专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08791163B2 Melatonin ligands having antidepressant activity as well as sleep inducing properties 有权
标题翻译：具有抗抑郁活性的褪黑激素配体以及睡眠诱导性质
公开(公告)号：US08791163B2
公开(公告)日：2014-07-29
申请号：US12160728
申请日：2007-01-12
申请人： Gabriella Gobbi , Marco Mor , Silvia Rivara , Franco Fraschini , Giorgio Tarzia , Annalida Bedini , Gilberto Spadoni , Valeria Lucini
发明人： Gabriella Gobbi , Marco Mor , Silvia Rivara , Franco Fraschini , Giorgio Tarzia , Annalida Bedini , Gilberto Spadoni , Valeria Lucini
IPC分类号： A61K31/16 , C07C233/00 , C07C233/35
CPC分类号： C07C233/43 , C07C233/36
摘要： Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, —OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and —Z—(CH2)p-A; R1 is selected from the group consisting of C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1-C4 alkyl, hydroxy-substituted C3-C8 cycloalkyl, and NHR5, wherein R5 is C1-C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an —O—(CH2)v bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; R4 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R6 is selected from the group consisting of hydrogen and C1-C6 alkyl; R7 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; and R8 is selected from the group consisting of hydrogen and C1-C4 alkyl.
摘要翻译：式I的新型褪黑素配体：或其药学上可接受的盐，其中：n为1或2; m为0,1或2; p为0,1,2,3,4,5,6,7或8; v为2或3; A是芳基或杂芳基; Z是O，S或NR8; Y选自氢，芳基，杂芳基，C 1 -C 6烷基，C 3 -C 6环烷基，R选自氢，羟基，-OCF 3，CF 3，C 1 -C 8烷基，C 1 -C 8 烷氧基，C1-C8烷硫基，卤素和-Z-（CH2）pA; R 1选自C 1 -C 4烷基，C 3 -C 6环烷基，CF 3，羟基取代的C 1 -C 4烷基，羟基取代的C 3 -C 8环烷基和NHR 5，其中R 5是C 1 -C 3烷基或C 3 -C 6 环烷基 R 2选自：氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 3选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R和R 3可以连接在一起形成一个-O-（CH 2）v桥，代表它们连接有5或6元杂环系的碳原子; R 4选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 6选自氢和C 1 -C 6烷基; R 7选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; 并且R 8选自氢和C 1 -C 4烷基。

2. 发明申请

US20100267836A1 NOVEL MELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES 有权
标题翻译：具有抗静电活性的新型胶原蛋白配体，如睡眠诱导性质
公开(公告)号：US20100267836A1
公开(公告)日：2010-10-21
申请号：US12160728
申请日：2007-01-12
申请人： Gabriella Gobbi , Marco Mor , Silvia Rivara , Franco Fraschini , Giorgio Tarzia , Annalida Bedini , Gilberto Spadoni , Valeria Lucini
发明人： Gabriella Gobbi , Marco Mor , Silvia Rivara , Franco Fraschini , Giorgio Tarzia , Annalida Bedini , Gilberto Spadoni , Valeria Lucini
IPC分类号： A61K31/165 , C07C233/05 , A61P25/22 , A61P25/24
CPC分类号： C07C233/43 , C07C233/36
摘要： Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, —OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and —Z—(CH2)p-A; R1 is selected from the group consisting of C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1-C4 alkyl, hydroxy-substituted C3-C8 cycloalkyl, and NHR5, wherein R5 is C1-C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an —O—(CH2)v bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; R4 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R6 is selected from the group consisting of hydrogen and C1-C6 alkyl; R7 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; and R8 is selected from the group consisting of hydrogen and C1-C4 alkyl.
摘要翻译：式I的新型褪黑素配体：或其药学上可接受的盐，其中：n为1或2; m为0,1或2; p为0,1,2,3,4,5,6,7或8; v为2或3; A是芳基或杂芳基; Z是O，S或NR8; Y选自氢，芳基，杂芳基，C 1 -C 6烷基，C 3 -C 6环烷基，R选自氢，羟基，-OCF 3，CF 3，C 1 -C 8烷基，C 1 -C 8 烷氧基，C1-C8烷硫基，卤素和-Z-（CH2）pA; R 1选自C 1 -C 4烷基，C 3 -C 6环烷基，CF 3，羟基取代的C 1 -C 4烷基，羟基取代的C 3 -C 8环烷基和NHR 5，其中R 5是C 1 -C 3烷基或C 3 -C 6 环烷基 R 2选自：氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 3选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R和R 3可以连接在一起形成一个-O-（CH 2）v桥，代表它们连接有5或6元杂环系的碳原子; R 4选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 6选自氢和C 1 -C 6烷基; R 7选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; 并且R 8选自氢和C 1 -C 4烷基。

3. 发明申请

US20160221932A1 Methods and Uses of Melatonin Ligands 审中-公开
标题翻译：褪黑素配体的方法与用途
公开(公告)号：US20160221932A1
公开(公告)日：2016-08-04
申请号：US14912143
申请日：2014-08-15
申请人： Sergio DOMINGUEZ LOPEZ , Gabriella GOBBI
发明人： Sergio Dominguez Lopez , Gabriella Gobbi
IPC分类号： C07C233/36
CPC分类号： C07C233/36 , A61K31/165
摘要： The disclosure provides methods and uses for alleviating and/or treating pain including pain disorders using melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is 0, S or NR8; Y is chosen from hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is chosen from hydrogen, hydroxyl, —OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and —Z—(CH2p-A; R1 is chosen from C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1-C4 alkyl, hydroxy-substituted C3-C6 cycloalkyl, and NHR5, wherein R5 is H, C1-C3 alkyl or C3-C6 cycloalkyl; R2 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl and halogen; R and R3 may be connected together to form an -0-(CH2)v bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; R4 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R6 is chosen from hydrogen and C1-C4 alkyl; R7 is chosen from hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl and halogen; and R8 is chosen from hydrogen and C1-C4 alkyl.
摘要翻译：本公开提供了使用式I的褪黑素配体减轻和/或治疗疼痛（包括疼痛障碍）的方法和用途：或其药学上可接受的盐，其中：n为1或2; m为0,1或2; p为0,1,2,3,4,5,6,7或8; v为2或3; A是芳基或杂芳基; Z为0，S或NR8; Y选自氢，芳基，杂芳基，C 1 -C 6烷基，C 3 -C 6环烷基，R选自氢，羟基，-OCF 3，CF 3，C 1 -C 8烷基，C 1 -C 8烷氧基，C 1 -C 8烷硫基，卤素和-Z-（CH 2 p -A; R 1选自C 1 -C 4烷基，C 3 -C 6环烷基，CF 3，羟基取代的C 1 -C 4烷基，羟基取代的C 3 -C 6环烷基和NHR 5，其中R 5是H，C 1 -C 3烷基或C 3 -C 6环烷基; R 2选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 3选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基， OCF 3，CF 3，羟基和卤素; R和R 3可以连接在一起以形成与它们连接的碳原子一起代表5-或6-元杂环体系的-O-（CH 2）v桥;选择R4 氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 6选自氢和C 1 -C 4烷基; R 7选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3 ，CF 3，羟基和卤素;且R 8选自氢和 C 1 -C 4烷基。

4. 发明公开

US20230172874A1 USE OF CANNABIDIOL FOR THE TREATMENT OF INSOMNIA ASSOCIATED TO PAIN 审中-公开
公开(公告)号：US20230172874A1
公开(公告)日：2023-06-08
申请号：US18061810
申请日：2022-12-05
申请人： Gabriella GOBBI , Danilo DE GREGORIO , Martha Graciela LÓPEZ-CANUL
发明人： Gabriella GOBBI , Danilo DE GREGORIO , Martha Graciela LÓPEZ-CANUL
IPC分类号： A61K31/05 , A61K31/454 , A61P25/20 , A61P21/00
CPC分类号： A61K31/05 , A61K31/454 , A61P25/20 , A61P21/00
摘要： Chronic pain or neuropathic pain (NP) is associated with sleep disorders, and in turn sleep disorders increase pain such as neuropathic pain. A limited number of drugs are available for treating NP associated insomnia, and side effects are common. The present application describes methods and uses based on CBD and analogs/derivatives thereof for the management of insomnia and/or sleep disorders associated to all types of chronic and/or NP. The present application also relates to the management of disorders associated with REM sleep using a CB1 inhibitor. The present application also relates to the use of sleep electroencephalogram (EEG) analysis for the assessment of chronic pain/NP.

5. 发明申请

US20150045442A1 NOVEL MELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES 审中-公开
标题翻译：具有抗静电活性的新型胶原蛋白配体，如睡眠诱导性质
公开(公告)号：US20150045442A1
公开(公告)日：2015-02-12
申请号：US14304473
申请日：2014-06-13
申请人： Gabriella GOBBI , Marco MOR , Silvia RIVARA , Franco FRASCHINI , Giorgio TARZIA , Annalida BEDINI , Gilberto SPADONI , Valeria LUCINI
发明人： Gabriella GOBBI , Marco MOR , Silvia RIVARA , Franco FRASCHINI , Giorgio TARZIA , Annalida BEDINI , Gilberto SPADONI , Valeria LUCINI
IPC分类号： C07C233/43
CPC分类号： C07C233/43 , C07C233/36
摘要： Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, —OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and —Z—(CH2)p-A; R1 is selected from the group consisting of C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1-C4 alkyl, hydroxy-substituted C3-C6 cycloalkyl, and NHR5, wherein R5 is C1-C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an —O—(CH2)v bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; R4 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R6 is selected from the group consisting of hydrogen and C1-C6 alkyl; R7 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; and R8 is selected from the group consisting of hydrogen and C1-C4 alkyl.
摘要翻译：式I的新型褪黑素配体：或其药学上可接受的盐，其中：n为1或2; m为0,1或2; p为0,1,2,3,4,5,6,7或8; v为2或3; A是芳基或杂芳基; Z是O，S或NR8; Y选自氢，芳基，杂芳基，C 1 -C 6烷基，C 3 -C 6环烷基，R选自氢，羟基，-OCF 3，CF 3，C 1 -C 8烷基，C 1 -C 8 烷氧基，C1-C8烷硫基，卤素和-Z-（CH2）pA; R 1选自C 1 -C 4烷基，C 3 -C 6环烷基，CF 3，羟基取代的C 1 -C 4烷基，羟基取代的C 3 -C 6环烷基和NHR 5，其中R 5是C 1 -C 3烷基或C 3 -C 6 环烷基 R 2选自：氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 3选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R和R 3可以连接在一起形成一个-O-（CH 2）v桥，代表它们连接有5或6元杂环系的碳原子; R 4选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; R 6选自氢和C 1 -C 6烷基; R 7选自氢，C 1 -C 4烷基，C 1 -C 4烷氧基，OCF 3，CF 3，羟基和卤素; 并且R 8选自氢和C 1 -C 4烷基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式