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1. 发明申请

US20080118475A1 Model System for Testing the Efficacy of Pharmaceutical Preparation on Inflammatory Processes in the Nervous System 审中-公开
标题翻译：用于测试药物制剂对炎症过程在神经系统中的功效的模型系统
公开(公告)号：US20080118475A1
公开(公告)日：2008-05-22
申请号：US11664584
申请日：2005-09-22
申请人： Frank Striggow , Till Mack , Peter Roehnert
发明人： Frank Striggow , Till Mack , Peter Roehnert
IPC分类号： A61K35/30 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0622 , C12N2503/02
摘要： Live cells obtained from a mammalian tissue or organ. The cells are maintained ex vivo on a porous membrane having a pore size of ≧0.02 μm at a physiologically acceptable pH, in the presence of a culture gas, in culture and in a culture medium. The inter-neighbour relationships and the signal transduction between the cells are retained.
摘要翻译：从哺乳动物组织或器官获得的活细胞。在生理学上可接受的pH下，在培养气体存在下，在培养基和培养基中，将细胞离体维持在孔径>0.02μm的多孔膜上。保持细胞间的邻居关系和信号转导。

2. 发明申请

US20070037785A1 Novel dipeptidyl peptidase IV inhibitors used for functionally influencing different cells and treating immunological, infammatory, neuronal, and other diseases 审中-公开
标题翻译：用于功能影响不同细胞和治疗免疫，炎症，神经元和其他疾病的新型二肽基肽酶IV抑制剂
公开(公告)号：US20070037785A1
公开(公告)日：2007-02-15
申请号：US10575883
申请日：2004-10-15
申请人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
发明人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
IPC分类号： A61K31/55 , A61K31/397 , A61K31/519 , A61K31/538 , A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4745 , A61K31/473 , A61K31/165
CPC分类号： C07C235/56 , C04B35/632 , C07C229/34 , C07C243/28 , C07C251/80 , C07C251/86 , C07C255/61 , C07C259/14 , C07C271/28 , C07C311/08 , C07C311/19 , C07C311/29 , C07C323/60 , C07C327/48 , C07C2601/10 , C07C2603/74 , C07D205/08 , C07D213/82 , C07D225/02 , C07D401/12 , C07D405/12 , C07D417/12 , C07F9/6506
摘要： The present invention relates to substances capable of specifically inhibiting Gly-Pro-p-nitroanilide cleaving peptidases, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
摘要翻译：本发明涉及能够特异性抑制Gly-Pro-对硝基苯胺裂解肽酶的物质，用于医疗领域。此外，本发明涉及至少一种这样的物质或至少一种含有至少一种这样的物质的药物或化妆品组合物用于预防或治疗疾病，特别是用于预防和治疗伴随着其他慢性炎性疾病，神经元疾病和脑损伤，皮肤病（尤其是痤疮，牛皮癣），肿瘤疾病和特定病毒感染（特别是其他疾病）的过度免疫应答（自身免疫疾病，过敏，移植排斥） SARS）。

3. 发明授权

US09527894B2 Polymutant tau protein variants and their use for recapitulating human tauopathies 有权
标题翻译： Polymutant tau蛋白变体及其用于重述人类tau蛋白病的用途
公开(公告)号：US09527894B2
公开(公告)日：2016-12-27
申请号：US14114036
申请日：2011-04-28
申请人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
发明人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , C07K14/4711
摘要： Disclosed herein are methods for identifying an agent for treating or preventing neurogenerative disease and to methods for recapitulating tauopathies using a tau protein that includes at least four different mutations that cause the condition frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and to nucleic acids encoding the tau protein.
摘要翻译：本文公开了用于鉴定用于治疗或预防神经生殖疾病的药剂的方法和使用tau蛋白重复tau蛋白病的方法，所述tau蛋白包括引起与染色体17（FTDP-17）相关的额颞痴呆和帕金森综合征的至少四种不同突变，以及涉及编码tau蛋白的核酸。

4. 发明授权

US07645461B2 Method of treating cerebral ischemia with hydrogenation products of frankincense extracts 失效
标题翻译：用乳香提取物氢化产物治疗脑缺血的方法
公开(公告)号：US07645461B2
公开(公告)日：2010-01-12
申请号：US10549323
申请日：2004-03-18
申请人： Frank Striggow , Werner Schmidt , Till Mack
发明人： Frank Striggow , Werner Schmidt , Till Mack
IPC分类号： A61K36/00 , A61K31/00 , A01K26/00 , A01N61/00
CPC分类号： A61K31/19 , A61K36/324
摘要： The invention relates to the use of the hydrogenation products of frankincense (olibanum), its hydrogenated ingredients as well as physiologically acceptable salts and derivatives thereof and hydrogenated frankincense extracts for the production of a medicament for the prophylactic and/or therapeutic treatment of cerebral ischemia, cranial/brain trauma and/or Alzheimer's disease. The use of frankincense, frankincense extract, substances contained in frankincense, their physiologically acceptable salts, their derivatives and the physiological salts thereof, pure boswellic acids, tirucallic acids or other triterpenes, their physiologically acceptable salts, derivatives of the salts thereof for the production of a medicament for the prophylactic and/or therapeutic treatment of cerebral ischemia and/or cranial/brain trauma is also provided according to the invention.
摘要翻译：本发明涉及乳香（olibanum）的氢化产物，其氢化成分及其生理上可接受的盐和衍生物以及氢化乳香提取物在制备用于预防和/或治疗性脑缺血的药物中的用途，颅脑/脑创伤和/或阿尔茨海默氏病。使用乳香，乳香提取物，乳香中含有的物质，其生理学上可接受的盐，其衍生物及其生理盐，纯的保乳酸，铁金属酸或其他三萜烯，其生理学上可接受的盐，其盐的衍生物，用于生产根据本发明还提供了用于预防和/或治疗脑缺血和/或颅/脑创伤的药物。

5. 发明申请

US20080138811A1 Tissue-Based Assay System for Alzheimer-Specific Degeneration and Pathology 审中-公开
标题翻译：基于组织的阿尔茨海默病特异性退化和病理学检测系统
公开(公告)号：US20080138811A1
公开(公告)日：2008-06-12
申请号：US11813524
申请日：2006-12-08
申请人： Till Mack , Frank Striggow , Ina Hinners
发明人： Till Mack , Frank Striggow , Ina Hinners
IPC分类号： C12Q1/68 , C12N5/00 , C12N15/87
CPC分类号： G01N33/5088 , C07K14/4711 , C12N2799/028 , G01N33/5014 , G01N2333/4709 , G01N2333/8114
摘要： The present invention relates to modified brain slice cultures and assay systems based thereon. In particular, the invention relates to a tissue-based assay system for screening agents capable of modulating etiopathology of neuronal cells, in particular in the context of Alzheimer's disease related brain lesions.
摘要翻译：本发明涉及基于其的改良的脑切片培养物和测定系统。特别地，本发明涉及一种用于筛选能够调节神经元细胞病理学的筛选试剂的组织测定系统，特别是在阿尔茨海默病相关脑损伤的情况下。

6. 发明申请

US20060177467A1 Use of incense or hydrogenation products for preventing and/or treating a cerebral ischemia and/or cerebral traumatic lesion 失效
标题翻译：使用香或氢化产品预防和/或治疗脑缺血和/或脑创伤病变
公开(公告)号：US20060177467A1
公开(公告)日：2006-08-10
申请号：US10549323
申请日：2004-03-18
申请人： Frank Striggow , Werner Schmidt , Till Mack
发明人： Frank Striggow , Werner Schmidt , Till Mack
IPC分类号： A61K36/324 , A61K31/19
CPC分类号： A61K31/19 , A61K36/324
摘要： The invention relates to the use of the hydrogenation products of frankincense (olibanum), its hydrogenated ingredients as well as physiologically acceptable salts and derivatives thereof and hydrogenated frankincense extracts for the production of a medicament for the prophylactic and/or therapeutic treatment of cerebral ischemia, cranial/brain trauma and/or Alzheimer's disease. The use of frankincense, frankincense extract, substances contained in frankincense, their physiologically acceptable salts, their derivatives and the physiological salts thereof, pure boswellic acids, tirucallic acids or other triterpenes, their physiologically acceptable salts, derivatives of the salts thereof for the production of a medicament for the prophylactic and/or therapeutic treatment of cerebral ischemia and/or cranial/brain trauma is also provided according to the invention.
摘要翻译：本发明涉及乳香（olibanum）的氢化产物，其氢化成分及其生理上可接受的盐和衍生物以及氢化乳香提取物在制备用于预防和/或治疗性脑缺血的药物中的用途，颅脑/脑创伤和/或阿尔茨海默氏病。使用乳香，乳香提取物，乳香中含有的物质，其生理学上可接受的盐，其衍生物及其生理盐，纯的保乳酸，铁金属酸或其他三萜烯，其生理学上可接受的盐，其盐的衍生物，用于生产根据本发明还提供了用于预防和/或治疗脑缺血和/或颅/脑创伤的药物。

7. 发明申请

US20120258960A1 NOVEL MULTIFUNCTIONAL PEPTIDASE INHIBITORS, ESPECIALLY FOR MEDICAL USE 审中-公开
标题翻译：新型多功能肽抑制剂，特别适用于医疗用途
公开(公告)号：US20120258960A1
公开(公告)日：2012-10-11
申请号：US13393748
申请日：2010-08-26
申请人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Peter Roehnert , Sofia Stefin , Frank Striggow , Michael Taeger
发明人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Peter Roehnert , Sofia Stefin , Frank Striggow , Michael Taeger
IPC分类号： A61K31/165 , C07D295/192 , A61K31/495 , C07D277/04 , A61K31/426 , C07D243/08 , A61K31/551 , A61K8/42 , A61K8/49 , A61P37/00 , A61P9/10 , A61P25/00 , A61P17/00 , A61P35/00 , A61P37/06 , A61P31/12 , A61P3/10 , C07C237/20
CPC分类号： C07C237/20 , C07C237/22 , C07C271/20 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/56 , C07D239/26 , C07D263/24 , C07D277/04 , C07D295/192 , C07D333/24
摘要： The invention relates to compounds of the general formula (1) or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formula (1) in medicine.
摘要翻译：本发明涉及通式（1）的化合物或其与有机和/或无机酸的酸加成盐; 以及在药物中使用通式（1）的化合物。

8. 发明申请

US20090247898A1 DEVICE AND METHOD FOR MEASURING IMPEDANCE IN ORGANOTYPIC TISSUES 审中-公开
标题翻译：用于测量有机组织阻力的装置和方法
公开(公告)号：US20090247898A1
公开(公告)日：2009-10-01
申请号：US12392045
申请日：2009-02-24
申请人： Andrea ROBITZKI , Andree Rothermel , Heinz-Georg Jahnke , Ina Sternberger , Frank Striggow , Till Mack
发明人： Andrea ROBITZKI , Andree Rothermel , Heinz-Georg Jahnke , Ina Sternberger , Frank Striggow , Till Mack
IPC分类号： A61B5/053
CPC分类号： G01N33/4836 , G01N27/041
摘要： The present invention refers to a device for measuring impedance in organotypic tissue comprising at least one recording chamber with a liquid permeable membrane supporting the organotypic tissue, at least one bottom electrode and at least one top electrode, wherein the liquid permeable membrane divides the recording chamber into a top chamber and a bottom chamber, wherein at least the bottom chamber contains culture medium for the organotypic tissue, and the bottom electrode(s) is/are located in the bottom chamber and the top electrode(s) is/are located in the top chamber, and wherein the organotypic tissue is located between the bottom electrode(s) and the top electrode(s). The present invention also refers to the use of the device according to the present invention for measuring impedance in organotypic tissue.Furthermore, the present invention relates to a method for analyzing the effect of test compounds on pathological and non-pathological organotypic tissue by measuring the impedance of the organotypic tissue, wherein the organotypic tissue is cultured in a culture medium during the time of the analysis and the impedance of the organotypic tissue is measured at least once before and at least once after treating the organotypic tissue with the test compound or the impedance of the organotypic tissue treated with the test compound is compared to a non-treated organotypic tissue, wherein the impedance is measured using at least one electrode at each of two opposing sides of the organotypic tissue, and the electrodes are contacted with the culture medium or the tissue during measuring the impedance.
摘要翻译：本发明涉及一种用于测量器官组织中的阻抗的装置，包括至少一个具有支撑器官组织的液体可渗透膜的记录室，至少一个底部电极和至少一个顶部电极，其中液体可透膜将记录室进入顶部腔室和底部腔室，其中至少底部腔室包含用于器官型组织的培养基，并且底部电极位于底部腔室中，并且顶部电极位于顶部腔室，并且其中所述器官型组织位于所述底部电极和所述顶部电极之间。本发明还涉及根据本发明的装置用于测量器官组织中的阻抗的用途。此外，本发明涉及通过测量器官型组织的阻抗来分析试验化合物对病理和非病理性器官组织的影响的方法，其中在分析期间将培养基培养在器官型组织中，在用测试化合物处理器官型组织之后至少一次测量器官型组织的阻抗，或者将用受试化合物治疗的器官型组织的阻抗与未处理的器官类型组织进行比较，其中阻抗使用在器官型组织的两个相对侧中的每一侧上的至少一个电极测量，并且在测量阻抗期间电极与培养基或组织接触。

9. 发明申请

US20070078130A1 Dual alanyl aminopeptidase and dipeptidyl peptidase iv inhibitors for functionally influencing different cells and for treating immunological inflammatory, neuronal and other diseases 失效
标题翻译：双丙氨酰氨基肽酶和二肽基肽酶iv抑制剂功能影响不同细胞和治疗免疫炎症，神经元和其他疾病
公开(公告)号：US20070078130A1
公开(公告)日：2007-04-05
申请号：US10575878
申请日：2004-10-15
申请人： Siegfried Ansorge , Ute Bank , Michael Taeger , Frank Striggow
发明人： Siegfried Ansorge , Ute Bank , Michael Taeger , Frank Striggow
IPC分类号： A61K31/5377 , A61K31/452 , C07D413/02 , C07D405/02
CPC分类号： C07C327/48 , C07C233/83 , C07C251/86 , C07D317/60 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/06 , C07D413/14
摘要： The present invention relates to substances capable of specifically inhibiting Ala-p-nitroanilide-cleaving peptidases and Gly-Pro-p-nitroanilide-cleaving peptidases as well, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
摘要翻译：本发明涉及能够特异性抑制丙氨酸对硝基苯胺切割肽酶和Gly-Pro-对硝基苯胺切割肽酶的物质，用于医疗领域。此外，本发明涉及至少一种这样的物质或至少一种含有至少一种这样的物质的药物或化妆品组合物用于预防或治疗疾病，特别是用于预防和治疗伴随着其他慢性炎性疾病，神经元疾病和脑损伤，皮肤病（尤其是痤疮，牛皮癣），肿瘤疾病和特定病毒感染（特别是其他疾病）的过度免疫应答（自身免疫疾病，过敏，移植排斥） SARS）。

10. 发明申请

US20070037752A1 Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases 审中-公开
标题翻译：用于功能影响不同细胞和治疗免疫，炎症，神经元和其他疾病的新型丙氨酰 - 氨基肽酶抑制剂
公开(公告)号：US20070037752A1
公开(公告)日：2007-02-15
申请号：US10575882
申请日：2004-10-15
申请人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
发明人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
IPC分类号： A61K38/06 , A61K31/655 , A61K31/55 , A61K31/5415 , A61K31/5377 , A61K31/53 , A61K31/522 , A61K31/407 , A61K31/4439 , A61K31/4152
CPC分类号： C07C327/48 , C07C259/06 , C07C317/44 , C07C325/02 , C07C2601/10 , C07C2601/14 , C07D207/46 , C07D221/14 , C07D233/90 , C07D241/52 , C07D253/06 , C07D257/04 , C07D261/20 , C07D307/46 , C07D323/00 , C07D333/36 , C07D339/08 , C07D405/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D513/04 , C07F9/5333
摘要： The invention relates to substances which specifically inhibit peptidases splitting ala-p-nitroanilide for use in medicine. The invention further relates to the use of at least one such substance or of a pharmaceutical or cosmetic composition containing at least one such substance for the prophylaxis and therapy of diseases, in particular the prophylaxis and therapy of diseases with an overshooting immune response (autoimmune diseases, allergies and transplant rejections), of other chronic inflammatory diseases, neuronal diseases and brain damages, skin diseases (acne and psoriasis, among others), tumor diseases and special virus infections (including SARS).
摘要翻译：本发明涉及特异性抑制肽酶裂解α-对硝基苯胺以用于药物的物质。本发明还涉及至少一种此类物质或含有至少一种此类物质的药物或化妆品组合物用于预防和治疗疾病，特别是预防和治疗具有过度免疫应答的疾病（自身免疫性疾病，过敏和移植排斥），其他慢性炎性疾病，神经元疾病和脑损伤，皮肤疾病（痤疮和牛皮癣等），肿瘤疾病和特殊病毒感染（包括SARS）。

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