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1. 发明申请

US20110059134A1 PREVENTION OF RECURRENT VIRAL DISEASE 审中-公开
标题翻译：预防病毒性疾病
公开(公告)号：US20110059134A1
公开(公告)日：2011-03-10
申请号：US12144146
申请日：2008-06-23
申请人： Laure Aurelian , Takahiro Gyotoku , Gary J. Calton
发明人： Laure Aurelian , Takahiro Gyotoku , Gary J. Calton
IPC分类号： A61K39/245 , A61P31/22
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/57 , C12N2710/16622 , C12N2710/16634
摘要： The present invention discloses compositions and methods for ameliorating or reducing recurrent viral disease, which compositions and methods result in an increase in virus specific immunoglobulin subclasses reflective of a preferential Th1 response.
摘要翻译：本发明公开了用于改善或减少复发性病毒性疾病的组合物和方法，该组合物和方法导致反映优先Th1应答的病毒特异性免疫球蛋白亚类的增加。

2. 发明授权

US07344839B2 Virus preparations and methods 失效
标题翻译：病毒的准备和方法
公开(公告)号：US07344839B2
公开(公告)日：2008-03-18
申请号：US11021275
申请日：2004-12-23
申请人： Gary J. Calton , Rita Fishelevich
发明人： Gary J. Calton , Rita Fishelevich
IPC分类号： C12Q1/68
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , C12N7/00 , C12N2710/16634
摘要： Methods are disclosed for the preparation of herpesvirus, such as herpes simplex virus type 2 for vaccine use. Such viruses can be grown on serum free or serum containing media and can be prepared from the virus containing culture supernatant or virus containing cells. The virus is prepared for subsequent pharmaceutical formulation by methods which may include treatment with solid phase affinity reagents containing sulfate- or sulfonate-comprising binding groups. Such sulfated polysaccharide groups as heparin or dextran sulfate may be used, and eluted with salt solutions. The process can be combined with other culture, harvesting and formulation steps.
摘要翻译：公开了用于制备疱疹病毒的方法，例如用于疫苗使用的2型单纯疱疹病毒。这样的病毒可以在含血清或含血清的培养基上生长，并且可以从含有病毒的培养物上清液或含有病毒的细胞制备。通过可以包括用含硫酸盐或磺酸盐结合基团的固相亲和试剂处理的方法制备用于后续药物制剂的病毒。可以使用这样的硫酸化多糖类作为肝素或硫酸葡聚糖，并用盐溶液洗脱。该过程可以与其他培养，收获和配制步骤相结合。

3. 发明授权

US6152150A Method of stain removal using a dry zeolite containing composition 失效
标题翻译：使用含有含沸石的组合物去除污渍的方法
公开(公告)号：US6152150A
公开(公告)日：2000-11-28
申请号：US366669
申请日：1999-08-03
申请人： John B. Cook , Gary J. Calton
发明人： John B. Cook , Gary J. Calton
IPC分类号： C11D3/12 , C11D3/37 , B08B7/00
CPC分类号： A61K8/26 , A61K8/88 , A61Q19/10 , C11D3/128 , C11D3/3719
摘要： A dry zeolite containing composition is used in a method for removing grease and/or oil stains from the human body is disclosed. In accordance with the method, zeolites having an average particle size of about 0.5 mm or less provide superior performance to remove grease and oil stains from the skin. Stain removing activities of the zeolite compositions may be enhanced by the addition of an imide.
摘要翻译：含有干沸石的组合物用于从人体去除油脂和/或油渍的方法。根据该方法，平均粒径为约0.5mm或更小的沸石提供优异的性能以从皮肤上除去油脂和油渍。可以通过加入酰亚胺来增强沸石组合物的去污活性。

4. 发明授权

US6068665A Stain removing compositions 失效
标题翻译：去污组合物
公开(公告)号：US6068665A
公开(公告)日：2000-05-30
申请号：US317567
申请日：1999-05-24
申请人： Gary J. Calton , John B. Cook
发明人： Gary J. Calton , John B. Cook
IPC分类号： C11D3/00 , C11D3/12 , C11D3/32 , C11D3/37 , D06L1/00 , C11D17/06 , D06L1/04
CPC分类号： C11D3/0031 , C11D11/0017 , C11D3/128 , C11D3/32 , C11D3/3719 , D06L1/005
摘要： An improved method for the removal of stains from textiles is disclosed. The method involves the use of novel mixtures of zeolites and imides. The method of the invention provides superior performance in the removal of stains, especially those from animal wastes or fluids. The zeolite/imide mixtures are useful to remove stains from various textile fabrics and fibers, e.g. carpets, clothing, and upholstered goods.
摘要翻译：公开了一种用于从纺织品中除去污渍的改进方法。该方法涉及使用沸石和酰亚胺的新型混合物。本发明的方法在去除污渍，特别是来自动物废物或流体的污渍方面提供了优异的性能。沸石/酰亚胺混合物可用于从各种纺织织物和纤维中除去污渍，例如，地毯，服装和软体货物。

5. 发明授权

US5869027A Method for odor reduction 失效
标题翻译：降低臭味的方法
公开(公告)号：US5869027A
公开(公告)日：1999-02-09
申请号：US635502
申请日：1996-04-22
申请人： Louis L. Wood , Gary J. Calton
发明人： Louis L. Wood , Gary J. Calton
IPC分类号： A61F13/15 , A01N37/18 , A61F13/472 , A61K8/00 , A61K8/02 , A61K8/04 , A61K8/11 , A61K8/41 , A61K8/49 , A61K8/66 , A61K8/88 , A61L9/00 , A61L9/01 , A61L9/04 , A61L11/00 , A61L15/46 , A61Q15/00
CPC分类号： A61Q15/00 , A61K8/0208 , A61K8/0241 , A61K8/11 , A61K8/4913 , A61K8/88 , A61L15/46 , A61K2800/622 , A61L2300/204
摘要： Imides reduce odors. Imides are especially efficient at reducing the odors of odoriferous an amine or ammonia. The imides may be incorporated in pads which are the recipients of odoriferous waste materials, dispersed in holding tanks or lagoons or dispersed over human and animal wastes. Polysuccinimide, copolymers of polysuccinimide, polyglutarimide and mixtures thereof are especially useful for the reduction of odors, especially of ammonia and an amine.
摘要翻译：降低气味。酰亚胺在减少气味的胺或氨的气味方面特别有效。酰亚胺可以加入到作为有气味废料的接收者的垫中，分散在储存罐或泻湖中或分散在人和动物废物上。聚琥珀酰亚胺，聚琥珀酰亚胺，聚戊二酰亚胺及其混合物的共聚物特别可用于降低气味，特别是氨和胺的气味。

6. 发明授权

US5610267A Process for preparing polysuccinimide by high temperature reaction 失效
标题翻译：通过高温反应制备聚琥珀酰亚胺的方法
公开(公告)号：US5610267A
公开(公告)日：1997-03-11
申请号：US357444
申请日：1994-12-16
申请人： Louis L. Wood , Gary J. Calton
发明人： Louis L. Wood , Gary J. Calton
IPC分类号： C02F1/00 , C02F5/12 , C05G3/00 , C08G69/10 , C08G69/48 , C08G73/10 , C11D3/37 , C08G63/44 , C08G67/02
CPC分类号： C02F5/125 , C02F5/12 , C05G3/00 , C08G69/10 , C08G69/48 , C08G73/1092 , C11D3/3719 , C02F1/001
摘要： Polyaspartate, useful for inhibition of incrustations due to materials causing hardness in water and of value in detergent formulations, can be prepared by reacting malic acid, maleic acid or fumaric acid with ammonia, in a molar ratio of 1:1-2.1 at temperatures greater than 140.degree. C., followed by conversion of the polysuccinimide formed in this reaction to a salt of polyaspartic acid by basic hydrolysis.
摘要翻译：聚天冬氨酸盐可以通过使苹果酸，马来酸或富马酸与氨在摩尔比为1：1-2.1的温度下反应而制备，因为在水中产生硬度和洗涤剂配方中的硬度的材料可以抑制结垢。然后将该反应中形成的聚琥珀酰亚胺通过碱水解转化成聚天冬氨酸的盐。

7. 发明授权

US5527863A Copolymers of polyaspartic acid and polycarboxylic acids and polyamines 失效
公开(公告)号：US5527863A
公开(公告)日：1996-06-18
申请号：US379368
申请日：1995-01-27
申请人： Louis L. Wood , Gary J. Calton
发明人： Louis L. Wood , Gary J. Calton
IPC分类号： C08G69/00 , C08G69/10 , C08G69/36 , C08G73/02 , C08G73/10 , C11D3/37 , C08L77/00 , C02F5/12
CPC分类号： C08G69/00 , C08G69/10 , C08G69/36 , C08G73/02 , C08G73/1092 , C11D3/3719
摘要： Copolymers of polyaspartic acid which are suitable for the inhibition of scale deposition were obtained by reacting maleic acid, an additional polycarboxylic acid and ammonia in a stoichiometric excess, at 120.degree.-350.degree. C., preferably 180.degree.-300.degree. C., to provide copolymers of polysuccinimide. In a second embodiment, a polyamine was added to the reaction mix. These intermediate polysuccinimide copolymers could then be converted to the salts of copolymers of polyaspartic acid by hydrolysis with a hydroxide.Such copolymers are useful in preventing deposition of scale from water and find applications in treating water. Other applications include scale prevention additives for detergents. In addition, such copolymers inhibit dental tartar and plaque formation.

8. 发明授权

US5484860A Process for the preparation of copolymers of polyaspartic acids 失效
标题翻译：制备聚天冬氨酸共聚物的方法
公开(公告)号：US5484860A
公开(公告)日：1996-01-16
申请号：US421619
申请日：1995-04-13
申请人： Louis L. Wood , Gary J. Calton
发明人： Louis L. Wood , Gary J. Calton
IPC分类号： A61K8/00 , A61K8/64 , A61Q11/00 , C08G69/00 , C08G69/10 , C08G69/36 , C08G73/02 , C08G73/10 , C08G85/00 , C11D3/37
CPC分类号： C08G69/00 , C08G69/10 , C08G69/36 , C08G73/02 , C08G73/1092 , C11D3/3719
摘要： Copolymers of polyaspartic acid which are suitable for the inhibition of scale deposition were obtained by reacting maleic acid, an additional polycarboxylic acid and ammonia in a stoichiometric excess, at 120.degree.-350.degree. C., preferably 180.degree.-300.degree. C., to provide copolymers of polysuccinimide. In a second embodiment, a polyamine was added to the reaction mix. These intermediate polysuccinimide copolymers could then be converted to the salts of copolymers of polyaspartic acid by hydrolysis with a hydroxide.Such copolymers are useful in preventing deposition of scale from water and find applications in treating water. Other applications include scale prevention additives for detergents. In addition, such copolymers inhibit dental tartar and plaque formation.
摘要翻译：通过使马来酸，额外的多元羧酸和化学计量过量的氨在120-350℃，优选180-300℃反应，得到适用于抑制垢沉积的聚天冬氨酸的共聚物，得到提供聚琥珀酰亚胺的共聚物。在第二个实施方案中，将多胺加入到反应混合物中。然后可以用氢氧化物水解将这些中间体聚琥珀酰亚胺共聚物转化成聚天冬氨酸的共聚物的盐。这种共聚物可用于防止水垢沉积，并用于处理水。其他应用包括用于洗涤剂的防垢添加剂。此外，这种共聚物抑制牙垢和斑块形成。

9. 发明授权

US5408028A Copolymers of polyaspartic acid and polycarboxylic acids and polyamines 失效
标题翻译：聚天冬氨酸和多元羧酸和多胺的共聚物
公开(公告)号：US5408028A
公开(公告)日：1995-04-18
申请号：US994922
申请日：1992-12-22
申请人： Louis L. Wood , Gary J. Calton
发明人： Louis L. Wood , Gary J. Calton
IPC分类号： C08G69/00 , C08G69/10 , C08G69/36 , C08G73/02 , C08G73/10 , C11D3/37 , C08G73/00
CPC分类号： C08G69/00 , C08G69/10 , C08G69/36 , C08G73/02 , C08G73/1092 , C11D3/3719
摘要： Copolymers of polyaspartic acid which are suitable for the inhibition of scale deposition were obtained by reacting maleic acid, an additional polycarboxylic acid and ammonia in a stoichiometric excess, at 120.degree.-350.degree. C., preferably 180.degree.-300.degree. C., to provide copolymers of polysuccinimide. In a second embodiment, a polyamine was added to the reaction mix. These intermediate polysuccinimide copolymers could then be converted to the salts of copolymers of polyaspartic acid by hydrolysis with a hydroxide.Such copolymers are useful in preventing deposition of scale from water and find applications in treating water. Other applications include scale prevention additives for detergents. In addition, such copolymers inhibit dental tartar and plaque formation.
摘要翻译：通过使马来酸，额外的多元羧酸和化学计量过量的氨在120-350℃，优选180-300℃反应，得到适用于抑制垢沉积的聚天冬氨酸的共聚物，得到提供聚琥珀酰亚胺的共聚物。在第二个实施方案中，将多胺加入到反应混合物中。然后可以用氢氧化物水解将这些中间体聚琥珀酰亚胺共聚物转化成聚天冬氨酸的共聚物的盐。这种共聚物可用于防止水垢沉积，并用于处理水。其他应用包括用于洗涤剂的防垢添加剂。此外，这种共聚物抑制牙垢和斑块形成。

10. 发明授权

US5357004A Copolymers of polyaspartic acid 失效
标题翻译：聚天冬氨酸的共聚物
公开(公告)号：US5357004A
公开(公告)日：1994-10-18
申请号：US195036
申请日：1994-02-14
申请人： Gary J. Calton , Louis L. Wood
发明人： Gary J. Calton , Louis L. Wood
IPC分类号： A61K47/48 , A61K8/72 , A61K8/88 , A61Q11/00 , B01D65/08 , C08G69/00 , C08G69/10 , C08G69/48 , C08G69/50 , C08G73/00 , C08G73/10 , C11D3/37
CPC分类号： C11D3/3719 , A61K8/88 , A61Q11/00 , C08G69/10 , C08G73/1092
摘要： Higher molecular weight copolymers of polyaspartic acid which are suitable for the inhibition of scale deposition may be obtained by reacting maleic acid and ammonia in a stoichiometric excess, with a diamine or a triamine, at 120.degree.-350.degree. C., preferably 180.degree.-300.degree. C., and then converting the copolymer of polysuccinimide formed to a salt of a copolymer of polyaspartic acid by hydrolysis with a hydroxide. Alkyl or substituted alkyl groups may be incorporated in the backbone of the polymer by adding a alkyl or substituted alkyl monoamine to maleic acid and ammonia and heating at 120.degree. C. or more until polymerization has occurred.
摘要翻译：通过使马来酸和氨与化学计量过量的二胺或三胺在120-350℃，优选180℃下反应，可以获得适用于抑制垢沉积的聚天冬氨酸的较高分子量共聚物。然后通过用氢氧化物水解将形成的聚琥珀酰亚胺的共聚物转化为聚天冬氨酸的共聚物的盐。烷基或取代的烷基可以通过在马来酸和氨中加入烷基或取代的烷基单胺并在120℃或更高温度下加热直到聚合发生，并入聚合物的主链中。

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