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1. 发明申请

US20110152201A1 EMULSION PRECONCENTRATES CONTAINING CYCLOSPORIN OR A MACROLIDE 审中-公开
标题翻译：含有环磷酰胺或环糊精的乳液预处理
公开(公告)号：US20110152201A1
公开(公告)日：2011-06-23
申请号：US13036458
申请日：2011-02-28
申请人： Michael Ambühl , Barbara Lückel , Friedrich Richter , Barbara Häberlin , Armin Meinzer
发明人： Michael Ambühl , Barbara Lückel , Friedrich Richter , Barbara Häberlin , Armin Meinzer
IPC分类号： A61K38/13 , A61P37/06
CPC分类号： A61K31/435 , A61K9/1075 , A61K9/4858 , A61K31/436 , A61K38/13
摘要： This invention provides an emulsion, e.g., microemulsion, pre-concentrate comprising a difficultly soluble active agent and a carrier medium. The active agent may, e.g., be a cyclosporin or a macrolide.
摘要翻译：本发明提供了乳液，例如微乳液，预浓缩物，其包含难溶的活性剂和载体介质。活性剂可以是例如环孢菌素或大环内酯。

2. 发明申请

US20060115533A1 Pharmaceutical compositions 审中-公开
公开(公告)号：US20060115533A1
公开(公告)日：2006-06-01
申请号：US11255359
申请日：2005-10-21
申请人： Patrice Guitard , Barbara Haeberlin , Rainer Link , Friedrich Richter
发明人： Patrice Guitard , Barbara Haeberlin , Rainer Link , Friedrich Richter
IPC分类号： A61K31/724 , A61K31/4745
CPC分类号： A61K31/4745 , A61K9/145 , A61K9/146 , A61K31/436 , A61K31/445 , Y10S514/885 , Y10S514/922 , Y10S514/95 , Y10S514/964 , Y10S514/97
摘要： A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium.

3. 发明申请

US20060058399A1 Emulsion preconcentrates containing cyclosporin or a macrolide 审中-公开
公开(公告)号：US20060058399A1
公开(公告)日：2006-03-16
申请号：US11266791
申请日：2005-11-04
申请人： Michael Ambuhl , Barbara Luckel , Friedrich Richter , Barbara Haberlin , Armin Meinzer
发明人： Michael Ambuhl , Barbara Luckel , Friedrich Richter , Barbara Haberlin , Armin Meinzer
IPC分类号： A61K47/32 , A61K38/13
CPC分类号： A61K31/435 , A61K9/1075 , A61K9/4858 , A61K31/436 , A61K38/13
摘要： This invention provides an emulsion, e.g., microemulsion, pre-concentrate comprising a difficultly soluble active agent and a carrier medium. The active agent may, e.g., be a cyclosporin or a macrolide.

4. 发明授权

US06599535B2 Pharmaceutical compositions 失效
公开(公告)号：US06599535B2
公开(公告)日：2003-07-29
申请号：US10194826
申请日：2002-07-12
申请人： Patrice Guitard , Barbara Haeberlin , Rainer Link , Friedrich Richter
发明人： Patrice Guitard , Barbara Haeberlin , Rainer Link , Friedrich Richter
IPC分类号： A61K914
CPC分类号： A61K31/4745 , A61K9/145 , A61K9/146 , A61K31/436 , A61K31/445 , Y10S514/885 , Y10S514/922 , Y10S514/95 , Y10S514/964 , Y10S514/97
摘要： A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium.

5. 发明授权

US5962014A Pharmaceutical compositions comprising cyclosporins 失效
公开(公告)号：US5962014A
公开(公告)日：1999-10-05
申请号：US812078
申请日：1997-03-06
申请人： Birgit Hauer , Armin Meinzer , Ulrich Posanski , Friedrich Richter
发明人： Birgit Hauer , Armin Meinzer , Ulrich Posanski , Friedrich Richter
IPC分类号： A61K20060101 , A61K9/107 , A61K9/48 , A61K38/00 , A61K38/13 , A61K45/08 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/34 , A61K9/127
CPC分类号： B82Y5/00 , A61K38/13 , A61K9/1075 , A61K9/4858 , Y10S514/937 , Y10S514/938
摘要： Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or �Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

6. 发明授权

US5866105A Pharmaceutical composition 失效
标题翻译：药物组成
公开(公告)号：US5866105A
公开(公告)日：1999-02-02
申请号：US466490
申请日：1995-06-06
申请人： Friedrich Richter , Marianne Roser
发明人： Friedrich Richter , Marianne Roser
IPC分类号： A61K9/70 , A61K20060101 , A61K8/41 , A61K9/00 , A61K31/13 , A61K31/135 , A61K31/137 , A61K47/32 , A61P17/00 , A61P31/04 , A61P31/10 , A61Q3/00 , A61Q3/02 , A61K7/043 , A61K7/04
CPC分类号： A61K9/7015 , A61K31/135 , A61K8/41 , A61Q3/00 , A61Q3/02 , A61K9/0014 , Y10S514/858
摘要： The invention concerns topical formulations such as nail varnishes comprising as the active agent the compound of formula I ##STR1## in free base form or in acid addition salt form, together with a polymeric film former and further excipients as appropriate. It also concerns a process of preparation of such preparations by mixing with an appropriate polymeric film former and conventional further excipients as appropriate, and a method of treatment of onychomycosis.
摘要翻译：本发明涉及局部制剂，例如指甲油，其包含游离碱形式或酸加成盐形式的活性剂式I化合物，以及适当的聚合物成膜剂和其它赋形剂。它还涉及通过适当地与合适的聚合物成膜剂和常规的其它赋形剂混合制备这种制剂的方法和治疗甲真菌病的方法。

7. 发明授权

US5681849A Pharmaceutical composition for topical applications 失效
标题翻译：用于局部应用的药物组合物
公开(公告)号：US5681849A
公开(公告)日：1997-10-28
申请号：US228841
申请日：1994-04-18
申请人： Friedrich Richter , Michel Steiger
发明人： Friedrich Richter , Michel Steiger
IPC分类号： A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K31/13 , A61K31/135 , A61K31/137 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/32 , A61P17/00 , A61P31/04 , A61K31/27
CPC分类号： A61K47/32 , A61K31/135 , A61K31/137 , A61K47/10 , A61K9/0014 , Y10S514/864 , Y10S514/944 , Y10S514/947
摘要： Non-greasy topical solutions, emulsion gels or lotions comprising as the active agent a compound of formula I ##STR1## and a lower alkanol, and if desired together with a solubilizing agent or an oil phase such as isopropyl myristate are useful delivery systems.
摘要翻译：非油性局部溶液，乳剂凝胶或洗剂，其包含作为活性剂的式I化合物和低级烷醇，如果需要，与增溶剂或油相如肉豆蔻酸异丙酯一起是有用的递送系统。

8. 发明授权

US5342625A Pharmaceutical compositions comprising cyclosporins 失效
标题翻译：包含环孢菌素的药物组合物
公开(公告)号：US5342625A
公开(公告)日：1994-08-30
申请号：US990734
申请日：1992-12-15
申请人： Birgit Hauer , Armin Meinzer , Ulrich Posanski , Friedrich Richter
发明人： Birgit Hauer , Armin Meinzer , Ulrich Posanski , Friedrich Richter
IPC分类号： A61K9/107 , A61K9/48 , A61K9/66 , A61K38/13 , A61K37/02 , C07K7/64
CPC分类号： A61K38/13 , A61K9/1075 , A61K9/4858 , Y10S514/885 , Y10S514/937 , Y10S514/938 , Y10S514/963 , Y10S514/964 , Y10S514/97 , Y10S514/974 , Y10S514/975
摘要： Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva].sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.
摘要翻译：包含环孢菌素的药物组合物，例如环孢素或[Nva] 2-环孢菌素，在“微乳液预浓缩”和微乳液形式。组合物通常包含（1.1）低分子量单 - 或多 - 氧 - 烷二醇的C 1-5烷基或四氢糠基二 - 或部分醚。 Transcutol或Glycofurol，作为亲水组分。还提供了组合物，其包含环孢菌素和（1.1），并且合适地还含有糖单酯，例如，棉子糖或蔗糖单月桂酸酯。剂型包括局部制剂，特别是口服剂型。

9. 发明授权

US4785223A Method of and an apparatus for generating a pulse train 失效
标题翻译：用于产生脉冲串的方法和装置
公开(公告)号：US4785223A
公开(公告)日：1988-11-15
申请号：US816045
申请日：1986-01-03
申请人： Dietrich Hank , Friedrich Richter
发明人： Dietrich Hank , Friedrich Richter
IPC分类号： B41F13/02 , B65H23/188 , G05B21/02 , G05D15/01
CPC分类号： B41F13/025 , B65H23/1882 , G05B21/02 , G05D15/01 , B65H2557/2644
摘要： A method of generating a sampling signal succesion for use in a control system utilizing pulse-length modulated control signals, especially for controlling the tension or position of a continuously advancing web, such as in rotary printing machines, includes sampling and storing an error signal after a time interval having a duration approximately equal to an equalization time of the controlled system and commencing with the termination of a preceding adjustment step while the control system is out of operation, generating a binary signal of a length in time which is proportional to the error signal, sampling and storing a sum of the error signal and a deviation error signal during an additional time interval considerably shorter than the time constant of the controlled system, and extending the binary signal proportionally to the deviation control signal. An arrangement for performing the method includes two sampling devices connected in parallel to the output of a comparator and each including a series arrangement of a normally open contact, a storage unit, and a normally closed contact, the output of one sampling device being connected directly to a first input of a summing device and through another contact of the other sampling device to a second input of the summing device, while the output of the other sampling device is connected directly to a third input of the summing device. The output of the summing device is connected to inputs of a pulse-length modulator and a signum-forming element, whose outputs are connected to a control device for a drive.
摘要翻译：一种采用脉冲长度调制控制信号的控制系统中产生采样信号成功的方法，特别是用于控制连续行进的卷筒纸（如旋转印刷机器）的张力或位置，包括采样和存储误差信号。具有大约等于受控系统的均衡时间的持续时间的时间间隔，并且在控制系统不工作时从终止先前的调整步骤开始，产生与误差成比例的时间长度的二进制信号在比受控系统的时间常数短的附加时间间隔期间，将误差信号和偏差误差信号之和信号，采样和存储，并将二进制信号成比例地延伸到偏差控制信号。用于执行该方法的装置包括与比较器的输出并联连接的两个采样装置，每个采样装置包括常开触点，存储单元和常闭触点的串联装置，一个采样装置的输出直接连接到另一采样装置的第一输入端，并通过另一个采样装置的另一个触点与求和装置的第二输入端相连，而另一采样装置的输出端直接连接到求和装置的第三输入端。求和装置的输出连接到脉冲长度调制器和信号形成元件的输入端，其输出端连接到用于驱动器的控制装置。

10. 发明授权

US5866159A Pharmaceutical compositions comprising cyclosporins 失效
公开(公告)号：US5866159A
公开(公告)日：1999-02-02
申请号：US811749
申请日：1997-03-06
申请人： Birgit Hauer , Armin Meinzer , Ulrich Posanski , Friedrich Richter
发明人： Birgit Hauer , Armin Meinzer , Ulrich Posanski , Friedrich Richter
IPC分类号： A61K20060101 , A61K9/107 , A61K9/48 , A61K38/00 , A61K38/13 , A61K45/08 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/34 , A61K9/127
CPC分类号： B82Y5/00 , A61K38/13 , A61K9/1075 , A61K9/4858 , Y10S514/937 , Y10S514/938
摘要： Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or �Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

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