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1. 发明申请

US20140296322A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE 审中-公开
标题翻译：结合物，颗粒，组合物及相关使用方法
公开(公告)号：US20140296322A1
公开(公告)日：2014-10-02
申请号：US14256642
申请日：2014-04-18
申请人： Scott Eliasof , Oliver S. Fetzer , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Jungyeon Hwang , Donald Bergstrom
发明人： Scott Eliasof , Oliver S. Fetzer , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Jungyeon Hwang , Donald Bergstrom
IPC分类号： A61K9/14 , C12N15/11 , C12N15/115 , C12N15/113
CPC分类号： A61K31/713 , A61K9/14 , A61K47/593 , A61K47/60 , A61K47/6921 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32 , Y10T428/2982
摘要： Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.
摘要翻译：用于递送核酸试剂的颗粒和共轭物。含有颗粒，共轭物或两者的组合物。使用颗粒，共轭物和组合物的方法。

2. 发明申请

US20110263688A1 COFERONS AND METHODS OF MAKING AND USING THEM 有权
标题翻译：制作和使用它们的公司及方法
公开(公告)号：US20110263688A1
公开(公告)日：2011-10-27
申请号：US12937053
申请日：2009-04-09
申请人： Francis Barany , Maneesh Pingle , Donald Bergstrom , Sarah Filippa Giardina
发明人： Francis Barany , Maneesh Pingle , Donald Bergstrom , Sarah Filippa Giardina
IPC分类号： A61K31/7052 , A61P35/00 , C40B40/04 , C07H21/00 , C40B30/04
CPC分类号： A61K47/545 , A61K31/69 , C07D233/64 , C07D307/92 , C07D309/30 , C07D319/24 , C07D493/22 , C07F5/02 , C07H7/02 , C07H9/02 , C40B30/04
摘要： A monomer useful in prepaπng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof
摘要翻译：可用于制备治疗化合物的单体包括潜在地结合靶分子的多样性元件，其解离常数小于300±11M，连接元件连接到多样性元件。连接体元件具有小于500道尔顿的分子量通过连接器直接或间接连接到所述多样性元件，并且能够与连接体元件的结合配偶体形成可逆共价键或非共价相互作用。所述单体可以共价或非共价连接在一起形成治疗性多聚体或其前体

3. 发明申请

US20070193208A1 EMBOSSED TAPE COLLATING STRIP FOR NAILS 审中-公开
标题翻译：用于钉子的胶合带收缩条
公开(公告)号：US20070193208A1
公开(公告)日：2007-08-23
申请号：US11307786
申请日：2006-02-22
申请人： Donald Bergstrom , Geronimo Lat , Lawrence Shelton , Thomas Malpass , Henry Schniedermeier
发明人： Donald Bergstrom , Geronimo Lat , Lawrence Shelton , Thomas Malpass , Henry Schniedermeier
IPC分类号： E04F21/00
CPC分类号： F16B15/08
摘要： A fastener assembly for use in a fastener driving tool includes a row of fasteners arranged substantially parallel to each other and a strip having a supporting substrate and an adhesive composition thereon. The supporting substrate has an elongated dimension extending generally in the direction of the row of fasteners. The substrate has embossings formed therein. The adhesive composition is bonded to the fasteners and maintains them in the substantially parallel arrangement in the row. A method for making the embossed strip is also disclosed.
摘要翻译：用于紧固件驱动工具的紧固件组件包括一排基本上彼此平行布置的紧固件，以及具有支撑基底和其上的粘合剂组合物的条。支撑衬底具有大致沿着紧固件排的方向延伸的细长尺寸。基板上形成有压花。粘合剂组合物结合到紧固件上并将它们保持在行中基本平行的布置。还公开了一种用于制造压花条的方法。

4. 发明申请

US20060017008A1 Dyed microspheres for characterization of photochemical reactor behavior 有权
标题翻译：用于表征光化学反应器行为的染色微球
公开(公告)号：US20060017008A1
公开(公告)日：2006-01-26
申请号：US11090312
申请日：2005-03-26
申请人： Ernest Blatchley , Chengyue Shen , Zorana Naunovic , Lian-Shin Lin , Dennis Lyn , Donald Bergstrom , Shiyue Fang , Yousheng Guan , Joseph Robinson , Kathyrn Ragheb , Gerald Gregori
发明人： Ernest Blatchley , Chengyue Shen , Zorana Naunovic , Lian-Shin Lin , Dennis Lyn , Donald Bergstrom , Shiyue Fang , Yousheng Guan , Joseph Robinson , Kathyrn Ragheb , Gerald Gregori
IPC分类号： H05B33/00
CPC分类号： G01N21/643 , Y10S435/968 , Y10S436/80 , Y10S436/805
摘要： A method for photochemical reactor characterization includes an application of using dyed microspheres exposed to UV irradiation under a collimated-beam system. Particle specific fluorescence intensity measurements are conducted using samples form the collimated beam and flow-through reactor results using flow cytometry. A numerical model may be used to simulate the behavior of the reactor system to provide a particle-tracking algorithm to interrogate the flow and intensity field simulations for purposes of developing a particle specific estimate of the dose delivery. A method for measuring UV dose distribution delivery in photochemical reactors is provided that includes introducing microspheres labeled with a photochemically-active compound in a UV reactor, The labeled microspheres are harvested downstream of the irradiated zone of a UV reactor and exposed to UV irradiation under a collimated beam of UV irradiation. The method further includes quantifying a UV dose-response behavior, conducting fluorescence intensity measurement on the labeled microspheres from the UV reactor, and developing an estimate of a dose distribution delivered by a UV reactor based on the numerical deconvolution of the sum of the UV dose response behavior and fluorescent intensity of exposed microspheres.
摘要翻译：用于光化学反应器表征的方法包括使用在准直束系统下暴露于UV照射下的染色微球的应用。使用流式细胞术，使用准直束和流通反应器结果的样品进行粒子特异性荧光强度测量。可以使用数值模型来模拟反应器系统的行为，以提供粒子跟踪算法来询问流量和强度场模拟，以便开发剂量递送的粒子特异性估计。提供了一种用于测量光化学反应器中的UV剂量分布递送的方法，其包括在UV反应器中引入用光化学活性化合物标记的微球体。在UV反应器的照射区域的下游收获标记的微球体，并在准直的紫外线照射。该方法还包括定量UV剂量反应行为，对来自UV反应器的标记的微球进行荧光强度测量，并且基于UV剂量的总和的数值去卷积，开发由UV反应器递送的剂量分布的估计暴露的微球的反应行为和荧光强度。

5. 发明申请

US20050037346A1 High fidelity detection of nucleic acid differences by ligase detection reaction 有权
标题翻译：通过连接酶检测反应高度保真检测核酸差异
公开(公告)号：US20050037346A1
公开(公告)日：2005-02-17
申请号：US10405882
申请日：2003-04-01
申请人： Francis Barany , Jianying Luo , Marilyn Khanna , Donald Bergstrom
发明人： Francis Barany , Jianying Luo , Marilyn Khanna , Donald Bergstrom
IPC分类号： C12N15/09 , C07H21/00 , C07K14/82 , C12N9/00 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501
摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
摘要翻译：利用连接酶检测反应在常规模板过量存在下用热稳定连接酶区分少数模板。该过程可以用突变连接酶，热稳定连接酶或修饰的寡核苷酸探针进行。该过程对癌症相关突变的检测特别有用。它具有提供少量模板数量或比例的定量测量的优点。

6. 发明申请

US20120295874A1 COFERONS AND METHODS OF MAKING AND USING THEM 有权
标题翻译：制作和使用它们的公司及方法
公开(公告)号：US20120295874A1
公开(公告)日：2012-11-22
申请号：US13500857
申请日：2010-10-07
申请人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
发明人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
IPC分类号： A61K31/69 , G01N33/566 , A61K31/397 , A61K31/506 , A61K31/505 , A61K31/454 , A61K31/415 , A61K31/357 , C07F5/02 , C07D403/14 , C07D239/42 , C07D401/12 , C07D231/38 , C07D207/24 , C07D205/04 , C07D319/12 , C07D413/14 , A61K31/4015 , G01N33/53
CPC分类号： C07D319/14 , C07D207/12 , C07D207/24 , C07D209/52 , C07D239/42 , C07D239/54 , C07D241/36 , C07D263/20 , C07D295/18 , C07D307/80 , C07D317/10 , C07D317/44 , C07D319/12 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D471/14 , C07D491/04 , C07D491/10 , C07D491/14 , C07F5/025 , C40B30/04
摘要： The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.
摘要翻译：本发明涉及可用于制备治疗化合物的单体。单体包括一个或多个药效团，其可以以小于300μM的解离常数潜在地结合靶分子，并连接到药效团。连接体元件具有小于500道尔顿的分子量，通过连接器直接或间接连接到药效团。

7. 发明授权

US09771345B2 Coferons and methods of making and using them 有权
公开(公告)号：US09771345B2
公开(公告)日：2017-09-26
申请号：US13500857
申请日：2010-10-07
申请人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
发明人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
IPC分类号： A61K31/69 , C07D319/14 , C07D207/12 , C07D207/24 , C07D209/52 , C07D239/42 , C07D239/54 , C07D241/36 , C07D263/20 , C07D295/18 , C07D307/80 , C07D317/10 , C07D317/44 , C07D319/12 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D471/14 , C07D491/04 , C07D491/10 , C07D491/14 , C07F5/02 , C40B30/04
CPC分类号： C07D319/14 , C07D207/12 , C07D207/24 , C07D209/52 , C07D239/42 , C07D239/54 , C07D241/36 , C07D263/20 , C07D295/18 , C07D307/80 , C07D317/10 , C07D317/44 , C07D319/12 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D471/14 , C07D491/04 , C07D491/10 , C07D491/14 , C07F5/025 , C40B30/04
摘要： The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.

8. 发明授权

US08853185B2 Coferons and methods of making and using them 有权
标题翻译：咖啡因及其使用方法
公开(公告)号：US08853185B2
公开(公告)日：2014-10-07
申请号：US12937053
申请日：2009-04-09
申请人： Francis Barany , Maneesh Pingle , Donald Bergstrom , Sarah Filippa Giardina
发明人： Francis Barany , Maneesh Pingle , Donald Bergstrom , Sarah Filippa Giardina
IPC分类号： A61K31/69 , C07F5/02 , C40B30/04 , C40B50/04
CPC分类号： A61K47/545 , A61K31/69 , C07D233/64 , C07D307/92 , C07D309/30 , C07D319/24 , C07D493/22 , C07F5/02 , C07H7/02 , C07H9/02 , C40B30/04
摘要： A monomer useful in prepaπng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof.
摘要翻译：可用于制备治疗化合物的单体包括潜在地结合靶分子的多样性元件，其解离常数小于300±11M，连接元件连接到多样性元件。连接体元件具有小于500道尔顿的分子量通过连接器直接或间接连接到所述多样性元件，并且能够与连接体元件的结合配偶体形成可逆共价键或非共价相互作用。所述单体可以共价或非共价连接在一起形成治疗性多聚体或其前体。

9. 发明申请

US20110166028A1 METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS 审中-公开
标题翻译：根据生物标志物基因表达介导的癌症基因表达预测方法
公开(公告)号：US20110166028A1
公开(公告)日：2011-07-07
申请号：US12674981
申请日：2008-08-22
申请人： Donald Bergstrom , Xudong Dai , James Hardwick , Cole Liberator , A. Thomas Look , Jennifer O'Neil , Sudhir Rao , Peter Strack , Christopher Winter , Theresa Zhang
发明人： Donald Bergstrom , Xudong Dai , James Hardwick , Cole Liberator , A. Thomas Look , Jennifer O'Neil , Sudhir Rao , Peter Strack , Christopher Winter , Theresa Zhang
IPC分类号： C40B30/00 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step.
摘要翻译：本发明涉及鉴定和使用与细胞增殖性疾病的治疗有关的基因表达谱，特别是使用Notch信号传导抑制剂由异常Notch信号转导介导的基因表达谱。特别地，本发明提供基因的身份，其个体或累积表达模式可用于各种测定。基因表达谱，无论是体现在核酸表达，蛋白质表达或其他表达形式中，都可用于选择患有Notch介导的癌症的受试者，其可能对用γ-分泌酶抑制剂或另一种Notch抑制剂治疗有反应。在用其他Notch抑制剂治疗的患者的分类中可以使用相同的标记。该方法还可以包括基于分类步骤提供诊断，预测或预测信息。所述方法可以进一步包括基于分类步骤来选择治疗。

10. 发明申请

US20110136116A1 DETECTION OF TARGET NUCLEIC ACID SEQUENCES USING FLUORESCENCE RESONANCE ENERGY TRANSFER 审中-公开
标题翻译：使用荧光共振能量转移检测目标核酸序列
公开(公告)号：US20110136116A1
公开(公告)日：2011-06-09
申请号：US12934866
申请日：2009-04-08
申请人： Francis Barany , Maneesh Pingle , Donald Bergstrom
发明人： Francis Barany , Maneesh Pingle , Donald Bergstrom
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6827 , Y10T436/143333 , C12Q2561/125 , C12Q2527/107 , C12Q2525/301
摘要： A method for identifying a plurality of target nucleic acid molecules in a sample. The method provides a plurality of oligonucleotide probe sets. Each set comprises a first and a second probe, each having a target-specific portion and a tunable portion with an acceptor or a donor group. The first probe further comprises an endcapped hairpin. A reaction comprises a denaturation and hybridization cycle. Under the hybridization, the set of probes hybridize in a base-specific manner to their respective target nucleotide sequences, and ligate to one another to form a ligation product. Under conditions that permit hybridization of the tunable portions of the ligation product to one another, an internally hybridized ligation product formed, which allows the detection of the fluorescence resonance energy transfer (FRET). A method comprising PCR amplification is also disclosed.
摘要翻译：用于鉴定样品中多个靶核酸分子的方法。该方法提供多个寡核苷酸探针组。每组包括第一和第二探针，每个具有目标特异性部分和具有受体或供体基团的可调部分。第一探针还包含封端的发夹。反应包括变性和杂交循环。在杂交下，探针组以碱基特异性方式与其各自的靶核苷酸序列杂交，并且彼此连接以形成连接产物。在允许连接产物的可调部分彼此杂交的条件下，形成内部杂交的连接产物，其允许检测荧光共振能量转移（FRET）。还公开了包括PCR扩增的方法。

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