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1. 发明申请

US20050271706A1 Controlled release bioactive agent delivery device 审中-公开
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US20050271706A1
公开(公告)日：2005-12-08
申请号：US11204271
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
IPC分类号： A61K9/00 , A61K31/58 , A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides methods for delivering bioactive agent to an eye, the methods including steps of providing a device at an implantation site within the eye, and maintaining the device at the implantation site to provide a therapeutically effective amount of the bioactive agent to the eye. The device includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension. A polymeric coated composition is provided in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of administering a therapeutically effective amount of bioactive agent to a posterior segment of an eye.
摘要翻译：本发明提供了将生物活性剂递送到眼睛的方法，所述方法包括以下步骤：在眼睛内的植入部位提供装置，并将装置保持在植入部位以向眼睛提供治疗有效量的生物活性剂。该装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中主体构件的至少一部分偏离延伸方向。提供与主体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。本发明还提供了将治疗有效量的生物活性剂施用于眼后段的方法。

2. 发明申请

US20050019371A1 Controlled release bioactive agent delivery device 失效
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US20050019371A1
公开(公告)日：2005-01-27
申请号：US10835530
申请日：2004-04-29
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner
IPC分类号： A61K9/00 , A61K31/58
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译：本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯，）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。

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