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1. 发明授权

US10376148B2 System and method for laser imaging and ablation of cancer cells using fluorescence 有权
公开(公告)号：US10376148B2
公开(公告)日：2019-08-13
申请号：US14097337
申请日：2013-12-05
申请人： Fred Wood , Dmitry Yavid , Joe Zott , Ron Goldman
发明人： Fred Wood , Dmitry Yavid , Joe Zott , Ron Goldman
IPC分类号： A61B5/00 , A61B18/20 , A61B18/00
摘要： A fluorescence imaging device detects fluorescence in parts of the visible and invisible spectrum, and projects the fluorescence image directly on the human body, as well as on a monitor, with improved sensitivity, video frame rate and depth of focus, and enhanced capabilities of detecting distribution and properties of multiple fluorophores. Direct projection of three-dimensional visible representations of florescence on three-dimensional body areas advantageously permits view of it during surgical procedures, including during cancer removal, reconstructive surgery and wound care, etc. A NIR laser and a human visible laser (HVL) are aligned coaxially and scanned over the operating field of view. When the NIR laser passes over the area where the florescent dye is present, it energizes the dye which emits at a shifted NIR frequency detected by a photo diode. The HVL is turned on when emission is detected, providing visual indication of those positions.

2. 发明授权

US09042966B2 Three dimensional imaging of veins 有权
标题翻译：静脉三维成像
公开(公告)号：US09042966B2
公开(公告)日：2015-05-26
申请号：US14276139
申请日：2014-05-13
申请人： Ron Goldman , Fred Wood , Stephen P. Conlon , Vincent Luciano
发明人： Ron Goldman , Fred Wood , Stephen P. Conlon , Vincent Luciano
IPC分类号： A61B6/00 , A61B5/00 , A61M5/42 , A61M5/46 , A61B19/00
CPC分类号： A61B5/489 , A61B5/0037 , A61B5/0059 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0079 , A61B5/0082 , A61B5/6824 , A61B5/6831 , A61B5/6887 , A61B5/743 , A61B5/7475 , A61B17/3403 , A61B2019/202 , A61B2090/366 , A61B2560/0214 , A61B2560/0425 , A61B2560/0431 , A61B2562/028 , A61M5/427 , A61M5/46
摘要： A three dimensional imaging system includes a first laser emitting light at a first wavelength, and a scanner for scanning the laser light in a pattern on the target area. A photo detector receives light reflected from the target area as a contrasted vein image, resulting from differential absorption and reflection therein of the first wavelength of light. The intensity of the first laser is incrementally increased, and the photo detector thereby receives a plurality of contrasted vein images, each being at incrementally distinct depths beneath the target skin surface. Image processing is performed on the plurality of vein images to successively layer the veins in the images according to their depth, to create a single processed vein image. A second laser emitting a second wavelength of light is used in combination with the scanner to project the processed vein image onto the target area to overlay the veins therein.
摘要翻译：一种三维成像系统包括：第一激光发射第一波长的光;以及扫描器，用于以目标区域上的图案扫描激光。光检测器接收从目标区域反射的光作为对比静脉图像，其由第一波长的光的差分吸收和反射产生。第一激光器的强度逐渐增加，并且光电检测器因此接收多个对比静脉图像，每个静脉图像在目标皮肤表面下方呈递增不同的深度。对多个静脉图像执行图像处理，以根据其深度对图像中的静脉进行连续层叠，以创建单个经处理的静脉图像。与扫描器组合使用发射第二波长的光的第二激光器将经处理的静脉图像投射到目标区域上以覆盖其中的静脉。

3. 发明申请

US20150105648A1 Multispectral Detection and Presentation of an Object's Characteristics 审中-公开
标题翻译：多光谱检测和对象特征的呈现
公开(公告)号：US20150105648A1
公开(公告)日：2015-04-16
申请号：US14053775
申请日：2013-10-15
申请人： Fred Wood , Ron Goldman , Vincent Luciano
发明人： Fred Wood , Ron Goldman , Vincent Luciano
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B5/0059 , A61B5/0077 , A61B5/0088 , A61B5/4887 , A61B5/489 , A61B2090/366 , A61M5/427
摘要： An apparatus for capturing a multispectral image of an object is described. The apparatus includes one or more means for transmitting a beam of laser light at a first wavelength and a beam of laser light at one or more additional wavelengths different from the first wavelength. There is a means for causing the beams of laser light to travel in a coaxial path and a moving mirror. The beams of light bounce off the mirror thereby producing a two dimensional projection pattern. This pattern travels from the mirror along a first path to an object and wherein some of the laser light penetrates the object and travels to an internal structure of the object. The reflection of the laser light returns to a photo detector along a path different from said first path.
摘要翻译：描述用于捕获对象的多光谱图像的装置。该装置包括用于以不同于第一波长的一个或多个附加波长传送第一波长的激光束和激光束的一个或多个装置。存在使激光束在同轴路径和移动镜中行进的装置。光束从镜子反射，从而产生二维投影图案。该图案沿着第一路径从反射镜行进到物体，并且其中一些激光穿透物体并行进到物体的内部结构。激光的反射沿着与所述第一路径不同的路径返回到光电检测器。

4. 发明授权

US08818493B2 Three-dimensional imaging of veins 有权
标题翻译：静脉三维成像
公开(公告)号：US08818493B2
公开(公告)日：2014-08-26
申请号：US13135591
申请日：2011-07-08
申请人： Ron Goldman , Fred Wood , Vincent Luciano , Stephen Conlon
发明人： Ron Goldman , Fred Wood , Vincent Luciano , Stephen Conlon
IPC分类号： A61B6/00
CPC分类号： A61B5/489 , A61B5/0037 , A61B5/0059 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0079 , A61B5/0082 , A61B5/6824 , A61B5/6831 , A61B5/6887 , A61B5/743 , A61B5/7475 , A61B17/3403 , A61B2019/202 , A61B2090/366 , A61B2560/0214 , A61B2560/0425 , A61B2560/0431 , A61B2562/028 , A61M5/427 , A61M5/46
摘要： An apparatus and method for creating a three dimensional imaging system is disclosed. There is a first source of laser light and a second source of laser light having a wavelength different from the wavelength of the laser light of the first source. The laser light from the first and second sources are combined, and the combined laser light is transmitted to a scanner. The scanner further transmits the combined light to a surface to be imaged.
摘要翻译：公开了一种用于创建三维成像系统的装置和方法。存在第一激光源和具有与第一光源的激光波长不同的波长的第二激光源。来自第一和第二源的激光被组合，组合的激光被传送到扫描器。扫描器还将组合的光传输到待成像的表面。

5. 发明申请

US20140194751A1 Scanned Laser Vein Contrast Enhancer Using One Laser for a Detection Mode and a Display Mode 有权
标题翻译：扫描激光静脉对比度增强器使用一个激光进行检测模式和显示模式
公开(公告)号：US20140194751A1
公开(公告)日：2014-07-10
申请号：US14168158
申请日：2014-01-30
申请人： Ron Goldman , Stephen P Conlon , Vincent Luciano , Fred Wood
发明人： Ron Goldman , Stephen P Conlon , Vincent Luciano , Fred Wood
IPC分类号： A61B5/00
CPC分类号： A61B5/489 , A61B5/004 , A61B5/0059 , A61B5/0062 , A61B5/0064 , A61B5/0079 , A61B5/0082 , A61B5/4887 , A61B5/7221 , A61B5/748 , A61B2560/0431 , A61B2562/0233 , A61B2562/028 , A61M5/427
摘要： The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head, The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.
摘要翻译：本发明是一种微型静脉增强器，其包括微型投影头，微型投影头可以以AFM，DBM和RTM三种模式之一操作。本发明的微型投影头投影患者的静脉的图像，其帮助从业者精确定位静脉用于静脉滴注，血液检查等。微型投影头可以具有用于电源的空腔，或者其可以具有位于微型静脉增强器的主体部分中的电源。微型静脉增强器可以附接到几个改进的针保护器中的一个，或者微型静脉增强器可以附接到类似于手电筒的用于手持使用的身体。本发明的微型静脉增强器还可以附接到放大镜，平板显示器等。

6. 发明申请

US20140187879A1 System and Method for Laser Imaging and Ablation of Cancer Cells Using Fluorescence 审中-公开
标题翻译：使用荧光的激光成像和癌细胞消融的系统和方法
公开(公告)号：US20140187879A1
公开(公告)日：2014-07-03
申请号：US14097337
申请日：2013-12-05
申请人： Fred Wood , Dmitry Yavid , Joe Zott , Ron Goldman
发明人： Fred Wood , Dmitry Yavid , Joe Zott , Ron Goldman
IPC分类号： A61B5/00 , A61B18/20
CPC分类号： A61B5/0071 , A61B5/0077 , A61B5/742 , A61B18/20 , A61B2018/00577
摘要： A fluorescence imaging device detects fluorescence in parts of the visible and invisible spectrum, and projects the fluorescence image directly on the human body, as well as on a monitor, with improved sensitivity, video frame rate and depth of focus, and enhanced capabilities of detecting distribution and properties of multiple fluorophores. Direct projection of three-dimensional visible representations of florescence on three-dimensional body areas advantageously permits view of it during surgical procedures, including during cancer removal, reconstructive surgery and wound care, etc. A NIR laser and a human visible laser (HVL) are aligned coaxially and scanned over the operating field of view. When the NIR laser passes over the area where the florescent dye is present, it energizes the dye which emits at a shifted NIR frequency detected by a photo diode. The HVL is turned on when emission is detected, providing visual indication of those positions.
摘要翻译：荧光成像装置在可见光和不可见光谱的一部分中检测荧光，并将荧光图像直接投射在人体以及显示器上，具有改进的灵敏度，视频帧率和焦深，以及增强的检测能力分布和多种荧光团的性质。荧光三维可视表示直接投影在三维身体区域有利于允许在手术过程中观察它，包括在癌症消除，重建手术和伤口护理等期间。近红外激光和人类可见激光（HVL）是同轴对齐并在操作视野上进行扫描。当NIR激光通过存在荧光染料的区域时，它激发以由光电二极管检测到的移位的NIR频率发射的染料。当检测到发射时，HVL被接通，提供这些位置的视觉指示。

7. 发明授权

US08706200B2 Scanned laser vein contrast enhancer 有权
标题翻译：扫描激光静脉造影增强剂
公开(公告)号：US08706200B2
公开(公告)日：2014-04-22
申请号：US13649234
申请日：2012-10-11
申请人： Ron Goldman , Stephen P. Conlon , Vincent Luciano , Fred Wood
发明人： Ron Goldman , Stephen P. Conlon , Vincent Luciano , Fred Wood
IPC分类号： A61B6/00
CPC分类号： A61B5/489 , A61B5/004 , A61B5/0059 , A61B5/0062 , A61B5/0064 , A61B5/0079 , A61B5/0082 , A61B5/4887 , A61B5/7221 , A61B5/748 , A61B2560/0431 , A61B2562/0233 , A61B2562/028 , A61M5/427
摘要： The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.
摘要翻译：本发明是一种微型静脉增强器，其包括微型投影头。微型投影头可以以AFM，DBM和RTM三种模式之一操作。本发明的微型投影头投影患者的静脉的图像，这有助于从业者精确定位静脉用于静脉滴注，血液检查等。微型投影头可以具有用于电源的空腔，或者其可以具有位于微型静脉增强器的主体部分中的电源。微型静脉增强器可以附接到几个改进的针保护器中的一个，或者微型静脉增强器可以附接到类似于手电筒的用于手持使用的身体。本发明的微型静脉增强器还可以附接到放大镜，平板显示器等。

8. 发明申请

US20140024952A1 Enhanced Laser Vein Contrast Enhancer with Projection of Analyzed Vein Data 有权
标题翻译：增强激光静脉造影增强与投影分析静脉数据
公开(公告)号：US20140024952A1
公开(公告)日：2014-01-23
申请号：US13910257
申请日：2013-06-05
申请人： Fred Wood , Ron Goldman , Stephen Conlon , Vincent Luciano
发明人： Fred Wood , Ron Goldman , Stephen Conlon , Vincent Luciano
IPC分类号： A61B5/00 , A61B5/117 , A61B5/153 , A61B5/15 , A61M5/42
CPC分类号： A61M5/427 , A61B5/0059 , A61B5/0064 , A61B5/0082 , A61B5/024 , A61B5/02416 , A61B5/1172 , A61B5/1176 , A61B5/15003 , A61B5/150343 , A61B5/150748 , A61B5/150786 , A61B5/153 , A61B5/4839 , A61B5/489 , A61B5/72 , A61B5/7495 , A61B90/98 , A61B2576/00 , A61M2205/276 , A61M2205/50 , A61M2205/52 , A61M2205/609
摘要： It is known in the art to use an apparatus to enhance the visual appearance of the veins and arteries in a patient to facilitate insertion of needles into those veins and arteries. This application discloses a number of inventions that add additional data collection and presentation capabilities to a handheld vein enhancement apparatus and a set of processes for the collection of blood and the delivery of IV medicines that use the handheld device to mediate the process.
摘要翻译：在本领域中已知使用装置来增强患者的静脉和动脉的视觉外观以便于将针插入到那些静脉和动脉中。本申请公开了许多发明，其增加了手持静脉增强装置的额外的数据收集和呈现能力，以及用于收集血液和使用手持装置介导过程的IV药物的递送的一组过程。

9. 发明授权

US08594770B2 Multispectral detection and presentation of an object's characteristics 有权
标题翻译：多光谱检测和呈现物体的特征
公开(公告)号：US08594770B2
公开(公告)日：2013-11-26
申请号：US12925166
申请日：2010-10-14
申请人： Fred Wood , Ron Goldman , Vincent Luciano
发明人： Fred Wood , Ron Goldman , Vincent Luciano
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0059 , A61B5/0077 , A61B5/0088 , A61B5/4887 , A61B5/489 , A61B2090/366 , A61M5/427
摘要： An apparatus for capturing a multispectral image of an object is described. The apparatus includes one or more means for transmitting a beam of laser light at a first wavelength and a beam of laser light at one or more additional wavelengths different from the first wavelength. There is a means for causing the beams of laser light to travel in a coaxial path and a moving mirror. The beams of light bounce off the mirror thereby producing a two dimensional projection pattern. This pattern travels from the mirror along a first path to an object and wherein some of the laser light penetrates the object and travels to an internal structure of the object. The reflection of the laser light returns to a photo detector along a path different from said first path.
摘要翻译：描述用于捕获对象的多光谱图像的装置。该装置包括用于以不同于第一波长的一个或多个附加波长传送第一波长的激光束和激光束的一个或多个装置。存在使激光束在同轴路径和移动镜中行进的装置。光束从镜子反射，从而产生二维投影图案。该图案沿着第一路径从反射镜行进到物体，并且其中一些激光穿透物体并行进到物体的内部结构。激光的反射沿着与所述第一路径不同的路径返回到光电检测器。

10. 发明授权

US08391960B2 Scanned laser vein contrast enhancer 有权
标题翻译：扫描激光静脉造影增强剂
公开(公告)号：US08391960B2
公开(公告)日：2013-03-05
申请号：US11807064
申请日：2007-05-25
申请人： Fred Wood , Ron Goldman , Stephen Conlon , Vincent Luciano
发明人： Fred Wood , Ron Goldman , Stephen Conlon , Vincent Luciano
IPC分类号： A61B6/00
CPC分类号： A61B5/489 , A61B5/004 , A61B5/0059 , A61B5/0062 , A61B5/0064 , A61B5/0079 , A61B5/0082 , A61B5/4887 , A61B5/7221 , A61B5/748 , A61B2560/0431 , A61B2562/0233 , A61B2562/028 , A61M5/427
摘要： The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.
摘要翻译：本发明是一种微型静脉增强器，其包括微型投影头。微型投影头可以以AFM，DBM和RTM三种模式之一操作。本发明的微型投影头投影患者的静脉的图像，其帮助从业者精确定位静脉用于静脉滴注，血液检查等。微型投影头可以具有用于电源的空腔，或者其可以具有位于微型静脉增强器的主体部分中的电源。微型静脉增强器可以附接到几个改进的针保护器中的一个，或者微型静脉增强器可以附接到类似于手电筒的用于手持使用的身体。本发明的微型静脉增强器还可以附接到放大镜，平板显示器等。

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