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1. 发明申请

US20140227706A1 Method for assessing progression of clinical state of malignant neoplasm by quantitative detection of DNA in blood 审中-公开
标题翻译：通过定量检测血液中的DNA来评估恶性肿瘤临床状态进展的方法
公开(公告)号：US20140227706A1
公开(公告)日：2014-08-14
申请号：US14118098
申请日：2012-05-16
申请人： Kikuya Kato , Fumio Imamura , Kazuya Taniguchi , Toru Kumagai , Junji Uchida , Kazumi Nishino
发明人： Kikuya Kato , Fumio Imamura , Kazuya Taniguchi , Toru Kumagai , Junji Uchida , Kazumi Nishino
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156
摘要： The object of the invention is to provide a method for quantitatively assessing the degree of progression of a malignant neoplasm in a patient who has been medicated. Provided is a method for assessing the progression of the clinical state of a malignant neoplasm in a subject who has been administered with a medicine for treating the malignant neoplasm, the method being characterized by comprising: (1) a step of determining the ratio of DNA molecules having an activation mutation that serves as an activation marker for the medicine to DNA molecules having a normal marker gene in DNA in the blood from the subject; (2) a step of determining the ratio of DNA molecules having a resistance mutation that serves as a resistance marker for the medicine to DNA molecules having a normal marker gene in the DNA in the blood from the subject; and (3) a step of comparing a value obtained in the step (2) with a value obtained in the step (1) to thereby assess whether or not the malignant neoplasm in the subject has acquired resistance to the treatment with the medicine.
摘要翻译：本发明的目的是提供一种用于定量评价已被给药的患者中的恶性肿瘤的进展程度的方法。本发明提供了一种用于评估已经给予恶性肿瘤治疗药物的受试者的恶性肿瘤的临床状态进展的方法，其特征在于包括：（1）测定DNA比例的步骤具有激活突变的分子，其用作药物的活化标记物，其具有来自受试者的血液中DNA中具有正常标记基因的DNA分子; （2）确定作为药物抗性标记的抗性突变的DNA分子与来自受试者的血液中的DNA中具有正常标记基因的DNA分子的比例的步骤; 和（3）将步骤（2）中获得的值与步骤（1）中获得的值进行比较的步骤，从而评估受试者的恶性肿瘤是否具有药物治疗的抵抗力。

2. 发明申请

US20110091924A1 Method of evaluating cancer type 审中-公开
标题翻译：癌症类型评估方法
公开(公告)号：US20110091924A1
公开(公告)日：2011-04-21
申请号：US12923147
申请日：2010-09-03
申请人： Akira Imaizumi , Toshihiko Ando , Naoyuki Okamoto , Fumio Imamura , Masahiko Higashiyama
发明人： Akira Imaizumi , Toshihiko Ando , Naoyuki Okamoto , Fumio Imamura , Masahiko Higashiyama
IPC分类号： C12Q1/02
CPC分类号： G01N33/574 , G01N33/6806
摘要： According to the method of evaluating cancer type of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the cancer type in the subject is evaluated based on the concentration value of at least one of Glu, ABA, Val, Met, Pro, Phe, Thr, Ile, Leu, and His contained in the measured amino acid concentration data of the subject.
摘要翻译：根据本发明的癌症类型的评价方法，测定从评价对象收集的血液中的氨基酸浓度值的氨基酸浓度数据，根据受试者的癌症类型的浓度值 Glu，ABA，Val，Met，Pro，Phe，Thr，Ile，Leu和His中的至少一个包含在受试者的测量的氨基酸浓度数据中。

3. 发明申请

US20100017144A1 Lung cancer evaluating apparatus, method, system, and program and recording medium therefor 有权
标题翻译：肺癌评估装置，方法，系统及程序及记录介质
公开(公告)号：US20100017144A1
公开(公告)日：2010-01-21
申请号：US12365272
申请日：2009-02-04
申请人： Akira Imaizumi , Nobukazu Ono , Ryosei Sakai , Toshihiko Ando , Naoyuki Okamoto , Fumio Imamura , Masahiko Higashiyama
发明人： Akira Imaizumi , Nobukazu Ono , Ryosei Sakai , Toshihiko Ando , Naoyuki Okamoto , Fumio Imamura , Masahiko Higashiyama
IPC分类号： G06F19/00
CPC分类号： G01N33/57423 , G06F19/16 , G06F19/18 , G06F19/22 , G06F19/24
摘要： According to the method of evaluating lung cancer, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a lung cancer state in the subject is evaluated based on the concentration value of at least one of Orn, Lys, ABA, Arg, Glu, His, Tau, Pro, Ala, Cit and Ile contained in the measured amino acid concentration data of the subject.
摘要翻译：根据肺癌的评价方法，测定从被评价对象收集的血液中的氨基酸的浓度值的氨基酸浓度数据，并且根据至少的浓度值来评价受试者的肺癌状态 Orn，Lys，ABA，Arg，Glu，His，Tau，Pro，Ala，Cit和Ile之一包含在被测物的测量的氨基酸浓度数据中。

4. 发明授权

US09664681B2 Lung cancer evaluating apparatus, method, system, and program and recording medium therefor 有权
公开(公告)号：US09664681B2
公开(公告)日：2017-05-30
申请号：US12365272
申请日：2009-02-04
申请人： Akira Imaizumi , Nobukazu Ono , Ryosei Sakai , Toshihiko Ando , Naoyuki Okamoto , Fumio Imamura , Masahiko Higashiyama
发明人： Akira Imaizumi , Nobukazu Ono , Ryosei Sakai , Toshihiko Ando , Naoyuki Okamoto , Fumio Imamura , Masahiko Higashiyama
IPC分类号： G01N33/48 , G01N33/50 , G01N33/574 , G06F19/22 , G06F19/24 , G06F19/16 , G06F19/18
CPC分类号： G01N33/57423 , G06F19/16 , G06F19/18 , G06F19/22 , G06F19/24
摘要： According to the method of evaluating lung cancer, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a lung cancer state in the subject is evaluated based on the concentration value of at least one of Orn, Lys, ABA, Arg, Glu, His, Tau, Pro, Ala, Cit and Ile contained in the measured amino acid concentration data of the subject.

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