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1. 发明授权

US09586239B2 Three wheel, mobile frame 有权
标题翻译：三轮，移动架
公开(公告)号：US09586239B2
公开(公告)日：2017-03-07
申请号：US14544720
申请日：2015-02-09
申请人： Donald E. Butler
发明人： Donald E. Butler
IPC分类号： B62D61/06 , B08B3/02 , B05B15/06 , B62B1/00
CPC分类号： B08B3/024 , B05B13/005 , B05B15/62 , B62B1/00
摘要： Three-wheel, mobile frame adapted to secure one or more nozzles, wand, and spray control power, pressure washer to a main spar with a caster type front wheel assembly connected to the main spar and main wheel assembly comprising two axle mounted, main wheels. The spar includes a support leg attached at a point behind the main wheel assembly and descending downward to prevent inadvertent back-tipping of the three-wheel, mobile frame in response to cleaning fluid discharged against the flat surface to be cleaned under pressure from the nozzle when the unit is not fully controlled by the operator. Multiple nozzles may be attached to a nozzle that is attached to the wand in place of a single nozzle.
摘要翻译：三轮移动框架适用于将一个或多个喷嘴，棒和喷雾控制功率，压力清洗器固定到主翼梁上，脚轮式前轮组件连接到主翼梁和主轮组件，其包括两个轴安装的主轮。翼梁包括附接在主轮组件后面的点并且向下下降的支撑腿，以防止三轮可移动框架响应于在喷嘴的压力下被排出待清洁的平坦表面的清洁流体的意外反倾翻当该单元未被操作者完全控制时。多个喷嘴可以附接到附接到棒的喷嘴而不是单个喷嘴。

2. 发明授权

US5506352A Process for the synthesis of 9-(.beta.-D-arabinofuranosyl)adenine, 5'-phosphate 失效
标题翻译：合成9-（β-D-阿拉伯呋喃糖基）腺嘌呤，5'-磷酸的方法
公开(公告)号：US5506352A
公开(公告)日：1996-04-09
申请号：US310360
申请日：1994-09-21
申请人： Donald E. Butler , Alan Millar
发明人： Donald E. Butler , Alan Millar
IPC分类号： C07H19/20 , C07H19/167 , C07H1/00
CPC分类号： C07H19/20
摘要： An improved process for the preparation of 9-(.beta.-D-arabinofuranosyl)adenine, 5'-phosphate, is described where dried 9-(.beta.-D-arabinofuranosyl)adenine is reacted with triethyl phosphate and phosphorous oxychloride in dichloromethane and the reaction mixture hydrolyzed and excess hydrogen chloride removed with propylene oxide as the acid scavenger. This process gives a yield of about 70-85%, which is nearly double the yields of the prior art.
摘要翻译：描述了制备9-（β-D-阿拉伯呋喃糖基）腺嘌呤（5'-磷酸）的改进方法，其中将干燥的9-（β-D-阿拉伯呋喃糖基）腺嘌呤与磷酸三乙酯和磷酰氯在二氯甲烷中反应，用环氧丙烷作为酸清除剂除去混合物水解和过量的氯化氢。该方法产生约70-85％的产率，这几乎是现有技术产量的两倍。

3. 发明授权

US5397792A Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis 失效
标题翻译：反式-6- [2-（取代 - 吡咯-1-基）烷基]吡喃-2-酮胆固醇合成抑制剂的方法
公开(公告)号：US5397792A
公开(公告)日：1995-03-14
申请号：US243673
申请日：1994-05-16
申请人： Donald E. Butler , Tung Van Le , Thomas N. Nanninga
发明人： Donald E. Butler , Tung Van Le , Thomas N. Nanninga
IPC分类号： C07D295/18 , A61K31/40 , A61K31/4025 , A61K31/4427 , A61K31/443 , A61K31/445 , A61P3/06 , C07C255/20 , C07C255/26 , C07C255/27 , C07D207/06 , C07D207/325 , C07D207/34 , C07D211/10 , C07D211/16 , C07D265/30 , C07D319/04 , C07D319/06 , C07D401/06 , C07D405/02 , C07D405/06 , C07D405/14 , C07D491/113 , C07D211/14 , C07D207/323
CPC分类号： C07D405/06 , C07D207/34
摘要： An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where .alpha.-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl) -N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide, as well as other valuable intermediates used in the processes and prodrugs which are bioconverted to hypolipidemic and hypocholesterolemic agents and pharmaceutical compositions of the same.
摘要翻译：描述了通过新的合成制备反式-6- [2-（取代 - 吡咯-1-基）烷基]吡喃-2-酮的改进方法，其中将α-金属化的N，N-二取代的乙酰胺转化为七具体而言，制备（2R-反式）-5-（4-氟苯基）-2-（1-甲基乙基）-N，4-二苯基-1- [2-（四氢-4 - 羟基-6-氧代-2H-吡喃-2-基）乙基] -1H-吡咯-3-甲酰胺，以及用于生物转化为降血脂和降血胆固醇药的方法和前药中的其它有价值的中间体和药物组合物一样。

4. 发明授权

US5155251A Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate 失效
标题翻译：合成（5R）-1,6-二甲基乙基-6-氰基-5-羟基-3-氧代己酸的方法
公开(公告)号：US5155251A
公开(公告)日：1992-10-13
申请号：US775162
申请日：1991-10-11
申请人： Donald E. Butler , Tung V. Le , Alan Millar , Thomas N. Nanninga
发明人： Donald E. Butler , Tung V. Le , Alan Millar , Thomas N. Nanninga
IPC分类号： C07D319/06 , C07C253/14 , C07C253/16 , C07C253/30 , C07C255/20 , C07C255/21 , C07D405/06
CPC分类号： C07C255/21
摘要： An improved process for the preparation of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate is described where a halo hydroxyester or other activated dihydroxyester is converted in two steps to the desired product.
摘要翻译：描述了制备（5R）-1,1-二甲基乙基-6-氰基-5-羟基-3-氧代 - 己酸酯的改进方法，其中卤代羟基酯或其它活化的二羟基酯在两个步骤中转化成所需产物。

5. 发明授权

US5149837A Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis 失效
标题翻译：反式-6- [2-（取代 - 吡咯-1-基）烷基]吡喃-2-酮胆固醇合成抑制剂的方法
公开(公告)号：US5149837A
公开(公告)日：1992-09-22
申请号：US834443
申请日：1992-02-12
申请人： Donald E. Butler , Carl F. Deering , Alan Millar , Thomas N. Nanninga , Bruce D. Roth
发明人： Donald E. Butler , Carl F. Deering , Alan Millar , Thomas N. Nanninga , Bruce D. Roth
IPC分类号： C07C235/80 , C07D207/34 , C07D319/06 , C07D319/08 , C07D405/06
CPC分类号： C07D319/08 , C07C235/80 , C07D207/34 , C07D319/06 , C07D405/06
摘要： An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-(4-fluoro-phenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-.alpha.-[2-methyl-1-oxopropyl]-.gamma.-oxo-N,.beta.-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.
摘要翻译：描述了通过新的合成制备反式-6- [2-（取代的 - 吡咯-1-基）烷基]吡喃-2-酮的改进方法，其中将1,6-庚二烯-4-醇转化为8 （2R-反式）和反 - （+/-）-5-（4-氟 - 苯基）-2-（1-甲基乙基）-N， 4-二苯基-1- [2-（叔氨基-4-羟基-6-氧代-2H-吡喃-2-基）乙基] -1H-吡咯-3-甲酰胺，通过新的合成法，其中4-甲基-3- N-氧代-N-苯基戊酰胺在八个操作中转化为所需产物，或者将4-氟-α-[2-甲基-1-氧代丙基]-γ-氧代-N，β-二苯基苯丁酰胺在一步转化成所需产物，另外，制备（2R-反式）-5-（4-氟苯基）-2-（1-甲基乙基）-N，4-二苯基-1- [2-（四氢-4-羟基-6 （（R）-4-氰基-3 - [[（1,1-二甲基乙基）二甲基甲硅烷基]氧基]丁酸的化合物作为其他有价值的中间体你在进程中。

6. 发明授权

US4617310A 5-oxo-2-pyrrolidinepropanoic acid derivatives and use as cognition activators 失效
标题翻译： 5-氧代-2-吡咯烷丙酸衍生物，用作认知激活剂
公开(公告)号：US4617310A
公开(公告)日：1986-10-14
申请号：US765749
申请日：1985-08-15
申请人： Donald E. Butler
发明人： Donald E. Butler
IPC分类号： C07D207/26 , C07D401/12 , C07D401/06 , A61K31/40 , A61K31/44 , A61K31/445 , C07D207/12
CPC分类号： C07D207/26 , C07D401/12
摘要： 5-Oxo-2-pyrrolidinepropanoic acids, base addition salts, esters and amides are useful as agents for the reversal of amnesia. Pharmaceutical compositions containing said compounds and methods for using said compositions for treating senility and reversal of amnesia are also taught.
摘要翻译： 5-氧代-2-吡咯烷丙酸，碱加成盐，酯和酰胺可用作逆转健忘症的药剂。还教导了含有所述化合物的药物组合物和使用所述组合物治疗衰老和逆转遗忘症的方法。

7. 发明授权

US4582909A Benzobicyclic lactam acids and derivatives as cognition activators 失效
标题翻译：苯环己内酰胺酸和衍生物作为认知激活剂
公开(公告)号：US4582909A
公开(公告)日：1986-04-15
申请号：US576288
申请日：1984-02-02
申请人： Donald E. Butler , Michael R. Pavia , Fred M. Hershenson
发明人： Donald E. Butler , Michael R. Pavia , Fred M. Hershenson
IPC分类号： C07D215/22 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61P25/28 , A61P43/00 , C07C205/56 , C07D209/34 , C07D209/38 , C07D215/227 , C07D401/12 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/06
CPC分类号： C07D215/227 , C07C205/56 , C07D209/34 , C07D209/38 , C07D401/12 , C07D405/04 , C07D455/04 , C07D471/04
摘要： Benzobicyclic lactam acids having a fused aromatic carbocyclic and a saturated lactam ring of five- or six-members, their salts, esters, and amides, are useful for reversing amnesia. Pharmaceutical compositions including these compounds, a method of preparing the compounds, and a method of treating senility and reversing amnesia are also disclosed.
摘要翻译：具有5或6个成员的稠合芳族碳环和饱和内酰胺环的苯并双环内酰胺，其盐，酯和酰胺可用于逆转遗忘。还公开了包括这些化合物的药物组合物，制备化合物的方法以及治疗衰老和逆转遗忘症的方法。

8. 发明授权

US4562195A Reversing amnesia with saturated tricyclic nitrogen-containing diones 失效
标题翻译：用饱和三环含氮狄更斯逆转遗忘
公开(公告)号：US4562195A
公开(公告)日：1985-12-31
申请号：US687182
申请日：1985-01-07
申请人： Donald E. Butler , Yvon J. L'Italien
发明人： Donald E. Butler , Yvon J. L'Italien
IPC分类号： C07D455/00 , A61K31/40 , A61K31/435 , A61K31/47 , A61P25/28 , A61P43/00 , C07D209/34 , C07D209/52 , C07D215/22 , C07D215/227 , C07D455/03 , C07D455/04 , C07D457/06 , C07D471/06 , C07D487/06
CPC分类号： C07D215/227 , C07D209/34 , C07D209/52 , C07D455/04 , C07D471/06 , C07D487/06
摘要： A class of novel saturated, fused-ring, tricyclic, nitrogen-containing diones are useful as agents in treating electro-convulsive shock-induced amnesia. A method of preparing the compounds, pharmaceutical compositions including the compounds, and a method of treating amnesia are disclosed.
摘要翻译：一类新颖的饱和，稠环，三环，含氮二氢睾酮可用作治疗电惊厥性休克诱发的遗忘症的药物。公开了制备化合物的方法，包括该化合物的药物组合物和治疗遗忘症的方法。

9. 发明授权

US4551470A Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid and derivatives, and use for reversing electroconvulsive shock amnesia 失效
标题翻译：六氢-3,5-二氧代-1H-吡咯嗪-2-羧酸及其衍生物，用于逆转电休克休克症
公开(公告)号：US4551470A
公开(公告)日：1985-11-05
申请号：US527718
申请日：1983-08-29
申请人： Donald E. Butler
发明人： Donald E. Butler
IPC分类号： C07D487/04 , A61K31/40 , C07D487/06
CPC分类号： C07D487/04
摘要： Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid, its esters, ammonium, metal, and organic amine salts are useful for the treatment of senility, for enhancing memory, and for reversing electroconvulsive shock induced amnesia in humans. Pharmaceutical compositions including these compounds, and a method of treatment employing these pharmaceutical compositions is disclosed.
摘要翻译：六氢-3,5-二氧代-1H-吡咯嗪-2-羧酸，其酯，铵，金属和有机胺盐可用于治疗衰老，增强记忆和逆转人类惊厥性休克诱发的健忘症。公开了包括这些化合物的药物组合物和使用这些药物组合物的治疗方法。

10. 发明授权

US4187379A 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds 失效
标题翻译： 3-芳氧基-2-吡啶甲腈1-氧化物
公开(公告)号：US4187379A
公开(公告)日：1980-02-05
申请号：US959802
申请日：1978-11-13
申请人： Donald E. Butler
发明人： Donald E. Butler
IPC分类号： C07D213/65 , C07D213/84 , C07D213/89 , C07D213/57
CPC分类号： C07D213/84 , C07D213/65 , C07D213/89
摘要： 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, are disclosed. The compounds can be produced by oxidizing a 3-aryloxy-2-pyridinecarbonitrile.
摘要翻译：公开了作为药理学特性有用的3-芳氧基-2-吡啶甲腈1-氧化物，特别是作为逆转健忘症的药剂。化合物可以通过氧化3-芳氧基-2-吡啶甲腈来制备。

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