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1. 发明授权

US07015231B2 Chemical compounds 失效
公开(公告)号：US07015231B2
公开(公告)日：2006-03-21
申请号：US10490831
申请日：2002-09-24
申请人： Karen Elizabeth Lackey , Edgar Raymond Wood, III
发明人： Karen Elizabeth Lackey , Edgar Raymond Wood, III
IPC分类号： A61K31/44 , C07D471/00
CPC分类号： C07D471/04
摘要： The present invention is related to aza-oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

2. 发明申请

US20120058113A1 CANCER TREATMENT METHOD 有权
标题翻译：癌症治疗方法
公开(公告)号：US20120058113A1
公开(公告)日：2012-03-08
申请号：US13294496
申请日：2011-11-11
申请人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
发明人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K31/517 , A61K31/337 , A61K31/4196 , A61K31/475 , A61K31/519 , A61K31/555 , A61K45/06 , C23C16/401 , H01L21/31633 , H01L2924/0002 , A61K2300/00 , H01L2924/00
摘要： A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
摘要翻译：描述了治疗癌症的方法，包括施用4-喹唑啉胺和至少一种其它抗肿瘤剂以及包括4-喹唑啉胺的药物组合。

3. 发明授权

US07338966B2 Substituted oxindole derivatives as tyrosine kinase inhibitors 失效
标题翻译：取代的羟吲哚衍生物作为酪氨酸激酶抑制剂
公开(公告)号：US07338966B2
公开(公告)日：2008-03-04
申请号：US11148635
申请日：2005-06-09
申请人： Karen Elizabeth Lackey , Edgar Raymond Wood, III
发明人： Karen Elizabeth Lackey , Edgar Raymond Wood, III
IPC分类号： A61K31/44 , C07D401/12
CPC分类号： C07D401/12 , C07D209/34 , C07D209/40 , C07D417/12
摘要： The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
摘要翻译：本发明涉及结构（I）的羟吲哚衍生物，含有它们的组合物及其使用和制造方法。这些化合物通常在药理学上作为通常通过改变促分裂原活化的信号通路而减轻的疾病状态中的药物有用，特别是在病理学上涉及异常细胞增殖的蛋白激酶的抑制或拮抗作用中。这种疾病状态包括肿瘤生长，再狭窄，动脉粥样硬化，疼痛和血栓形成。特别地，本发明涉及一系列取代的羟吲哚化合物，其表现出Trk家族蛋白酪氨酸激酶抑制，并且其可用于癌症治疗和慢性疼痛适应症。

4. 发明授权

US07071217B2 Substituted oxindole derivatives as tyrosine kinase inhibitors 失效
标题翻译：取代的羟吲哚衍生物作为酪氨酸激酶抑制剂
公开(公告)号：US07071217B2
公开(公告)日：2006-07-04
申请号：US10362743
申请日：2001-08-23
申请人： Scott Howard Dickerson , Robert N Hunter , Lee Frederick Kuyper , Karen Elizabeth Lackey , Michael J. Luzzio , Edgar Raymond Wood, III
发明人： Scott Howard Dickerson , Robert N Hunter , Lee Frederick Kuyper , Karen Elizabeth Lackey , Michael J. Luzzio , Edgar Raymond Wood, III
IPC分类号： A61K31/44 , C07D401/02
CPC分类号： C07D401/12 , C07D209/34 , C07D209/40 , C07D417/12
摘要： The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis, In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
摘要翻译：本发明涉及结构（I）的羟吲哚衍生物，含有它们的组合物及其使用和制造方法。这些化合物通常在药理学上作为通常通过改变促分裂原活化的信号通路而减轻的疾病状态中的药物有用，特别是在病理学上涉及异常细胞增殖的蛋白激酶的抑制或拮抗作用中。这种疾病状态包括肿瘤生长，再狭窄，动脉粥样硬化，疼痛和血栓形成。特别地，本发明涉及一系列取代的羟吲哚化合物，其表现出Trk家族蛋白酪氨酸激酶抑制，并且其可用于癌症治疗和慢性疼痛适应症。

5. 发明申请

US20110312982A1 Cancer Treatment Method 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：US20110312982A1
公开(公告)日：2011-12-22
申请号：US13223480
申请日：2011-09-01
申请人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
发明人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
IPC分类号： A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , A61K31/337 , A61K31/4196 , A61K31/475 , A61K31/519 , A61K31/555 , A61K45/06 , C23C16/401 , H01L21/31633 , H01L2924/0002 , A61K2300/00 , H01L2924/00
摘要： A method of treating cancer is described including administration of a 4-quinazolinamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolinamines.
摘要翻译：描述了治疗癌症的方法，包括施用4-喹唑啉胺和至少一种其它抗肿瘤剂以及包括4-喹唑啉胺的药物组合。

6. 发明申请

US20100249160A1 Cancer Treatment Method 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：US20100249160A1
公开(公告)日：2010-09-30
申请号：US12815831
申请日：2010-06-15
申请人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenie Xia
发明人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenie Xia
IPC分类号： A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , A61K31/337 , A61K31/4196 , A61K31/475 , A61K31/519 , A61K31/555 , A61K45/06 , C23C16/401 , H01L21/31633 , H01L2924/0002 , A61K2300/00 , H01L2924/00
摘要： A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
摘要翻译：描述了治疗癌症的方法，包括施用4-喹唑啉胺和至少一种其它抗肿瘤剂以及包括4-喹唑啉胺的药物组合。

7. 发明授权

US07141576B2 Cancer treatment method 有权
标题翻译：癌症治疗方法
公开(公告)号：US07141576B2
公开(公告)日：2006-11-28
申请号：US10466290
申请日：2002-01-14
申请人： Karen Elizabeth Lackey , Neil Spector , Edgar Raymond Wood, III. , Wenle Xia
发明人： Karen Elizabeth Lackey , Neil Spector , Edgar Raymond Wood, III. , Wenle Xia
IPC分类号： A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , A61K31/337 , A61K31/4196 , A61K31/475 , A61K31/519 , A61K31/555 , A61K45/06 , C23C16/401 , H01L21/31633 , H01L2924/0002 , A61K2300/00 , H01L2924/00
摘要： A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as pharmaceutical combinations and compositions containing the same.
摘要翻译：描述了治疗癌症的方法，包括施用4-喹唑啉胺和至少一种其它抗肿瘤剂以及含有它们的药物组合和组合物。

8. 发明申请

US20150366868A1 CANCER TREATMENT METHOD 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：US20150366868A1
公开(公告)日：2015-12-24
申请号：US14831909
申请日：2015-08-21
申请人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
发明人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
IPC分类号： A61K31/517 , A61K31/4196
CPC分类号： A61K31/517 , A61K31/337 , A61K31/4196 , A61K31/475 , A61K31/519 , A61K31/555 , A61K45/06 , C23C16/401 , H01L21/31633 , H01L2924/0002 , A61K2300/00 , H01L2924/00
摘要： A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
摘要翻译：描述了治疗癌症的方法，包括施用4-喹唑啉胺和至少一种其它抗肿瘤剂以及包括4-喹唑啉胺的药物组合。

9. 发明授权

US08444988B2 Cancer treatment method 有权
标题翻译：癌症治疗方法
公开(公告)号：US08444988B2
公开(公告)日：2013-05-21
申请号：US13294496
申请日：2011-11-11
申请人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
发明人： Karen Elizabeth Lackey , Robert J. Mullin , Neil Spector , Edgar Raymond Wood, III , Wenle Xia
IPC分类号： A61K39/395
CPC分类号： A61K31/517 , A61K31/337 , A61K31/4196 , A61K31/475 , A61K31/519 , A61K31/555 , A61K45/06 , C23C16/401 , H01L21/31633 , H01L2924/0002 , A61K2300/00 , H01L2924/00
摘要： A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
摘要翻译：描述了治疗癌症的方法，包括施用4-喹唑啉胺和至少一种其它抗肿瘤剂以及包括4-喹唑啉胺的药物组合。

10. 发明授权

US06964977B2 Oxindole derivatives 失效
标题翻译：羟吲哚衍生物
公开(公告)号：US06964977B2
公开(公告)日：2005-11-15
申请号：US10362739
申请日：2001-08-23
申请人： Philip Anthony Harris , Robert N Hunter , Robert Walton McNutt, Jr. , Lee Frederick Kuyper , Karen Elizabeth Lackey , Michael Robert Peel , Edgar Raymond Wood, III
发明人： Philip Anthony Harris , Robert N Hunter , Robert Walton McNutt, Jr. , Lee Frederick Kuyper , Karen Elizabeth Lackey , Michael Robert Peel , Edgar Raymond Wood, III
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/454 , A61K31/53 , A61P7/02 , A61P9/10 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D209/14 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04 , A61K31/415
CPC分类号： C07D401/12 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/454 , A61K31/53 , C07D209/14 , C07D209/34 , C07D403/12 , C07D405/12 , C07D487/04
摘要： The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
摘要翻译：本发明涉及结构（I）的羟吲哚衍生物，含有它们的组合物及其使用和制造方法。这些化合物通常在药理学上作为通常通过改变促分裂原活化的信号通路而减轻的疾病状态中的药物有用，特别是在病理学上涉及异常细胞增殖的蛋白激酶的抑制或拮抗作用中。这种疾病状态包括肿瘤生长，再狭窄，动脉粥样硬化，疼痛和血栓形成。特别地，本发明涉及一系列取代的羟吲哚化合物，其表现出Trk家族蛋白酪氨酸激酶抑制，并且其可用于癌症治疗和慢性疼痛适应症。

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