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1. 发明授权

US5344576A Continuous particle separation process 失效
标题翻译：连续粒子分离过程
公开(公告)号：US5344576A
公开(公告)日：1994-09-06
申请号：US22848
申请日：1993-02-25
申请人： Charles Carr , Edward Sybert , Aldis E. Adamson
发明人： Charles Carr , Edward Sybert , Aldis E. Adamson
IPC分类号： B01D24/02 , B01D29/00 , B01D36/00 , B03B9/00 , B07B9/00 , C12M1/12 , B01D37/00 , B01D33/54
CPC分类号： B07B9/00 , B03B9/00 , C12M45/02 , C12M45/05 , C12M47/04 , Y10T436/25375
摘要： A continuous process for the separation of small particles from larger particles in a biological preparation passes a liquid stream of the preparation through a first filter or screen, which retains larger particles, passing smaller particles in the liquid. The large particles have retained on their surfaces wetting water, in which are entrained some of the small particles. The large particles are directed to a liquid having a concentration of smaller particles lower than the concentration of smaller particles in the wetting water, and mixed therein. The smaller particles separate from the larger particles in the mixed suspension, which is then directed to a second filter or screen, for further separation. The smaller particle/liquid stream may be recycled to the biological preparation stage, the liquid suspension for the large particles, or to a separator means where the smaller particles are separated off from the liquid stream. As the system is susceptible of being practiced as a continuous closed system, given an adequate liquid supply, the filtering steps may be repeated any number of times. When separated at the filters or screens, at least a portion of the stream of small particles and liquid must be directed to the separation means, so that said small particles may be eventually separated.
摘要翻译：用于从生物制剂中的较大颗粒分离小颗粒的连续方法将制剂的液体流通过第一过滤器或筛网，其保留较大的颗粒，使较小的颗粒通过液体。大颗粒在其表面上保留润湿水，其中夹带有一些小颗粒。大颗粒被引导到具有低于润湿水中较小颗粒的浓度的较小颗粒的浓度的液体，并在其中混合。较小的颗粒与混合悬浮液中的较大颗粒分离，然后将其引导至第二过滤器或筛网，用于进一步分离。较小的颗粒/液体流可以循环到生物制剂阶段，用于大颗粒的液体悬浮液或者将较小颗粒与液体流分离的分离器装置。由于系统容易被实践为连续封闭系统，因此给定足够的液体供应，过滤步骤可以重复任意次数。当在过滤器或筛网处分离时，小颗粒和液体流的至少一部分必须被引导到分离装置，使得所述小颗粒可能最终分离。

2. 发明授权

US5080807A Continuous particle separation process 失效
标题翻译：连续粒子分离过程
公开(公告)号：US5080807A
公开(公告)日：1992-01-14
申请号：US639276
申请日：1991-01-10
申请人： Charles Carr , Edward Sybert , Aldis E. Adamson
发明人： Charles Carr , Edward Sybert , Aldis E. Adamson
IPC分类号： B01D24/02 , B01D29/00 , B01D36/00 , B03B9/00 , B07B9/00 , C12M1/12
CPC分类号： B07B9/00 , B03B9/00 , C12M45/02 , C12M45/05 , C12M47/04 , Y10T436/25375
摘要： A continuous process for the separation of small particles from larger particles in a biological preparation passes a liquid stream of the preparation through a first filter or screen, which retains larger particles, passing smaller particles in the liquid. The large particles have retained on their surfaces wetting water, in which are entrained some of the small particles. The large particles are directed to a liquid having a concentration of smaller particles lower than the concentration of smaller particles in the wetting water, and mixed therein. The smaller particles separate from the larger particles in the mixed suspension, which is then directed to a second filter or screen, for further separation. The smaller particle/liquid stream may be recycled to the biological preparation stage, the liquid suspension for the large particles, or to a separator means where the smaller particles are separated off from the liquid stream. As the system is susceptible of being practiced as a continuous closed system, given an adequate liquid supply, the filtering steps may be repeated any number of times. When separated at the filters or screens, at least a portion of the stream of small particles and liquid must be directed to the separation means, so that said small particles may be eventually separated.
摘要翻译：用于从生物制剂中的较大颗粒分离小颗粒的连续方法将制剂的液体流通过第一过滤器或筛网，其保留较大的颗粒，使较小的颗粒通过液体。大颗粒在其表面上保留润湿水，其中夹带有一些小颗粒。大颗粒被引导到具有低于润湿水中较小颗粒的浓度的较小颗粒的浓度的液体，并在其中混合。较小的颗粒与混合悬浮液中的较大颗粒分离，然后将其引导至第二过滤器或筛网，用于进一步分离。较小的颗粒/液体流可以循环到生物制剂阶段，用于大颗粒的液体悬浮液或者将较小颗粒与液体流分离的分离器装置。由于系统容易被实践为连续封闭系统，因此给定足够的液体供应，过滤步骤可以重复任意次数。当在过滤器或筛网处分离时，小颗粒和液体流的至少一部分必须被引导到分离装置，使得所述小颗粒可能最终分离。

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