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    • 2. 发明申请
    • METHODS FOR PREDICTING EMBRYO VIABILITY
    • 预测胚胎发生率的方法
    • US20160161509A1
    • 2016-06-09
    • US15042439
    • 2016-02-12
    • Paul H. PevsnerFrederick NaftolinJamie GrifoFrederick Licciardi
    • Paul H. PevsnerFrederick NaftolinJamie GrifoFrederick Licciardi
    • G01N33/76G01N33/50G01N33/68
    • G01N33/76G01N33/5091G01N33/689G01N2333/59G01N2560/00G01N2800/368G01N2800/38
    • The present invention provides methods for predicting the viability of an embryo or for predicting the likelihood of a negative outcome during pregnancy by identifying the presence or absence of or determining the amount of one or more pregnancy associated markers such as molecular isoforms of hCG in a sample. In many instances, the invention is applicable to embryos generated by in vitro fertilization techniques, for instance, to embryos developing in a growth media. The present invention further provides methods for determining the amount of a pregnancy associated markers such as molecular isoforms of hCG (hCG) in a sample. The present invention also provides a diagnostic kit for predicting the viability of an embryo or for predicting the likelihood of a negative outcome during pregnancy by identifying the presence of or determining the amount of one or more pregnancy associated markers such as molecular isoforms of hCG in a sample.
    • 本发明提供了用于预测胚胎存活力或用于通过鉴定样品中存在或不存在或确定一种或多种妊娠相关标志物例如hCG的分子同种型的量来预测怀孕期间阴性结果的可能性的方法 。 在许多情况下,本发明可应用于通过体外受精技术产生的胚胎,例如胚胎在生长培养基中发育。 本发明进一步提供了用于确定妊娠相关标志物的量的方法,例如样品中hCG(hCG)的分子同种型。 本发明还提供了一种诊断试剂盒,用于预测胚胎的存活力或通过鉴定一种或多种妊娠相关标志物的量的存在或确定一种或多种妊娠相关标志物的量来预测怀孕期间的阴性结果的可能性, 样品。