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    • 5. 发明授权
    • Methods of determining endogenous thrombin potential (ETP) and thrombin substrates for use in said methods
    • 确定用于所述方法的内源性凝血酶电位(ETP)和凝血酶底物的方法
    • US06207399B1
    • 2001-03-27
    • US08860808
    • 1997-09-05
    • Hendrik Coenraad HemkerDirk Thomas Sigurd RijkersGodefridus Ignatius Tesser
    • Hendrik Coenraad HemkerDirk Thomas Sigurd RijkersGodefridus Ignatius Tesser
    • C12Q156
    • C07K5/0806A61K38/00C07K5/06026C07K5/06052C07K5/0812C07K5/0819C07K5/1021C07K14/75C12Q1/56G01N2333/974Y02P20/55
    • A method for determining the endogenous thrombin potential of a sample having a total anticoagulant activity of or equivalent to at least 0.07 U ISH/ml, includes using a thrombin substrate or a salt thereof that is soluble in the sample to determine the ETP of the sample. Suitable thrombin substrate include those of the formula P-Val-Xaa-S, in which P is an amino protective group, that is non-aromatic and polar, Val is a valine residue attached via a peptide bond to Xaa, Xaa is an amino acid residue comprising a terminal guanidino group or ureido group separated by at least 2 carbon atoms from the peptide backbond the amino acid residue is attached to S and S is a signal group such as a chromophore that can be enzymatically hydrolyzed. Other substrates include substrates comprising the structure Zaa-Pipecolyl-Yaa-S or Zaa-Pro-Yaa-S, wherein Zaa represents D-Phenylalanine, D-Tryptophan or D-Tyrosine, Pro represents proline, Yaa is an amino acid residue other than arginine and S is a signal marker can also be used. The substrates Boc-Gly-Val-Arg-pNA and H-Glu-Gly-Gly-Val-Arg-pNA are also applicable. Furthermore ETP determination methods can be improved by addition of hydroxylamine to the sample to circumvent defibrination of the sample.
    • 确定具有至少0.07U ISH / ml的总抗凝活性或等于至少0.07U ISH / ml的样品的内源凝血酶潜力的方法包括使用可溶于样品的凝血酶底物或其盐来确定样品的ETP 。 合适的凝血酶底物包括式P-Val-Xaa-S,其中P是氨基保护基,其是非芳族和极性的,Val是通过肽键与Xaa连接的缬氨酸残基,Xaa是氨基 酸性残基包含由背链离开至少2个碳原子的末端胍基或脲基,氨基酸残基连接到S上,S是可以酶水解的发色团等信号基团。 其他底物包括包含Zaa-Pipecolyl-Yaa-S或Zaa-Pro-Yaa-S结构的底物,其中Zaa表示D-苯丙氨酸,D-色氨酸或D-酪氨酸,Pro表示脯氨酸,Yaa是除 精氨酸和S是信号标记也可以使用。 底物Boc-Gly-Val-Arg-pNA和H-Glu-Gly-Gly-Val-Arg-pNA也是适用的。 此外,通过向样品中加入羟胺可以改善ETP测定方法,以避免样品的去纤维化。
    • 6. 发明授权
    • Wet part of a paper making machine
    • 湿纸部分造纸机
    • US5958189A
    • 1999-09-28
    • US618748
    • 1996-03-20
    • Ulrich BegemannDirk Thomas
    • Ulrich BegemannDirk Thomas
    • D21F1/08D21F1/66
    • D21F1/66D21F1/08
    • A wet part of a paper making machine includes a distributor to which a main stream of a stock suspension is fed and which has a number of connections. The connections are connected by means of split stream lines to a machine-wide flow box which has a machine-wide slice nozzle (headbox). The split stream lines are connected (directly or indirectly) to the flow box. The slice nozzle is connected to at least one continuous web-forming screen. At least one collection trough is connected to the screen, as well as, optionally, to a backwater tank to accept the backwater trapped by the collection trough. Dilution water lines are provided to introduce backwater into the split stream lines to adjust the stock density of the split streams. The dilution water lines are connected directly to the collection trough.
    • 造纸机的湿部分包括一个分配器,一个原料悬浮液的主流被供给到该分配器,并具有许多连接。 连接通过分流线连接到具有机器范围的切片喷嘴(流浆箱)的机器范围的流动箱。 分流线路(直接或间接)连接到流动箱。 切片喷嘴连接到至少一个连续的卷筒纸形成屏幕。 至少一个收集槽连接到筛网,以及可选地连接到回水罐,以接收由收集槽捕获的回水。 提供稀释水管线以将回水引入分流流水线以调节分流流的储备密度。 稀释水管线直接连接到收集槽。
    • 7. 发明授权
    • Process for controlling or regulating the basis weight of a paper or cardboard web
    • 用于控制或调节纸或纸板网的基重的方法
    • US06521089B1
    • 2003-02-18
    • US09573270
    • 2000-05-18
    • Wolfgang GriechDirk Thomas
    • Wolfgang GriechDirk Thomas
    • D21F108
    • D21G9/0027D21F1/08D21F1/66Y10S162/11
    • Device and process for controlling or regulating a basis weight of a web in a web manufacturing process of a web producing machine. The device includes a first control circuit, adapted to adjust the basis weight, that includes at least one adjustable device for influencing the basis weight and at least one basis weight sensor. A second control circuit having at least one sensor for detecting a concentration of incoming backwater is also provided. The process includes measuring the basis weight of the material web, adjusting the basis weight of the web with a first control device having at least one device for influencing the basis weight, detecting a retention change in a second control circuit, and counteracting the retention change by influencing a concentration of a stock suspension placed one of onto a wire and between wires.
    • 用于在卷材生产机的卷筒纸制造过程中控制或调节纸幅的基重的装置和方法。 该装置包括适于调节基重的第一控制电路,该第一控制电路包括用于影响基重的至少一个可调节装置和至少一个基重传感器。 还提供了具有至少一个用于检测进水回流浓度的传感器的第二控制电路。 该方法包括测量材料纤维网的基重,用具有影响基重​​的至少一个装置的第一控制装置调节幅材的基重,检测第二控制电路中的保持变化并抵消保持变化 通过影响放置在电线之间和电线之间的原料悬浮液的浓度。
    • 8. 发明授权
    • Process and headbox system for improving consistency cross-direction profile of fiber web
    • 流程和流浆箱系统,用于提高纤维网的一致性横向轮廓
    • US06299731B1
    • 2001-10-09
    • US09401951
    • 1999-09-23
    • Ulrich BegemannDirk Thomas
    • Ulrich BegemannDirk Thomas
    • D21F108
    • D21F1/08
    • Process and apparatus for improving a consistency cross-direction profile of a fiber web in the wet section. The process includes distributing a fiber suspension across a machine width from a headbox to one of on a wire and between two wires, adjusting a cross-sectional basis weight by sectionally mixing, across the machine width, a first suspension having a first solid content and a first percentage composition and a second suspension having second solid content that is one of lower and higher than the first solid content, and a second percentage composition of the solids content of the second suspension differs from the first percentage composition, and sectionally admixing at least a third suspension across the machine width, the third suspension having a solids content that is one of lower and higher than the solids content of at least one of the first and second solids content, and having a third percentage composition that differs from at least one of the first and second percentage compositions. The apparatus includes one of a first machine-wide feed and a first set of individual feeds for the first suspension, a second set of individual feeds for the second suspension, control devices coupled to the second set of individual feeds for regulating a flow of the second suspension, a turbulence generator, a headbox nozzle. At least a third set of individual feeds for a third suspension is positioned at least one of upstream from the turbulence generator and to act equally on each section across the machine width. The third suspension has a solids content that differs from the solids contents of the first and second suspensions, and additional control devices coupled to the third set of individual feeds for regulating a flow of the third suspension.
    • 用于改善湿区段中纤维网的一致性横向轮廓的方法和装置。 该方法包括将纤维悬浮液跨过机箱宽度从流浆箱分配到线材中的一个和两根丝线之间,通过在机器宽度上横截面地混合具有第一固体含量的第一悬浮液和 第一百分比组合物和第二悬浮液,其具有第二固体含量低于和高于第一固体含量的第二固体含量,第二悬浮液的固体含量的第二百分比组成与第一百分比组成不同,并且至少部分混合 跨越机器宽度的第三悬浮液,​​所述第三悬浮液具有固体含量低于和高于所述第一和第二固体含量中的至少一种的固体含量之一的固体含量,并且具有不同于至少一种 的第一和第二百分比组成。 该装置包括用于第一悬架的第一机器进给和第一组单独进给中的一个,用于第二悬架的第二组单独进给,与第二组单独进给联接的控制装置,用于调节 第二悬架,湍流发生器,流浆箱喷嘴。 用于第三悬架的至少第三组单独进料定位在来自湍流发生器的上游中的至少一个,并且跨越机器宽度均匀地在每个部分上起作用。 第三悬浮液具有不同于第一和第二悬浮液的固体含量的固体含量,以及耦合到第三组单独进料的附加控制装置,用于调节第三悬浮液的流动。