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1. 发明授权

US06265200B1 HIV-3 retrovirus and its use 失效
标题翻译： HIV-3逆转录病毒及其用途
公开(公告)号：US06265200B1
公开(公告)日：2001-07-24
申请号：US09379270
申请日：1999-08-23
申请人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
发明人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
IPC分类号： C12N700
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1045 , C07K16/1054 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N33/56988 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new variety of retrovirus designated HIV-3, also known as HIV-1 subtype O, samples of which are deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. Further described are variants of the virus.
摘要翻译：描述了一种新的多种逆转录病毒，称为HIV-3，也称为HIV-1亚型O，其样品保藏在欧洲动物细胞培养物收集库（ECACC）V88060301中。进一步描述的是病毒的变体。

2. 发明授权

US06172192B2 Toxoplasma gondii antigen Tg20 失效
标题翻译：弓形虫抗原Tg20
公开(公告)号：US06172192B2
公开(公告)日：2001-01-09
申请号：US09101135
申请日：1998-06-30
申请人： Dirk Jacobs , Eric Saman , Hugo Van Heuverswyn
发明人： Dirk Jacobs , Eric Saman , Hugo Van Heuverswyn
IPC分类号： C07K100
CPC分类号： C07K14/45 , A61K39/00 , A61K48/00 , A61K2039/51 , C07K2319/00 , Y10S435/961 , Y10S435/968 , Y10S435/971 , Y10S435/973 , Y10S435/975
摘要： The present invention relates to isolated and pure Toxoplasma gondii antigenic fragments, recombinant polypeptides, nucleic acids encoding them, primers and probes derived from the same, as well as the use of these polypeptides, nucleic acids, primers and probes in methods and kits for the diagnosis and prevention of T. gondii infection in mammals (humans and animals).
摘要翻译：本发明涉及分离和纯的弓形体抗原片段，重组多肽，编码它们的核酸，来自其的引物和探针，以及这些多肽，核酸，引物和探针在用于诊断和预防哺乳动物（人和动物）感染弓形虫感染。

3. 发明授权

US5795743A HIV-3 retrovirus antigen compositions 失效
标题翻译： HIV-3逆转录病毒抗原组合物
公开(公告)号：US5795743A
公开(公告)日：1998-08-18
申请号：US486836
申请日：1995-06-07
申请人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
发明人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
IPC分类号： G01N33/569 , A61K39/00 , C07K14/00 , C07K14/155 , C07K14/16 , C07K16/00 , C07K16/10 , C12N7/00 , C12N7/01 , C12N15/02 , C12N15/09 , C12N15/48 , C12N15/49 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/92 , G01N33/53 , G01N33/577 , C12N7/02
CPC分类号： C07K14/005 , C07K16/1045 , C07K16/1054 , C12N7/00 , G01N33/56988 , A61K2039/505 , A61K39/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new variety of retrovirus designated HIV-3 samples of which are deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. Further described are antigens obtained from the virus, particularly proteins p12, p16, p25 and glycoproteins gp41 and gp120 to be used in the diagnosis of ARC or AIDS caused by HIV-3. Immunogenic compositions to be used as vaccines contain an envelope glycoprotein of HIV-3 such as gp41 or gp120.
摘要翻译：描述了一种新的多种逆转录病毒，称为HIV-3样品，其保藏在欧洲动物细胞培养物库（ECACC）V88060301中。进一步描述了从病毒获得的抗原，特别是用于诊断由HIV-3引起的ARC或AIDS的蛋白质p12，p16，p25和糖蛋白gp41和gp120。用作疫苗的免疫原性组合物含有HIV-3的包膜糖蛋白，例如gp41或gp120。

4. 发明授权

US5567603A HIV-3 retrovirus and its use 失效
标题翻译： HIV-3逆转录病毒及其用途
公开(公告)号：US5567603A
公开(公告)日：1996-10-22
申请号：US228519
申请日：1994-04-15
申请人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
发明人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
IPC分类号： G01N33/569 , A61K39/00 , C07K14/00 , C07K14/155 , C07K14/16 , C07K16/00 , C07K16/10 , C12N7/00 , C12N7/01 , C12N15/02 , C12N15/09 , C12N15/48 , C12N15/49 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/92 , G01N33/53 , G01N33/577 , C07H21/04
CPC分类号： C07K14/005 , C07K16/1045 , C07K16/1054 , C12N7/00 , G01N33/56988 , A61K2039/505 , A61K39/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new retrovirus designated HIV-3, samples of which have been deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. The morphological and immunological properties exhibited by the HIV-3 retrovirus class include:a diameter of approximately 120 nm; a tropism for T4 lymphocytes; cultivation in T4 receptor-bearing immortalized cell lines; cytotoxicity for the lymphocytes that it infects; a magnesium dependent reverse transcriptase activity;the genomic RNA of HIV-3 hybridizes neither with the sequences of HIV-1 nor with the sequences of HIV-2 under stringent hybridization conditions;lysates of the virus contain a p25 protein which is immunologically distinct from the p19 protein of HTLV-I and the p24 proteins of HIV-1 and HIV-2 as determined by Western blot analysis, respectively;lysates of the virus contain a gp120 protein which is immunologically distinct from the gp110 protein of HTLV-I, the gp120 of HIV-1 and the gp120 of HIV-2 as determined by Western blot analysis;the lysate of the virus contains in addition a gp41 glycoprotein with a molecular weight of 40,000-45,000; andlysates of the virus contain a p12 protein which is immunologically distinct from the p12 proteins of HIV-1 and HIV-2 as determined by Western blot analysis.Also described are nucleic acid sequences derived from HIV-3 RNA which can be used as hybridization probes to detect the presence of HIV-3 virus.
摘要翻译：描述了一种新的逆转录病毒，称为HIV-3，其样品已经存放在欧洲动物细胞培养物库（ECACC）V88060301中。 HIV-3逆转录病毒类的形态学和免疫学特性包括：直径约120nm; T4淋巴细胞趋向性; 在含有T4受体的永生化细胞系中培养; 感染淋巴细胞的细胞毒性; 镁依赖逆转录酶活性; 在严格杂交条件下，HIV-3的基因组RNA既不与HIV-1的序列也不与HIV-2的序列杂交; 该病毒的裂解物含有与HTLV-1的p19蛋白和HIV-1和HIV-2的p24蛋白免疫区别的p25蛋白，分别通过蛋白质印迹分析确定; 病毒的裂解物含有与HIV-1的gp110和HIV-2的gp120的HIV-2的gp110蛋白免疫区别的gp120蛋白，通过Western印迹分析测定; 病毒的裂解物另外含有分子量为40,000-45,000的gp41糖蛋白; 并且病毒的裂解物含有通过蛋白质印迹分析测定的与HIV-1和HIV-2的p12蛋白免疫学上不同的p12蛋白。还描述了衍生自HIV-3RNA的核酸序列，其可用作检测HIV-3病毒存在的杂交探针。

5. 发明授权

US06593079B1 Method for simultaneous detection of HIV antigens and HIV antibodies 有权
标题翻译：同时检测HIV抗原和HIV抗体的方法
公开(公告)号：US06593079B1
公开(公告)日：2003-07-15
申请号：US09381009
申请日：2000-01-12
申请人： Frederic Donie , Elke Faatz , Barbara Upmeier , Eva Hoess , Marie-Ange Buyse , Eric Saman
发明人： Frederic Donie , Elke Faatz , Barbara Upmeier , Eva Hoess , Marie-Ange Buyse , Eric Saman
IPC分类号： C12Q106
CPC分类号： G01N33/56988 , C07K16/1054
摘要： The invention concerns a process for diagnosis of an HIV infection by means of an immunoassay using the specific detection of the p24 antigen of HIV1, HIV1-Sub0 and/or the p26 antigen of HIV2, at least one antibody against the env region of HIV1, HIV1-Sub0 and/or of HIV2 and at least one antibody against the pol and/or gag region of HIV1, HIV1-Sub0 and/or HIV2, reagent kits and test strips suitable for diagnostic procedure as well as monoclonal antibodies against p24 and their use.
摘要翻译：本发明涉及通过免疫测定来诊断HIV感染的方法，其使用HIV2的HIV1，HIV1-Sub0和/或p26抗原的p24抗原的特异性检测，至少一种针对HIV1的env区域的抗体， HIV1-Sub0和/或HIV2的抗体和抗HIV1，HIV1-Sub0和/或HIV2的pol和/或gag区域的至少一种抗体，适用于诊断程序的试剂盒和测试条以及针对p24的单克隆抗体及其使用。

6. 发明授权

US5304466A HIV-3 retrovirus and its use 失效
标题翻译： HIV-3逆转录病毒及其用途
公开(公告)号：US5304466A
公开(公告)日：1994-04-19
申请号：US460913
申请日：1990-03-23
申请人： Robert De Leys , Bart Vanderborght , Eric Saman , H. Van Heuverswyn
发明人： Robert De Leys , Bart Vanderborght , Eric Saman , H. Van Heuverswyn
IPC分类号： G01N33/569 , A61K39/00 , C07K14/00 , C07K14/155 , C07K14/16 , C07K16/00 , C07K16/10 , C12N7/00 , C12N7/01 , C12N15/02 , C12N15/09 , C12N15/48 , C12N15/49 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/92 , G01N33/53 , G01N33/577 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , C07K16/1045 , C07K16/1054 , C12N7/00 , G01N33/56988 , A61K2039/505 , A61K39/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new retrovirus designated HIV-3 and deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. Further described are antigens obtained from the virus, particularly proteins p12, p16, p25 and glycoproteins gp41 and gp120 to be used in the diagnosis of ARC or AIDS caused by HIV-3. Immunogenic compositions to be used as vaccines contain an envelope glycoprotein of HIV-3 such as gp41 or gp120.
摘要翻译： PCT No.PCT / EP89 / 00643 Sec。 371 1990年3月23日 102（e）1990年3月23日PCT PCT 1989年6月8日PCT公布。出版物WO89 / 12094 日期为1989年12月14日。描述了一种名为HIV-3的新型逆转录病毒，并存放在欧洲动物细胞培养物库（ECACC）V88060301中。进一步描述了从病毒获得的抗原，特别是用于诊断由HIV-3引起的ARC或AIDS的蛋白质p12，p16，p25和糖蛋白gp41和gp120。用作疫苗的免疫原性组合物含有HIV-3的包膜糖蛋白，例如gp41或gp120。

7. 发明授权

US06511801B1 HIV-1 group O antigens and uses thereof 失效
标题翻译： HIV-1组O抗原及其用途
公开(公告)号：US06511801B1
公开(公告)日：2003-01-28
申请号：US09462917
申请日：2000-04-03
申请人： Eric DeLaporte , Martine Peeters , Eric Saman , Marleen Vanden Haesevelde
发明人： Eric DeLaporte , Martine Peeters , Eric Saman , Marleen Vanden Haesevelde
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C12N7/00 , C12N2740/15022 , C12N2740/16021 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： The claimed invention relates to an HIV-1 group O envelope antigen comprising SEQ ID NO: 100, and the use of said antigen as a reagent in the diagnosis of HIV-1 group O infection, and a kit therefore.
摘要翻译：所要求保护的发明涉及包含SEQ ID NO：100的HIV-1组O包膜抗原，以及所述抗原作为HIV-1组O感染诊断中的试剂的用途，因此涉及试剂盒。

8. 发明授权

US06296855B1 17-KDA Brucella abortus antigen, recombinant polypeptides, nucleic acids coding for the same and use thereof in diagnostic and prophylactic methods and kits 失效
标题翻译： 17-KDA布鲁氏菌流产抗原，重组多肽，编码相同的核酸和在诊断和预防方法和试剂盒中的应用
公开(公告)号：US06296855B1
公开(公告)日：2001-10-02
申请号：US08849634
申请日：1997-12-01
申请人： Fabienne Hemmen , Eric Saman
发明人： Fabienne Hemmen , Eric Saman
IPC分类号： A61K3902
CPC分类号： C12Q1/689 , A61K39/00 , C07K14/23 , C07K2319/02 , Y10S424/825
摘要： The present invention relates to an isolated 17-kDa Brucclla antigen characterized by an amino acid sequence having at least 60% homology, preferably at least 70% homology, more preferably having at least 80% homology to the amino acid sequence as shown in SEQ ID No. 1 or 2, with said antigen being specifically recognized by sera from Brucella field infected individuals, more particulary an antigen characterized by the amino acid sequence as shown in SEQ ID No. 1 or 2. The invention also relates to recombinantly produced 17 kDa Brucella antigen, nucleic acids coding for the same and the use thereof in diagnostic and prophylactic methods and kits.
摘要翻译：本发明涉及分离的17-kDa布鲁氏菌抗原，其特征在于与SEQ ID NO：1所示的氨基酸序列具有至少60％的同源性，优选至少70％的同源性，更优选与SEQ ID NO：所述抗原由来自布鲁氏菌感染的个体的血清特异性地识别，更特别的是以SEQ ID No.1或2所示的氨基酸序列为特征的抗原。本发明还涉及重组产生的17kDa 布鲁氏杆菌抗原，编码相同的核酸及其在诊断和预防方法和试剂盒中的用途。

9. 发明授权

US6013484A HIV-3 retrovirus and its use 失效
标题翻译： HIV-3逆转录病毒及其用途
公开(公告)号：US6013484A
公开(公告)日：2000-01-11
申请号：US900902
申请日：1997-07-25
申请人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
发明人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
IPC分类号： G01N33/569 , A61K39/00 , C07K14/00 , C07K14/155 , C07K14/16 , C07K16/00 , C07K16/10 , C12N7/00 , C12N7/01 , C12N15/02 , C12N15/09 , C12N15/48 , C12N15/49 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/92 , G01N33/53 , G01N33/577 , C12P21/04 , C12N5/12 , C12N5/24
CPC分类号： C07K14/005 , C07K16/1045 , C07K16/1054 , C12N7/00 , G01N33/56988 , A61K2039/505 , A61K39/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new variety of retrovirus designated HIV-3, samples of which are deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. Further described are antigens obtained from the virus, particularly proteins p12, p16, p25 and glycoproteins gp41 and gp120 to be used in the diagnosis of ARC or AIDS caused by HIV-3. Immunogenic compositions to be used as vaccines contain an envelope glycoprotein of HIV-3 such as gp41 or gp120.
摘要翻译：描述了一种新型的指定为HIV-3的逆转录病毒，其样品保藏在欧洲动物细胞培养物库（ECACC）V88060301中。进一步描述了从病毒获得的抗原，特别是用于诊断由HIV-3引起的ARC或AIDS的蛋白质p12，p16，p25和糖蛋白gp41和gp120。用作疫苗的免疫原性组合物含有HIV-3的包膜糖蛋白，例如gp41或gp120。

10. 发明授权

US5858647A Methods for detecting antibodies against HIV-3 retrovirus �and its use! 失效
标题翻译：检测HIV-3逆转录病毒抗体的方法[及其用途]
公开(公告)号：US5858647A
公开(公告)日：1999-01-12
申请号：US474360
申请日：1995-06-07
申请人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
发明人： Robert De Leys , Bart Vanderborght , Eric Saman , Hugo Van Heuverswyn
IPC分类号： G01N33/569 , A61K39/00 , C07K14/00 , C07K14/155 , C07K14/16 , C07K16/00 , C07K16/10 , C12N7/00 , C12N7/01 , C12N15/02 , C12N15/09 , C12N15/48 , C12N15/49 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/92 , G01N33/53 , G01N33/577 , G01N33/564
CPC分类号： C07K14/005 , C07K16/1045 , C07K16/1054 , C12N7/00 , G01N33/56988 , A61K2039/505 , A61K39/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new variety of retrovirus designated HIV-3, samples of which are deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. Further described are antigens obtained from the virus, particularly proteins p12, p16, p25 and glycoproteins gp41 and gp120 to be used in the diagnosis of ARC or AIDS caused by HIV-3. The methods to detect antibodies against HIV-3 retrovirus in a biological fluid involve contacting the suspect body fluid with a composition containing one or more of the proteins or glycoproteins of HIV-3 or with a lysate of the virus, or with an antigen possessing epitopes common to HIV-3, and detecting the immunological conjugate formed between the anti-HIV-3 antibodies and the antigen(s) used.
摘要翻译：描述了一种新型的指定为HIV-3的逆转录病毒，其样品保藏在欧洲动物细胞培养物库（ECACC）V88060301中。进一步描述了从病毒获得的抗原，特别是用于诊断由HIV-3引起的ARC或AIDS的蛋白质p12，p16，p25和糖蛋白gp41和gp120。在生物流体中检测针对HIV-3逆转录病毒的抗体的方法包括将可疑体液与含有一种或多种HIV-3的蛋白质或糖蛋白或与病毒的裂解物或具有抗原的组合物接触与HIV-3共同，并检测抗HIV-3抗体与所用抗原之间形成的免疫缀合物。

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