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1. 发明授权

US08415144B2 Cell culture methods and devices utilizing gas permeable materials 有权
标题翻译：使用透气材料的细胞培养方法和装置
公开(公告)号：US08415144B2
公开(公告)日：2013-04-09
申请号：US11505122
申请日：2006-08-16
申请人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
发明人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
IPC分类号： C12M1/22 , C12M1/00 , C12M3/00
CPC分类号： C12M23/08 , C12M23/24 , C12M25/06 , C12M25/14 , C12N5/00 , C12N5/0602 , C12N2500/02
摘要： Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.
摘要翻译：公开了用于细胞培养的透气装置和方法，包括细胞培养装置和在高度含有培养基的方法以及某些气体可渗透的表面积与中等体积比。这些装置和方法允许提高细胞培养效率并提高效率。

2. 发明授权

US08158427B2 Cell culture methods and devices utilizing gas permeable materials 有权
公开(公告)号：US08158427B2
公开(公告)日：2012-04-17
申请号：US13194363
申请日：2011-07-29
申请人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
发明人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
IPC分类号： C12N5/07 , C12M3/04 , C12M3/06
CPC分类号： C12M23/08 , C12M23/24 , C12M25/06 , C12M25/14 , C12N5/00 , C12N5/0602 , C12N2500/02
摘要： Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.

3. 发明申请

US20110287542A1 CELL CULTURE METHODS AND DEVICES UTILIZING GAS PERMEABLE MATERIALS 有权
公开(公告)号：US20110287542A1
公开(公告)日：2011-11-24
申请号：US13194298
申请日：2011-07-29
申请人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
发明人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
IPC分类号： C12N5/02
CPC分类号： C12M23/08 , C12M23/24 , C12M25/06 , C12M25/14 , C12N5/00 , C12N5/0602 , C12N2500/02
摘要： Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.

4. 发明申请

US20110212519A1 COMPARTMENTALIZED DEVICE FOR CELL CULTURE, CELL PROCESSING AND SAMPLE DIALYSIS 有权
标题翻译：用于细胞培养，细胞处理和样品透析的分层装置
公开(公告)号：US20110212519A1
公开(公告)日：2011-09-01
申请号：US12715191
申请日：2010-03-01
申请人： John R. Wilson , Daniel P. Welch , Alison Robeck , Douglas A. Page
发明人： John R. Wilson , Daniel P. Welch , Alison Robeck , Douglas A. Page
IPC分类号： C12N5/07
CPC分类号： C12M27/12 , C12M23/24 , C12M23/34
摘要： A versatile compartmentalized cell culture device, with a selectively permeable membrane separating the compartments, provides many attributes relative to traditional devices. It can be configured for high-density cell culture, co-culture, and sample dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments. The wide combination of attributes not found in other membrane based cell culture and bioprocessing devices includes more cell capacity, more cell secreted product capacity, higher cell and product density, increased medium capacity, minimized use of exogenous growth factors, compatibility with standard cell culture equipment and protocols, increased scale up efficiency, capacity to function when rolling or standing still, capacity for perfusion without the need for pumps, and more efficient sample dialysis.
摘要翻译：具有分离隔室的选择性渗透膜的多功能隔室细胞培养装置相对于传统装置提供许多属性。它可以配置为在滚动或静置时进行高密度细胞培养，共培养和样品透析。它也可以配置为在隔室之间连续移动液体。在其他基于膜的细胞培养和生物处理装置中没有发现的属性的广泛组合包括更多的细胞容量，更多的细胞分泌产物能力，更高的细胞和产物密度，增加的培养基能力，最小化外源生长因子的使用，与标准细胞培养设备的相容性和方案，增加放大效率，滚动或静止时功能的能力，无需泵的灌注能力，以及更有效的样品透析。

5. 发明授权

US08501468B2 Culturing cells in a compartmentalized roller bottle 有权
标题翻译：在分隔的滚瓶中培养细胞
公开(公告)号：US08501468B2
公开(公告)日：2013-08-06
申请号：US12715191
申请日：2010-03-01
申请人： John R. Wilson , Daniel P. Welch , Alison Robeck , Douglas A. Page
发明人： John R. Wilson , Daniel P. Welch , Alison Robeck , Douglas A. Page
IPC分类号： C12N5/00
CPC分类号： C12M27/12 , C12M23/24 , C12M23/34
摘要： A versatile compartmentalized cell culture device, with a selectively permeable membrane separating the compartments, provides many attributes relative to traditional devices. It can be configured for high-density cell culture, co-culture, and sample dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments. The wide combination of attributes not found in other membrane based cell culture and bioprocessing devices includes more cell capacity, more cell secreted product capacity, higher cell and product density, increased medium capacity, minimized use of exogenous growth factors, compatibility with standard cell culture equipment and protocols, increased scale up efficiency, capacity to function when rolling or standing still, capacity for perfusion without the need for pumps, and more efficient sample dialysis.
摘要翻译：具有分离隔室的选择性渗透膜的多功能隔室细胞培养装置相对于传统装置提供许多属性。它可以配置为在滚动或静置时进行高密度细胞培养，共培养和样品透析。它也可以配置为在隔室之间连续移动液体。在其他基于膜的细胞培养和生物处理装置中没有发现的属性的广泛组合包括更多的细胞容量，更多的细胞分泌产物能力，更高的细胞和产物密度，增加的培养基能力，最小化外源生长因子的使用，与标准细胞培养设备的相容性和方案，增加放大效率，滚动或静止时功能的能力，无需泵的灌注能力，以及更有效的样品透析。

6. 发明授权

US08168432B2 Cell culture methods and devices utilizing gas permeable materials 有权
公开(公告)号：US08168432B2
公开(公告)日：2012-05-01
申请号：US13029762
申请日：2011-02-17
申请人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
发明人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
IPC分类号： C12N5/07 , C12M3/04 , C12M3/06
CPC分类号： C12M23/08 , C12M23/24 , C12M25/06 , C12M25/14 , C12N5/00 , C12N5/0602 , C12N2500/02
摘要： Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.

7. 发明授权

US07799560B2 Compartmentalized device for cell culture, cell processing, and sample dialysis 有权
标题翻译：用于细胞培养，细胞处理和样品透析的分隔装置
公开(公告)号：US07799560B2
公开(公告)日：2010-09-21
申请号：US10985339
申请日：2004-11-10
申请人： John R. Wilson , Daniel P. Welch , Alison Robeck , Douglas A. Page
发明人： John R. Wilson , Daniel P. Welch , Alison Robeck , Douglas A. Page
IPC分类号： C12M3/06 , C12M1/12 , C12N5/00
CPC分类号： C12M27/12 , C12M23/08 , C12M23/34
摘要： A versatile compartmentalized cell culture device, with a selectively permeable membrane separating the compartments, provides many attributes relative to traditional devices. It can be configured for high-density cell culture, co-culture, and sample dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments. The wide combination of attributes not found in other membrane based cell culture and bioprocessing devices includes more cell capacity, more cell secreted product capacity, higher cell and product density, increased medium capacity, minimized use of exogenous growth factors, compatibility with standard cell culture equipment and protocols, increased scale up efficiency, capacity to function when rolling or standing still, capacity for perfusion without the need for pumps, and more efficient sample dialysis.
摘要翻译：具有分离隔室的选择性渗透膜的多功能隔室细胞培养装置相对于传统装置提供许多属性。它可以配置为在滚动或静置时进行高密度细胞培养，共培养和样品透析。它也可以配置为在隔室之间连续移动液体。在其他基于膜的细胞培养和生物处理装置中没有发现的属性的广泛组合包括更多的细胞容量，更多的细胞分泌产物能力，更高的细胞和产物密度，增加的培养基能力，最小化外源生长因子的使用，与标准细胞培养设备的相容性和方案，增加放大效率，滚动或静止时功能的能力，无需泵的灌注能力，以及更有效的样品透析。

8. 发明授权

US07032287B1 Edge grip chuck 有权
标题翻译：边夹夹
公开(公告)号：US07032287B1
公开(公告)日：2006-04-25
申请号：US10198948
申请日：2002-07-19
申请人： Blaine R. Spady , Christopher W. Blaufus , Douglas A. Page , Dan M. Colban
发明人： Blaine R. Spady , Christopher W. Blaufus , Douglas A. Page , Dan M. Colban
IPC分类号： B23Q7/00 , B05C13/00 , B05C13/02
CPC分类号： H01L21/68728 , H01L21/68707 , Y10T29/49998 , Y10T279/19 , Y10T279/1986
摘要： An actuated edge grip chuck includes tabs with raised portions that press against the side of a substrate as opposed clamping on the top or bottom surfaces. The edge grip chuck includes a solid-state actuator to move a moveable tab into an open position. The solid-state actuator may be, e.g., a piezoelectric actuator or a shape memory alloy. The tab may be biased into the closed position such that when a substrate is held by the edge by the moveable tab and one or more fixed tabs. If desired, more than one moveable tab may be used.
摘要翻译：致动的边缘夹持卡盘包括具有凸起部分的突出部，其相对于顶部或底部表面上的夹紧而抵靠基板的侧面。边缘夹持夹具包括一个固态致动器，用于将可移动的突片移动到打开位置。固态致动器可以是例如压电致动器或形状记忆合金。突片可以被偏置到关闭位置，使得当基板被可移动突片和一个或多个固定突片保持在边缘时。如果需要，可以使用多于一个的可动片。

9. 发明授权

US09255243B2 Cell culture methods and devices utilizing gas permeable materials 有权
公开(公告)号：US09255243B2
公开(公告)日：2016-02-09
申请号：US10961814
申请日：2004-10-08
申请人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
发明人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
IPC分类号： C12M3/00 , C12M1/24 , C12M1/04 , C12M1/12
CPC分类号： C12M23/08 , C12M23/24 , C12M25/06 , C12M25/14 , C12N5/00 , C12N5/0602 , C12N2500/02
摘要： Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.

10. 发明授权

US08158426B2 Cell culture methods and devices utilizing gas permeable materials 有权
标题翻译：使用透气材料的细胞培养方法和装置
公开(公告)号：US08158426B2
公开(公告)日：2012-04-17
申请号：US13194298
申请日：2011-07-29
申请人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
发明人： John R. Wilson , Douglas A. Page , Dan Welch , Alison Robeck
IPC分类号： C12N5/07 , C12M3/04 , C12M3/06
CPC分类号： C12M23/08 , C12M23/24 , C12M25/06 , C12M25/14 , C12N5/00 , C12N5/0602 , C12N2500/02
摘要： Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.
摘要翻译：公开了用于细胞培养的透气装置和方法，包括细胞培养装置和在高度含有培养基的方法以及某些气体可渗透的表面积与中等体积比。这些装置和方法允许提高细胞培养效率并提高效率。

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