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1. 发明授权

US09492376B2 Polymer-conjugated albumin hydrogels for controlled release of therapeutic agents 有权
标题翻译：聚合物缀合的白蛋白水凝胶用于治疗剂的控制释放
公开(公告)号：US09492376B2
公开(公告)日：2016-11-15
申请号：US13133241
申请日：2009-12-07
申请人： Dror Seliktar , Liat Oss-Ronen
发明人： Dror Seliktar , Liat Oss-Ronen
IPC分类号： A61K38/38 , A61K47/42 , A61K9/00 , A61K47/48 , A61K31/37 , A61K9/22
CPC分类号： A61K9/0024 , A61K31/37 , A61K47/42 , A61K47/6903
摘要： A hydrogel system comprising polymer-conjugated albumin molecules is provided for controlled release delivery of therapeutic agents. The polymer is a functionalized synthetic polymer, preferably PEG-diacrylate. The polymer-conjugated albumin is preferably mono-PEGylated albumin. The hydrogel system may comprise a matrix to which the polymer-conjugated albumin molecules are linked via a functional group of the polymer. The matrix may be formed from the same polymer of the polymer-albumin conjugate.
摘要翻译：提供包含聚合物共轭白蛋白分子的水凝胶体系用于治疗剂的控制释放递送。聚合物是官能化的合成聚合物，优选PEG-二丙烯酸酯。聚合物结合的白蛋白优选是单PEG化的白蛋白。所述水凝胶体系可以包含基质，所述聚合物结合的白蛋白分子通过所述聚合物的官能团连接到基质上。基质可以由聚合物 - 白蛋白缀合物的相同聚合物形成。

2. 发明授权

US08007774B2 Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same 有权
标题翻译：由由合成聚合物交联的天然存在的蛋白质主链组成的基质及其生成和使用方法
公开(公告)号：US08007774B2
公开(公告)日：2011-08-30
申请号：US11472437
申请日：2006-06-22
申请人： Dror Seliktar , Liora Almany
发明人： Dror Seliktar , Liora Almany
IPC分类号： A61F13/00
CPC分类号： A61L27/225 , A61K38/363 , A61K38/39 , A61K38/45 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61L27/18 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/418 , A61L2430/02 , A61L2430/06 , A61L2430/34 , C12M25/14 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12Y203/02013 , C08L71/02
摘要： The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.
摘要翻译：本发明涉及由合成聚合物交联的天然存在的蛋白质主链组成的生物可降解支架。具体而言，本发明提供了聚乙二醇化纤维蛋白原骨架及其生产和使用它们来治疗需要组织再生的疾病的方法。

3. 发明授权

US08846020B2 Scaffolds formed from polymer-protein conjugates, methods of generating same and uses thereof 有权
标题翻译：由聚合物 - 蛋白质缀合物形成的支架，其生产方法及其用途
公开(公告)号：US08846020B2
公开(公告)日：2014-09-30
申请号：US13515298
申请日：2010-12-16
申请人： Dror Seliktar , Yonatan Shachaf
发明人： Dror Seliktar , Yonatan Shachaf
IPC分类号： A61K47/48 , C08G65/333 , C08L89/00 , C12N5/071
CPC分类号： A61K47/48215 , A61K35/12 , A61K38/18 , A61K38/363 , A61K47/50 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61L27/222 , A61L27/225 , A61L27/227 , A61L27/48 , C12N5/0068 , C12N2533/30 , C12N2533/52
摘要： Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking. Compositions-of-matter comprising cross-linked conjugates are provided herein, as well as processes for producing same. Methods of controlling a physical property of compositions-of-matter are also provided herein. The conjugates and compositions-of-matter may be used for various applications, such as cell growth, tissue formation, and treatment of disorders characterized by tissue damage or loss, as described herein.
摘要翻译：本文提供了缀合物，其包含连接至至少两个聚合物部分的蛋白质，其中至少一个显示出反向热凝胶化。缀合物适用于通过非共价和/或共价交联进行交联。本文提供了包含交联共轭物的物质组合物，以及其生产方法。本文还提供了控制物质组成物理性质的方法。缀合物和物质组合物可以用于各种应用，例如细胞生长，组织形成和以组织损伤或损失为特征的疾病的治疗，如本文所述。

4. 发明申请

US20060233854A1 Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same 有权
标题翻译：由由合成聚合物交联的天然存在的蛋白质主链组成的基质及其生成和使用方法
公开(公告)号：US20060233854A1
公开(公告)日：2006-10-19
申请号：US11472437
申请日：2006-06-22
申请人： Dror Seliktar , Liora Almany
发明人： Dror Seliktar , Liora Almany
IPC分类号： A61F13/00 , A61K38/18 , A61K38/21 , A61K38/48
CPC分类号： A61L27/225 , A61K38/363 , A61K38/39 , A61K38/45 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61L27/18 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/418 , A61L2430/02 , A61L2430/06 , A61L2430/34 , C12M25/14 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12Y203/02013 , C08L71/02
摘要： The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.
摘要翻译：本发明涉及由合成聚合物交联的天然存在的蛋白质骨架组成的生物可降解支架。具体而言，本发明提供了聚乙二醇化纤维蛋白原骨架及其生产和使用它们来治疗需要组织再生的疾病的方法。

5. 发明授权

US08858925B2 Pegylated fibrinogen precursor molecule 有权
标题翻译：聚乙二醇化纤维蛋白原前体分子
公开(公告)号：US08858925B2
公开(公告)日：2014-10-14
申请号：US13181562
申请日：2011-07-13
申请人： Dror Seliktar , Liora Almany
发明人： Dror Seliktar , Liora Almany
IPC分类号： A61F13/00 , A61L27/24 , A61K47/48 , A61K38/36 , A61L27/18 , A61L27/22 , A61L27/38 , A61L27/52 , C12N5/00
CPC分类号： A61L27/225 , A61K38/363 , A61K38/39 , A61K38/45 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61L27/18 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/418 , A61L2430/02 , A61L2430/06 , A61L2430/34 , C12M25/14 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12Y203/02013 , C08L71/02
摘要： The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.
摘要翻译：本发明涉及由合成聚合物交联的天然存在的蛋白质主链组成的生物可降解支架。具体而言，本发明提供了聚乙二醇化纤维蛋白原骨架及其生产和使用它们来治疗需要组织再生的疾病的方法。

6. 发明申请

US20110238000A1 POLYMER-CONJUGATED ALBUMIN HYDROGELS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS 有权
标题翻译：用于控制释放治疗药物的聚合物结合的氢溴酸盐
公开(公告)号：US20110238000A1
公开(公告)日：2011-09-29
申请号：US13133241
申请日：2009-12-07
申请人： Dror Seliktar , Liat Oss-Ronen
发明人： Dror Seliktar , Liat Oss-Ronen
IPC分类号： A61M37/00 , A61K47/42 , A61K38/43 , A61K31/785 , A61K38/38 , A61P7/04 , A61P3/02 , A61P31/00 , A61P31/12 , A61P23/00 , A61P29/00 , A61P35/00
CPC分类号： A61K9/0024 , A61K31/37 , A61K47/42 , A61K47/6903
摘要： A hydrogel system comprising polymer-conjugated albumin molecules is provided for controlled release delivery of therapeutic agents. The polymer is a functionalized synthetic polymer, preferably PEG-diacrylate. The polymer-conjugated albumin is preferably mono-PEGylated albumin. The hydrogel system may comprise a matrix to which the polymer-conjugated albumin molecules are linked via a functional group of the polymer. The matrix may be formed from the same polymer of the polymer-albumin conjugate.
摘要翻译：提供包含聚合物共轭白蛋白分子的水凝胶体系用于治疗剂的控制释放递送。聚合物是官能化的合成聚合物，优选PEG-二丙烯酸酯。聚合物结合的白蛋白优选是单PEG化的白蛋白。所述水凝胶体系可以包含基质，所述聚合物结合的白蛋白分子通过所述聚合物的官能团连接到基质上。基质可以由聚合物 - 白蛋白缀合物的相同聚合物形成。

7. 发明授权

US5928945A Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage 失效
标题翻译：剪切流应力对软骨细胞或软骨细胞干细胞产生软骨的应用
公开(公告)号：US5928945A
公开(公告)日：1999-07-27
申请号：US753104
申请日：1996-11-20
申请人： Dror Seliktar , Noushin Dunkelman , Alvin Edward Peterson , Ronda Elizabeth Schreiber , Jane Willoughby , Gail K. Naughton
发明人： Dror Seliktar , Noushin Dunkelman , Alvin Edward Peterson , Ronda Elizabeth Schreiber , Jane Willoughby , Gail K. Naughton
IPC分类号： C12M3/00 , C12M3/02 , C12M3/04 , C12N5/00 , C12N5/077 , C12N11/02 , C12N5/06 , C12N3/00 , C12N5/08 , C12N11/00
CPC分类号： C12N5/0655 , C12M21/08 , C12M25/14 , C12M35/04
摘要： Mammalian cells capable of producing cartilage are cultured under a shear flow stress of about 1 to about 100 dynes/cm.sup.2 to produce artificial cartilage for surgical transplantation to replace damaged or missing cartilage. Shear flow stressed cells display enhanced maintenance of chondrocyte phenotype and produce an extracellular matrix containing an enhanced ratio of type II collagen to type I collagen. The cells may be chondrocytes, chondrocyte stem cells or cells such as myoblasts or fibroblasts that transdifferentiate into chondrocytes. A bioreactor is used containing a growth chamber having a substrate on which the cells capable of producing cartilage are attached, and means for applying relative movement between a liquid culture medium and the substrate to provide the shear flow stress. The substrate may be a scaffold, or a nonporous surface such as the surface of a rotatable drum or disc, or the surface of a static plate that supports cell growth in a monolayer. Cartilage is produced by covering the substrate with a liquid growth medium, inoculating into the medium cells capable of producing cartilage, allowing the cells to attach to the substrate, applying and maintaining relative movement between the growth medium and the cells to provide the shear flow stress to produce shear flow stressed cells, and culturing the shear flow stressed cells to produce cartilage.
摘要翻译：能够产生软骨的哺乳动物细胞在约1至约100达因/平方厘米的剪切流动应力下培养以产生用于外科移植的人造软骨以替代损坏或缺失的软骨。剪切流应力细胞表现出增强的软骨细胞表型的维持，并产生含有II型胶原与I型胶原蛋白比例增加的细胞外基质。细胞可能是软骨细胞，软骨细胞干细胞或细胞如分化成软骨细胞的成肌细胞或成纤维细胞。使用包含生长室的生物反应器，所述生长室具有附着有能够产生软骨的细胞的基底，以及用于在液体培养基和基底之间施加相对运动以提供剪切流动应力的装置。基底可以是支架或无孔表面，例如可旋转的鼓或盘的表面，或支撑单层细胞生长的静态板的表面。通过用液体生长培养基覆盖基质来生产软骨，接种到能够产生软骨的培养基细胞中，使细胞附着到基质上，施加和保持生长培养基和细胞之间的相对运动以提供剪切流应力产生剪切流应力细胞，并培养剪切流应力细胞产生软骨。

8. 发明申请

US20120258068A1 SCAFFOLDS FORMED FROM POLYMER-PROTEIN CONJUGATES, METHODS OF GENERATING SAME AND USES THEREOF 有权
标题翻译：聚合蛋白结合形成的方法及其生成方法及其用途
公开(公告)号：US20120258068A1
公开(公告)日：2012-10-11
申请号：US13515298
申请日：2010-12-16
申请人： Dror Seliktar , Shachaf Yonatan
发明人： Dror Seliktar , Shachaf Yonatan
IPC分类号： A61K47/48 , C08G65/333 , C08L89/00 , C12N5/071
CPC分类号： A61K47/48215 , A61K35/12 , A61K38/18 , A61K38/363 , A61K47/50 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61L27/222 , A61L27/225 , A61L27/227 , A61L27/48 , C12N5/0068 , C12N2533/30 , C12N2533/52
摘要： Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking. Compositions-of-matter comprising cross-linked conjugates are provided herein, as well as processes for producing same. Methods of controlling a physical property of compositions-of-matter are also provided herein. The conjugates and compositions-of-matter may be used for various applications, such as cell growth, tissue formation, and treatment of disorders characterized by tissue damage or loss, as described herein.
摘要翻译：本文提供了缀合物，其包含连接至至少两个聚合物部分的蛋白质，其中至少一个显示出反向热凝胶化。缀合物适用于通过非共价和/或共价交联进行交联。本文提供了包含交联共轭物的物质组合物，以及其生产方法。本文还提供了控制物质组成物理性质的方法。缀合物和物质组合物可以用于各种应用，例如细胞生长，组织形成和以组织损伤或损失为特征的疾病的治疗，如本文所述。

9. 发明申请

US20110038828A1 MATRIX COMPOSED OF A NATURALLY-OCCURRING PROTEIN BACKBONE CROSS LINKED BY A SYNTHETIC POLYMER AND METHODS OF GENERATING AND USING SAME 有权
标题翻译：由合成聚合物交联的天然蛋白质背景组成的基质及其生成和使用方法
公开(公告)号：US20110038828A1
公开(公告)日：2011-02-17
申请号：US12912809
申请日：2010-10-27
申请人： DROR SELIKTAR , LIORA ALMANY
发明人： DROR SELIKTAR , LIORA ALMANY
IPC分类号： A61K31/74 , C07K14/00 , C07K14/475 , C07K14/48 , C07K14/75 , C07K14/78 , C07K14/435 , C08B1/00 , A61P17/02 , C12N9/50 , C12N11/08 , C08G63/91 , A61K38/16
CPC分类号： A61K38/363 , A61K9/0024 , A61K9/06 , A61K35/34 , A61K38/00 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61L24/106 , A61L27/18 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/38 , A61L27/52 , C07K14/75 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C08L71/02
摘要： A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.
摘要翻译：提供一种治疗以组织损伤为特征的病症的方法。该方法包括向需要的受试者提供一种组合物，其包含连接于变性纤维蛋白原或纤维蛋白原的治疗部分的合成聚合物，该组合物被配制用于以药代动力学调节的方式释放纤维蛋白原的治疗部分，从而治疗以组织损伤或畸形为特征的病症。

10. 发明授权

US07842667B2 Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same 有权
标题翻译：由由合成聚合物交联的天然存在的蛋白质主链组成的基质及其生成和使用方法
公开(公告)号：US07842667B2
公开(公告)日：2010-11-30
申请号：US11472520
申请日：2006-06-22
申请人： Dror Seliktar , Liora Almany
发明人： Dror Seliktar , Liora Almany
IPC分类号： A61K38/00 , A61F2/00
CPC分类号： A61K38/363 , A61K9/0024 , A61K9/06 , A61K35/34 , A61K38/00 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61L24/106 , A61L27/18 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/38 , A61L27/52 , C07K14/75 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C08L71/02
摘要： A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.
摘要翻译：提供一种治疗以组织损伤为特征的病症的方法。该方法包括向需要的受试者提供一种组合物，其包含连接于变性纤维蛋白原或纤维蛋白原的治疗部分的合成聚合物，该组合物被配制用于以药代动力学调节的方式释放纤维蛋白原的治疗部分，从而治疗以组织损伤或畸形为特征的病症。

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