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1. 发明申请

US20060223756A1 Endothelial cell specifically binding peptides 审中-公开
标题翻译：内皮细胞特异性结合肽
公开(公告)号：US20060223756A1
公开(公告)日：2006-10-05
申请号：US10537847
申请日：2003-12-17
申请人： Gene Liau , Steingrimur Stefansson , Joseph Su
发明人： Gene Liau , Steingrimur Stefansson , Joseph Su
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07H21/04 , C12P21/04
CPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/005 , C07K2319/33 , C12N2710/10222 , C12N2710/10243 , C12N2710/10245 , C12N2740/13043 , C12N2740/13045
摘要： The present invention relates to peptides that specifically bind to endothelial cells. The peptides can be incorporated into gene delivery vector particles and can also direct therapeutic agents, including proteins such as growth factors and cytokines as well as small molecules. The vector particles, peptides, or small molecules can be used for the treatment of cancer and cardiovascular diseases such as ischemic heart disease, peripheral limb disease, vein graft stenosis and restenosis.
摘要翻译：本发明涉及特异性结合内皮细胞的肽。肽可以并入基因递送载体颗粒中，还可以引导治疗剂，包括生长因子和细胞因子等蛋白质以及小分子。载体颗粒，肽或小分子可用于治疗癌症和心血管疾病，如缺血性心脏病，外周肢疾病，静脉移植狭窄和再狭窄。

2. 发明申请

US20050202017A1 Hb-954 as a target for modulating angiogenesis 审中-公开
标题翻译： Hb-954作为调节血管发生的靶标
公开(公告)号：US20050202017A1
公开(公告)日：2005-09-15
申请号：US10525456
申请日：2003-08-29
申请人： Katharine Dixon , Gene Liau , Cynthia Serdikoff
发明人： Katharine Dixon , Gene Liau , Cynthia Serdikoff
IPC分类号： A61K38/00 , A61K39/395 , A61K48/00 , C07K14/705 , C07K16/30 , C12N1/21 , C12N15/12 , G01N33/574
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention describes assays for the identification of compounds useful for the modulation of angiogenesis. The methods of the invention involve cell-free and cell-based assays that identify compounds which bind to and/or activate or inhibit the activity of HB-954, a G protein-coupled receptor, optionally followed by an in vivo assay of the effect of the compound on angiogenesis. The invention also describes compounds which bind to and/or activate or inhibit the activity of HB-954 as well as pharmaceutical compositions comprising such compounds. In addition, the invention includes nucleic acid molecules comprising a nucleotide sequence encoding all or a portion of HB-954, gene therapy vectors comprising such sequences, polypeptides comprising all or a portion of HB-954 and antibodies directed against HB-954.
摘要翻译：本发明描述了用于鉴定可用于调节血管发生的化合物的测定。本发明的方法包括无细胞和基于细胞的测定法，其鉴定结合和/或活化或抑制G蛋白偶联受体的HB-954的活性的化合物，任选地随后进行体内测定的化合物对血管生成的影响。本发明还描述了结合和/或活化或抑制HB-954活性的化合物以及包含这些化合物的药物组合物。此外，本发明包括包含编码HB-954的全部或一部分的核苷酸序列的核酸分子，包含此类序列的基因治疗载体，包含全部或部分HB-954的多肽和针对HB-954的抗体。

3. 发明申请

US20070213255A1 Novel Hyaluronan-Binding Proteins and Encoding Genes 审中-公开
标题翻译：新型透明质酸结合蛋白和编码基因
公开(公告)号：US20070213255A1
公开(公告)日：2007-09-13
申请号：US11550102
申请日：2006-10-17
申请人： Gregg Hastings , Gene Liau , Elena Tsifrina
发明人： Gregg Hastings , Gene Liau , Elena Tsifrina
IPC分类号： A61K38/00 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , C12P21/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/5008 , C07K14/705 , G01N33/502 , G01N33/68 , G01N2333/47
摘要： The present invention relates to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP, novel members of the hyaluronan receptor family. The invention provides isolated nucleic acid molecules encoding human to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, proliferative conditions, metastasis, inflammation, ischemia, host defense dysfunction, immune surveillance dysfunction, arthritis, multiple sclerosis, autoimmunity, immune dysfunction, and allergy.
摘要翻译：本发明涉及全长WF-HABP，WF-HABP，OE-HABP和BM-HABP，是透明质酸受体家族的新成员。本发明提供了编码人全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的分离的核酸分子。还提供了全长WF-HABP，WF-HABP，OE-HABP和BM-HABP多肽，载体，宿主细胞和用于制备它们的重组方法也是如此。本发明还涉及用于鉴定全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体活性的激动剂和拮抗剂的筛选方法。还提供了用于检测与全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的异常表达相关的疾病状态的诊断方法。进一步提供治疗疾病状态的治疗方法，包括但不限于增殖性病症，转移，炎症，缺血，宿主防御功能障碍，免疫监视功能障碍，关节炎，多发性硬化，自身免疫，免疫功能障碍和过敏。

4. 发明授权

US07229959B1 Supplemented fibrin matrix delivery systems 失效
标题翻译：补充纤维蛋白基质递送系统
公开(公告)号：US07229959B1
公开(公告)日：2007-06-12
申请号：US08479038
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
发明人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
IPC分类号： A61K38/36
CPC分类号： C12N5/069 , A61K31/25 , A61K31/337 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/513 , A61K33/06 , A61K38/00 , A61K38/363 , A61K38/37 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one or more analgesics, antimicrobial compositions, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.
摘要翻译：本发明提供补充和未补充的组织密封剂及其生产和使用方法。公开了补充有至少一种抗体的组织密封剂。该组合物可进一步补充有例如一种或多种止痛剂，抗微生物组合物，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，脱矿质骨或骨形态发生蛋白，软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。

5. 发明授权

US07189410B1 Supplemented and unsupplemented tissue sealants, methods of their production and use 失效
标题翻译：补充和未补充的组织密封剂，其生产和使用的方法
公开(公告)号：US07189410B1
公开(公告)日：2007-03-13
申请号：US08474078
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Wilson H. Burgess , Hernan Nunez , Manish Singh , Gene Liau , Thomas Maciag
发明人： William N. Drohan , Martin J. MacPhee , Wilson H. Burgess , Hernan Nunez , Manish Singh , Gene Liau , Thomas Maciag
IPC分类号： A61K9/70 , A61F13/00 , A61L24/10
CPC分类号： A61L15/32 , A61F13/0213 , A61F13/0253 , A61F13/0259 , A61F13/36 , A61F2013/00106 , A61F2013/00285 , A61F2013/00472 , A61F2013/0054 , A61F2013/00906 , A61F2013/00927 , A61F2013/00931 , A61K9/70
摘要： This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant bandage.
摘要翻译：本发明提供一种纤维蛋白密封胶绷带，其中所述纤维蛋白封闭剂可补充至少一种选自例如一种或多种调节化合物，抗体，抗微生物组合物，止痛剂，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。还公开了制备和/或使用未补充或补充的纤维蛋白密封胶绷带的方法。

6. 再颁专利

USRE39298E1 Supplemented and unsupplemented tissue sealants, methods of their production and use 有权
标题翻译：补充和未补充的组织密封剂，其生产和使用的方法
公开(公告)号：USRE39298E1
公开(公告)日：2006-09-19
申请号：US10465860
申请日：2003-06-20
申请人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Thomas Maciag , Manish Singh
发明人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Thomas Maciag , Manish Singh
IPC分类号： A61K35/14 , A61K31/74 , A61F2/28
CPC分类号： A61K38/363 , A61B17/00491 , A61B2017/00495 , A61F2002/2817 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0066 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C12N5/0062 , C12N5/069 , C12N2533/56 , A61K2300/00
摘要： This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.
摘要翻译：本发明提供了补充组织密封剂的局部递送的方法，其中补充的组织密封剂包含至少一种选自一种或多种抗体，止痛剂，抗凝剂，抗炎化合物，抗微生物组合物，抗增殖剂，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。还提供了使用位点特异性补充组织密封剂的方法，包括制备生物材料。

7. 发明授权

US07196054B1 Methods for treating wound tissue and forming a supplemented fibrin matrix 失效
标题翻译：治疗伤口组织并形成补充纤维蛋白基质的方法
公开(公告)号：US07196054B1
公开(公告)日：2007-03-27
申请号：US08485883
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Thomas Maciag , Wilson H. Burgess
发明人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Thomas Maciag , Wilson H. Burgess
IPC分类号： A61K38/36
CPC分类号： C12N5/069 , A61K31/25 , A61K31/337 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/513 , A61K33/06 , A61K38/00 , A61K38/363 , A61K38/37 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antimicrobial composition. The composition may be further supplemented with, for example, one or more antibodies, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.
摘要翻译：本发明提供补充和未补充的组织密封剂及其生产和使用方法。公开了补充有至少一种抗微生物组合物的组织密封剂。该组合物可以进一步补充有例如一种或多种抗体，止痛剂，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。

8. 再颁专利

USRE39321E1 Supplemented and unsupplemented tissue sealants, methods of their production and use 有权
标题翻译：补充和未补充的组织密封剂，其生产和使用的方法
公开(公告)号：USRE39321E1
公开(公告)日：2006-10-03
申请号：US10465853
申请日：2003-06-20
申请人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Jeffrey O. Hollinger , Thomas Maciag
发明人： Martin J. MacPhee , William N. Drohan , Gene Liau , Hernan Nunez , Wilson H. Burgess , Jeffrey O. Hollinger , Thomas Maciag
IPC分类号： A61K34/14 , A61K38/22 , A61K38/44 , A61K38/49
CPC分类号： A61K38/37 , A61K38/18 , A61K38/1825 , A61K38/1833 , A61K38/363 , A61K38/4833 , A61K45/06 , A61L24/0015 , A61L24/0036 , A61L24/106 , A61L2300/00 , A61K2300/00
摘要： This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, antiinflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant dressing.
摘要翻译：本发明提供一种纤维蛋白密封剂敷料，其中所述纤维蛋白封闭剂可补充至少一种选自例如一种或多种调节化合物，抗体，抗微生物组合物，止痛剂，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。还公开了制备和/或使用未补充或补充的纤维蛋白密封剂敷料的方法。

9. 发明授权

US06610534B2 Induction of blood vessel formation through administration of polynucleotides encoding sphingosine kinases 失效
公开(公告)号：US06610534B2
公开(公告)日：2003-08-26
申请号：US09970516
申请日：2001-10-04
申请人： Gene Liau , Steingrimur Stefansson , Joseph Su
发明人： Gene Liau , Steingrimur Stefansson , Joseph Su
IPC分类号： C12N1563
CPC分类号： A61K38/45 , A61K48/00 , C12N9/1205 , C12N2799/021 , A61K2300/00
摘要： A method of inducing blood vessel formation in an animal by administering to the animal a polynucleotide encoding a sphingosine kinase, or an analogue, fragment, or derivative thereof. The polynucleotide may be contained in an appropriate expression vector, such as a viral vector. The delivery of sphingosine kinase through administration of an expression vector which expresses sphingosine kinase provides for the formation of larger blood vessels containing a well defined structure that is supported by mural cells such as pericytes and smooth muscle cells.

10. 发明授权

US06197325B1 Supplemented and unsupplemented tissue sealants, methods of their production and use 失效
标题翻译：补充和未补充的组织密封剂，其生产和使用的方法
公开(公告)号：US06197325B1
公开(公告)日：2001-03-06
申请号：US08474084
申请日：1995-06-07
申请人： Martin James MacPhee , William Nash Drohan , Carlos I. Lasa, Jr. , Gene Liau , Christian Haudenschild
发明人： Martin James MacPhee , William Nash Drohan , Carlos I. Lasa, Jr. , Gene Liau , Christian Haudenschild
IPC分类号： A61K3514
CPC分类号： A61K38/1808 , A61K31/513 , A61K31/65 , A61K33/06 , A61K33/14 , A61K35/19 , A61K38/00 , A61K38/1841 , A61K38/363 , A61K38/37 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N5/069 , C12N2533/56 , Y10S623/915 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.
摘要翻译：本发明提供了补充组织密封剂的局部递送的方法，其中补充的组织密封剂包含至少一种选自一种或多种抗体，止痛剂，抗凝剂，抗炎化合物，抗微生物组合物，抗增殖剂，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，软化骨或骨形态发生蛋白，软骨诱导因子，寡聚体聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。还提供了使用位点特异性补充组织密封剂的方法，包括制备生物材料。

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