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1. 发明授权

US09546994B2 Biomarkers for type 2 diabetes 有权
标题翻译： 2型糖尿病生物标志物
公开(公告)号：US09546994B2
公开(公告)日：2017-01-17
申请号：US14421637
申请日：2013-08-13
申请人： Helmholtz Zentrum Munchen—Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH) , Deutsche Diabetes-Forschungsgesellschaft e.V.—Trager des Deutschen Diabetes-Zentrums Dusseldorf , Eberhard Karls Universitat Tubingen, Medizinische Fakultat
发明人： Wolfgang Rathmann , Christian Herder , Thomas Illig , Jerzy Adamski , Rui Wang-Sattler , Zhongao Yu , H.-Erich Wichmann , Hans-Ulrich Haring , Michael Roden , Annette Peters , Christine Meisinger , Martin Hrabe De Angelis , Thomas Meitinger
IPC分类号： G01N33/92 , G01N33/487 , G01N33/68 , G01N24/08 , G01N30/02 , G01N30/72 , G01N33/49
CPC分类号： G01N33/487 , G01N24/08 , G01N30/02 , G01N30/7206 , G01N33/49 , G01N33/6893 , G01N33/92 , G01N2030/025 , G01N2030/027 , G01N2500/10 , G01N2800/042 , G01N2800/50
摘要： The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric metabolite having the same molecular weight as acetylcarnitine C2 but different chemical formula; wherein a decrease in the amount of a metabolite selected from said first group or an increase in the amount of a metabolite selected from said second group as compared to the amount of the corresponding metabolite(s) of a control is indicative of a predisposition to develop type 2 diabetes mellitus. Further, the invention relates to a method of identifying a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith or serving as a lead compound for developing a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith and a method of selecting a therapy to prevent type 2 diabetes mellitus. Also, the invention relates to a kit.
摘要翻译：本发明涉及鉴定受试者中2型糖尿病发病倾向的方法，所述方法包括以下步骤：在从所述受试者获得的样品中评估选自（a）的一种或多种代谢物的量，第一组包括代谢物甘氨酸，溶血磷脂酰胆碱酰基C18：2，溶血磷脂酰胆碱酰基C17：0，溶血磷脂酰胆碱酰基C18：0，溶血磷脂酰胆碱酰基C18：1，磷脂酰胆碱酰基 - 烷基C34：2，磷脂酰胆碱酰基 - 烷基C36：2，磷脂酰胆碱酰基 - 烷基C36：3和具有与甘氨酸相同分子量的等压代谢物，溶血磷脂酰胆碱酰基C18：2，溶血磷脂酰胆碱酰基C17：0，溶血磷脂酰胆碱酰基C18：0，溶血磷脂酰胆碱酰基C18：1，磷脂酰胆碱酰基 - 烷基C34：2，磷脂酰胆碱酰基 - 烷基C36：2或磷脂酰胆碱酰基 - 烷基C36：3但化学式不同; 和/或（b）包含代谢物乙酰肉碱C2和具有与乙酰肉碱C2相同的分子量但不同化学式的等压代谢物的第二组; 其中与对照的相应代谢物的量相比，选自所述第一组的代谢物的量的减少或选自所述第二组的代谢物的量的增加表明发生倾向 2型糖尿病此外，本发明涉及鉴定能够预防2型糖尿病和与其相关的疾病或作为用于开发能够预防2型糖尿病和相关疾病的化合物的铅化合物的化合物的方法，以及选择治疗预防2型糖尿病。此外，本发明涉及一种试剂盒。

2. 发明申请

US20150204839A1 BIOMARKERS FOR TYPE 2 DIABETES 有权
标题翻译： 2型糖尿病生物标志物
公开(公告)号：US20150204839A1
公开(公告)日：2015-07-23
申请号：US14421637
申请日：2013-08-13
申请人： Helmholtz Zentrum Munchen-Deutsches Forschungszen- trum fur Gesundheit and Umweit (GmbH) , Deutsche Diabetes-Forschungsgesellschaft e.V.- Trager des Deutschen Diabetes-Zentrums Dusseldorf , Eberhard Karls Universitat Tubingen, Medizinische Fakultat
发明人： Wolfgang Rathmann , Christian Herder , Thomas Illig , Jerzy Adamski , Rui Wang-Sattler , Zhongao Yu , H.-Erich Wichmann , Hans-Ulrich Haring , Michael Roden , Annette Peters , Christine Meisinger , Martin Hrabe De Angelis , Thomas Meitinger
IPC分类号： G01N33/487 , G01N24/08 , G01N30/72 , G01N33/49 , G01N30/02
CPC分类号： G01N33/487 , G01N24/08 , G01N30/02 , G01N30/7206 , G01N33/49 , G01N33/6893 , G01N33/92 , G01N2030/025 , G01N2030/027 , G01N2500/10 , G01N2800/042 , G01N2800/50
摘要： The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric metabolite having the same molecular weight as acetylcarnitine C2 but different chemical formula; wherein a decrease in the amount of a metabolite selected from said first group or an increase in the amount of a metabolite selected from said second group as compared to the amount of the corresponding metabolite(s) of a control is indicative of a predisposition to develop type 2 diabetes mellitus. Further, the invention relates to a method of identifying a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith or serving as a lead compound for developing a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith and a method of selecting a therapy to prevent type 2 diabetes mellitus. Also, the invention relates to a kit.
摘要翻译：本发明涉及鉴定受试者中2型糖尿病发病倾向的方法，所述方法包括以下步骤：在从所述受试者获得的样品中评估选自（a）的一种或多种代谢物的量，第一组包括代谢物甘氨酸，溶血磷脂酰胆碱酰基C18：2，溶血磷脂酰胆碱酰基C17：0，溶血磷脂酰胆碱酰基C18：0，溶血磷脂酰胆碱酰基C18：1，磷脂酰胆碱酰基 - 烷基C34：2，磷脂酰胆碱酰基 - 烷基C36：2，磷脂酰胆碱酰基 - 烷基C36：3和具有与甘氨酸相同分子量的等压代谢物，溶血磷脂酰胆碱酰基C18：2，溶血磷脂酰胆碱酰基C17：0，溶血磷脂酰胆碱酰基C18：0，溶血磷脂酰胆碱酰基C18：1，磷脂酰胆碱酰基 - 烷基C34：2，磷脂酰胆碱酰基 - 烷基C36：2或磷脂酰胆碱酰基 - 烷基C36：3但化学式不同; 和/或（b）包含代谢物乙酰肉碱C2和具有与乙酰肉碱C2相同的分子量但不同化学式的等压代谢物的第二组; 其中与对照的相应代谢物的量相比，选自所述第一组的代谢物的量的减少或选自所述第二组的代谢物的量的增加表明发生倾向 2型糖尿病此外，本发明涉及鉴定能够预防2型糖尿病和与其相关的疾病或作为用于开发能够预防2型糖尿病和相关疾病的化合物的铅化合物的化合物的方法，以及选择治疗预防2型糖尿病。此外，本发明涉及一种试剂盒。

3. 发明申请

US20210251722A1 SPACER FOR ENDODONTIC INSTRUMENT 有权
公开(公告)号：US20210251722A1
公开(公告)日：2021-08-19
申请号：US17236533
申请日：2021-04-21
申请人： Eberhard Karls Universitat Tubingen Medizinische Fakultat
发明人： Ashraf Elayouti
IPC分类号： A61C5/44
摘要： A spacer for an endodontic instrument includes a base surface with a diameter dG, a top surface with a diameter dD, which is smaller than the diameter dG, an axis of rotation, a lateral surface, a height h, an opening with a longitudinal axis for receiving an endodontic instrument and a cylindrical recess for receiving a stopper on the base surface. The spacer is frustoconically formed, and the opening extends from the base surface to the top surface. The longitudinal axis of the opening is coaxial to the axis of rotation of the spacer, and the cylindrical recess is coaxial to the opening.

4. 发明申请

US20220056141A1 Improved Anti-FLT3 Antigen Binding Proteins 有权
公开(公告)号：US20220056141A1
公开(公告)日：2022-02-24
申请号：US17275647
申请日：2019-09-11
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS , EBERHARD KARLS UNIVERSITAT TUBINGEN
发明人： Gundram Jung , Helmut Salih , Fabian Vogt , Latifa Zekri-Metref , Martin Pflltgler , Isabelle Ehnes
IPC分类号： C07K16/28 , C07K16/46 , A61P35/02
摘要： The present invention provides novel human fins related tyrosine kinase 3 (FLT3) antigen binding proteins, such as antibodies, having improved FLT3 binding affinity, and/or anti-tumor activity. The FLT3 antibodies of the invention were generated by mutation of a parent FLT3 antibody and tested in in vitro in binding assays as well as in vivo in a mouse tumor model and in human patient tumor samples. The antibodies of the invention are provided as monospecific constructs or in a bispecific FLT3×CD3 antibody format and show excellent target affinity and/or tumor cell killing. The present invention also relates methods for producing the antigen binding proteins of the invention as well as nucleic acids encoding them, vectors for and host cells for their expression. The invention further relates to methods of treating or diagnosing a disease such as leukemia using an FLT3 antigen binding protein (ABP) of the invention.

5. 发明申请

US20190158966A1 HEARING AID THAT CAN BE INTRODUCED INTO THE AUDITORY CANAL AND HEARING AID SYSTEM 审中-公开
公开(公告)号：US20190158966A1
公开(公告)日：2019-05-23
申请号：US16250885
申请日：2019-01-17
申请人： EBERHARD KARLS UNIVERSITAT TUBINGEN MEDIZINISCHE FAKULTAT
发明人： Ernst DALHOFF , Hans-Peter ZENNER
IPC分类号： H04R25/00 , H04R17/00
摘要： In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).

6. 发明申请

US20180148739A1 RECOMBINANT ORF VIRUS VECTOR 审中-公开
公开(公告)号：US20180148739A1
公开(公告)日：2018-05-31
申请号：US15875389
申请日：2018-01-19
申请人： Eberhard Karls Universitat Tubingen Medizinische Fakultat
发明人： Hans-Joachim Rziha , Ralf Amann
IPC分类号： C12N15/86 , A61K39/00
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/5154 , C12N2015/8572 , C12N2015/8581 , C12N2710/24031 , C12N2710/24041 , C12N2710/24222 , C12N2710/24243 , C12N2840/10
摘要： A nucleic acid molecule can code for an Orf virus vector promoter. A recombinant Orf virus vector can be included in a cell. The nucleic acid molecule, the vector and/or the cell can be included in a composition. The recombinant Orf virus vector can be used for the production of a foreign gene.

7. 发明授权

US10616699B2 Hearing aid that can be introduced into the auditory canal and hearing aid system 有权
公开(公告)号：US10616699B2
公开(公告)日：2020-04-07
申请号：US16250885
申请日：2019-01-17
申请人： EBERHARD KARLS UNIVERSITAT TUBINGEN MEDIZINISCHE FAKULTAT
发明人： Ernst Dalhoff , Hans-Peter Zenner
IPC分类号： H04R25/00 , H04R17/00
CPC分类号： H04R25/606 , H04R17/00 , H04R25/554 , H04R2225/025 , H04R2460/09
摘要： In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).

8. 发明授权

US10219087B2 Hearing aid that can be introduced into the auditory canal and hearing aid system 有权
公开(公告)号：US10219087B2
公开(公告)日：2019-02-26
申请号：US15107888
申请日：2014-12-18
申请人： EBERHARD KARLS UNIVERSITAT TUBINGEN MEDIZINISCHE FAKULTAT
发明人： Ernst Dalhoff , Hans-Peter Zenner
IPC分类号： H04R25/00 , H04R17/00
摘要： In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).

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