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1. 发明申请

US20110104202A1 Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency 有权
标题翻译：改良流感病毒监测和提高疫苗效率
公开(公告)号：US20110104202A1
公开(公告)日：2011-05-05
申请号：US12964491
申请日：2010-12-09
申请人： Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
发明人： Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
IPC分类号： A61K39/145 , A61P31/16 , C12Q1/70
CPC分类号： C12Q1/02 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16161 , G01N33/56983 , G01N2333/11 , G01N2469/20
摘要： The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines.
摘要翻译：流感病毒血凝素（HA）分子的免疫原性可以通过HA序列中氨基酸的取代而增加。通过改变受体特异性和/或抗体 - 抗原结合，特异性HA残基（例如H5HA的223位的天冬酰胺）的取代增加血凝素抑制（HI）测定的敏感性。含有这种取代的HA分子将有助于开发诊断参考病毒和改进的流感疫苗。

2. 发明授权

US07788397B1 Method for mitigating adverse processor loading in a personal computer implementation of a wireless local area network adapter 有权
标题翻译：用于减轻无线局域网适配器的个人计算机实现中的不利处理器负载的方法
公开(公告)号：US07788397B1
公开(公告)日：2010-08-31
申请号：US10625799
申请日：2003-07-23
申请人： Richard Douglas Schultz , George Rodney Nelson, Jr. , John Erich Hoffmann
发明人： Richard Douglas Schultz , George Rodney Nelson, Jr. , John Erich Hoffmann
IPC分类号： G06F15/16 , G08C17/00 , H04B1/38
CPC分类号： H04L43/16 , H04L43/0894
摘要： A personal computer's (PC) microprocessor is used to provide both the physical layer (PHY) and media access control (MAC) processing functions required to implement a wireless local area network (WLAN) adapter. This technique uses the polling mechanism associated with the power save (PS) functionality of WLAN protocol to relieve networking stress on the host processing system. It does this while maintaining networking integrity and packet delivery. The WLAN protocol polling mechanism is used to briefly inhibit the transfer of packets from the WLAN access point (AP) during peak periods of network traffic and/or host processor loading. Because the modulation, demodulation, and MAC functions, typically implemented in dedicated hardware on existing adapters are implemented in software running on the host PC microprocessor, other host system processes and applications can interfere with these time critical functions. Conversely, latency introduced by WLAN specific processing tasks during peak periods of network traffic may cause unacceptable delays to the other processes and applications requiring microprocessor attention. In addition to its primary stated purpose of allowing WLAN mobile stations to save power, this technique will use power save polling as a method for controlling delivery of network packets when the host is heavily loaded or when peak interrupt latencies make reliable packet delivery difficult or impossible.
摘要翻译：个人计算机（PC）微处理器用于提供实现无线局域网（WLAN）适配器所需的物理层（PHY）和媒体访问控制（MAC）处理功能。该技术使用与WLAN协议的功率节省（PS）功能相关联的轮询机制来减轻主机处理系统上的网络压力。它同时保持网络完整性和数据包传输。 WLAN协议轮询机制用于在网络流量和/或主处理器加载的高峰期期间短暂禁止从WLAN接入点（AP）传送数据包。由于通常在现有适配器上的专用硬件中实现的调制，解调和MAC功能在主机PC微处理器上运行的软件中实现，所以其他主机系统进程和应用程序可能会干扰这些时间关键功能。相反，由网络流量高峰期的WLAN特定处理任务引入的延迟可能会对需要微处理器注意的其他进程和应用程序造成不可接受的延迟。除了主要规定的允许WLAN移动台节省电力的目的之外，该技术还将使用省电轮询作为在主机严重加载时控制网络分组传送的方法，或者当峰值中断延迟使得可靠的分组传送困难或不可能时。

3. 发明授权

US07577122B1 Method for minimizing receive packet processing for a personal computer implementation of a wireless local area network adapter 有权
标题翻译：用于使无线局域网适配器的个人计算机实现的接收分组处理最小化的方法
公开(公告)号：US07577122B1
公开(公告)日：2009-08-18
申请号：US10460684
申请日：2003-06-12
申请人： Richard Douglas Schultz , John Erich Hoffmann
发明人： Richard Douglas Schultz , John Erich Hoffmann
IPC分类号： H04W4/00
CPC分类号： H04L27/0012 , H04L27/2602 , H04L27/2647
摘要： A method and wireless local area network (WLAN) adapter for the reduction of receive packet processing in a communications system receiver. The method includes establishing a set of criteria which identifies a packet as one requiring demodulation. The method further includes detecting a packet preamble to trigger at least one waveform identification function and determining with the at least one waveform identification function of the detected packet meets an established criteria for demodulation. The established criteria may include at least one of data rate, modulation type, signal to noise ratio, or coding rate. If the detected packet meets the established criteria for demodulation, a host processor may be interrupted to begin demodulation.
摘要翻译：一种用于减少通信系统接收机中的接收分组处理的方法和无线局域网（WLAN）适配器。该方法包括建立一组标准，该标准将分组标识为需要解调的分组。该方法还包括检测分组前导码以触发至少一个波形识别功能，并且利用检测到的分组的至少一个波形识别功能确定满足已建立的解调标准。所建立的标准可以包括数据速率，调制类型，信噪比或编码率中的至少一个。如果检测到的分组满足已建立的用于解调的标准，则主机处理器可能被中断以开始解调。

4. 发明申请

US20050266026A1 Multi plasmid system for the production of influenza virus 失效
标题翻译：用于生产流感病毒的多质粒系统
公开(公告)号：US20050266026A1
公开(公告)日：2005-12-01
申请号：US11133345
申请日：2005-05-20
申请人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
发明人： Erich Hoffmann , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC分类号： A61K39/12 , A61K39/145 , C07K14/11 , C12N7/02 , C12N7/04 , C12N15/85 , C12N15/86
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译：提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。提供了用于多质粒流感病毒表达系统的双向表达载体。另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。

5. 发明授权

US06400317B2 Method and apparatus for antenna control in a communications network 有权
标题翻译：通信网络中天线控制的方法和装置
公开(公告)号：US06400317B2
公开(公告)日：2002-06-04
申请号：US09776397
申请日：2001-02-02
申请人： Antoine J. Rouphael , Daniel Innis Riley , John Erich Hoffmann , George Rodney Nelson, Jr. , James Arthur Proctor, Jr.
发明人： Antoine J. Rouphael , Daniel Innis Riley , John Erich Hoffmann , George Rodney Nelson, Jr. , James Arthur Proctor, Jr.
IPC分类号： H04B700
CPC分类号： H01Q1/246 , H01Q3/2605 , H04B7/0874
摘要： An antenna apparatus for increasing the capacity in a cellular communication system. The antenna operates in conjunction with a mobile subscriber unit and provides a plurality of antenna elements, each coupled to a respective signal control component to provide a weight to the signal transmitted from each element. The weight for each antenna element is adjusted to achieve optimum reception during, for example, an idle mode when a pilot signal is received. The weight values cause the antenna array to create a beam former for signals to be transmitted from the mobile subscriber unit, and a directional receiving array to more optimally detect and receive signals transmitted from the base station. By directionally receiving and transmitting signals, multipath fading and intercell interference are greatly reduced. The weights are adjusted at the transmitting site in accord with signal quality metric information determined at the receiving site. The signal quality metric information is returned to the transmitting site where the optimum signal quality metric is determined. The weights at the transmitting site are then set to provide the antenna directional angle represented by the optimum signal quality metric.
摘要翻译：一种用于增加蜂窝通信系统中的容量的天线装置。天线与移动用户单元结合操作并提供多个天线元件，每个天线元件耦合到相应的信号控制部件，以向从每个元件传输的信号提供权重。当接收到导频信号时，调整每个天线元件的权重以在例如空闲模式期间实现最佳接收。重量值导致天线阵列产生用于从移动用户单元发射的信号的波束成形器，以及定向接收阵列，以更好地检测和接收从基站发送的信号。通过定向接收和发送信号，大大减少了多径衰落和小区间干扰。根据在接收点确定的信号质量度量信息，在发送站点处调整权重。信号质量度量信息被返回到确定最佳信号质量度量的发送站点。然后将发送站点处的权重设置为提供由最佳信号质量度量表示的天线方向角度。

6. 发明授权

US1732603A Signaling device for automobiees 失效
标题翻译：汽车信号装置
公开(公告)号：US1732603A
公开(公告)日：1929-10-22
申请号：US21459927
申请日：1927-08-22
申请人： ERICH HOFFMANN
发明人： ERICH HOFFMANN
IPC分类号： B60Q1/34
CPC分类号： B60Q1/34

7. 发明授权

US09804479B2 Image capturing system 有权
公开(公告)号：US09804479B2
公开(公告)日：2017-10-31
申请号：US14980051
申请日：2015-12-28
申请人： Erich Hoffmann
发明人： Erich Hoffmann
IPC分类号： G03B17/56 , G03B29/00 , F16M13/02
CPC分类号： G03B17/561 , F16M11/041 , F16M11/10 , F16M11/2021 , F16M13/022 , G03B29/00
摘要： An image capturing system includes an electronic device that may capture an image. A vessel is provided and the vessel may be carried. A mounting unit is removably coupled to the vessel. The electronic device is removably coupled to the mounting unit. Thus, the electronic device may capture an image of a user when the user holds the vessel. Thus, the user does not have to set the vessel down to capture the image.

8. 发明申请

US20130017216A1 Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency 有权
标题翻译：改良流感病毒监测和提高疫苗效率
公开(公告)号：US20130017216A1
公开(公告)日：2013-01-17
申请号：US13614835
申请日：2012-09-13
申请人： Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
发明人： Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
IPC分类号： A61K39/145 , A61P37/04 , A61P31/16
CPC分类号： C12Q1/02 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16161 , G01N33/56983 , G01N2333/11 , G01N2469/20
摘要： The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines.
摘要翻译：流感病毒血凝素（HA）分子的免疫原性可以通过HA序列中氨基酸的取代而增加。通过改变受体特异性和/或抗体 - 抗原结合，特异性HA残基（例如H5HA的223位的天冬酰胺）的取代增加血凝素抑制（HI）测定的敏感性。含有这种取代的HA分子将有助于开发诊断参考病毒和改进的流感疫苗。

9. 发明申请

US20120288521A1 MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS 有权
标题翻译：用于生产流感病毒的多级PLASMID系统
公开(公告)号：US20120288521A1
公开(公告)日：2012-11-15
申请号：US13296933
申请日：2011-11-15
申请人： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
发明人： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04 , C12N7/01 , C12N15/74
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译：提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。提供了用于多质粒流感病毒表达系统的双向表达载体。另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。

10. 发明授权

US08293247B2 Modified influenza virus for monitoring and improving vaccine efficiency 有权
标题翻译：用于监测和改善疫苗效率的改良流感病毒
公开(公告)号：US08293247B2
公开(公告)日：2012-10-23
申请号：US12964491
申请日：2010-12-09
申请人： Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
发明人： Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
IPC分类号： A61K39/145
CPC分类号： C12Q1/02 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16161 , G01N33/56983 , G01N2333/11 , G01N2469/20
摘要： The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines.
摘要翻译：流感病毒血凝素（HA）分子的免疫原性可以通过HA序列中氨基酸的取代而增加。通过改变受体特异性和/或抗体 - 抗原结合，特异性HA残基（例如H5HA的223位的天冬酰胺）的取代增加血凝素抑制（HI）测定的敏感性。含有这种取代的HA分子将有助于开发诊断参考病毒和改进的流感疫苗。

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