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1. 发明申请

US20100291023A1 METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES 审中-公开
标题翻译：扩增异源或内源可溶性分子半衰期的方法
公开(公告)号：US20100291023A1
公开(公告)日：2010-11-18
申请号：US12602434
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van de Winkel , Aran Frank Labrijn , Paul Parren , Frank Beurskens , Willem Karel Bleeker , Patrick Van Berkel
IPC分类号： A61K38/20 , A61K38/21 , A61K39/395 , C07K16/44 , C07K16/42
CPC分类号： C07K16/283 , C07K16/2812 , C07K16/2863 , C07K16/2887 , C07K2317/732
摘要： The present invention relates to methods for extending the in vivo half-life of an exogenous soluble therapeutic molecule administered to a subject, by administering to said subject the exogenous soluble molecule and a monovalent antibody that binds to the exogenous soluble molecule, as well as method for treating a disease or disorder associated with an insufficient level of an endogenous soluble molecule in a subject, by administering to said subject a monovalent antibody that binds to the endogenous soluble molecule.
摘要翻译：本发明涉及通过向所述受试者施用外源可溶性分子和结合外源可溶性分子的单价抗体以及方法，用于延长给予受试者的外源可溶性治疗分子的体内半衰期的方法，以及方法用于治疗与受试者内源性可溶性分子水平不足相关的疾病或病症，通过向所述受试者施用结合内源性可溶性分子的单价抗体。

2. 发明授权

US07827083B2 Method and apparatus for pricing a commodity 失效
标题翻译：商品定价方法和装置
公开(公告)号：US07827083B2
公开(公告)日：2010-11-02
申请号：US11671482
申请日：2007-02-06
申请人： Frank Beurskens
发明人： Frank Beurskens
IPC分类号： G06Q40/00
CPC分类号： G06Q30/06 , G06Q30/0206 , G06Q40/00 , G06Q40/04 , G06Q40/06
摘要： A method of pricing a commodity involving selecting a predetermined market factor, determining at a first time period a first market condition, and providing a formula capable of comparing a predetermined market factor to a market condition to determine the existence of a favorable pricing condition. The method prices a first portion of the commodity when the application of the formula to the predetermined market factor and the first market condition indicates the existence of a first favorable pricing condition. The method prices a second portion of the commodity when the application of the formula to the predetermined market factor and a second market condition indicates the existence of a second favorable pricing condition.
摘要翻译：一种对商品定价的方法，涉及选择预定的市场因素，在第一时间段确定第一市场状况，并提供能够将预定市场因素与市场状况进行比较的公式，以确定存在有利的定价条件。当将公式应用于预定市场因素和第一市场条件时，该方法对商品的第一部分进行价格表示存在第一有利的定价条件。当将公式应用于预定市场因素和第二市场条件时，该方法对商品的第二部分进行价格表明存在第二有利的定价条件。

3. 发明申请

US20140242075A1 ANTIBODY VARIANTS AND USES THEREOF 审中-公开
标题翻译：抗体变异体及其用途
公开(公告)号：US20140242075A1
公开(公告)日：2014-08-28
申请号：US14130543
申请日：2012-07-06
申请人： Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
发明人： Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
IPC分类号： C07K16/28
摘要： Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.
摘要翻译：本文描述的是包含变体Fc结构域的多肽和相关抗体。当多肽，抗体或抗体与细胞表面上的其靶标，抗原或抗原结合时，变体Fc结构域提供稳定的Fc：Fc相互作用，从而提供改善的效应子功能，例如CDC反应。

4. 发明申请

US20100000801A1 SYSTEM AND METHOD FOR PROVIDING RECIPES ON A SCALE 审中-公开
标题翻译：用于在规模上提供食谱的系统和方法
公开(公告)号：US20100000801A1
公开(公告)日：2010-01-07
申请号：US12167089
申请日：2008-07-02
申请人： Richard E. Smith , Brian Hipsher , Kevin A. Russo , Ronald W. Tamkin , Frank Beurskens
发明人： Richard E. Smith , Brian Hipsher , Kevin A. Russo , Ronald W. Tamkin , Frank Beurskens
IPC分类号： G01G19/40 , G01G23/00
CPC分类号： G01G19/4144 , G01G23/3728 , G01G23/3735
摘要： A weighing scale adapted to automatically present one or more recipes to a user thereof, and a method of presenting such recipes. The recipes are preferably, but not necessarily, related in some way to a product being weighed or otherwise examined by the weighing scale. A recipe software application selects one or more recipes from a database of recipes and presents the recipes on one or more display devices of the weighing scale. One or more of the presented recipes may be selected by a user for delivery in one or more forms. Recipes may be delivered to a user according to the present invention, by one or more of providing the user with a printout of the selected recipe(s), by emailing the selected recipe(s) to a user, and/or by providing the user with a website URL from which the selected recipe(s) can be downloaded.
摘要翻译：适于自动向其用户呈现一个或多个食谱的称重秤，以及呈现这样的食谱的方法。配方优选地但不一定地以某种方式与被称重的产品或由称重秤进行的其它方式相关。食谱软件应用程序从食谱数据库中选择一个或多个配方，并将配方呈现在称重秤的一个或多个显示设备上。所呈现的食谱中的一个或多个可以由用户选择以一种或多种形式递送。可以通过一个或多个向用户提供所选择的配方的打印输出，通过将所选择的食谱通过电子邮件发送给用户，和/或通过提供具有可以从其中下载所选择的食谱的网站URL的用户。

5. 发明授权

US10759867B2 Antibody variants and uses thereof 有权
公开(公告)号：US10759867B2
公开(公告)日：2020-09-01
申请号：US14130543
申请日：2012-07-06
申请人： Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
发明人： Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
IPC分类号： G01N33/53 , C12N15/00 , C07K16/00 , C07K16/28 , C07K16/36 , A61K39/00
摘要： Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.

6. 发明申请

US20100306867A1 TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS 有权
标题翻译：生产从这些动物获得的单一人类抗体和抗体的转基因动物
公开(公告)号：US20100306867A1
公开(公告)日：2010-12-02
申请号：US12602419
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
IPC分类号： A01K67/027 , C07H21/04 , G01N33/53 , C07K16/18 , C12N15/63
CPC分类号： C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
摘要： The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
摘要翻译：本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法动物以及通过这种免疫方法可获得的单价抗体。

7. 发明申请

US20090155204A1 Methods for treating disorders involving monocytes 审中-公开
标题翻译：用于治疗涉及单核细胞的疾病的方法
公开(公告)号：US20090155204A1
公开(公告)日：2009-06-18
申请号：US12291494
申请日：2008-11-11
申请人： Frank Beurskens , Janine Schuurman , Paul Parren , Jorgen Petersen , Ole Baadsgaard
发明人： Frank Beurskens , Janine Schuurman , Paul Parren , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K38/20 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要： Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译：公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。

8. 发明授权

US07200572B2 Method and apparatus for pricing a commodity 有权
标题翻译：商品定价方法和装置
公开(公告)号：US07200572B2
公开(公告)日：2007-04-03
申请号：US09776162
申请日：2001-02-02
申请人： Frank Beurskens
发明人： Frank Beurskens
IPC分类号： G06Q40/00
CPC分类号： G06Q30/06 , G06Q30/0206 , G06Q40/00 , G06Q40/04 , G06Q40/06
摘要： A method of pricing a commodity involving selecting a predetermined market factor, determining at a first time period a first market condition, and providing a formula capable of comparing a predetermined market factor to a market condition to determine the existence of a favorable pricing condition. The method prices a first portion of the commodity when the application of the formula to the predetermined market factor and the first market condition indicates the existence of a first favorable pricing condition. The method prices a second portion of the commodity when the application of the formula to the predetermined market factor and a second market condition indicates the existence of a second favorable pricing condition.
摘要翻译：一种对商品进行定价的方法，涉及选择预定的市场因素，在第一时间段确定第一市场状况，并提供能够将预定市场因素与市场状况进行比较的公式，以确定存在有利的定价条件。当将公式应用于预定市场因素和第一市场状况时，该方法对商品的第一部分进行价格表明存在第一有利的定价条件。当将公式应用于预定市场因素和第二市场条件时，该方法对商品的第二部分进行价格表明存在第二有利的定价条件。

9. 发明授权

US10155816B2 Recombinant monovalent antibodies and methods for production thereof 有权
公开(公告)号：US10155816B2
公开(公告)日：2018-12-18
申请号：US12095023
申请日：2006-11-28
申请人： Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
发明人： Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
IPC分类号： C07K16/18 , C07K19/00 , C07K16/28
摘要： The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.

10. 发明授权

US09322035B2 Recombinant IgG4 monovalent antibodies 有权
标题翻译：重组IgG4单价抗体
公开(公告)号：US09322035B2
公开(公告)日：2016-04-26
申请号：US12602419
申请日：2008-05-30
申请人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
发明人： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
IPC分类号： C07K16/00 , C12N15/85 , C07K16/28
CPC分类号： C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
摘要： The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
摘要翻译：本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法动物以及通过这种免疫方法可获得的单价抗体。

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