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1. 发明授权

US07858319B2 Method of screening for drug hypersensitivity reaction 有权
标题翻译：筛查药物超敏反应的方法
公开(公告)号：US07858319B2
公开(公告)日：2010-12-28
申请号：US12428034
申请日：2009-04-22
申请人： Seth Hetherington , Arlene R Hughes , Eric H Lai , Michael Mosteller, Jr. , Denise D Shortino
发明人： Seth Hetherington , Arlene R Hughes , Eric H Lai , Michael Mosteller, Jr. , Denise D Shortino
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of both the TNFα and HLA genes.
摘要翻译：描述了评估对包括阿巴卡韦在内的核苷抗病毒化合物的超敏反应的临床体征的风险的方法。方法包括对TNFα基因多态性，1类HLA基因或TNFα和HLA基因两者的组合进行基因分型。

2. 发明授权

US07550261B2 Method of screening for drug hypersensitivity reaction 有权
标题翻译：筛查药物超敏反应的方法
公开(公告)号：US07550261B2
公开(公告)日：2009-06-23
申请号：US10214023
申请日：2002-08-07
申请人： Seth Hetherington , Arlene R Hughes , Eric H Lai , Michael Mosteller, Jr. , Denise D Shortino
发明人： Seth Hetherington , Arlene R Hughes , Eric H Lai , Michael Mosteller, Jr. , Denise D Shortino
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of both the TNFα and HLA genes.
摘要翻译：描述了评估对包括阿巴卡韦在内的核苷抗病毒化合物的超敏反应的临床体征的风险的方法。方法包括对TNFalpha基因多态性，1级HLA基因或TNFalpha和HLA基因的组合进行基因分型。

3. 发明授权

US5084157A Gel electrophoresis using time dependent contour controlled electric fields 失效
标题翻译：使用时间依赖轮廓控制电场的凝胶电泳
公开(公告)号：US5084157A
公开(公告)日：1992-01-28
申请号：US170925
申请日：1988-03-21
申请人： Steven M. Clark , Eric H. Lai
发明人： Steven M. Clark , Eric H. Lai
IPC分类号： G01N27/447
CPC分类号： G01N27/44713 , G01N27/44773
摘要： An apparatus for separating particles within a medium which is capable of generating electric fields having adjustable magnitudes and orientations is disclosed herein. The electrophoretic apparatus of the present invention includes electrode arrangement for providing a plurality of sets of opposing individually responsive electrodes for generating electric fields within the medium, each field having at least one magnitude and direction. The invention further includes a control circuit for selectively controlling electrodes within the electrode sets to vary the magnitudes and directions of the electric fields at locations within the medium. The electric fields induce differing rates of motion of the particles thereby separating the particles.
摘要翻译：本文公开了一种用于分离能够产生具有可调幅度和取向的电场的介质内的颗粒的装置。本发明的电泳装置包括电极装置，用于提供多组相对的单独响应电极，用于在介质内产生电场，每个场具有至少一个幅度和方向。本发明还包括控制电路，用于选择性地控制电极组内的电极，以改变介质内部位置的电场的幅度和方向。电场引起颗粒的不同运动速率，从而分离颗粒。

4. 发明授权

US4224533A Edge triggered flip flop with multiple clocked functions 失效
标题翻译：具有多个时钟功能的边沿触发触发器
公开(公告)号：US4224533A
公开(公告)日：1980-09-23
申请号：US931596
申请日：1978-08-07
申请人： Eric H. Lai
发明人： Eric H. Lai
IPC分类号： H03K3/286 , H03K3/356 , H03K3/3562 , H03K5/13 , H03K3/353 , H03K17/18 , H03K17/26
CPC分类号： H03K3/356026
摘要： A single flip flop is integrated with MOS circuitry which enables the single flip flop to be triggered by each of several individual clocked functions without interfering with one another. The flip flop responds only to low to high transitions of each clock signal input. This is accomplished by feeding back the flip flop output to each trigger circuit in such a way as to temporarily disconnect the trigger circuit from the flip flop during the time period between two successive low to high transitions of a particular clock signal, so that the flip flop can be triggered by other clocked functions without interference from the particular clock signal.
摘要翻译：单个触发器与MOS电路集成，使得单个触发器能够由几个单独的时钟功能中的每一个触发而不会彼此干扰。触发器仅响应每个时钟信号输入的低到高转换。这是通过将触发器输出反馈到每个触发电路来实现的，以便在特定时钟信号的两个连续的低到高转变之间的时间段期间暂时断开触发电路与触发器的触发电路，使得翻转触发器可以由其他时钟功能触发，而不会受到特定时钟信号的干扰。

5. 发明申请

US20090306099A1 Method of Screening for Drug Hypersensitivity Reaction 有权
标题翻译：筛选药物超敏反应的方法
公开(公告)号：US20090306099A1
公开(公告)日：2009-12-10
申请号：US12428034
申请日：2009-04-22
申请人： Seth HETHERINGTON , Arlene R. HUGHES , Eric H. LAI , Michael MOSTELLER, JR. , Denise D. SHORTINO
发明人： Seth HETHERINGTON , Arlene R. HUGHES , Eric H. LAI , Michael MOSTELLER, JR. , Denise D. SHORTINO
IPC分类号： A61K31/52 , A61P31/18
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of both the TNFα and HLA genes.
摘要翻译：描述了评估对包括阿巴卡韦在内的核苷抗病毒化合物的超敏反应的临床体征的风险的方法。方法包括对TNFalpha基因多态性，1级HLA基因或TNFalpha和HLA基因的组合进行基因分型。

6. 发明授权

US5453162A Method and apparatus for gel electrophoresis using two electric fields 失效
标题翻译：使用两个电场的凝胶电泳的方法和装置
公开(公告)号：US5453162A
公开(公告)日：1995-09-26
申请号：US119033
申请日：1993-09-09
申请人： Chandran R. Sabanayagam , George M. Holzwarth , Eric H. Lai
发明人： Chandran R. Sabanayagam , George M. Holzwarth , Eric H. Lai
IPC分类号： G01N27/447 , B01D57/02
CPC分类号： G01N27/44773
摘要： Disclosed is a method and apparatus for gel electrophoresis which simultaneously employs two or more electric fields in a single gel. According to this invention, which is defined as Multiple-Zone Pulsed-Field Gel Electrophoresis (MZPFGE), the electric field is set to different values in two or more spatially distinct regions of the gel. The difference in values may be related to time dependence, field amplitude or both.
摘要翻译：公开了一种用于凝胶电泳的方法和装置，其同时在单个凝胶中使用两个或更多个电场。根据本发明，其定义为多区脉冲场凝胶电泳（MZPFGE），电场在凝胶的两个或更多个空间上不同的区域中设定为不同的值。值的差异可能与时间依赖性，场幅度或两者有关。

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