensitive teeth.

3. 发明授权

US06491900B2 Anti-carious candies and confections 有权
标题翻译：反龋糖果和糖果
公开(公告)号：US06491900B2
公开(公告)日：2002-12-10
申请号：US09771473
申请日：2001-01-26
申请人： Laurence C. Chow , Shozo Takagi , Gerald L. Vogel
发明人： Laurence C. Chow , Shozo Takagi , Gerald L. Vogel
IPC分类号： A61K716
CPC分类号： A23G3/368 , A23G3/362 , A23G4/064 , A61K6/0017 , A61K6/0085 , A61K8/19 , A61K8/24 , A61K9/0058 , A61Q11/00
摘要： Candies and confectioneries containing non-toxic sparingly soluble calcium and phosphate compounds as additives, cause the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than five minutes. Released calcium phosphate ions diffuse into partially demineralized tooth enamel or dentin, leasing to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. Agents and methods for remineralization of teeth, for reducing or eradicating cariogenic challenge in plaque following sucrose intake for producing effective anticaries actions without the use of fluoride and for desensitizing hypersensitive teeth are disclosed.
摘要翻译：含有无毒性微溶钙和磷酸盐化合物作为添加剂的糖果和糖果会使钙和磷酸根离子逐渐持续不断地释放到口腔中，持续时间不少于5分钟。释放的磷酸钙离子扩散到部分去矿物质牙釉质或牙本质中，租用于龋齿病变，牙斑，开口牙质小管和暴露牙本质的再矿化和修复。公开了用于牙齿再矿化的剂和方法，用于在不使用氟化物和脱敏过敏牙齿的情况下，在蔗糖摄取后减少或消除斑块中的致龋性挑战，以产生有效的防龋作用。

4. 发明授权

US09011823B2 Enhanced anti-carious dentifrices, rinses, lozenges, candies and chewing gums and methods of using same 有权
标题翻译：增强的抗龋齿洁齿剂，漱口剂，锭剂，糖果和口香糖及其使用方法
公开(公告)号：US09011823B2
公开(公告)日：2015-04-21
申请号：US11048445
申请日：2005-02-01
申请人： Gerald L. Vogel , Laurence C. Chow , Shozo Takagi
发明人： Gerald L. Vogel , Laurence C. Chow , Shozo Takagi
IPC分类号： A61Q11/00 , A61K8/21 , A61K33/04 , A61K9/68 , A61K8/30
CPC分类号： A61K8/19 , A61K8/21 , A61K8/30 , A61K2800/5922 , A61Q11/00
摘要： Mouth rinses, dentifrices, lozenges, confections, chewing gums, and similar delivery vehicles containing non-toxic soluble calcium are used prior to administration of a fluoride-containing composition to increase the effectiveness of the fluoride therapy. An effective amount of calcium is released into the oral cavity and allowed to penetrate into the oral tissue. Calcium-bound fluoride deposits form in the oral tissue upon subsequent administration of the fluoride-containing composition to provide increased salivary, plaque and oral tissue fluoride concentrations.
摘要翻译：在给予含氟化合物组合物以提高氟化物治疗的有效性之前，使用口腔清洗剂，洁牙剂，锭剂，糖果，口香糖和含有无毒可溶性钙的类似递送载体。将有效量的钙释放到口腔中并允许渗入口腔组织。随后施用含氟化物的组合物，在口腔组织中形成钙结合的氟化物沉积物，以提供增加的唾液，斑块和口服组织氟化物浓度。

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