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1. 发明申请

US20050181446A1 Protein variants having modified immunogenicity 审中-公开
标题翻译：具有改变的免疫原性的蛋白质变体
公开(公告)号：US20050181446A1
公开(公告)日：2005-08-18
申请号：US09957806
申请日：2001-09-21
申请人： Erwin Roggen , Steffen Ernst , Allan Svendsen , Esben Friis , Claus Osten
发明人： Erwin Roggen , Steffen Ernst , Allan Svendsen , Esben Friis , Claus Osten
IPC分类号： A21D2/26 , A21D8/04 , C07K1/04 , C07K5/103 , C07K5/11 , C07K5/113 , C07K14/00 , C07K16/40 , C07K16/42 , C11D3/386 , C12N9/02 , C12N9/20 , C12N15/53 , C12N15/55 , C12Q1/70 , C12N5/06 , C12P21/02 , G01N33/48 , G01N33/50 , G01N33/53 , G06F19/00
CPC分类号： C12N9/54 , A21D2/267 , A21D8/042 , A61K39/00 , C07K1/047 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K14/001 , C07K16/40 , C07K16/4283 , C11D3/38627 , C11D3/38645 , C12N9/0061 , C12N9/20 , C12Y110/03002 , C12Y304/21062 , Y10S435/911
摘要： The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids situated within 5 Å from the epitope amino acids constituting the epitope sequence, changing one or more of the amino acids defining the epitope area of the parent protein by genetical engineering mutations of a DNA sequence encoding the parent protein, introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and use thereof, as well as to a method for producing said protein variant.
摘要翻译：本发明涉及选择与亲本蛋白相比具有改良的免疫原性的蛋白质变体的方法，其包括获得抗体结合肽序列的步骤，使用该序列来定位母体蛋白的3维结构上的表位序列，限定表位包括位于构成表位序列的表位氨基酸5埃范围内的氨基酸，通过编码母体蛋白质的DNA序列的遗传工程突变改变限定母体蛋白表位区域的一个或多个氨基酸，引入突变的 DNA序列转化为合适的宿主，培养所述宿主并表达蛋白质变体，并使用亲本蛋白作为参考来评估蛋白质变体的免疫原性。本发明还涉及蛋白质变体及其用途，以及生产所述蛋白质变体的方法。

2. 发明申请

US20050079593A1 Modified enzymes having polymer conjugates 审中-公开
标题翻译：具有聚合物共轭物的改性酶
公开(公告)号：US20050079593A1
公开(公告)日：2005-04-14
申请号：US10623292
申请日：2003-07-18
申请人： Claus von der Osten , Arne Olsen , Erwin Roggen
发明人： Claus von der Osten , Arne Olsen , Erwin Roggen
IPC分类号： C12N9/02 , A61K47/48 , C07K14/00 , C11D3/37 , C11D3/386 , C12N9/10 , C12N9/20 , C12N9/48 , C12N9/90 , C12N15/57 , C12N9/00 , C07K14/47
CPC分类号： C11D3/386 , A61K47/56 , A61K47/60 , C11D3/37
摘要： The present invention relates to polypeptide-polymer conjugates having added and/or removed one or more attachment groups for coupling polymeric molecules on the surface of the polypeptide structure, a method for preparing polypeptide-polymer conjugates of the invention, the use of said conjugated for reducing the immunogenicity and allergenicity and compositions comprising said conjugate.
摘要翻译：本发明涉及多肽 - 聚合物缀合物，其具有添加和/或除去一个或多个用于偶联多肽结构表面上的聚合物分子的连接基团，本发明的多肽 - 聚合物缀合物的制备方法，所述缀合物降低免疫原性和变应原性以及包含所述缀合物的组合物。

3. 发明申请

US20070225207A1 Group 1 Mite Polypeptide Variants 审中-公开
标题翻译：组1螨多肽变体
公开(公告)号：US20070225207A1
公开(公告)日：2007-09-27
申请号：US11587239
申请日：2005-04-21
申请人： Vincent Batori , Erwin Roggen , Steffen Ernst , Stina Lyngstrand
发明人： Vincent Batori , Erwin Roggen , Steffen Ernst , Stina Lyngstrand
IPC分类号： A61K38/00 , C07H21/04 , C07K14/00 , C12N15/00 , C12N5/06 , C12P1/04
CPC分类号： C07K14/43531 , A61K39/00 , A61K2039/57
摘要： This invention concerns variants of a group 1 mite polypeptide, wherein the mature polypeptide of the variants comprise one or more mutations in the positions or corresponding to positions consisting of P11, I14, D15, L16, M19-P24, Q28, F37, S38, T43, A46-A49, Q53-L57, V63, A66-H69, H72, D74-R77, I80, Y82, Q84, H85, S92, I113, S114, P121, V124, K126, R128-A130, A132-S136, A139, L147, A149-H152, T157, Q160, N163, H170, A171, S178, V183, D184, R189, D193, F204, A206, N207, P217, L222 of SEQ ID NO: 1 or alternatively 11, 14, 15, 16, 19-24, 28, 37, 38, 43, 46-49, 53-57, 63, 66-69, 72, 74-77, 80, 82, 84, 85, 92, 113, 114, 121, 124, 126, 128-130, 132-136, 139, 147, 149-152, 157, 160, 163, 170, 178, 183, 189, 193, 204, 206, 207, 217, 222 of the mature Der p 1 polypeptide.
摘要翻译：本发明涉及组1螨多肽的变体，其中变体的成熟多肽包含位置或对应于由P11，I14，D15，L16，M19-P24，Q28，F37，S38等组成的位置的一个或多个突变。 T43，A46-A49，Q53-L57，V63，A66-H69，H72，D74-R77，I80，Y82，Q84，H85，S92，I113，S114，P121，V124，K126，R128-A130，A132-S136， SEQ ID NO：1的A139，L147，A149-H152，T157，Q160，N163，H170，A171，S178，V183，D184，R189，D193，F204，A206，N207，P217，L222或者11,14,15 ，16,19-24,28,37,38,43,46-49,53-57,63,66-69,72,74-77,80,82,84,85,92,113,114,121 ，成熟Der的第124,126,128-130,132-136,139,147,149-152,157,160,163,170,178,183,189,193,204,206,207,217,222。 p 1多肽。

4. 发明申请

US20050142641A1 Group I mite polypeptide variants 审中-公开
标题翻译： I组螨多肽变体
公开(公告)号：US20050142641A1
公开(公告)日：2005-06-30
申请号：US10831027
申请日：2004-04-23
申请人： Nanna Soni , Esben Friis , Erwin Roggen , Stina Lyngstrand
发明人： Nanna Soni , Esben Friis , Erwin Roggen , Stina Lyngstrand
IPC分类号： A61K38/095 , A61K39/00 , C07K14/435 , C07H21/04 , C12N5/06
CPC分类号： C07K14/43531 , A61K38/00 , A61K39/00
摘要： This invention concerns variants of group 1 mite polypeptides, wherein the mature polypeptide of the variant comprise one or more mutations in the positions or corresponding to the positions consisting of A10, A12, E13, G29, G30, G32, A46, Y47, S54, L55, D64, A66, S67, G73, T75, I80, Q84, N86, G87, S92, Y93, Y96, A98, R99, E100, Q101, R104, R105, P106, Q109, R110, F111, G112, I113, A132, I144, K145, D146, D148, R151, I158, I159, Q160, R161, D162, N163, G164, Y165, Q166, N179, A180, G182, V183, D184, A205, I208 of SEQ ID NO: 1 or 10, 12, 13, 29, 30, 32, 46, 47, 54, 55, 64, 66, 67, 73, 75, I80, 84, 86, 87, 92, Y93, 96, 98, 99, 100, 101, 104, 105, 106, 109, 110, 111, 112, 113, 132, 144, 145, 146, 148, 151, 158, 159, 160, 161, 162, 163, 164, 165, 166, 179, 180, 182, 183, 184, 205, 208 of the mature Der p 1 polypeptide.
摘要翻译：本发明涉及组1螨多肽的变体，其中变体的成熟多肽包含一个或多个在A10，A12，E13，G29，G30，G32，A46，Y47，S54， L55，D64，A66，S67，G73，T75，I80，Q84，N86，G87，S92，Y93，Y96，A98，R99，E100，Q101，R104，R105，P106，Q109，R110，F111，G112，或SEQ ID NO：1的A132，I144，K145，D146，D148，R151，I158，I159，Q160，R161，D162，N163，G164，Y165，Q166，N179，A180，G182，V183，D184，A205， 10，12，13，29，30，32，46，47，54，55，64，66，67，73，75，I80，84，86，87，92，Y93,96,98,99,100， 101,104,105,106,109,110,111,112,113,132,144,145,146,148,151,158,159,160,161,162,163,164,165,166,179， 180,182,183,184,205,208的成熟Der p 1多肽。

5. 发明申请

US20060228791A1 Subtilases and subtilase variants having altered immunogenicity 审中-公开
标题翻译：具有改变的免疫原性的分泌酶和脱落酶变体
公开(公告)号：US20060228791A1
公开(公告)日：2006-10-12
申请号：US10516164
申请日：2003-06-25
申请人： Erwin Roggen , Nina Nilsson , Steffen Ernst , Carsten Andersen , Ninna Berg
发明人： Erwin Roggen , Nina Nilsson , Steffen Ernst , Carsten Andersen , Ninna Berg
IPC分类号： C11D3/386 , C07H21/04 , C12P21/06 , C12N9/56 , C12N1/21 , C12N15/74
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention relates to subtilase variants and subtilases with an altered immunogenicity, particularly subtilase variants and subtilases with a reduced allergenecity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.
摘要翻译：本发明涉及具有改变的免疫原性的枯草芽孢杆菌变体和减毒酶，特别是具有降低的变应原性的枯草芽孢杆菌变体和枯草芽孢杆菌素。此外，本发明涉及所述脱羧酶变体和枯草芽孢杆菌的表达及其用途，例如洗涤剂和口腔护理产品。

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