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1. 发明申请

US20050147627A1 Toll-like receptor 5 ligands and methods of use 有权
标题翻译： Toll样受体5配体及使用方法
公开(公告)号：US20050147627A1
公开(公告)日：2005-07-07
申请号：US10991347
申请日：2004-11-16
申请人： Alan Aderem , Fumitaka Hayashi , Kelly Smith , David Underhill , Adrian Ozinsky
发明人： Alan Aderem , Fumitaka Hayashi , Kelly Smith , David Underhill , Adrian Ozinsky
IPC分类号： A61K39/00 , C07K14/195 , C07K14/255 , A61K39/02 , C12N9/00
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/55516 , C07K14/255 , C07K2319/00
摘要： The invention provides an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ (SEQ ID NO:44), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL (SEQ ID NO:45); EGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVNG (SEQ ID NO:46) or MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS (SEQ ID NO:47), or a modification thereof. Also provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:49) or EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:50), or a modification thereof. Further provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ (SEQ ID NO:44) and substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. Methods of using immunomodulatory flagellin peptides additionally are provided.
摘要翻译：本发明提供具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ（SEQ ID NO：44）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节性鞭毛蛋白肽。免疫调节鞭毛蛋白肽也可以具有基本相同的氨基酸序列TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL（SEQ ID NO：45）; 或其修饰物。（SEQ ID NO：46）或MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS（SEQ ID NO：47）或其修饰。还提供了具有基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节鞭毛蛋白肽。免疫调节鞭毛蛋白肽也可以具有基本上相同的氨基酸序列TLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：49）或EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：50）或其修饰。还提供了具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ（SEQ ID NO：44）和基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有类似受体5的氨基酸序列的免疫调节鞭毛蛋白肽（TLR5）结合。另外提供了使用免疫调节鞭毛蛋白肽的方法。

2. 发明授权

US5944983A Hydrotreating catalyst and hydrotreating process of hydrocarbon oil by using the same 失效
标题翻译：加氢处理催化剂和烃油的加氢处理方法
公开(公告)号：US5944983A
公开(公告)日：1999-08-31
申请号：US67214
申请日：1998-04-28
申请人： Fumitaka Hayashi , Akira Kamo , Hiroshi Toshima , Akira Saiai
发明人： Fumitaka Hayashi , Akira Kamo , Hiroshi Toshima , Akira Saiai
IPC分类号： B01J23/88 , B01J21/12 , B01J23/85 , B01J35/10 , C10G11/04 , C10G45/04 , C10G45/08
CPC分类号： B01J35/10 , B01J21/12 , C10G11/04 , C10G45/04 , B01J23/85 , B01J35/108
摘要： This invention relates to a hydrotreating catalyst for a hydrocarbon oil and also to a process for hydrotreating the hydrocarbon oil by using the catalyst. More specifically, the present invention is concerned with a hydrotreating catalyst formed by having a hydrogenation-active component supported on a silica-alumina carrier and having a specific pore distribution and also with a hydrotreating process making use of the catalyst for the removal of sulfur compounds and nitrogen compounds from a hydrocarbon oil.
摘要翻译：本发明涉及一种用于烃油的加氢处理催化剂，也涉及使用催化剂加氢烃油的方法。更具体地说，本发明涉及通过将负载在二氧化硅 - 氧化铝载体上并具有特定孔分布的氢化活性组分以及利用用于除去硫化合物的催化剂的加氢处理方法形成的加氢处理催化剂以及来自烃油的氮化合物。

3. 发明授权

US09150423B2 Ammonia synthesis catalyst and ammonia synthesis method 有权
标题翻译：氨合成催化剂和氨合成方法
公开(公告)号：US09150423B2
公开(公告)日：2015-10-06
申请号：US13824227
申请日：2011-12-06
申请人： Hideo Hosono , Michikazu Hara , Masaaki Kitano , Sung Wng Kim , Satoru Matsuishi , Yoshitake Toda , Toshiharu Yokoyama , Fumitaka Hayashi
发明人： Hideo Hosono , Michikazu Hara , Masaaki Kitano , Sung Wng Kim , Satoru Matsuishi , Yoshitake Toda , Toshiharu Yokoyama , Fumitaka Hayashi
IPC分类号： C01C1/04 , B01J35/00 , B01J37/08 , B01J37/16 , B01J37/18 , B01J23/46 , B01J23/745 , B01J23/75 , B01J35/10 , B01J37/02 , B01J21/04
CPC分类号： C01C1/0411 , B01J21/04 , B01J23/462 , B01J23/745 , B01J23/75 , B01J35/002 , B01J35/0033 , B01J35/1009 , B01J37/0201 , B01J37/086 , B01J37/16 , B01J37/18 , Y02P20/52
摘要： The present invention provides a catalyst substance that is stable and performs well in the synthesis of ammonia, one of the most important chemical substances for fertilizer ingredients and the like. The catalyst substance exhibits catalytic activity under mild synthesis conditions not requiring high pressure, and is also advantageous from a resource perspective. Further provided is a method for producing the same. This catalyst comprises a supported metal catalyst that is supported on a mayenite type compound including conduction electrons of 1015 cm−3 or more and serving as a support for the ammonia synthesis catalyst. The mayenite type compound used as the support may take any form, including that of powder, a porous material, a sintered body, a thin-film, or a single crystal. Use of this catalyst makes it possible to increase the electron donating ability toward a transition metal.
摘要翻译：本发明提供一种氨合成稳定性良好的催化剂物质，其为化肥成分等最重要的化学物质之一。催化剂物质在不需要高压的温和合成条件下表现出催化活性，并且从资源角度来看也是有利的。进一步提供其制造方法。该催化剂包含负载在包含1015cm-3以上的导电电子的钙铝石型化合物作为氨合成催化剂的载体的载体金属催化剂。用作载体的钙铝石型化合物可以是任何形式，包括粉末，多孔材料，烧结体，薄膜或单晶。使用该催化剂使得可以增加向过渡金属的给电能力。

4. 发明授权

US08703146B2 Toll-like receptor 5 ligands and methods of use 有权
标题翻译： Toll样受体5配体及使用方法
公开(公告)号：US08703146B2
公开(公告)日：2014-04-22
申请号：US10991347
申请日：2004-11-16
申请人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
发明人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
IPC分类号： A61K39/112
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/55516 , C07K14/255 , C07K2319/00
摘要： The invention provides an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ (SEQ ID NO:44), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL (SEQ ID NO:45); EGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVNG (SEQ ID NO:46) or MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS (SEQ ID NO:47), or a modification thereof. Also provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:49) or EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:50), or a modification thereof. Further provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ (SEQ ID NO:44) and substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. Methods of using immunomodulatory flagellin peptides additionally are provided.
摘要翻译：本发明提供具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ（SEQ ID NO：44）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节鞭毛蛋白肽。免疫调节鞭毛蛋白肽也可以具有基本相同的氨基酸序列TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL（SEQ ID NO：45）; 或其修饰物。（SEQ ID NO：46）或MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS（SEQ ID NO：47）或其修饰。还提供了具有基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节鞭毛蛋白肽。免疫调节鞭毛蛋白肽也可以具有基本上相同的氨基酸序列TLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：49）或EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：50）或其修饰。还提供了具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ（SEQ ID NO：44）和基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有类似受体5的氨基酸序列的免疫调节鞭毛蛋白肽（TLR5）结合。另外提供了使用免疫调节鞭毛蛋白肽的方法。

5. 发明申请

US20110008318A1 TOLL-LIKE RECEPTOR 5 LIGANDS AND METHODS OF USE 审中-公开
公开(公告)号：US20110008318A1
公开(公告)日：2011-01-13
申请号：US12546593
申请日：2009-08-24
申请人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
发明人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
IPC分类号： A61K39/395 , A61K39/00 , C07K14/195 , C07K14/52 , C07K14/00 , C12N1/20 , A61P37/04
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/55516 , C07K14/255 , C07K2319/00
摘要： The invention provides an immunomodulatory flagellin peptide having at least about 10 amino acids of substantially the amino acid sequence GAVQNRFNSAIT, or a modification thereof, and having toll-like receptor 5 (TLR5) binding. Methods of inducing an immune response are also provided.
摘要翻译：本发明提供了具有基本上具有氨基酸序列GAVQNRFNSAIT或其修饰，并具有toll样受体5（TLR5）结合的至少约10个氨基酸的免疫调节鞭毛蛋白肽。还提供诱导免疫应答的方法。

6. 发明授权

US06306289B1 Catalyst for hydrogenation treatment and method for hydrogenation treatment of hydrocarbon oil 失效
标题翻译：用于氢化处理的催化剂和烃油的氢化处理方法
公开(公告)号：US06306289B1
公开(公告)日：2001-10-23
申请号：US09423833
申请日：1999-11-16
申请人： Fumitaka Hayashi , Akira Kamo , Hiroshi Toshima
发明人： Fumitaka Hayashi , Akira Kamo , Hiroshi Toshima
IPC分类号： C10G4500
CPC分类号： B01J23/88 , B01J21/02 , B01J21/10 , B01J21/12 , B01J23/85 , B01J23/882 , B01J23/883 , B01J35/002 , B01J35/10 , B01J35/1019 , B01J35/108 , B01J37/0205 , B01J37/03 , C10G45/08
摘要： A hydrotreating catalyst having both a high desulfurization activity and a denitrogenation activity and a method of hydrotreating a hydrocarbon oil using the same is provided. A hydrotreatment catalyst comprising a silica-alumina carrier loaded with at least one hydrogenation-active component; wherein (1) the silica content is in the range of 2 to 40% by weight based on the total weight of the carrier; and (2) in the spectrum obtained by nuclear magnetic resonance analysis (29Si-NMR), (i) the area of the peak at −80 ppm is 10% or more of the combined area of all the peaks; and (ii) the combined area of peaks at −80 ppm, −86 ppm and −92 ppm is 20% or more of the combined area of all peaks; a hydrotreating catalyst comprising a silica-alumina carrier containing a specific amount of a third component loaded with at lest one hydrogenation-active metal component and having a specific pore structure; and a method of hydrotreating a hydrocarbon oil comprising contacting a hydrocarbon oil with hydrogen in the presence of said hydrotreating catalyst.
摘要翻译：提供具有高脱硫活性和脱氮活性的加氢处理催化剂，以及使用其加氢处理烃油的方法。一种加氢处理催化剂，其包含负载有至少一种氢化活性组分的二氧化硅 - 氧化铝载体; 其中（1）基于所述载体的总重量，二氧化硅含量在2-40重量％的范围内; 和（2）在通过核磁共振分析（29Si-NMR）获得的光谱中，（i）-80ppm处的峰面积为所有峰的组合面积的10％以上; 和（ii）-80ppm，-86ppm和-92ppm的峰的组合面积为所有峰的组合面积的20％或更多; 加氢处理催化剂，其包含含有特定量的第三组分的二氧化硅 - 氧化铝载体，所述第三组分装载有至少一种氢化活性金属组分并具有特定孔结构; 以及加氢处理烃油的方法，包括在所述加氢处理催化剂存在下使烃油与氢气接触。

7. 发明授权

US09085616B2 Toll-like receptor 5 ligands and methods of use 有权
标题翻译： Toll样受体5配体及使用方法
公开(公告)号：US09085616B2
公开(公告)日：2015-07-21
申请号：US13191093
申请日：2011-07-26
申请人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
发明人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
IPC分类号： A61K39/39 , C07K14/21 , C07K14/195 , C07K14/24 , C07K14/255 , A61P31/04 , C07K14/25 , C07K14/20 , C07K14/32 , C07K14/33 , A61K39/02 , A61P37/04 , C07K14/28 , C07K14/245 , A61K39/00
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/55516 , C07K14/255 , C07K2319/00
摘要： The invention provides methods to elicit an immune response with an immunomodulatory flagellin polypeptide having toll-like receptor 5 (TLR5) binding, and further comprising an ADCC targeting molecule.
摘要翻译：本发明提供了用具有toll样受体5（TLR5）结合的免疫调节鞭毛蛋白多肽引发免疫应答的方法，并且还包含ADCC靶向分子。

8. 发明申请

US20130183224A1 AMMONIA SYNTHESIS CATALYST AND AMMONIA SYNTHESIS METHOD 有权
标题翻译：氨合成催化剂和氨合成方法
公开(公告)号：US20130183224A1
公开(公告)日：2013-07-18
申请号：US13824227
申请日：2011-12-06
申请人： Hideo Hosono , Michikazu Hara , Masaaki Kitano , Sung Wng Kim , Satoru Matsuishi , Yoshitake Toda , Toshiharu Yokoyama , Fumitaka Hayashi
发明人： Hideo Hosono , Michikazu Hara , Masaaki Kitano , Sung Wng Kim , Satoru Matsuishi , Yoshitake Toda , Toshiharu Yokoyama , Fumitaka Hayashi
IPC分类号： C01C1/04
CPC分类号： C01C1/0411 , B01J21/04 , B01J23/462 , B01J23/745 , B01J23/75 , B01J35/002 , B01J35/0033 , B01J35/1009 , B01J37/0201 , B01J37/086 , B01J37/16 , B01J37/18 , Y02P20/52
摘要： The present invention provides a catalyst substance that is stable and performs well in the synthesis of ammonia, one of the most important chemical substances for fertilizer ingredients and the like. The catalyst substance exhibits catalytic activity under mild synthesis conditions not requiring high pressure, and is also advantageous from a resource perspective. Further provided is a method for producing the same. This catalyst comprises a supported metal catalyst that is supported on a mayenite type compound including conduction electrons of 1015 cm−3 or more and serving as a support for the ammonia synthesis catalyst. The mayenite type compound used as the support may take any form, including that of powder, a porous material, a sintered body, a thin-film, or a single crystal. Use of this catalyst makes it possible to increase the electron donating ability toward a transition metal.
摘要翻译：本发明提供一种氨合成稳定性良好的催化剂物质，其为化肥成分等最重要的化学物质之一。催化剂物质在不需要高压的温和合成条件下表现出催化活性，并且从资源角度来看也是有利的。进一步提供其制造方法。该催化剂包含负载在包含1015cm-3以上的导电电子的钙铝石型化合物作为氨合成催化剂的载体的载体金属催化剂。用作载体的钙铝石型化合物可以是任何形式，包括粉末，多孔材料，烧结体，薄膜或单晶。使用该催化剂使得可以增加向过渡金属的给电能力。

9. 发明申请

US20120269855A1 TOLL-LIKE RECEPTOR 5 LIGANDS AND METHODS OF USE 有权
公开(公告)号：US20120269855A1
公开(公告)日：2012-10-25
申请号：US13191093
申请日：2011-07-26
申请人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
发明人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
IPC分类号： A61K39/39 , C07K14/21 , C07K14/195 , C07K14/24 , C07K14/255 , A61P31/04 , C07K14/25 , C07K14/20 , C07K14/32 , C07K14/33 , A61K39/02 , A61P37/04 , C07K14/28 , C07K14/245
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/55516 , C07K14/255 , C07K2319/00
摘要： The invention provides methods to elicit an immune response with an immunomodulatory flagellin polypeptide having toll-like receptor 5 (TLR5) binding, and further comprising an ADCC targeting molecule.
摘要翻译：本发明提供了用具有toll样受体5（TLR5）结合的免疫调节鞭毛蛋白多肽引发免疫应答的方法，并且还包含ADCC靶向分子。

10. 发明授权

US07915381B2 Toll-like receptor 5 ligands and methods of use 失效
标题翻译： Toll样受体5配体及使用方法
公开(公告)号：US07915381B2
公开(公告)日：2011-03-29
申请号：US10125692
申请日：2002-04-17
申请人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
发明人： Alan Aderem , Fumitaka Hayashi , Kelly D. Smith , David M. Underhill , Adrian Ozinsky
IPC分类号： A61K48/00 , A61K39/02 , A61K31/715 , C12N9/00
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/55516 , C07K14/255 , C07K2319/00
摘要： The invention provides an immunomodulatory flagellin peptide having at least about 10 amino acids of substantially the amino acid sequence GAVQNRFNSAIT (SEQ ID NO:2), or a modification thereof, and having toll-like receptor 5 (TLR5) binding. Methods of inducing an immune response are also provided.
摘要翻译：本发明提供具有基本上具有氨基酸序列GAVQNRFNSAIT（SEQ ID NO：2）或其修饰，并且具有toll样受体5（TLR5）结合的至少约10个氨基酸的免疫调节鞭毛蛋白肽。还提供诱导免疫应答的方法。

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