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1. 发明授权

US4539199A Sustained release pharmaceutical compositions 失效
标题翻译：持续释放药物组合物
公开(公告)号：US4539199A
公开(公告)日：1985-09-03
申请号：US384084
申请日：1982-06-01
申请人： Erno Orban , Janos Borvendeg , Laszlo Nagy , Marta Sotinee Tolvay , Erzsebet Bander
发明人： Erno Orban , Janos Borvendeg , Laszlo Nagy , Marta Sotinee Tolvay , Erzsebet Bander
IPC分类号： A61K47/48 , A01N25/12 , A61K31/78
CPC分类号： A61K47/48176
摘要： Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.
摘要翻译：用于持续释放药物组合物的药物组合物，其包含含有伯，仲或叔氨基的药物活性化合物的水溶性盐与含有酸基的合成共聚物的碱金属盐或铵盐的反应产物，并且选自由甲基丙烯酸/甲基丙烯酸甲酯，甲基丙烯酸/丙烯酸甲酯和甲基丙烯酸/丙烯酸甲酯/甲基丙烯酸甲酯共聚物和药学上可接受的赋形剂组成的组。含有伯，仲或叔氨基的药物活性化合物的水溶性盐在水性介质中与选自上述共聚物的共聚物的碱金属盐或铵盐反应，将所得产物转化为药物组合物。

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