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    • 9. 发明申请
    • NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES
    • 新型杂环衍生物及其用途
    • US20140315888A1
    • 2014-10-23
    • US14347950
    • 2012-09-28
    • Pil Su HoDong Oh YoonSun Young HanWon Il LeeJung Sook KimWoul Seong ParkSung Oh AhnHye Jung Kim
    • Pil Su HoDong Oh YoonSun Young HanWon Il LeeJung Sook KimWoul Seong ParkSung Oh AhnHye Jung Kim
    • C07D471/14
    • C07D471/14C07D487/14C07D498/14C07D519/00
    • The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
    • 本发明涉及可用于制备用于治疗与组胺4受体的各种功能相关的疾病的药物的新型杂环化合物。 特别地,所述药物可用于治疗炎性疾病,过敏,疼痛,鼻息肉,鼻炎,慢性鼻窦炎,鼻塞,鼻痒,哮喘,慢性阻塞性肺病,类风湿性关节炎,特应性皮炎,牛皮癣,湿疹,瘙痒, 瘙痒皮肤,荨麻疹,特发性慢性荨麻疹,硬皮病,结膜炎,角膜结膜炎,眼部炎症,干眼症,心脏功能障碍,心律失常,动脉粥样硬化,多发性硬化,炎性肠病(包括结肠炎,克罗恩病,溃疡性结肠炎),炎性疼痛,神经性疼痛 ,骨关节炎,自身免疫性甲状腺疾病,免疫介导(也称为I型)糖尿病,狼疮,术后粘连,前庭障碍和癌症。