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1. 发明申请

US20100279947A1 Modifications of apoptin 审中-公开
标题翻译：凋亡素的修饰
公开(公告)号：US20100279947A1
公开(公告)日：2010-11-04
申请号：US11998194
申请日：2007-11-28
申请人： Mathieu Hubertus Maria Noteborn , Jennifer Leigh Rohn , Dominik Mumberg , Peter Donner
发明人： Mathieu Hubertus Maria Noteborn , Jennifer Leigh Rohn , Dominik Mumberg , Peter Donner
IPC分类号： A61K38/16 , C07K14/005 , C12N15/63 , C12N5/10 , C07K16/08 , C07H21/04 , G01N33/53 , A61P35/00
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K48/00 , C07K14/4747 , C07K16/18 , C07K2319/00 , C12N2750/10022 , C12N2750/10043
摘要： Phosphorylated Apoptin is described. Apoptin is tumor-specifically phosphorylated and part of the Apoptin apoptotic pathway in tumor cells is elucidated. New therapeutic possibilities, for example, novel therapeutic compounds that can work alone or, sequentially to, or jointly with other known compounds. Also, the use of tumor-specifically phosphorylation of Apoptin for diagnostic purposes is described. Such a diagnostic purpose can, for example, be a method for detecting the presence of cancer cells or cells that are cancer prone or a method to identify a putative cancer inducing agent or a method for the in vitro treatment effect of Apoptin on tumor cells by testing the phosphorylation state of Apoptin. Even more, the invention provides possibilities to further elucidate the apoptotic pathway and to identify for example crucial mediators of phosphorylation in human tumor cells. Interfering with such a mediator could provide new anti-cancer therapies.
摘要翻译：描述了磷酸化的Apoptin。凋亡素是肿瘤特异性磷酸化的，并且阐明肿瘤细胞中部分凋亡途径的凋亡途径。新的治疗可能性，例如，可以单独或连续地或与其它已知化合物一起工作的新型治疗化合物。此外，描述了用于诊断目的的使用肿瘤特异性磷酸化的Apoptin。这样的诊断目的可以是例如用于检测癌细胞或癌症倾向的细胞的存在的方法或者鉴定推定的癌症诱导剂的方法或者通过以下方法检测凋亡素对肿瘤细胞的体外治疗效果的方法测试Apoptin的磷酸化状态。更进一步地，本发明提供进一步阐明凋亡途径并鉴定例如人肿瘤细胞中磷酸化的关键介质的可能性。干扰这种介质可以提供新的抗癌疗法。

2. 发明申请

US20110021493A1 SUBSTITUTED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF 有权
标题翻译：取代的三聚体化合物及其使用方法
公开(公告)号：US20110021493A1
公开(公告)日：2011-01-27
申请号：US12678288
申请日：2008-09-02
申请人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirsten Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffman , Gerhard Siemeister , Ulf Bömer
发明人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirsten Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffman , Gerhard Siemeister , Ulf Bömer
IPC分类号： C07D495/14 , A61K31/519 , A61K31/496 , A61K31/5377 , C07D491/147 , A61K31/4375 , A61K31/553 , A61K31/55 , A61P35/04 , A61P9/12 , A61P17/06 , A61P1/00
CPC分类号： C07D495/14 , C07D491/147 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译：本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。

3. 发明授权

US08524722B2 Substituted tricyclic compounds and methods of use thereof 有权
标题翻译：取代的三环化合物及其使用方法
公开(公告)号：US08524722B2
公开(公告)日：2013-09-03
申请号：US12678288
申请日：2008-09-02
申请人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
发明人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
IPC分类号： A01N43/54 , A01N43/40 , A61K31/505 , A61K31/445 , C07D239/00 , C07D471/00 , C07D491/00 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号： C07D495/14 , C07D491/147 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译：本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。

4. 发明授权

US07319034B2 Modifications of apoptin 失效
标题翻译：凋亡素的修饰
公开(公告)号：US07319034B2
公开(公告)日：2008-01-15
申请号：US10083849
申请日：2001-10-19
申请人： Mathieu Hubertus Maria Noteborn , Jennifer Leigh Rohn , Dominik Mumberg , Peter Donner
发明人： Mathieu Hubertus Maria Noteborn , Jennifer Leigh Rohn , Dominik Mumberg , Peter Donner
IPC分类号： C12N15/85
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K48/00 , C07K14/4747 , C07K16/18 , C07K2319/00 , C12N2750/10022 , C12N2750/10043
摘要： Phosphorylated Apoptin is described. Apoptin is tumor-specifically phosphorylated and part of the Apoptin apoptotic pathway in tumor cells is elucidated. New therapeutic possibilities, for example, novel therapeutic compounds that can work alone or, sequentially to, or jointly with other known compounds. Also, the use of tumor-specifically phosphorylation of Apoptin for diagnostic purposes is described. Such a diagnostic purpose can, for example, be a method for detecting the presence of cancer cells or cells that are cancer prone or a method to identify a putative cancer inducing agent or a method for the in vitro treatment effect of Apoptin on tumor cells by testing the phosphorylation state of Apoptin. Even more, the invention provides possibilities to further elucidate the apoptotic pathway and to identify for example crucial mediators of phosphorylation in human tumor cells. Interfering with such a mediator could provide new anti-cancer therapies.
摘要翻译：描述了磷酸化的Apoptin。凋亡素是肿瘤特异性磷酸化的，并且阐明肿瘤细胞中部分凋亡途径的凋亡途径。新的治疗可能性，例如，可以单独或连续地或与其它已知化合物一起工作的新型治疗化合物。此外，描述了用于诊断目的的使用肿瘤特异性磷酸化的Apoptin。这样的诊断目的可以是例如用于检测癌细胞或癌症倾向的细胞的存在的方法或者鉴定推定的癌症诱导剂的方法或者通过以下方法检测凋亡素对肿瘤细胞的体外治疗效果的方法测试Apoptin的磷酸化状态。更进一步地，本发明提供进一步阐明凋亡途径并鉴定例如人肿瘤细胞中磷酸化的关键介质的可能性。干扰这种介质可以提供新的抗癌疗法。

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