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    • 3. 发明授权
    • Taste masked pharmaceutical liquid formulations
    • 味道掩蔽的药液配方
    • US06482823B1
    • 2002-11-19
    • US09598157
    • 2000-06-21
    • Danny YuEdward Roche
    • Danny YuEdward Roche
    • A61K31535
    • A61K31/5383A61K9/0095A61K9/5026A61K9/5042
    • A liquid composition for oral administration comprising a pharmaceutically active medicament coated with a taste masking effective amount of a polymer blend of (a) dimethylaminoethyl methacrylate and neutral methacrylic acid ester (MM/MAE) and (b) a cellulose ester, in an aqueous vehicle, wherein the polymer weight ratio of the cellulose ester to the MM/MAE is about 40:60 to about 90:10, preferably about 60:40. The liquid composition utilizes a “reverse enteric coating” which is soluble in the acid pH's of the stomach, generally about 1.0 to 4.0, but relatively insoluble at the non-acidic pH's of the mouth. The coatings provide for rapid release and absorption of the drug, which is generally desirable in the case of liquid dosage forms.
    • 一种用于口服给药的液体组合物,其包含药物活性药物,其涂覆有有效量的(a)甲基丙烯酸二甲基氨基乙酯和中性甲基丙烯酸酯(MM / MAE)和(b)纤维素酯的聚合物共混物的水性载体 ,其中纤维素酯与MM / MAE的聚合物重量比为约40:60至约90:10,优选约60:40。 液体组合物利用可溶于胃的酸性pH值的“反向肠溶衣”,通常为约1.0至4.0,但在口的非酸性pH下相对不溶。 涂层提供药物的快速释放和吸收,在液体剂型的情况下通常是合乎需要的。