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1. 发明授权

US08957082B2 Tetrahydropyrrolopyrimidinediones and their use in therapy 有权
标题翻译：四氢吡咯并嘧啶二酮及其在治疗中的应用
公开(公告)号：US08957082B2
公开(公告)日：2015-02-17
申请号：US13449045
申请日：2012-04-17
申请人： Nicholas Charles Ray , Harry Finch , Christine Edwards , Elizabeth O'Connor
发明人： Nicholas Charles Ray , Harry Finch , Christine Edwards , Elizabeth O'Connor
IPC分类号： C07D487/04 , A61K31/519 , A61P11/08 , A61P11/06 , A61P11/00 , A61K47/48 , C07D519/00
CPC分类号： C07D487/04 , A61K47/55 , C07D519/00
摘要： The subject invention provides compounds of formula (I): Including monomers and multimers thereof that are inhibitors of human neutrophil elastase (HNE) activity and are useful in the treatment of diseases or conditions in which HNE plays a part.
摘要翻译：本发明提供式（I）化合物：包括作为人嗜中性粒细胞弹性蛋白酶（HNE）活性抑制剂的单体和多聚体，可用于治疗HNE起作用的疾病或病症。

2. 发明授权

US08861540B2 Industry-specific communication framework 有权
标题翻译：行业特定的沟通框架
公开(公告)号：US08861540B2
公开(公告)日：2014-10-14
申请号：US11711128
申请日：2007-02-27
申请人： Benjamin Wu , Bridget Elizabeth O'Connor , Hari Gopalkrishnan
发明人： Benjamin Wu , Bridget Elizabeth O'Connor , Hari Gopalkrishnan
IPC分类号： H04L12/28 , H04L12/58 , H04L29/08 , H04M7/00 , H04L29/06 , H04M1/2745 , H04M1/247
CPC分类号： H04L67/306 , H04L51/04 , H04L51/36 , H04L65/105 , H04L65/1069 , H04L67/28 , H04L67/2838 , H04M1/2473 , H04M1/27455 , H04M7/0045 , H04M2201/42
摘要： A system includes a client device and a server including a communication module configured to be accessed by the client device through which a user of the client device connects to another user via one of a plurality of communication services connected to the server, wherein one of the plurality of communication services is telephony.
摘要翻译：一种系统包括客户端设备和服务器，其包括被配置为由客户端设备访问的通信模块，通过该客户端设备，客户端设备的用户经由连接到服务器的多个通信服务中的一个连接到另一个用户，其中，多个通信服务是电话。

3. 发明授权

US07644089B2 System and method for corporate-wide policy management 有权
标题翻译：全公司政策管理的制度和方法
公开(公告)号：US07644089B2
公开(公告)日：2010-01-05
申请号：US11025871
申请日：2004-12-29
申请人： Ford Mackinnon Stewart , Bridget Elizabeth O'Connor , Hari Gopalkrishnan , Sabet Elias
发明人： Ford Mackinnon Stewart , Bridget Elizabeth O'Connor , Hari Gopalkrishnan , Sabet Elias
IPC分类号： G06F17/00
CPC分类号： G06Q10/06
摘要： An organization asset database (ADb) is described that contains a complete, up-to-date, secure, and easily accessible inventory of the organization's assets. Each asset is mapped onto a structure that represents the organizational hierarchy of the organization, which provides for multiple levels of accountability for each asset. Each asset has one or more roles in relation to other assets in the ADb and has one or more entitlements in relation to other assets in the ADb. The relationship between assets ensures that the ADb is complete and up-to-date and allows for easy filtering and retrieval of the information contained in the ADb.
摘要翻译：描述了一个组织资产数据库（ADb），其中包含一个完整的，最新，安全且易于访问的组织资产清单。每个资产都映射到代表组织的组织层次结构的结构，为每个资产提供多层次的问责制。每个资产在ADb中与其他资产有一个或多个角色，并且与ADb中的其他资产有一个或多个权利。资产之间的关系确保ADB完整和最新，并允许轻松过滤和检索ADb中包含的信息。

4. 发明授权

US07353265B2 Method and system for monitoring and managing assets, applications, and services using aggregated event and performance data thereof 有权
标题翻译：使用聚合事件及其性能数据监控和管理资产，应用程序和服务的方法和系统
公开(公告)号：US07353265B2
公开(公告)日：2008-04-01
申请号：US10924572
申请日：2004-08-24
申请人： Hari Gopalkrishnan , Benjamin Wu , Bridget Elizabeth O'Connor
发明人： Hari Gopalkrishnan , Benjamin Wu , Bridget Elizabeth O'Connor
IPC分类号： G06F15/173
CPC分类号： G06F11/3409 , G06F11/3466 , G06F11/3495 , G06F2201/86
摘要： A method and system for monitoring and managing applications and services. A repository comprising information identifying a plurality of assets and one or more relationships among the assets is maintained. One or more assets used to support an application are identified, along with one or more applications that are included in a service. Event and performance data are collected by a plurality of tools that perform monitoring and/or managing of the identified assets, the application, and/or the service. The gathered event and performance data is aggregated. The user is provided with a portal to access the aggregated event and performance data. Through this portal, the user can determine an impact of an event or a performance issue on the application or service based on the aggregated event or performance data and the relationships among the assets.
摘要翻译：一种用于监控和管理应用程序和服务的方法和系统。保存包含识别多个资产的信息和资产之间的一个或多个关系的存储库。识别用于支持应用程序的一个或多个资产以及服务中包含的一个或多个应用程序。事件和性能数据由执行所识别的资产，应用和/或服务的监视和/或管理的多个工具来收集。收集的事件和性能数据被聚合。为用户提供了访问聚合事件和性能数据的门户。通过该门户，用户可以基于聚合事件或性能数据以及资产之间的关系来确定事件或性能问题对应用程序或服务的影响。

5. 发明申请

US20120202826A1 Tetrahydropyrrolopyrimidinediones And Their Use In Therapy 有权
标题翻译：四氢吡咯并嘧啶二酮及其在治疗中的应用
公开(公告)号：US20120202826A1
公开(公告)日：2012-08-09
申请号：US13449045
申请日：2012-04-17
申请人： Nicholas Charles RAY , Harry Finch , Christine Edwards , Elizabeth O'Connor
发明人： Nicholas Charles RAY , Harry Finch , Christine Edwards , Elizabeth O'Connor
IPC分类号： A61K31/519 , A61P1/00 , A61P11/06 , A61P17/06 , C07D519/00 , A61P11/00
CPC分类号： C07D487/04 , A61K47/55 , C07D519/00
摘要： The subject invention provides compounds of formula (I): Including monomers and multimers thereof that are inhibitors of human neutrophil elastase (HNE) activity and are useful in the treatment of diseases or conditions in which HNE plays a part.
摘要翻译：本发明提供式（I）化合物：包括作为人嗜中性粒细胞弹性蛋白酶（HNE）活性抑制剂的单体和多聚体，并且可用于治疗HNE起作用的疾病或病症。

6. 发明授权

US08198288B2 Tetrahydropyrrolopyrimidinediones and their use in therapy 有权
标题翻译：四氢吡咯并嘧啶二酮及其在治疗中的应用
公开(公告)号：US08198288B2
公开(公告)日：2012-06-12
申请号：US12264621
申请日：2008-11-04
申请人： Nicholas Charles Ray , Harry Finch , Christine Edwards , Elizabeth O'Connor
发明人： Nicholas Charles Ray , Harry Finch , Christine Edwards , Elizabeth O'Connor
IPC分类号： C07D487/04 , A61K31/519 , A61P11/08 , A61P17/06
CPC分类号： C07D487/04
摘要： The subject invention provides compounds of formula (1): including monomers and multimers thereof that are inhibitors of human neutrophil elastase (HNE) activity and are useful in the treatment of diseases or conditions in which HNE plays a part.
摘要翻译：本发明提供式（1）化合物：包括作为人中性粒细胞弹性蛋白酶（HNE）活性抑制剂的单体和多聚体，并且可用于治疗HNE起作用的疾病或病症。

7. 发明申请

US20050106576A1 Methods of using cleavable solid phases for isolating nucleic acids 审中-公开
标题翻译：使用可切割固相分离核酸的方法
公开(公告)号：US20050106576A1
公开(公告)日：2005-05-19
申请号：US10714763
申请日：2003-11-17
申请人： Hashem Akhavan-Tafti , Renuka de Silva , Nicole Cilli , William Cripps , Richard Handley , Elizabeth O'Connor , Lekkala Reddy , Sarada Siripurapu
发明人： Hashem Akhavan-Tafti , Renuka de Silva , Nicole Cilli , William Cripps , Richard Handley , Elizabeth O'Connor , Lekkala Reddy , Sarada Siripurapu
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C07H21/04 , C07B2200/11
摘要： Solid phase materials for binding nucleic acids and methods of their use are disclosed. The materials feature a cleavable linker portion which can be cleaved to release bound nucleic acids. The solid phase materials comprise a solid support portion comprising a matrix selected from silica, glass, insoluble synthetic polymers, and insoluble polysaccharides to which is attached a nucleic acid binding portion for attracting and binding nucleic acids, the nucleic acid binding portion (NAB) being linked by a cleavable linker portion to the solid support portion. Preferred nucleic acid binding portions comprise a ternary or quaternary onium group. The materials can be in the form of microparticles, fibers, beads, membranes, test tubes or microwells and can further comprise a magnetic core portion. Methods of binding nucleic acids using the cleavable solid supports are disclosed as are their use in methods of isolating or purifying nucleic acids.
摘要翻译：公开了用于结合核酸的固相材料及其使用方法。这些材料具有可切割的接头部分，其可以被切割以释放结合的核酸。固相材料包括固体支持部分，其包含选自二氧化硅，玻璃，不溶性合成聚合物的基质和与核酸结合部分连接以吸附和结合核酸的不溶性多糖，所述核酸结合部分（NAB）为通过可切割的连接部分连接到固体支持部分。优选的核酸结合部分包含三元或季铵基团。材料可以是微粒，纤维，珠，膜，试管或微孔的形式，并且还可以包括磁芯部分。在分离或纯化核酸的方法中公开了使用可切割固体支持物结合核酸的方法。

8. 发明授权

US07680918B2 Monitoring and management of assets, applications, and services using aggregated event and performance data thereof 有权
标题翻译：使用聚合事件及其性能数据监控和管理资产，应用程序和服务
公开(公告)号：US07680918B2
公开(公告)日：2010-03-16
申请号：US12007355
申请日：2008-01-09
申请人： Hari Gopalkrishnan , Benjamin Wu , Bridget Elizabeth O'Connor
发明人： Hari Gopalkrishnan , Benjamin Wu , Bridget Elizabeth O'Connor
IPC分类号： G06F15/173
CPC分类号： G06F11/3409 , G06F11/3466 , G06F11/3495 , G06F2201/86
摘要： A method and system for monitoring and managing applications and services. A repository comprising information identifying a plurality of assets and one or more relationships among the assets is maintained. One or more assets used to support an application are identified, along with one or more applications that are included in a service. Event and performance data are collected by a plurality of tools that perform monitoring and/or managing of the identified assets, the application, and/or the service. The gathered event and performance data is aggregated. The user is provided with a portal to access the aggregated event and performance data. Through this portal, the user can determine an impact of an event or a performance issue on the application or service based on the aggregated event or performance data and the relationships among the assets.
摘要翻译：一种用于监控和管理应用程序和服务的方法和系统。保存包含识别多个资产的信息和资产之间的一个或多个关系的存储库。识别用于支持应用程序的一个或多个资产以及服务中包含的一个或多个应用程序。事件和性能数据由执行所识别的资产，应用和/或服务的监视和/或管理的多个工具来收集。收集的事件和性能数据被聚合。为用户提供了访问聚合事件和性能数据的门户。通过该门户，用户可以基于聚合事件或性能数据以及资产之间的关系来确定事件或性能问题对应用程序或服务的影响。

9. 发明申请

US20090093477A1 TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE IN THERAPY 有权
公开(公告)号：US20090093477A1
公开(公告)日：2009-04-09
申请号：US12264621
申请日：2008-11-04
申请人： Nicholas Charles RAY , Harry FINCH , Christine EDWARDS , Elizabeth O'CONNOR
发明人： Nicholas Charles RAY , Harry FINCH , Christine EDWARDS , Elizabeth O'CONNOR
IPC分类号： A61K31/519 , C07D487/04 , A61P11/00 , A61K31/5377
CPC分类号： C07D487/04
摘要： Compounds of formula (I) and multimers thereof are inhibitors of human neutrophil elastase activity, and of utility in the treatment of, e.g., COPD: wherein A is aryl or heteroaryl; D is oxygen or sulphur; R1, R2 and R3 are independently each hydrogen, halogen, nitro, cyano, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, hydroxy or C1-C6-alkoxy or C2-C6-alkenyloxy, wherein C1-C6-alkyl and C1-C6-alkoxy can be further substituted with one to three identical or different radicals selected from the group consisting of halogen, hydroxy and C1-C4-alkoxy;R and R4 each independently represent a radical of formula—[X]m-[Alk1]p-[Q]n-[Alk2]q-[X1]k-Z wherein k, m, n, p and q are independently 0 or 1; Alk1 and Alk2 each independently represent an optionally substituted C1-C6 alkylene, or C2-C6 alkenylene radical which may optionally contain an ether (O—), thioether (—S—) or amino (—NRA—) link wherein RA is hydrogen or C1-C3 alkyl; Q represents (i) O—, —S—, —S(═O)—, —S(═O)2—, —S+(RA)—, —N(RA)—, —N+(RA)(RB)—, —C(═O)—, —C(═O)O—, —OC(═O)—, —C(═O)NRA—, —NRAC(═O)—, —S(O2)NRA—, —NRAS(O2)—, —NRAC(═O)NRB—, —NRAC(═NRA)NRB—, —C(═NRD)NRE, —NREC(═NRD), wherein RA, RB, RD and RE are independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, or RA and RB, or RD and RE taken together with the nitrogen to which they are attached form a monocyclic heterocyclic ring of 5 to 7 ring atoms which my contain a further heteroatom selected from N, O and S, or (ii) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 3-6 ring members; X represents —(C═O)—, —S(O2)—, —C(═O)O—, —(C═O)NRA—, or —S(O2)NRA—, wherein RA is hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl; X1 represents —O—, —S—, or —NH; and Z is hydrogen or an optionally substituted mono- or bicyclic carbocyclic or heterocyclic radical having 3-6 ring members.

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