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1. 发明申请

US20140112936A1 METHODS OF NEUTRALIZING VIRAL INFECTION 审中-公开
标题翻译：中和感染的方法
公开(公告)号：US20140112936A1
公开(公告)日：2014-04-24
申请号：US13884823
申请日：2011-11-09
申请人： Bing Chen , Gary H. Frey , Jia Chen
发明人： Bing Chen , Gary H. Frey , Jia Chen
IPC分类号： A61K39/21 , G01N33/569
摘要： Isolated, antigenic polypeptides including a pre-hairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a pre-hairpin intermediate conformation of gp41 and methods of making antibodies a that bind to pre-hairpin intermediate conformation of gp41 are also provided. Vaccines against a pre-hairpin Fd intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, pre-hairpin intermediate conformation of gp41 are further provided.
摘要翻译：提供分离的抗原多肽，包括gp41的前发夹中间体构象和编码这种多肽的载体。还提供了结合gp41的前发夹中间构象的抗体和制备抗体a的方法，其结合gp41的前发夹中间构象。还提供了针对gp41的预发夹Fd中间构象的疫苗，以及治疗感染HIV的受试者，预防HIV感染和抑制HIV介导的活性的方法。还提供了筛选结合gp41的分离的前发夹中间构象的化合物的方法。

2. 发明授权

US10675346B2 Antigenic polypeptides comprising pre-hairpin intermediate conformations of HIV-1 GP41 有权
公开(公告)号：US10675346B2
公开(公告)日：2020-06-09
申请号：US13884823
申请日：2011-11-09
申请人： Bing Chen , Gary H. Frey , Jia Chen
发明人： Bing Chen , Gary H. Frey , Jia Chen
IPC分类号： A61K39/21 , C07K14/005 , G01N33/569 , A61K39/00
摘要： Isolated, antigenic polypeptides including a pre-hairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Exemplary pre-hairpin intermediate conformations of gp41 include an oligomerization domain; a heptad repeat 2 motif; and a membrane-proximal external region, where the polypeptide lacks a heptad repeat 1 motif, and where the isolated, antigenic polypeptides elicit production of a broadly neutralizing antibody against HIV when injected into a subject. Antibodies that bind to a pre-hairpin intermediate conformation of gp41 and methods of making antibodies a that bind to pre-hairpin intermediate conformation of gp41 are also provided. Vaccines against a pre-hairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, pre-hairpin intermediate conformation of gp41 are further provided.

3. 发明申请

US20110086041A1 Fusion-Intermediate State of HIV-1 gP41 Targeted by Broadly Neutralizing Antibodies 有权
标题翻译：通过广泛中和抗体靶向的HIV-1 gP41的融合中间状态
公开(公告)号：US20110086041A1
公开(公告)日：2011-04-14
申请号：US12869967
申请日：2010-08-27
申请人： Bing Chen , Gary H. Frey , Stephen C. Harrison
发明人： Bing Chen , Gary H. Frey , Stephen C. Harrison
IPC分类号： A61K39/42 , C07K14/16 , C12N15/63 , A61K39/00 , A61P31/18 , G01N33/53 , C40B30/04 , C07K16/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N2710/14143 , C12N2740/16122 , C12N2740/16134
摘要： Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.
摘要翻译：提供了分离的抗原多肽，包括gp41的前体前体中间体构象和编码这些多肽的载体。还提供了结合gp41的前凝胶中间体构象的抗体和制备抗体a的方法，其与gp41的前凝胶中间构象结合。还提供了针对gp41的前凝胶中间构象的疫苗以及治疗HIV感染者，预防HIV感染和抑制HIV介导活性的方法。还提供了筛选结合gp41的分离的前贴片中间构象的化合物的方法。

4. 发明授权

US08741310B2 Fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies 有权
标题翻译：通过广泛中和抗体靶向的HIV-1 gp41的融合中间状态
公开(公告)号：US08741310B2
公开(公告)日：2014-06-03
申请号：US12869967
申请日：2010-08-27
申请人： Bing Chen , Gary H. Frey , Stephen C. Harrison
发明人： Bing Chen , Gary H. Frey , Stephen C. Harrison
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N2710/14143 , C12N2740/16122 , C12N2740/16134
摘要： Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.
摘要翻译：提供了分离的抗原多肽，包括gp41的前体前体中间体构象和编码这些多肽的载体。还提供了结合gp41的前凝胶中间体构象的抗体和制备抗体a的方法，其与gp41的前凝胶中间构象结合。还提供了针对gp41的前凝胶中间构象的疫苗以及治疗HIV感染者，预防HIV感染和抑制HIV介导活性的方法。还提供了筛选结合gp41的分离的前贴片中间构象的化合物的方法。

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