专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060078989A1 Dedifferentiated, programmable stem cells of monocytic origin, and their production and use 有权
公开(公告)号：US20060078989A1
公开(公告)日：2006-04-13
申请号：US11282684
申请日：2005-11-21
申请人： Bernd Kremer , Fred Fandrich , Maren Ruhnke
发明人： Bernd Kremer , Fred Fandrich , Maren Ruhnke
IPC分类号： C12N5/08
CPC分类号： A61L27/3886 , A61K35/12 , A61K2035/124 , A61L27/3804 , A61L27/3834 , A61L27/3895 , C12N5/0607 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N5/0629 , C12N5/0647 , C12N5/0653 , C12N5/067 , C12N5/0676 , C12N5/069 , C12N2500/30 , C12N2500/44 , C12N2501/10 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/20 , C12N2501/22 , C12N2501/23 , C12N2501/235 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2502/14 , C12N2506/03 , C12N2506/11 , C12N2510/00
摘要： The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for the production of target cells and target tissue.

2. 发明授权

US4422284A Apparatus and method for harvesting seed bearing cones 失效
标题翻译：用于收获种子轴承锥体的装置和方法
公开(公告)号：US4422284A
公开(公告)日：1983-12-27
申请号：US139577
申请日：1980-04-11
申请人： Helmut E. Fandrich , Fred Fandrich
发明人： Helmut E. Fandrich , Fred Fandrich
IPC分类号： A01D46/24 , A01D46/00
CPC分类号： A01D46/24
摘要： Apparatus and method for harvesting seed bearing cones from a tree, the apparatus having a retrieving structure and holding structure to define a collecting enclosure therebetween to receive cone bearing material with structure to unload the collecting enclosure. The apparatus has a guide to encircle the tree to ensure generally axial movement, and separating structure adjacent an upper portion thereof which separates cone containing material from the tree resulting from upwards movement of the apparatus. In one embodiment the separating structure has a plurality of recesses to receive the tree trunk, the recesses being provided with knives which cut the branches when the trunk enters the recess and the device is moved upwardly up the trunk. Alternatively, the separating structure has recesses to receive branches and is provided with rake means to rake the cones from the branches. The method includes lowering of the apparatus generally axially down the tree and shifting the apparatus generally laterally to engage a portion of the tree within one of the recesses. Apparatus is moved axially upwardly so that edges of the recesses remove cone containing material from the tree.
摘要翻译：用于从树上收获种子承载锥体的装置和方法，所述装置具有回收结构和保持结构，以在其间限定收集箱，以容纳具有卸载收集箱的结构的锥形轴承材料。该装置具有环绕树的引导件以确保大致轴向运动，并且邻近其上部分离结构，其将包含材料的锥体包含在装置的向上移动中。在一个实施例中，分离结构具有多个用于接收树干的凹部，凹部设置有当躯干进入凹部时切割分支的装置，并且装置向上移动到树干上。或者，分离结构具有用于接收分支的凹部，并且设置有用于从分支耙出锥体的耙式装置。该方法包括大体沿轴向向下降低树上的装置，并大致侧向移动装置，以将树的一部分接合在一个凹部内。装置轴向向上移动，使得凹部的边缘从树上除去含有锥体的材料。

3. 发明申请

US20090233363A1 Dedifferentiated, Programmable Stem Cells of Monocytic Origin, and Their Production and Use 审中-公开
标题翻译：去分化，可编程的单核细胞干细胞及其生产和使用
公开(公告)号：US20090233363A1
公开(公告)日：2009-09-17
申请号：US12474183
申请日：2009-05-28
申请人： Bernd Karl Friedrich Kremer , Fred Fandrich , Maren nee Schulze Ruhnke
发明人： Bernd Karl Friedrich Kremer , Fred Fandrich , Maren nee Schulze Ruhnke
IPC分类号： C12N5/06
CPC分类号： A61L27/3886 , A61K35/12 , A61K2035/124 , A61L27/3804 , A61L27/3834 , A61L27/3895 , C12N5/0607 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N5/0629 , C12N5/0647 , C12N5/0653 , C12N5/067 , C12N5/0676 , C12N5/069 , C12N2500/30 , C12N2500/44 , C12N2501/10 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/20 , C12N2501/22 , C12N2501/23 , C12N2501/235 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2502/14 , C12N2506/03 , C12N2506/11 , C12N2510/00
摘要： The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for the production of target cells and target tissue.
摘要翻译：本发明涉及通过在含有M-CSF和IL-3的培养基中培养单核细胞从人单核细胞生产成人去分化的可编程干细胞。本发明还涉及含有去分化的可编程干细胞的药物制剂，以及这些干细胞用于产生靶细胞和靶组织的用途。

4. 发明申请

US20070072291A1 Dedifferentiated, programmable stem cells of monocytic origin, and their production and use 审中-公开
标题翻译：单分散来源的分化型可编程干细胞及其生产和使用
公开(公告)号：US20070072291A1
公开(公告)日：2007-03-29
申请号：US11543922
申请日：2006-10-06
申请人： Bernd Kremer , Fred Fandrich , Maren Schulze
发明人： Bernd Kremer , Fred Fandrich , Maren Schulze
IPC分类号： C12N5/02 , C12N5/00
CPC分类号： A61L27/3886 , A61K35/12 , A61K2035/124 , A61L27/3804 , A61L27/3834 , A61L27/3895 , C12N5/0607 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N5/0629 , C12N5/0647 , C12N5/0653 , C12N5/067 , C12N5/0676 , C12N5/069 , C12N2500/30 , C12N2500/44 , C12N2501/10 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/20 , C12N2501/22 , C12N2501/23 , C12N2501/235 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2502/14 , C12N2506/03 , C12N2506/11 , C12N2510/00
摘要： The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for the production of target cells and target tissue.
摘要翻译：本发明涉及通过在含有M-CSF和IL-3的培养基中培养单核细胞从人单核细胞生产成人去分化的可编程干细胞。本发明还涉及含有去分化的可编程干细胞的药物制剂，以及这些干细胞用于产生靶细胞和靶组织的用途。

5. 发明申请

US20170152302A1 ANTI-APOPTOTIC FUSION PROTEINS FOR REDUCING MYOCARDIAL INFARCTION SIZE 审中-公开
公开(公告)号：US20170152302A1
公开(公告)日：2017-06-01
申请号：US15205838
申请日：2016-07-08
申请人： Fred Fandrich
发明人： Ulrich Kunzendorf , Stefan Krautwald
IPC分类号： C07K14/81 , C07K14/005
CPC分类号： C07K14/8121 , A61K38/00 , C07K14/005 , C07K14/811 , C07K2319/10 , C12N2710/24122
摘要： The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing the fusion protein into a mammalian cell and an anti-apoptotic protein comprising the amino acid of the sequence of SEQ ID NO:1 or an anti-apoptotically active variant or fragment thereof. The invention also relates to a pharmaceutical composition comprising such a fusion protein, in particular for blocking apoptosis in a patient in need thereof. The invention also provides a polynucleotide encoding such a fusion protein, an expression vector comprising the polynucleotide and a host cell comprising the expression vector. In a further aspect, the invention relates to the use of any of theses materials for the preparation of a medicament for blocking apoptosis in a patient in need thereof.

6. 发明申请

US20090239295A1 Dedifferentiated, Programmable Stem Cells of Monocytic Origin, and Their Production and Use 审中-公开
公开(公告)号：US20090239295A1
公开(公告)日：2009-09-24
申请号：US12474191
申请日：2009-05-28
申请人： Bernd Karl Friedrich Kremer , Fred Fandrich , Maren nee Schulze Ruhnke
发明人： Bernd Karl Friedrich Kremer , Fred Fandrich , Maren nee Schulze Ruhnke
IPC分类号： C12N5/00
CPC分类号： A61L27/3886 , A61K35/12 , A61K2035/124 , A61L27/3804 , A61L27/3834 , A61L27/3895 , C12N5/0607 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N5/0629 , C12N5/0647 , C12N5/0653 , C12N5/067 , C12N5/0676 , C12N5/069 , C12N2500/30 , C12N2500/44 , C12N2501/10 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/20 , C12N2501/22 , C12N2501/23 , C12N2501/235 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2502/14 , C12N2506/03 , C12N2506/11 , C12N2510/00
摘要： The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for the production of target cells and target tissue.

7. 发明申请

US20060286670A1 Transplant acceptance inducing cells of monocytic origin and their preparation and use 审中-公开
标题翻译：移植接受诱导单核细胞来源的细胞及其制备和使用
公开(公告)号：US20060286670A1
公开(公告)日：2006-12-21
申请号：US10520931
申请日：2003-07-11
申请人： Bernd Kremer , Fred Fandrich , Maren Schulze
发明人： Bernd Kremer , Fred Fandrich , Maren Schulze
IPC分类号： C12N5/00 , C12N5/02 , C12N5/08
CPC分类号： A61K39/001 , A61K2035/122 , A61K2035/124 , A61K2039/5154 , C07K16/28 , C07K16/2833 , C12N5/0636 , C12N5/0645 , C12N2501/22 , C12N2501/24 , C12N2502/11
摘要： The invention relates to transplant acceptance inducing cells of monocytic origin, their production as well as their use for generating transplant acceptance. The invention also relates to the monoclonal antibody GM-7, which specifically recognises human transplant acceptance inducing cells of the invention. The invention further relates to the use of the antibody GM-7 for detection and/or selection transplant-acceptance inducing cells.
摘要翻译：本发明涉及单核细胞来源的移植接受诱导细胞，其生产以及其用于产生移植接受的用途。本发明还涉及特异性识别本发明的人移植接受诱导细胞的单克隆抗体GM-7。本发明还涉及抗体GM-7用于检测和/或选择移植接受诱导细胞的用途。

8. 发明申请

US20050221483A1 Dedifferentiated, programmable stem cells of monocytic origin, and their production and use 有权
标题翻译：单分散来源的分化型可编程干细胞及其生产和使用
公开(公告)号：US20050221483A1
公开(公告)日：2005-10-06
申请号：US11137444
申请日：2005-05-26
申请人： Bernd Kremer , Fred Fandrich , Maren nee Ruhnke
发明人： Bernd Kremer , Fred Fandrich , Maren nee Ruhnke
IPC分类号： A61K35/12 , A61K35/28 , A61L27/00 , A61L27/38 , A61P1/16 , A61P1/18 , A61P5/00 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/00 , A61P25/00 , C12N5/071 , C12N5/074 , C12N5/077 , C12N5/0789 , C12N5/079 , C12N5/0793 , C12N5/08
CPC分类号： A61L27/3886 , A61K35/12 , A61K2035/124 , A61L27/3804 , A61L27/3834 , A61L27/3895 , C12N5/0607 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N5/0629 , C12N5/0647 , C12N5/0653 , C12N5/067 , C12N5/0676 , C12N5/069 , C12N2500/30 , C12N2500/44 , C12N2501/10 , C12N2501/11 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/20 , C12N2501/22 , C12N2501/23 , C12N2501/235 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2502/14 , C12N2506/03 , C12N2506/11 , C12N2510/00
摘要： The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for the production of target cells and target tissue.
摘要翻译：本发明涉及通过在含有M-CSF和IL-3的培养基中培养单核细胞从人单核细胞生产成人去分化的可编程干细胞。本发明还涉及含有去分化的可编程干细胞的药物制剂，以及这些干细胞用于产生靶细胞和靶组织的用途。

9. 发明申请

US20050123525A1 Composition and method for inducing immune tolerance towards cell, tissue and/or organ transplants 审中-公开
标题翻译：诱导对细胞，组织和/或器官移植的免疫耐受的组合物和方法
公开(公告)号：US20050123525A1
公开(公告)日：2005-06-09
申请号：US10986156
申请日：2004-11-12
申请人： Ulrich Martin , Axel Haverich , Fred Fandrich
发明人： Ulrich Martin , Axel Haverich , Fred Fandrich
IPC分类号： A61K35/12 , A61K35/16 , A61K35/50 , A61K35/54 , A61K48/00 , C12N5/0735 , C12N5/08
CPC分类号： C12N5/0606 , A61K35/50 , A61K35/54 , A61K2035/122 , A61K2300/00
摘要： The present invention relates to a composition comprising embryonic stem cells or haematopoietic stem cells or precursor cells being obtained by differentiation of said embryonic stem cells as well as trophoblasts, trophoblasts precursor and/or placental cell derived from said trophopblasts, all cell types being derived from the same embryonic stem cell origin. Further, the present invention relates to the induction of immune tolerance in an Individual as well as methods for cell, tissue and organ transplantation. The composition according to the present invention may be used in the treatment or therapy of transplantation or gene therapy or in the field of tissue engineering.
摘要翻译：本发明涉及包含胚胎干细胞或造血干细胞或前体细胞的组合物，所述胚胎干细胞或造血干细胞或前体细胞通过分化所述胚胎干细胞以及滋养细胞，滋养细胞前体和/或源自所述嗜酸性粒细胞的胎盘细胞获得，所有细胞类型来源于相同的胚胎干细胞起源。此外，本发明涉及个体中免疫耐受的诱导以及细胞，组织和器官移植的方法。根据本发明的组合物可用于移植或基因治疗或组织工程领域的治疗或治疗。

10. 发明申请

US20060188485A1 Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations 审中-公开
标题翻译：自体自体耐受诱导单核细胞来源的细胞及其在药物制剂中的应用
公开(公告)号：US20060188485A1
公开(公告)日：2006-08-24
申请号：US10563956
申请日：2004-01-09
申请人： Bernd Karl Friedrich Kremer , Fred Fandrich , Maren Schulze
发明人： Bernd Karl Friedrich Kremer , Fred Fandrich , Maren Schulze
IPC分类号： A61K35/14 , A61K38/19 , C12N5/08 , A61K38/21
CPC分类号： A61K39/0008 , A61K2035/122 , A61K2035/124 , A61K2039/5154 , C12N5/0636 , C12N5/0645 , C12N2501/22 , C12N2501/24
摘要： The invention relates to cells of monocytic origin suitable for the prevention and/or treatment of diseases associated with disturbed self-tolerance, in particular autoimmune diseases and allergies, and to pharmaceutical preparations containing these cells. The cells are autologous in relation to the patient to whom they are to be administered. The invention further relates to a process for the generation and/or, propagation of autologous regulatory T cells.
摘要翻译：本发明涉及适用于预防和/或治疗与受干扰的自身耐受，特别是自身免疫性疾病和过敏有关的疾病以及含有这些细胞的药物制剂的单核细胞来源的细胞。这些细胞与要给予它们的患者相关是自体的。本发明还涉及自体调节性T细胞的产生和/或增殖的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式