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1. 发明授权

US08106197B2 Aminoheteroaryl compounds as protein kinase inhibitors 有权
标题翻译：氨基杂芳基化合物作为蛋白激酶抑制剂
公开(公告)号：US08106197B2
公开(公告)日：2012-01-31
申请号：US11598765
申请日：2006-11-14
申请人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： C07D241/02
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要翻译：提供式（1）的氨基吡啶和氨基吡嗪化合物，包括这些化合物的组合物及其使用方法。优选的式1化合物具有作为蛋白激酶抑制剂的活性，包括作为c-MET的抑制剂。

2. 发明申请

US20070072874A1 Aminoheteroaryl compounds as protein kinase inhibitors 有权
标题翻译：氨基杂芳基化合物作为蛋白激酶抑制剂
公开(公告)号：US20070072874A1
公开(公告)日：2007-03-29
申请号：US11598765
申请日：2006-11-14
申请人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： A61K31/4965 , A61K31/497 , A61K31/4439 , A61K31/4412 , C07D403/02
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要翻译：提供式（

3. 发明授权

US06861418B2 4-aryl substituted indolinones 失效
标题翻译： 4-芳基取代的二氢吲哚酮
公开(公告)号：US06861418B2
公开(公告)日：2005-03-01
申请号：US10736243
申请日：2003-12-16
申请人： Jingrong Cui , Ruofei Zhang , Hong Shen , Ji Yu Chu , Fang-Jie Zhang , Marcel Koenig , Steven Huy Do , Xiaoyuan Li , Chung Chen Wei , Peng Cho Tang
发明人： Jingrong Cui , Ruofei Zhang , Hong Shen , Ji Yu Chu , Fang-Jie Zhang , Marcel Koenig , Steven Huy Do , Xiaoyuan Li , Chung Chen Wei , Peng Cho Tang
IPC分类号： A61K31/136 , A61K31/337 , A61K31/404 , A61K31/416 , A61K31/4192 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/16 , A61P13/08 , A61P13/12 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/10 , A61P35/00 , A61P37/02 , A61P43/00 , C07D209/34 , C07D209/42 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/33 , A61K31/4738 , C07D209/04 , C07D311/94
CPC分类号： C07D403/14 , C07D209/34 , C07D401/14 , C07D403/06 , C07D417/14 , C07D487/04
摘要： The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention also relates to methods for treating protein kinase related disorders.
摘要翻译：本发明涉及能够调节蛋白激酶信号转导以调节，调节和/或抑制异常细胞增殖的4-芳基吲哚啉酮及其药物组合物。本发明还涉及治疗蛋白激酶相关病症的方法。

4. 发明申请

US20050038066A1 Geometrically restricted 3-cyclopentylidene-1,3-dihydroindol-2-ones as potent protein tyrosine kinase inhibitors 失效
标题翻译：几何限制3-亚环戊基-1,3-二氢吲哚-2-酮作为有效的蛋白酪氨酸激酶抑制剂
公开(公告)号：US20050038066A1
公开(公告)日：2005-02-17
申请号：US10911637
申请日：2004-08-05
申请人： Fang-Jie Zhang , Jingrong Cui , Chung Chen Wei , Peng Tang
发明人： Fang-Jie Zhang , Jingrong Cui , Chung Chen Wei , Peng Tang
IPC分类号： A61K31/404 , A61K31/4745 , C07D20060101 , C07D209/34 , C07D209/42 , C07D403/04 , C07D403/06 , C07D403/14 , C07D471/02 , C07D471/04 , C07D43/02
CPC分类号： C07D209/34 , C07D209/42 , C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula: wherein R1-R12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
摘要翻译：本发明涉及下列通式的某些亚磺酰氨基取代的几何受限的二氢吲哚酮：其中R1-R12和X是本文定义的变量。本发明优选实施方案的亚磺酰氨基取代的几何限制性二氢吲哚酮调节蛋白激酶（“PKs”）的活性。因此，本发明的化合物可用于治疗与异常PK活性相关的疾病。还公开了包含这些化合物的药物组合物，利用包含这些化合物的药物组合物治疗疾病的方法及其制备方法。

5. 发明申请

US20060009493A1 Indolinone hydrazides as c-Met inhibitors 审中-公开
标题翻译：吲哚酮酰肼作为c-Met抑制剂
公开(公告)号：US20060009493A1
公开(公告)日：2006-01-12
申请号：US10875508
申请日：2004-06-25
申请人： Marcel Koenig , Jingrong Cui , Chung Wei , Steven Do , Fang-Jie Zhang , Tomas Vojkovsky , John Ramphal , Guang Yang , Matthew Mattson , Christopher Nelson , Peng Tang
发明人： Marcel Koenig , Jingrong Cui , Chung Wei , Steven Do , Fang-Jie Zhang , Tomas Vojkovsky , John Ramphal , Guang Yang , Matthew Mattson , Christopher Nelson , Peng Tang
IPC分类号： C07D43/02 , A61K31/4439
CPC分类号： C07D209/40 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04
摘要： The present invention relates to compounds of the formulae (I)-(XII), wherein R1-R71, A, B, X, Y, G, L and Z are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.
摘要翻译：本发明涉及式（I） - （XII）的化合物，其中R 1 -R 71，A，B，X，Y，G，L和 Z在本文中定义，及其药学上可接受的盐。这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症。

6. 发明授权

US07230098B2 Aminoheteroaryl compounds as protein kinase inhibitors 有权
标题翻译：氨基杂芳基化合物作为蛋白激酶抑制剂
公开(公告)号：US07230098B2
公开(公告)日：2007-06-12
申请号：US10786610
申请日：2004-02-26
申请人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Jean Cui , Dilip Bhumralkar , Iriny Botrous , Ji Yu Chu , Lee A. Funk , Cathleen Elizabeth Hanau , G. Davis Harris , Lei Jia , Joanne Johnson , Stephen A. Kolodziej , Pei-Pei Kung , Xiaoyuan (Sharon) Li , Jason (Qishen) Lin , Jerry Jialun Meng , Mitchell David Nambu , Christopher G. Nelson , Mason Alan Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： C07D417/00 , C07D413/00 , C07D401/00 , C07D211/68 , C07D211/72
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET
摘要翻译：提供式（1）的氨基吡啶和氨基吡嗪化合物，包括这些化合物的组合物及其使用方法。优选的式1化合物具有作为蛋白激酶抑制剂的活性，包括作为c-MET的抑制剂

7. 发明申请

US20060223998A1 Synthetic LSD metabolite for preparing haptens used in an LSD metabolite immunoassay 审中-公开
标题翻译：用于制备用于LSD代谢物免疫测定中的半抗原的合成LSD代谢物
公开(公告)号：US20060223998A1
公开(公告)日：2006-10-05
申请号：US11093676
申请日：2005-03-30
申请人： Fang-Jie Zhang , Hshiou-ting Liu
发明人： Fang-Jie Zhang , Hshiou-ting Liu
IPC分类号： C07D457/02
CPC分类号： C07D457/06
摘要： A general method for the synthesis of OH-LSD and its analogs has been successfully developed. This method is convenient and efficient and allows preparation of a series of OH-LSD analogs with linkers attached at various (C-8, N-6 or N-1) positions.
摘要翻译：合成OH-LSD及其类似物的一般方法已经成功开发。该方法方便高效，可以制备一系列具有连接在各种（C-8，N-6或N-1）位上的接头的OH-LSD类似物。

8. 发明申请

US20050075340A1 Triazolotriazine compounds and uses thereof 失效
标题翻译：三唑并三嗪化合物及其用途
公开(公告)号：US20050075340A1
公开(公告)日：2005-04-07
申请号：US10874743
申请日：2004-06-24
申请人： Fang-Jie Zhang , Tomas Vojkovsky , Ping Huang , Congxin Liang , Steven Do , Marcel Koenig , Jingrong Cui
发明人： Fang-Jie Zhang , Tomas Vojkovsky , Ping Huang , Congxin Liang , Steven Do , Marcel Koenig , Jingrong Cui
IPC分类号： A61P35/00 , C07D487/04 , A61K31/53
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of the Formula (I), and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐。这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症。

9. 发明申请

US20190257698A1 MICROPROBE 审中-公开
公开(公告)号：US20190257698A1
公开(公告)日：2019-08-22
申请号：US16216995
申请日：2018-12-11
申请人： Lan Yang , Fang-Jie Shu , Xuefeng Jiang , Guangming Zhao
发明人： Lan Yang , Fang-Jie Shu , Xuefeng Jiang , Guangming Zhao
IPC分类号： G01K11/32 , G02B1/04 , G02B6/32 , G01K11/26
摘要： A microprobe is provided that includes a microsphere optical resonator operatively coupled to a nanoscatterer. The microsphere optical resonator includes a back surface and a front surface opposite the front surface. The front surface is configured to receive a focused laser beam, and the nanoscatterer is positioned adjacent to the back surface.

10. 发明授权

US08966056B2 Uniform service access system and access method 有权
标题翻译：统一的服务访问系统和访问方式
公开(公告)号：US08966056B2
公开(公告)日：2015-02-24
申请号：US12739725
申请日：2007-12-25
申请人： Jianjun Yang , Shengbo Luo , Fang Jie , Sanping Zhang
发明人： Jianjun Yang , Shengbo Luo , Fang Jie , Sanping Zhang
IPC分类号： G06F15/173 , H04L29/06 , H04Q3/00
CPC分类号： H04L65/1096 , H04Q3/0025 , H04Q3/0045 , H04Q3/0054
摘要： A uniform service access system is provided by the present invention, comprising: service providing means; a PARLAY state machine, configured to trigger an application service of the service providing means according to service request information and to generate call control information according to the application service information; a PARLAY adapter, configured to realize the conversion of the information transmission formats between the PARLAY state machine and a network state machine; the network state machine, configured to send uplink call generating service request information to the PARLAY adapter and to send downlink call control information to a network protocol adapter, the network protocol adapter, configured to realize a conversion of information transmission formats between the network state machine and a service switch equipment; the service switch equipment configured to trigger the application service according to a terminal call and to control a call according to the call control information from the network protocol adapter. An access method is further provided correspondingly. The present invention can realize an intelligent service supporting different network access.
摘要翻译：本发明提供统一的业务接入系统，包括：业务提供装置; PARLAY状态机，被配置为根据服务请求信息触发服务提供装置的应用服务，并根据应用服务信息生成呼叫控制信息; PARLAY适配器，被配置为实现PARLAY状态机和网络状态机之间的信息传输格式的转换; 所述网络状态机被配置为向所述PARLAY适配器发送上行呼叫生成服务请求信息，并将下行呼叫控制信息发送到网络协议适配器，所述网络协议适配器被配置为实现所述网络状态机之间的信息传输格式的转换和服务交换机设备; 所述服务交换机设备被配置为根据终端呼叫触发所述应用服务，并且根据来自所述网络协议适配器的呼叫控制信息来控制呼叫。相应地进一步提供访问方法。本发明可以实现支持不同网络接入的智能业务。

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