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1. 发明授权

US4610249A Means and method for the noninvasive fragmentation of body concretions 失效
标题翻译：身体结构非侵入性破碎的手段和方法
公开(公告)号：US4610249A
公开(公告)日：1986-09-09
申请号：US608114
申请日：1984-05-08
申请人： Robert A. Makofski , Joe T. Massey , F. Fausten Mark , Francis B. Weiskopf, Jr. , William H. Guier , Patrick C. Walsh , Fray F. Marshall
发明人： Robert A. Makofski , Joe T. Massey , F. Fausten Mark , Francis B. Weiskopf, Jr. , William H. Guier , Patrick C. Walsh , Fray F. Marshall
IPC分类号： A61B8/08 , A61B17/22 , G10K15/06
CPC分类号： A61B17/2258 , A61B8/0833 , G10K15/06
摘要： Apparatus and method for noninvasive fragmentation of body concretions. The apparatus has an integral unit including an ultrasonic locating transducer and positioning structure. The concretion is localized with ultrasonics and then shattered upon generation of a shockwave, using a relfector with first and second foci. A spark gap at the first focus generates the shockwave which propagates to the second focus coincident with the concretion. The ultrasonic tranducer is positioned so that an axis of the transducer is coincident with a straight line passing through the first and second foci.
摘要翻译：用于非侵入性破碎身体结构的装置和方法。该装置具有包括超声波定位换能器和定位结构的整体单元。凝固物用超声波定位，然后在产生冲击波时破碎，使用具有第一和第二焦点的反射器。第一焦点处的火花隙产生冲击波，其传播到与凝结一致的第二焦点。超声波换能器被定位成使得换能器的轴与穿过第一和第二焦点的直线重合。

2. 发明申请

US20080280294A1 Inherited Mitochondrial Dna Mutations in Cancer 审中-公开
标题翻译：继承的线粒体Dna突变在癌症
公开(公告)号：US20080280294A1
公开(公告)日：2008-11-13
申请号：US11813660
申请日：2005-12-27
申请人： John Petros , Amanda Baumann , Douglas C. Wallace , Carrie Sun , Muta Issa , Fray F. Marshall
发明人： John Petros , Amanda Baumann , Douglas C. Wallace , Carrie Sun , Muta Issa , Fray F. Marshall
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： A method is provided for identifying a subject likely to have, or at risk of developing a disease condition correlated with increased reactive oxygen species (ROS), including cancer, by identifying in the subject a missense mutation in a nucleic acid of Complex III, IV and/or V of the OXPHOS system. This invention also provides a method of identifying a likelihood of having a heritable predisposition to cancer by detecting a homoplasmic missense mutation in non-tumor tissue of an OXPHOS system gene. This invention also provides a method for detecting likelihood of having cancer, predisposition to cancer, and likelihood of passing a predisposition to cancer to progeny involving identifying in non-tumor tissue of the subject a missense mutation in a complex III, IV and/or V gene of the mitochondrial OXPHOS system. The mutation may be a nuclear or mitochondrial mutation. The invention has been exemplified with respect to prostate cancer. When the mutation is homoplasmic in non-tumor tissue this is an indication it is an inherited and inheritable trait, and that the subject is likely to pass on the mutation to her progeny in the case of mutations in mitochondrial DNA or his or her progeny in the case of mutations in nuclear DNA. Both homoplasmic and heteroplasmic mutations in non-tumor tissue can indicate the presence of cancer.
摘要翻译：提供了一种方法，用于通过在受试者中识别复合物III，IV的核酸中的错义突变来识别可能具有或有发展与增加的活性氧（ROS）（包括癌症）相关的疾病状况的对象的受试者和/或V。本发明还提供了一种通过检测OXPHOS系统基因的非肿瘤组织中的同质错义突变来鉴定具有遗传性易患癌症的可能性的方法。本发明还提供了一种用于检测癌症可能性，癌症易感性和将癌症倾向通过后代的可能性的方法，其涉及在复合体III，IV和/或V中的受试者的非肿瘤组织中鉴定错义突变线粒体OXPHOS系统的基因。突变可能是核或线粒体突变。关于前列腺癌，已经举例说明了本发明。当突变在非肿瘤组织中是同质的时，这表明它是一种遗传和遗传性状，并且在线粒体DNA突变或其后代的情况下，受试者很可能将突变传给她的后代核DNA突变的情况。非肿瘤组织中均质和异质性突变均可表明存在癌症。

3. 发明授权

US4821729A Means and method for the noninvasive fragmentation of body concretions having means for accurately locating a concretion 失效
标题翻译：具有用于精确定位凝结物的装置的身体结构的非侵入性碎裂的手段和方法
公开(公告)号：US4821729A
公开(公告)日：1989-04-18
申请号：US905218
申请日：1986-09-09
申请人： Robert A. Makofski , Joe T. Massey , F. Fausten Mark , Francis B. Weiskopf, Jr. , William H. Guier , Patrick C. Walsh , Fray F. Marshall
发明人： Robert A. Makofski , Joe T. Massey , F. Fausten Mark , Francis B. Weiskopf, Jr. , William H. Guier , Patrick C. Walsh , Fray F. Marshall
IPC分类号： A61B8/08 , A61B17/22 , A61B17/225 , G10K15/06
CPC分类号： A61B17/2258 , A61B8/0833 , G10K15/06
摘要： Apparatus and method for noninvasive fragmentation of body concretions. The apparatus has an integral unit including an ultrasonic locating transducer a relative position determining device, a shockwave generating device and a positioning structure. The method for locating a body concretion includes the steps of locating the body concretion with ultrasonics, the position of the shockwave generating device relative to the concretion, accurately positioning the shockwave generating device at the location of the concretion and then shattering the concretion by generating a shockwave. The shockwave generating device includes a reflector with first and second foci, a location verifying ultrasonic transducer which is positioned so that an axis of the verifying transducer is coincident with a straight line passing through the first and second foci and a spark gap at the first focus which generates the shockwave.
摘要翻译：用于非侵入性破碎身体结构的装置和方法。该装置具有包括超声波定位换能器，相对位置确定装置，冲击波产生装置和定位结构的整体单元。用于定位身体结石的方法包括以下步骤：用超声波定位身体凝结物，冲击波产生装置相对于凝结物的位置，将冲击波产生装置精确定位在凝结物的位置，然后通过产生冲击波。冲击波产生装置包括具有第一和第二焦点的反射器，位置验证超声波换能器，其定位成使得验证换能器的轴与穿过第一和第二焦点的直线和在第一焦点处的火花隙一致产生冲击波。

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