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1. 发明授权

US4517289A Monoclonal antibodies for human tissue cross-matching 失效
标题翻译：用于人体组织交叉匹配的单克隆抗体
公开(公告)号：US4517289A
公开(公告)日：1985-05-14
申请号：US409183
申请日：1982-08-18
申请人： Edgar L. Milford , Charles B. Carpenter , Jean M. Paradysz
发明人： Edgar L. Milford , Charles B. Carpenter , Jean M. Paradysz
IPC分类号： G01N33/53 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C12N15/02 , C12P21/08 , G01N33/577 , G01N33/54 , A61K39/395 , C12N5/00 , C12N15/00 , C12R1/91
CPC分类号： C07K16/2833 , Y10S435/81 , Y10S435/948 , Y10S435/966 , Y10S435/975 , Y10S436/821 , Y10S530/806 , Y10S530/809 , Y10S530/83
摘要： Immortal, antibody-producing, hybridomally-produced clones which produce antibodies that react specifically with human HLA antigens and which are produced from rat lymphocyte cells sensitized against cells from a rat strain having different histocompatibility antigens are disclosed along with methods of producing the clones and antibodies and methods of using the antibodies in tissue crossing tests.
摘要翻译：公开了产生与人HLA抗原特异性反应的抗体并且由对来自具有不同组织相容性抗原的大鼠菌株的细胞敏感的大鼠淋巴细胞产生的抗体产生的杂交产生的克隆以及产生克隆和抗体的方法以及在组织交叉试验中使用抗体的方法。

2. 发明授权

US07931901B2 T-cell membrane protein (TIRC7), peptides and antibodies derived therefrom and uses thereof 有权
标题翻译： T细胞膜蛋白（TIRC7），从其衍生的肽和抗体及其用途
公开(公告)号：US07931901B2
公开(公告)日：2011-04-26
申请号：US11510868
申请日：2006-08-25
申请人： Nalan Utku , Steven R. Gullans , Edgar L. Milford
发明人： Nalan Utku , Steven R. Gullans , Edgar L. Milford
IPC分类号： A61K39/395
CPC分类号： C07H21/04 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K14/7051 , C07K16/28 , C07K2317/73 , Y10S514/825
摘要： Described are generally a T cell immune response cDNA 7 (TIRC7) encoding a novel T-cell transmembrane protein as well as peptides und polypeptides derived therefrom and antibodies recognizing said (poly)peptides. More particularly, peptide and polypeptide as well as antibodies being capable of inhibiting T-cell stimulation through the T-cell membrane protein (TIRC7) are provided. Furthermore, vectors comprising the aforementioned polynucleotides and host cells transformed therewith as well as their use in the production of the above-defined proteins, peptides or polypeptides are described. Additionally, pharmaceutical and diagnostic compositions are provided comprising any one of the afore described polynucleotide, vector, protein, peptide, polypeptide, or antibody. Furthermore, methods and uses for modulating immune responses through the novel TIRC7 membrane protein as well as pharmaceutical compositions comprising agents which act on the TIRC7 membrane protein or its ligand are described. Also, the use of said polynucleotide, vector, protein, peptide, polypeptide, or antibody for the preparation of pharmaceutical compositions for use in organ transplantation, for the treatment of autoimmune, allergic or infectious diseases, or for treatment of tumors is provided. Furthermore, methods for modulating (antigen-specific) T cell unresponsiveness inducing maintaining or reversing T cell unresponsiveness by inhibiting or stimulating an (unresponsive) T cell through the novel TIRC7 membrane protein are encompassed herein.
摘要翻译：通常描述了编码新型T细胞跨膜蛋白的T细胞免疫应答cDNA 7（TIRC7）以及从其衍生的肽和多肽和识别所述（多）肽的抗体。更具体地，提供肽和多肽以及能够通过T细胞膜蛋白（TIRC7）抑制T细胞刺激的抗体。此外，描述了包含上述多核苷酸的载体和其转化的宿主细胞以及它们在制备上述定义的蛋白质，肽或多肽中的用途。另外，提供包含前述多核苷酸，载体，蛋白质，肽，多肽或抗体中的任一种的药物和诊断组合物。此外，描述了通过新型TIRC7膜蛋白调节免疫应答的方法和用途以及包含作用于TIRC7膜蛋白或其配体的试剂的药物组合物。此外，提供了所述多核苷酸，载体，蛋白质，肽，多肽或抗体用于制备用于器官移植的药物组合物，用于治疗自身免疫性，过敏性或感染性疾病或用于治疗肿瘤的用途。此外，本文包括调节（抗原特异性）T细胞无反应性的诱导维持或逆转T细胞无反应性的方法，其通过抑制或刺激（非反应性）T细胞通过新型TIRC7膜蛋白。

3. 发明授权

US07863418B2 T-cell membrane protein (TIRC7) and peptides derived therefrom 有权
标题翻译： T细胞膜蛋白（TIRC7）及其衍生的肽
公开(公告)号：US07863418B2
公开(公告)日：2011-01-04
申请号：US11126866
申请日：2005-05-10
申请人： Nalan Utku , Steven R. Gullans , Edgar L. Milford
发明人： Nalan Utku , Steven R. Gullans , Edgar L. Milford
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07H21/04 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K14/7051 , C07K16/28 , C07K2317/73 , Y10S514/825
摘要： Described are a T cell immune response cDNA 7 (TIRC7) encoding a T-cell transmembrane protein, peptides and polypeptides derived therefrom and antibodies recognizing such (poly)peptides. Peptides, polypeptides and antibodies capable of inhibiting T-cell stimulation through the T-cell membrane protein (TIRC7) are provided. Vectors comprising polynucelotides encoding such polypeptides and peptides, host cells transformed therewith, and their use in the production of such, peptides or polypeptides are also described.
摘要翻译：描述了编码T细胞跨膜蛋白的T细胞免疫应答cDNA 7（TIRC7），从其衍生的肽和多肽和识别这种（多）肽的抗体。提供能够通过T细胞膜蛋白（TIRC7）抑制T细胞刺激的肽，多肽和抗体。还描述了包含编码这种多肽和肽的多核苷酸，由其转化的宿主细胞的载体，以及它们在制备这些肽或多肽中的用途。

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