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1. 发明授权

US08323467B2 Dual chamber, multi-analyte test strip with opposing electrodes 有权
标题翻译：具有相对电极的双室多分析物测试条
公开(公告)号：US08323467B2
公开(公告)日：2012-12-04
申请号：US12606467
申请日：2009-10-27
申请人： Gavin MacFie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
发明人： Gavin MacFie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N2035/00118
摘要： A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer. The second patterned spacer layer has a second sample-receiving chamber, with first and second end openings, defined therein. The test strip additionally has a second electrically conductive layer, with a second working electrode, disposed above the second patterned spacer layer, a second insulating layer disposed above the second electrically conductive layer, a first analyte reagent layer disposed on the first working electrode within the first sample-receiving chamber; and a second analyte reagent layer disposed on the second working electrode within the second sample-receiving chamber. The second counter/reference electrode layer is exposed to the second sample receiving chamber and is in an opposing relationship to the second working electrode.
摘要翻译：双室多分析物测试条具有设置在第一绝缘层上的第一绝缘层，第一导电层和第一工作电极，以及位于第一导电层上方的第一图案化间隔层。第一图案化间隔层具有第一样品接收室，其中限定在其中的第一和第二端部开口覆盖在第一工作电极上。测试条还包括暴露于第一样品接收室并与第一工作电极相对关系的第一计数器/参考电极层。测试条还包括设置在第一计数器/参考电极层上的计数器/参考绝缘层和设置在反向/参考基板上的第二计数器/参考电极层。还包括在测试条中的是位于第二计数器/参考电极层上方的第二图案化间隔层。第二图案化间隔层具有第二样品接收室，其中限定有第一和第二端部开口。测试条另外具有第二导电层，第二工作电极设置在第二图案化间隔层上方，设置在第二导电层上方的第二绝缘层，设置在第二工作电极内的第一分析物试剂层，第一采样室; 以及设置在第二样品接收室内的第二工作电极上的第二分析物试剂层。第二计数器/参考电极层暴露于第二样品接收室，并且与第二工作电极相对。

2. 发明授权

US08932449B2 Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution 有权
标题翻译：分析测试条，其具有具有预定尺寸和分布的电化学活性和惰性区域的电极
公开(公告)号：US08932449B2
公开(公告)日：2015-01-13
申请号：US13554378
申请日：2012-07-20
申请人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
发明人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
IPC分类号： G01N27/00 , G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底层和图案化的导体层（例如，金图案化导体层）设置在电绝缘层上。图案化导体层包括至少一个电极，其中电极具有电化学惰性区域和电化学活性区域。此外，电化学惰性区域和电化学活性区域具有预定尺寸和预定分布，使得在使用电化学基分析测试条期间电极的电化学响应基本上等于预定的电化学响应。

3. 发明申请

US20110094882A1 TEST METER FOR USE WITH A DUAL CHAMBER, MULTI-ANALYTE TEST STRIP WITH OPPOSING ELECTRODES 有权
标题翻译：用于双室的测试仪，带有电极的多分析测试条
公开(公告)号：US20110094882A1
公开(公告)日：2011-04-28
申请号：US12606496
申请日：2009-10-27
申请人： Gavin MACFIE , Graeme WEBSTER , Marco F. CARDOSI , Christopher Philip LEACH , Steven SETFORD , Selwayan SAINI
发明人： Gavin MACFIE , Graeme WEBSTER , Marco F. CARDOSI , Christopher Philip LEACH , Steven SETFORD , Selwayan SAINI
IPC分类号： G01N33/50
CPC分类号： G01N27/3272 , G01N2035/00118
摘要： A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip. The signal processing module is configured to receive a first signal via the first electrical connector and the third electrical connector and employ the first signal for the determination of a first analyte (such as glucose) in a bodily fluid sample (for example, whole blood sample) applied to the dual-chamber, multi-analyte test strip. Moreover, the signal processing module is also configured to receive a second signal via the second electrical connector and fourth electrical connector and employ the second signal for the determination of a second analyte (e.g., a ketone analyte) in the bodily fluid sample applied to the dual-chamber, multi-analyte test strip. Furthermore, the third and fourth electrical contacts provide contact in an opposing manner.
摘要翻译：用于双腔多分析物测试条的测试仪包括测试条接收模块和信号处理模块。测试条接收模块具有第一电连接器，其被配置用于接触测试条的第一工作电极的第一分析物接触焊盘; 第二电连接器，其被配置用于接触测试条的第二工作电极的第二分析物接触焊盘;第三电连接器，其被配置用于接触测试条的第一计数器/参考电极层的第一计数器/参考接触焊盘，以及第四电连接器，其被配置为接触测试条的第二计数器/参考电极层的第二计数器/参考接触焊盘。信号处理模块被配置为经由第一电连接器和第三电连接器接收第一信号，并且采用第一信号来确定体液样品中的第一分析物（例如葡萄糖）（例如，全血样品）应用于双室多分析物测试条。此外，信号处理模块还被配置为经由第二电连接器和第四电连接器接收第二信号，并且使用第二信号来确定施加到所述第二电连接器和第四电连接器的体液样品中的第二分析物（例如，酮分析物）双室多分析物测试条。此外，第三和第四电触点以相反的方式提供接触。

4. 发明申请

US20110048972A1 MULTI-ANALYTE TEST STRIP WITH SHARED COUNTER/REFERENCE ELECTRODE AND INLINE ELECTRODE CONFIGURATION 审中-公开
标题翻译：具有共享计数器/参考电极和在线电极配置的多分析测试条
公开(公告)号：US20110048972A1
公开(公告)日：2011-03-03
申请号：US12551157
申请日：2009-08-31
申请人： James MOFFAT , Kathryn Macleod , Christopher Philip Leach , Gavin Macfie , Geoffrey Lillie , Marco F. Cardosi
发明人： James MOFFAT , Kathryn Macleod , Christopher Philip Leach , Gavin Macfie , Geoffrey Lillie , Marco F. Cardosi
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272
摘要： A multi-analyte test strip includes a first insulating layer and an electrically conductive layer disposed on the first insulating layer. The electrically conductive layer has a first working electrode with a first analyte contact pad, a shared counter/reference electrode with a counter/reference electrode contact pad, and a second working electrode with a second analyte contact pad. The multi-analyte test strip also includes a second insulating layer disposed above the first insulating layer and a patterned spacer layer positioned between the first insulating layer and the first electrically conductive layer with the patterned spacer layer defining a bodily fluid sample-receiving chamber that overlies the first working electrode, the shared counter/reference electrode and the second working electrode. The multi-analyte test strip further includes a mediator reagent layer disposed over the first working electrode, the shared counter/reference electrode and the second working electrode; a first analyte reagent layer disposed over the first working electrode and mediator reagent layer; and a second analyte reagent layer disposed over the second working electrode and mediator reagent layer. Furthermore, the first analyte electrode, shared counter/reference electrode and second analyte electrode of the multi-analyte test strip are disposed on the first insulating layer in a planar inline configuration.
摘要翻译：多分析物测试条包括设置在第一绝缘层上的第一绝缘层和导电层。导电层具有第一工作电极，其具有第一分析物接触焊盘，共用的计数器/参考电极，其具有计数器/参考电极接触焊盘，以及具有第二分析物接触焊盘的第二工作电极。多分析物测试条还包括设置在第一绝缘层上方的第二绝缘层和位于第一绝缘层和第一导电层之间的图案化间隔层，其中图案化间隔层限定体液样品接收室，第一工作电极，共用计数器/参考电极和第二工作电极。多分析物测试条还包括设置在第一工作电极，共用计数器/参考电极和第二工作电极之上的介体试剂层; 设置在第一工作电极和介体试剂层上的第一分析物试剂层; 以及设置在第二工作电极和介体试剂层上的第二分析物试剂层。此外，多分析物测试条的第一分析物电极，共用计数器/参考电极和第二分析物电极以平面一字排列配置在第一绝缘层上。

5. 发明授权

US08940141B2 Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution 有权
公开(公告)号：US08940141B2
公开(公告)日：2015-01-27
申请号：US12783437
申请日：2010-05-19
申请人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
发明人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
IPC分类号： C12M1/00 , G01N27/26 , G01N33/487 , G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.

6. 发明申请

US20110284393A1 ANALYTICAL TEST STRIP WITH AN ELECTRODE HAVING ELECTROCHEMICALLY ACTIVE AND INERT AREAS OF A PREDETERMINED SIZE AND DISTRIBUTION 有权
标题翻译：具有预计尺寸和分布的电化学活性和惰性区域的电极的分析测试条
公开(公告)号：US20110284393A1
公开(公告)日：2011-11-24
申请号：US12783437
申请日：2010-05-19
申请人： Gavin MACFIE , Craig Redpath , James Iain Rodgers , Neil Whitehead
发明人： Gavin MACFIE , Craig Redpath , James Iain Rodgers , Neil Whitehead
IPC分类号： G01N27/26 , G01N33/50
CPC分类号： G01N27/3272
摘要： An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底层和图案化的导体层（例如，金图案化导体层）设置在电绝缘层上。图案化导体层包括至少一个电极，其中电极具有电化学惰性区域和电化学活性区域。此外，电化学惰性区域和电化学活性区域具有预定尺寸和预定分布，使得在使用电化学基分析测试条期间电极的电化学响应基本上等于预定的电化学响应。

7. 发明授权

US09201038B2 System and methods to account for interferents in a glucose biosensor 有权
标题翻译：考虑葡萄糖生物传感器中干扰物的系统和方法
公开(公告)号：US09201038B2
公开(公告)日：2015-12-01
申请号：US13556923
申请日：2012-07-24
申请人： Gavin Macfie , Zuifang Liu
发明人： Gavin Macfie , Zuifang Liu
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： Various embodiments that allow for improved accuracy in the measurement of glucose with a glucose meter and a biosensor, principally, by using pulsed signal inputs to the biosensor and selecting at least one specific pulsed output from the biosensor to determine a glucose concentration that is less affected by interfering chemical substances that might be present in the fluid sample.
摘要翻译：允许用葡萄糖计和生物传感器测量葡萄糖的精确度的各种实施方案，主要是通过使用脉冲信号输入到生物传感器并从生物传感器中选择至少一种特定的脉冲输出来确定较少受影响的葡萄糖浓度通过干扰可能存在于流体样品中的化学物质。

8. 发明申请

US20140027312A1 SYSTEM AND METHODS TO ACCOUNT FOR INTERFERENTS IN A GLUCOSE BIOSENSOR 有权
标题翻译：用于葡萄糖生物传感器干扰的系统和方法
公开(公告)号：US20140027312A1
公开(公告)日：2014-01-30
申请号：US13556923
申请日：2012-07-24
申请人： Gavin MACFIE , Zuifang LIU
发明人： Gavin MACFIE , Zuifang LIU
IPC分类号： C12Q1/54 , G01N27/416
CPC分类号： G01N27/3274
摘要： Various embodiments that allow for improved accuracy in the measurement of glucose with a glucose meter and a biosensor, principally, by using pulsed signal inputs to the biosensor and selecting at least one specific pulsed output from the biosensor to determine a glucose concentration that is less affected by interfering chemical substances that might be present in the fluid sample.
摘要翻译：允许用葡萄糖计和生物传感器测量葡萄糖的精确度的各种实施方案，主要是通过使用脉冲信号输入到生物传感器并从生物传感器中选择至少一种特定的脉冲输出来确定较少受影响的葡萄糖浓度通过干扰可能存在于流体样品中的化学物质。

9. 发明授权

US08632664B2 Test meter for use with a dual chamber, multi-analyte test strip with opposing electrodes 有权
标题翻译：用于具有相对电极的双室多分析物测试条的测试仪
公开(公告)号：US08632664B2
公开(公告)日：2014-01-21
申请号：US12606496
申请日：2009-10-27
申请人： Gavin Macfie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
发明人： Gavin Macfie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N2035/00118
摘要： A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip. The signal processing module is configured to receive a first signal via the first electrical connector and the third electrical connector and employ the first signal for the determination of a first analyte (such as glucose) in a bodily fluid sample (for example, whole blood sample) applied to the dual-chamber, multi-analyte test strip. Moreover, the signal processing module is also configured to receive a second signal via the second electrical connector and fourth electrical connector and employ the second signal for the determination of a second analyte (e.g., a ketone analyte) in the bodily fluid sample applied to the dual-chamber, multi-analyte test strip. Furthermore, the third and fourth electrical contacts provide contact in an opposing manner.
摘要翻译：用于双腔多分析物测试条的测试仪包括测试条接收模块和信号处理模块。测试条接收模块具有第一电连接器，其被配置用于接触测试条的第一工作电极的第一分析物接触焊盘; 第二电连接器，其被配置用于接触测试条的第二工作电极的第二分析物接触焊盘;第三电连接器，其被配置用于接触测试条的第一计数器/参考电极层的第一计数器/参考接触焊盘，以及第四电连接器，其被配置为接触测试条的第二计数器/参考电极层的第二计数器/参考接触焊盘。信号处理模块被配置为经由第一电连接器和第三电连接器接收第一信号，并且采用第一信号来确定体液样品中的第一分析物（例如葡萄糖）（例如，全血样品）应用于双室多分析物测试条。此外，信号处理模块还被配置为经由第二电连接器和第四电连接器接收第二信号，并且使用第二信号来确定施加到所述第二电连接器和第四电连接器的体液样品中的第二分析物（例如，酮分析物）双室多分析物测试条。此外，第三和第四电触点以相反的方式提供接触。

10. 发明申请

US20120312699A1 DIFFERENTIABLE ANALYTICAL TEST STRIP AND TEST METER COMBINATION 审中-公开
标题翻译：不同的分析测试条和测试仪组合
公开(公告)号：US20120312699A1
公开(公告)日：2012-12-13
申请号：US13154875
申请日：2011-06-07
申请人： Graeme WEBSTER , Peter TEMPLETON , David ELDER , Lawrence RITCHIE , James MOFFAT , Gavin MACFIE
发明人： Graeme WEBSTER , Peter TEMPLETON , David ELDER , Lawrence RITCHIE , James MOFFAT , Gavin MACFIE
IPC分类号： G01N27/28 , G01N33/66
CPC分类号： G01N27/3273
摘要： An analytical test strip and test meter combination for use in the determination of an analyte in a bodily fluid sample includes an analytical test strip and a test meter, and a method for determination thereof. The analytical test strip has an electrode, a first electrical contact pad in electrical communication with the electrode and configured to communicate an electrical response of the electrode to the test meter; and a second electrical contact pad in electrical communication with the electrode and configured to communicate an electrical response of the electrode to the test meter should the test meter be in electrical communication with the second electrical contact pad. In addition, the second electrical contact pad has electrical continuity with the first electrical contact pad and the first and second electrical contact pads are disposed in either of first and second predetermined spatial relationships to one another.
摘要翻译：用于测定体液样品中的分析物的分析测试条和测试仪组合包括分析测试条和测试仪，以及用于确定其的方法。分析测试条具有电极，与电极电连通的第一电接触焊盘，并被配置为将电极的电响应传递到测试仪; 以及第二电接触焊盘，其与所述电极电连通并且被配置为如果所述测试仪器与所述第二电接触焊盘电气连通，则将所述电极的电响应传达到所述测试仪表。此外，第二电接触焊盘与第一电接触焊盘具有电连续性，并且第一和第二电接触焊盘彼此以第一和第二预定空间关系中的任一个布置。

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