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1. 发明申请

US20080261206A1 Oligonucleotide for Detection of a Microorganism, Diagnostic Kits and Methods for Detection of Microorganisms Using the Oligonucleotide 审中-公开
标题翻译：用于检测微生物的寡核苷酸，诊断试剂盒和使用寡核苷酸检测微生物的方法
公开(公告)号：US20080261206A1
公开(公告)日：2008-10-23
申请号：US11574405
申请日：2005-08-28
申请人： Cheol-Min Kim , Hee-Kyung Park , Eun-Sil Song , Jun-Hyung Park , Hyun-Jung Jang , Byeong-Chul Kang
发明人： Cheol-Min Kim , Hee-Kyung Park , Eun-Sil Song , Jun-Hyung Park , Hyun-Jung Jang , Byeong-Chul Kang
IPC分类号： C12Q1/68 , C40B40/06 , C07H21/00
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： The present invention relates to a method so called Bacterial Digitalcode System (BaDis) that identifies microorganism by using bacterial-specific, genus-specific and species-specific oligonucleotides from a variety of samples or specimens for detection and differential diagnosis of microorganism. Particularly, the present invention relates to bacterial-specific, genus-specific and species-specific oligonucleotides designed by the target nucleotide sequences of 23S rDNA or ITS gene, polymerase chain reaction (hereinafter, referred to as “PCR”) kits using the oligonucleotides as a primer, the microarray containing the oligonucleotides as a probe, and methods for detecting microorganism by using the oligonucleotides. Therefore, the present invention can be applied to detect the presence of microorganism and diagnose differentially all microorganism such as pathogenic bacteria of infectious diseases, bacteria inducing food poisoning, bacteria contaminating biomedical products and environmental pollutants.
摘要翻译：本发明涉及一种所谓的细菌数字代码系统（BaDis）的方法，其通过使用来自各种样品或样品的细菌特异性，属特异性和物种特异性寡核苷酸来鉴定微生物，用于微生物的鉴定和鉴别诊断。特别地，本发明涉及由23S rDNA或ITS基因的靶核苷酸序列设计的细菌特异性，属特异性和物种特异性寡核苷酸，使用寡核苷酸作为聚合酶链反应（以下称为“PCR”）试剂盒引物，含有寡核苷酸作为探针的微阵列，以及通过使用寡核苷酸检测微生物的方法。因此，本发明可以应用于检测微生物的存在并差异地诊断所有微生物，如感染性疾病的病原菌，诱导食物中毒的细菌，细菌污染的生物医学产品和环境污染物。

2. 发明申请

US20090286691A1 Oligonucleotide for Detection of Bacteria Associated with Sepsis and Microarrays and Method for Detection of the Bacteria Using the Oligonucleotide 审中-公开
标题翻译：用于检测与败血症和微阵列相关的细菌的寡核苷酸和使用寡核苷酸检测细菌的方法
公开(公告)号：US20090286691A1
公开(公告)日：2009-11-19
申请号：US12161691
申请日：2006-01-20
申请人： Cheol-Min Kim , Hee-Kyung Park , Hyun-Jung Jang , Eun-Sil Song
发明人： Cheol-Min Kim , Hee-Kyung Park , Hyun-Jung Jang , Eun-Sil Song
IPC分类号： C40B30/04 , C07H21/04 , C12Q1/68 , C40B40/06 , C40B40/08
CPC分类号： C12Q1/689
摘要： The present invention relates to oligonucleotides for detection of sepsis-causing bacteria and a detection method using the oligonucleotides, more particularly to a microarry comprising at least one of gram positive bacteria-specific and gram negative bacteria-specific oligonucleotides, sepsis-causing bacteria's genus-specific and species-specific oligonucleotides designed from the ITS target region which is hypervariable base sequence of sepsis-causing bacteria as probes, and a detection method and a diagnosis kit by using the same.According to the present invention, the present invention can provide an antibiotics therapy for accurately removing infectious agent related to sepsis by detecting existence of sepsis-causing bacteria and identifying gram positive- and gram negative-bacteria and genus and species of the bacteria, at once. And, the present invention can prevent a patient from abuse and misuse of antibiotics and decrease time of hospital treatment and medical cost of the patient. Further, the present invention has advantage of preventing complications and reducing mortality rate.
摘要翻译：本发明涉及用于检测败血症细菌的寡核苷酸和使用寡核苷酸的检测方法，更具体地涉及包含革兰氏阳性细菌特异性和革兰氏阴性细菌特异性寡核苷酸中的至少一种的微阵列，败血症细菌的属 - 由作为败血症的细菌作为探针的高变碱基序列的ITS靶区设计的特异性和物种特异性寡核苷酸，以及使用该检测方法和诊断试剂盒。根据本发明，本发明可以提供一种用于通过检测脓毒症引起的细菌的存在并一次鉴定革兰氏阳性和革兰氏阴性细菌以及细菌的种类和物种来精确地去除与败血症相关的传染原的抗生素治疗。并且，本发明可以防止患者滥用和滥用抗生素，并减少患者的医院治疗时间和医疗费用。此外，本发明具有防止并发症和降低死亡率的优点。

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