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1. 发明授权

US08986214B2 System and method for using tissue contact information in an automated mapping of cardiac chambers employing magnetically shaped fields 有权
标题翻译：在使用磁性场的心室的自动测绘中使用组织接触信息的系统和方法
公开(公告)号：US08986214B2
公开(公告)日：2015-03-24
申请号：US12707085
申请日：2010-02-17
申请人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Eli Gang , Laszlo Farkas
发明人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Eli Gang , Laszlo Farkas
IPC分类号： A61B5/02 , A61B5/053 , A61B5/06 , A61B5/107 , A61B5/00 , A61B5/0402
CPC分类号： A61B5/0538 , A61B5/0402 , A61B5/06 , A61B5/062 , A61B5/1075 , A61B5/6851 , A61B5/6852 , A61B5/6869 , A61B5/6885
摘要： The invention relates to a method for using tissue contact technology to optimize automated cardiac chamber mapping algorithms to both speed up the mapping process and guarantee the definition of the actual chamber limits. The invention further comprises a method for conveying tissue type information to such automatic mapping algorithms so as to allow them to adapt their point collection density within areas of particular interest. The method is enhanced by the use of a magnetic chamber that employs electromagnetic coils configured as a waveguide that radiate magnetic fields by shaping the necessary flux density axis on and around the catheter distal tip so as to push, pull and rotate the tip on demand and as defined by such automatic mapping algorithms.
摘要翻译：本发明涉及一种使用组织接触技术来优化自动心室映射算法以加速映射过程并保证实际室限定义的方法。本发明还包括一种用于将组织类型信息传送到这种自动映射算法的方法，以便使它们能够将它们的点收集密度调整到特别感兴趣的区域内。该方法通过使用磁场室来增强，该磁室采用被配置为波导的电磁线圈，其通过在导管远端顶端上和周围形成必要的通量密度轴而辐射磁场，以便按需推动，拉动和旋转尖端，如这种自动映射算法所定义的。

2. 发明申请

US20090248014A1 APPARATUS FOR MAGNETICALLY DEPLOYABLE CATHETER WITH MOSFET SENSOR AND METHOD FOR MAPPING AND ABLATION 审中-公开
标题翻译：具有MOSFET传感器的磁性可分配电缆的设备及其映射和排列方法
公开(公告)号：US20090248014A1
公开(公告)日：2009-10-01
申请号：US12480566
申请日：2009-06-08
申请人： Yehoshua Shachar , Laszlo Farkas , Eli Gang
发明人： Yehoshua Shachar , Laszlo Farkas , Eli Gang
IPC分类号： A61B18/14 , A61B5/053
CPC分类号： A61B18/1492 , A61B5/0402 , A61B5/7285 , A61B6/541 , A61B8/543 , A61B34/20 , A61B34/73 , A61B2017/00026 , A61B2017/0011 , A61B2018/00214 , A61B2018/00839 , A61B2018/1467 , A61B2018/183 , A61B2034/2051 , A61B2034/301 , A61B2034/742
摘要： A mapping and ablation catheter is described. In one embodiment, the catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wavefronts. In one embodiment, the system maps the change in potential in the vicinity of an activation wavefront. In one embodiment, the mapping system tracks the spread of excitation in the heart, with properties such as propagation velocity changes. In one embodiment, during measurement, the manifold carrying the sensor array expands from a closed position state to a deployable open state. Spatial variation of the electrical potential is captured by the system's ability to occupy the same three-dimensional coordinate set for repeated measurements of the desired site. In one embodiment, an interpolation algorithm tracks the electrogram data points to produce a map relative to the electrocardiogram data.
摘要翻译：描述了一种映射和消融导管。在一个实施例中，导管包括MOSFET传感器阵列，其提供信号测量的更好的保真度以及数据收集，并且减少由各向同性和各向异性波前面的空间分布产生的误差。在一个实施例中，系统映射激活波前附近的电位变化。在一个实施例中，映射系统利用诸如传播速度变化的特性跟踪心脏中激发的扩展。在一个实施例中，在测量期间，承载传感器阵列的歧管从关闭位置状态扩展到可展开状态。电位的空间变化由系统占据相同三维坐标组的能力来捕获，以重复测量所需位置。在一个实施例中，插值算法跟踪电描记图数据点以产生相对于心电图数据的图。

3. 发明授权

US06132390A Handle for manipulation of a stylet used for deflecting a tip of a lead or catheter 失效
标题翻译：用于操纵用于偏转铅或导管尖端的探针的手柄
公开(公告)号：US06132390A
公开(公告)日：2000-10-17
申请号：US175164
申请日：1998-10-19
申请人： H. Stephen Cookston , Eli Gang , John Wright
发明人： H. Stephen Cookston , Eli Gang , John Wright
IPC分类号： A61B1/00 , A61B5/042 , A61M25/01 , A61N1/05
CPC分类号： A61M25/0147 , A61M25/01 , A61M25/0155 , A61M25/0158 , A61N1/056 , A61N1/0565 , A61B5/042
摘要： A deflectable stylet is comprised of a hollow tube with a reduced diameter distal portion including a semi-cylindrical ground portion to provide localized flexure wherein tension is applied to an axial tension wire fixed to the distal end of the hollow tube. The hollow tube is coupled to a rotationally fixed tip coupled to a rotationally fixed handle body. The handle body and the tip are telescoped longitudinally with respect to each other along the longitudinal axis of the hollow tube by means of a rotatable nut that advances out of or backs the handle into the tip. The tension wire is coupled to the handle body so that when the nut is rotated in a first direction and the handle body backed out, tension is applied to the wire which is then withdrawn from the hollow tube fixed to the tip causing the stylet to curve at its distal end. Rotation of the nut in the opposite direction reduces the tension on the wire causing the stylet to straighten at its distal end. By this means fine, micrometer adjustments of the curvature of the stylet are reliably and repeatedly made. A conical tip of the handle is coupled to the catheter and provides stress relief to the stylet. The tip is freely rotatable with respect to the handle, but can be locked to the terminal pin of the catheter so that an active fixation pacemaker lead is activatable by rotation of the tip.
摘要翻译：可偏转的探针包括具有减小直径的远端部分的中空管，其包括半圆柱形接地部分以提供局部弯曲，其中张力施加到固定到中空管的远端的轴向张力线。中空管联接到联接到旋转固定手柄主体的旋转固定末端。手柄主体和尖端通过可旋转的螺母沿着中空管的纵向轴线相对于彼此纵向地伸缩，该可旋转的螺母将手柄前进或后退到尖端中。张力丝联接到把手主体，使得当螺母沿第一方向旋转并且手柄本体被拉出时，张力被施加到线，然后将其从固定到尖端的中空管中取出，使得探针弯曲在其远端。螺母沿相反方向的旋转减少了钢丝绳上的张力，导致探针在其远端伸直。通过这种方式，可以可靠且重复地进行精细的微米调节探针的曲率。手柄的圆锥形尖端与导管相连，并为探针提供应力消除。尖端相对于手柄可自由旋转，但是可以锁定到导管的端子销，使得通过尖端的旋转来激活主动定心起搏器引线。

4. 发明授权

US09381063B2 Method and apparatus for magnetically guided catheter for renal denervation employing MOSFET sensor array 有权
标题翻译：使用MOSFET传感器阵列进行肾去神经导磁导管的方法和装置
公开(公告)号：US09381063B2
公开(公告)日：2016-07-05
申请号：US13549341
申请日：2012-07-13
申请人： Eli Gang , Yehoshua Josh Shachar
发明人： Eli Gang , Yehoshua Josh Shachar
IPC分类号： A61B18/04 , A61B18/14 , A61B5/05 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/05 , A61B18/04 , A61B34/30 , A61B34/73 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00839
摘要： A system for a mapping and ablation catheter. The catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wave fronts and error associated with near and far field's signal averages. The system maps the change in bioelectric potential in the vicinity of an activation wave front. During measurement, the manifold carrying the sensor array translates and rotates so as to achieve a measure of high potential employing an impedance value. The system of guiding and controlling the movement of the catheter distal end is able to deliver energy for ablating the renal artery nerve and thereby providing a safe and efficient method and apparatus for neuromodulation.
摘要翻译：一种映射和消融导管的系统。该导管包括MOSFET传感器阵列，其提供信号测量的更好的保真度以及数据收集，并且减少由各向同性和各向异性波阵面的空间分布产生的误差以及与近场和远场信号平均值相关的误差。该系统映射激活波前附近的生物电位变化。在测量期间，承载传感器阵列的歧管平移和旋转，以便采用阻抗值实现高电位的测量。引导和控制导管远端运动的系统能够输送用于消融肾动脉神经的能量，从而提供用于神经调节的安全有效的方法和装置。

5. 发明授权

US08457714B2 System and method for a catheter impedance seeking device 失效
标题翻译：导管阻抗寻求装置的系统和方法
公开(公告)号：US08457714B2
公开(公告)日：2013-06-04
申请号：US12323231
申请日：2008-11-25
申请人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Laszlo Farkas , David Johnson , Eli Gang
发明人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Laszlo Farkas , David Johnson , Eli Gang
IPC分类号： A61B5/05 , A61B17/00
CPC分类号： A61B5/06 , A61B5/062 , A61B5/068 , A61B34/30 , A61B34/76 , A61B2034/2051 , A61B2034/301 , A61B2090/065
摘要： A tissue-contact seeking method and apparatus is described that enhances catheter position detection and control systems in making and maintaining continuous tissue contact in a highly dynamic frame, such as under the rigors of cardiac motion. Tissue-seeking logical routines use a tissue contact sensing system to advance a catheter to relatively continuous tissue contact, or detect obstacles, in cooperation with the catheter position detection and control systems. Additional logical routines are capable of optimizing the contact direction of the catheter tip by controlling the rotation angle and chamber position of the introducer.
摘要翻译：描述了组织接触寻求方法和装置，其增强了导管位置检测和控制系统，以在高度动态的框架（例如心脏运动的严格性）下制造和维持连续组织接触。组织寻求逻辑例程使用组织接触感测系统将导管推进到与导管位置检测和控制系统协作的相对连续的组织接触或检测障碍物。附加的逻辑程序能够通过控制导引器的旋转角度和腔室位置来优化导管尖端的接触方向。

6. 发明申请

US20100305429A1 SYSTEM AND METHOD FOR USING TISSUE CONTACT INFORMATION IN AN AUTOMATED MAPPING OF CARDIAC CHAMBERS EMPLOYING MAGNETICLY SHAPED FIELDS 有权
标题翻译：使用组织接触信息的自动化映射的系统和方法使用磁带形成场的心脏呼吸器
公开(公告)号：US20100305429A1
公开(公告)日：2010-12-02
申请号：US12707085
申请日：2010-02-17
申请人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Eli Gang , Laszlo Farkas
发明人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Eli Gang , Laszlo Farkas
IPC分类号： A61B5/05
CPC分类号： A61B5/0538 , A61B5/0402 , A61B5/06 , A61B5/062 , A61B5/1075 , A61B5/6851 , A61B5/6852 , A61B5/6869 , A61B5/6885
摘要： The invention relates to a method for using tissue contact technology to optimize automated cardiac chamber mapping algorithms to both speed up the mapping process and guarantee the definition of the actual chamber limits. The invention further comprises a method for conveying tissue type information to such automatic mapping algorithms so as to allow them to adapt their point collection density within areas of particular interest. The method is enhanced by the use of a magnetic chamber that employs electromagnetic coils configured as a waveguide that radiate magnetic fields by shaping the necessary flux density axis on and around the catheter distal tip so as to push, pull and rotate the tip on demand and as defined by such automatic mapping algorithms.
摘要翻译：本发明涉及一种使用组织接触技术来优化自动心室映射算法以加速映射过程并保证实际室限定义的方法。本发明还包括一种用于将组织类型信息传送到这种自动映射算法的方法，以便使它们能够将它们的点收集密度调整到特别感兴趣的区域内。该方法通过使用磁场室来增强，该磁室采用被配置为波导的电磁线圈，其通过在导管远端顶端上和周围形成必要的通量密度轴而辐射磁场，以便按需推动，拉动和旋转尖端，如这种自动映射算法所定义的。

7. 发明授权

US09220425B2 Method and apparatus for measuring biopotential and mapping ephaptic coupling employing a catheter with MOSFET sensor array 有权
标题翻译：使用具有MOSFET传感器阵列的导管测量生物电位和映射ephaptic耦合的方法和装置
公开(公告)号：US09220425B2
公开(公告)日：2015-12-29
申请号：US13621727
申请日：2012-09-17
申请人： Yehoshua Shachar , Eli Gang
发明人： Yehoshua Shachar , Eli Gang
IPC分类号： A61B5/04 , A61B5/0428 , A61B5/00 , A61B5/042 , A61B5/0478
CPC分类号： A61B5/04001 , A61B5/042 , A61B5/04284 , A61B5/0478 , A61B5/6858
摘要： This invention relates generally to electro-anatomical mapping method and an apparatus using a catheter and more particularly to a mapping catheter having an embedded MOSFET sensor array for detecting local electrophysiological parameters such as biopotential signals within an excitable cellular matrix geometry, for determining physiological as well as electrical characteristics of conduction path and its underlying substrate within the endocardial and epicardial spaces, the arterial structure and in ganglionic plexus. The apparatus with its MOSFET sensor is geometrically configured as a decapolar linear array and optionally with an 8×8 sensor matrix placed on a balloon-like structure.
摘要翻译：本发明一般涉及电解剖映射方法和使用导管的装置，更具体地说，涉及具有嵌入式MOSFET传感器阵列的映射导管，用于检测局部电生理参数，例如可兴奋的细胞矩阵几何中的生物电位信号，用于确定生理学作为心内膜和心外膜空间，动脉结构和神经节丛中的传导路径及其下面的底物的电特性。其MOSFET传感器的装置几何构造为十极线阵列，并且可选地具有放置在气球状结构上的8×8传感器矩阵。

8. 发明申请

US20140018792A1 METHOD AND APPARATUS FOR MAGNETICALLY GUIDED CATHETER FOR RENAL DENERVATION EMPLOYING MOSFET SENSOR ARRAY 审中-公开
标题翻译：用于使用MOSFET传感器阵列进行肾衰竭的磁导引导管的方法和装置
公开(公告)号：US20140018792A1
公开(公告)日：2014-01-16
申请号：US13549341
申请日：2012-07-13
申请人： Eli Gang , Yehoshua Josh Shachar
发明人： Eli Gang , Yehoshua Josh Shachar
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/05 , A61B18/04 , A61B34/30 , A61B34/73 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00839
摘要： A system for a mapping and ablation catheter. The catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wave fronts and error associated with near and far field's signal averages. The system maps the change in bioelectric potential in the vicinity of an activation wave front. During measurement, the manifold carrying the sensor array translates and rotates so as to achieve a measure of high potential employing an impedance value. The system of guiding and controlling the movement of the catheter distal end is able to deliver energy for ablating the renal artery nerve and thereby providing a safe and efficient method and apparatus for neuromodulation.
摘要翻译：一种映射和消融导管的系统。该导管包括MOSFET传感器阵列，其提供信号测量的更好的保真度以及数据收集，并且减少由各向同性和各向异性波阵面的空间分布产生的误差以及与近场和远场信号平均值相关的误差。该系统映射激活波前附近的生物电位变化。在测量期间，承载传感器阵列的歧管平移和旋转，以便采用阻抗值实现高电位的测量。引导和控制导管远端运动的系统能够输送用于消融肾动脉神经的能量，从而提供用于神经调节的安全有效的方法和装置。

9. 发明授权

US07869854B2 Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation 有权
标题翻译：用于具有MOSFET传感器的磁性可展开导管的装置和用于映射和消融的方法
公开(公告)号：US07869854B2
公开(公告)日：2011-01-11
申请号：US11362542
申请日：2006-02-23
申请人： Yehoshua Shachar , Laszlo Farkas , Eli Gang
发明人： Yehoshua Shachar , Laszlo Farkas , Eli Gang
IPC分类号： A61B5/04
CPC分类号： A61B18/1492 , A61B5/0402 , A61B5/7285 , A61B6/541 , A61B8/543 , A61B34/20 , A61B34/73 , A61B2017/00026 , A61B2017/0011 , A61B2018/00214 , A61B2018/00839 , A61B2018/1467 , A61B2018/183 , A61B2034/2051 , A61B2034/301 , A61B2034/742
摘要： A mapping and ablation catheter is described. In one embodiment, the catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wavefronts. In one embodiment, the system maps the change in potential in the vicinity of an activation wavefront. In one embodiment, the mapping system tracks the spread of excitation in the heart, with properties such as propagation velocity changes. In one embodiment, during measurement, the manifold carrying the sensor array expands from a closed position state to a deployable open state. Spatial variation of the electrical potential is captured by the system's ability to occupy the same three-dimensional coordinate set for repeated measurements of the desired site. In one embodiment, an interpolation algorithm tracks the electrogram data points to produce a map relative to the electrocardiogram data.
摘要翻译：描述了一种映射和消融导管。在一个实施例中，导管包括MOSFET传感器阵列，其提供信号测量的更好的保真度以及数据收集，并且减少由各向同性和各向异性波前面的空间分布产生的误差。在一个实施例中，系统映射激活波前附近的电位变化。在一个实施例中，映射系统利用诸如传播速度变化的特性跟踪心脏中激发的扩展。在一个实施例中，在测量期间，承载传感器阵列的歧管从关闭位置状态扩展到可展开状态。电位的空间变化由系统占据相同三维坐标组的能力来捕获，以重复测量所需位置。在一个实施例中，插值算法跟踪电描记图数据点以产生相对于心电图数据的图。

10. 发明申请

US20070197891A1 Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation 有权
标题翻译：用于具有MOSFET传感器的磁性可展开导管的装置和用于映射和消融的方法
公开(公告)号：US20070197891A1
公开(公告)日：2007-08-23
申请号：US11362542
申请日：2006-02-23
申请人： Yehoshua Shachar , Laszlo Farkas , Eli Gang
发明人： Yehoshua Shachar , Laszlo Farkas , Eli Gang
IPC分类号： A61B5/04 , A61B19/00
CPC分类号： A61B18/1492 , A61B5/0402 , A61B5/7285 , A61B6/541 , A61B8/543 , A61B34/20 , A61B34/73 , A61B2017/00026 , A61B2017/0011 , A61B2018/00214 , A61B2018/00839 , A61B2018/1467 , A61B2018/183 , A61B2034/2051 , A61B2034/301 , A61B2034/742
摘要： A mapping and ablation catheter is described. In one embodiment, the catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wavefronts. In one embodiment, the system maps the change in potential in the vicinity of an activation wavefront. In one embodiment, the mapping system tracks the spread of excitation in the heart, with properties such as propagation velocity changes. In one embodiment, during measurement, the manifold carrying the sensor array expands from a closed position state to a deployable open state. Spatial variation of the electrical potential is captured by the system's ability to occupy the same three-dimensional coordinate set for repeated measurements of the desired site. In one embodiment, an interpolation algorithm tracks the electrogram data points to produce a map relative to the electrocardiogram data.
摘要翻译：描述了一种映射和消融导管。在一个实施例中，导管包括MOSFET传感器阵列，其提供信号测量的更好的保真度以及数据收集，并且减少由各向同性和各向异性波前面的空间分布产生的误差。在一个实施例中，系统映射激活波前附近的电位变化。在一个实施例中，映射系统利用诸如传播速度变化的特性跟踪心脏中激发的扩展。在一个实施例中，在测量期间，承载传感器阵列的歧管从关闭位置状态扩展到可展开状态。电位的空间变化由系统占据相同三维坐标集的能力来捕获，以重复测量所需位置。在一个实施例中，插值算法跟踪电描记图数据点以产生相对于心电图数据的图。

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