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1. 发明授权

US08101200B2 Targeted therapeutic agent release devices and methods of making and using the same 失效
标题翻译：靶向治疗剂释放装置及其制造和使用方法
公开(公告)号：US08101200B2
公开(公告)日：2012-01-24
申请号：US09834307
申请日：2001-04-12
申请人： Richard J. Whitbourne , Daniel Hullihen , Michael R. Violante , Frank Guo-Bin Wang , Xianping Zhang
发明人： Richard J. Whitbourne , Daniel Hullihen , Michael R. Violante , Frank Guo-Bin Wang , Xianping Zhang
IPC分类号： A61F2/00
CPC分类号： A61K9/0024 , A61L27/34 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/606
摘要： Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In one aspect of the present invention there are provided devices to accomplish the aforesaid delivery of therapeutic agents and methods to accomplish the delivery by positioning a device in the body using minimally invasive techniques such as, for example, catheterization or via trochar. The devices may contain a carrier substrate and a coating on the substrate. The carrier substrate provides structural integrity to the device and the coating thereon contains at least one layer of polymeric material containing one or more medicaments. Optionally, there may be a non-medicated binder coat between the carrier substrate and the medicated polymer layer. The medicated polymer layer may contain a hydrophilic/hydrophobic polymer composition.
摘要翻译：通常，本发明提供了用于将高效，有效浓度的治疗剂（例如药物，抗生素等）的药物递送到患者体内的特定部位（例如肿瘤和感染的病变）的装置和方法。在本发明的一个方面，提供了用于实现上述递送治疗剂的装置和通过使用微创技术（例如导管插入术或定位装置）将装置定位在体内来实现递送的方法。所述装置可以包含载体基底和基底上的涂层。载体基底为装置提供结构完整性，并且其上的涂层包含至少一层含有一种或多种药物的聚合材料层。任选地，在载体基质和含药聚合物层之间可以存在非药物粘合剂涂层。含药聚合物层可以含有亲水/疏水聚合物组合物。

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