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1. 发明授权

US09623016B2 Antibacterial compounds 有权
公开(公告)号：US09623016B2
公开(公告)日：2017-04-18
申请号：US14776111
申请日：2014-03-14
申请人： Emergent Virology LLC
发明人： Urban Ramstedt , Kelly Warfield
IPC分类号： A61K31/445 , A61K31/655 , A01N43/40
CPC分类号： A61K31/445 , A01N43/40 , A61K31/655 , Y02A50/473
摘要： Provided are iminosugars having antibacterial properties and methods of treating and/or preventing bacterial infections with such iminosugars. The present disclosure relates to antibacterial compounds and, in particular, to iminosugars having antibacterial activity. One embodiment is a method of treating or preventing a bacterial infection comprising administering to a subject in need thereof an antibacterial effective amount of a compound of the following formula: or a pharmaceutically acceptable salt thereof.

2. 发明授权

US09943532B2 Iminosugars and methods of treating viral diseases 有权
公开(公告)号：US09943532B2
公开(公告)日：2018-04-17
申请号：US15399213
申请日：2017-01-05
申请人： Emergent Virology LLC , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20 , A61K31/70 , A61K31/665
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.

3. 发明申请

US20160221993A1 DEOXYNOJIRIMYCIN DERIVATIVES AND METHODS OF THEIR USING 审中-公开
标题翻译：脱氧吉西汀衍生物及其使用方法
公开(公告)号：US20160221993A1
公开(公告)日：2016-08-04
申请号：US15022005
申请日：2014-09-15
申请人： EMERGENT VIROLOGY LLC
发明人： Urban RAMSTEDT , Raju PENMASTA , Hitesh BATRA , Tam NGUYEN
IPC分类号： C07D405/06 , C07D211/40
CPC分类号： C07D405/06 , C07D211/40 , C07D211/46
摘要： The present application provide novel iminosugars and their use in treatment of viral infections, such as Dengue infection and Influenza A infection. The present inventors discovered certain deoxynojirimycin derivatives may be effective against one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition caused by or associated with one or more viruses. In certain embodiments, the deoxynojirimycin derivatives may increase a survival rate or probability for a subject infected with one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus.
摘要翻译：本申请提供新型亚氨基糖苷及其在治疗病毒感染（例如登革热感染和甲型流感感染）中的用途。本发明人发现某些脱氧野尻霉素衍生物可能对一种或多种病毒有效，所述病毒可以是例如登革病毒和/或属于正粘病毒科的病毒，例如甲型流感病毒。特别地，这种脱氧野尻霉素衍生物可用于治疗由一种或多种病毒引起或与一种或多种病毒相关的疾病或病症。在某些实施方案中，脱氧野尻霉素衍生物可以增加感染一种或多种病毒的个体的存活率或概率，所述病毒可以是例如登革病毒和/或属于正粘病毒科的病毒，例如流感A 病毒。

4. 发明申请

US20170304333A1 IMINOSUGARS AND METHODS OF TREATING VIRAL DISEASES 有权
公开(公告)号：US20170304333A1
公开(公告)日：2017-10-26
申请号：US15399213
申请日：2017-01-05
申请人： Emergent Virology LLC , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
发明人： Urban RAMSTEDT , Brennan KLOSE , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/70 , A61K31/665 , A61K31/445
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.

5. 发明申请

US20160243096A1 METHODS OF TREATING ORTHOMYXOVIRAL INFECTIONS 审中-公开
标题翻译：治疗口腔感染的方法
公开(公告)号：US20160243096A1
公开(公告)日：2016-08-25
申请号：US15145981
申请日：2016-05-04
申请人： Emergent Virology LLC , University of Oxford
发明人： Urban RAMSTEDT , Brennan KLOSE , Nicole ZITZMANN , Raymond A. DWEK , Terry D. BUTTERS
IPC分类号： A61K31/445 , C07D211/46 , A61K31/655
CPC分类号： A61K31/445 , A61K31/655 , C07D211/46
摘要： Provided are novel iminosugars and methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Orthomyxoviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：提供了新的亚氨基糖苷以及使用亚氨基二糖如DNJ衍生物治疗和/或预防由属于正粘病毒科的病毒引起或与之相关的疾病或病症的方法。

6. 发明授权

US10144727B2 Deoxynojirimycin derivatives and methods of their using 有权
公开(公告)号：US10144727B2
公开(公告)日：2018-12-04
申请号：US15022005
申请日：2014-09-15
申请人： Emergent Virology LLC
发明人： Urban Ramstedt , Raju Penmasta , Hitesh Batra , Tam Nguyen
IPC分类号： C07D405/06 , C07D211/46 , C07D211/40
摘要： The present application provide novel iminosugars and their use in treatment of viral infections, such as Dengue infection and Influenza A infection. The present inventors discovered certain deoxynojirimycin derivatives may be effective against one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition caused by or associated with one or more viruses. In certain embodiments, the deoxynojirimycin derivatives may increase a survival rate or probability for a subject infected with one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus.

7. 发明申请

US20180273473A1 IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
公开(公告)号：US20180273473A1
公开(公告)日：2018-09-27
申请号：US15524535
申请日：2015-11-04
申请人： Emergent Virology, LLC
发明人： Urban RAMSTEDT , Kelly Lyn WARFIELD , Anthony TRESTON
IPC分类号： C07D211/46 , C07D401/14 , C07D401/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/10
CPC分类号： C07D211/46 , A61K31/45 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/06 , C07D413/10 , C07D413/12 , C07D473/34 , C07D487/04
摘要： Formula IA, and their use for treating viral infections.

8. 发明授权

US09579334B2 Iminosugars and methods of treating viral diseases 有权
标题翻译：伊莫诺斯和治疗病毒性疾病的方法
公开(公告)号：US09579334B2
公开(公告)日：2017-02-28
申请号：US14696686
申请日：2015-04-27
申请人： Emergent Virology LLC , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20 , A61K31/70 , A61K31/665
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
摘要翻译：提供了使用亚氨基二糖治疗或预防由登革热病毒引起或与登革热病毒有关的病毒感染的方法。

9. 发明授权

US10428022B2 Iminosugars useful for the treatment of viral diseases 有权
公开(公告)号：US10428022B2
公开(公告)日：2019-10-01
申请号：US15524535
申请日：2015-11-04
申请人： Emergent Virology, LLC
发明人： Urban Ramstedt , Kelly Lyn Warfield , Anthony Treston
IPC分类号： A61K31/45 , C07D211/46 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D473/34 , C07D487/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D413/10 , C07D413/12
摘要： Formula IA, and their use for treating viral infections.

10. 发明申请

US20190282558A1 Methods of Treating Zika Virus Infection 审中-公开
公开(公告)号：US20190282558A1
公开(公告)日：2019-09-19
申请号：US16301924
申请日：2017-05-16
申请人： Emergent Virology LLC
发明人： Anthony Michael TRESTON , Kelly Lyn WARFIELD
IPC分类号： A61K31/4525 , A61P31/14 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/52
摘要： This disclosure provides methods for treating or preventing a disease or condition caused by or associated with a Zika virus infection in a subject. The methods can comprise administering to a subject in need thereof an effective amount of an iminosugar compound as described herein.

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