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1. 发明授权

US06044424A Hot-plug power supply for high-availability computer systems 失效
标题翻译：高可用性计算机系统的热插拔电源
公开(公告)号：US06044424A
公开(公告)日：2000-03-28
申请号：US985562
申请日：1997-12-05
申请人： Dilip Amin
发明人： Dilip Amin
IPC分类号： G06F1/26
CPC分类号： G06F1/263
摘要： A system and method for minimizing disruption of operating power in a high-availability computer as new power supplies are hot-inserted. In the preferred embodiment, the high-availability computer includes a plurality hot-plug power supplies, a logic circuit system, and a power distribution system for distributing operating power from the power supplies to the logic circuit system. Preferably, the output capacitance of each power supply is significantly less than the total capacitance of the logic circuit system and the power distribution system, such that, as each power supply is hot-inserted into the computer, only a minute amount of electric charges will be transferred from the power distribution system and the logic circuit system to the power supply. As a small amount of charge transfer would generate only a small voltage drop, any glitch produced by hot-insertion would be significantly reduced. In order to compensate for an increased glitch recovery time attributable to the increased capacitance, the power supply of the present invention may use a poly-phase voltage regulator. Further, the computer system of the present invention may include a timer for indicating to the service person that the power supply of the present invention has been successfully installed on an operating computer.
摘要翻译：一种用于在热插拔新电源时最大限度地降低高可用性计算机中的操作功率中断的系统和方法。在优选实施例中，高可用性计算机包括多个热插拔电源，逻辑电路系统和用于将功率从电源分配到逻辑电路系统的配电系统。优选地，每个电源的输出电容显着小于逻辑电路系统和配电系统的总电容，使得当每个电源被热插入到计算机中时，只有微量的电荷将从配电系统和逻辑电路系统转移到电源。由于少量的电荷转移将仅产生小的电压降，所以通过热插入产生的任何毛刺将显着减少。为了补偿由于增加的电容引起的增加的毛刺恢复时间，本发明的电源可以使用多相电压调节器。此外，本发明的计算机系统可以包括用于向服务人员指示本发明的电源已经成功地安装在操作计算机上的定时器。

2. 发明授权

US5385912A Multicyclic tertiary amine polyaromatic squalene synthase inhibitors 失效
标题翻译：多元叔胺多芳族角鲨烯合酶抑制剂
公开(公告)号：US5385912A
公开(公告)日：1995-01-31
申请号：US959898
申请日：1992-10-13
申请人： Kent Neuenschwander , Dilip Amin , Anthony C. Scotese , Robert L. Morris
发明人： Kent Neuenschwander , Dilip Amin , Anthony C. Scotese , Robert L. Morris
IPC分类号： A61K31/435 , A61K31/44 , A61K31/505 , A61P3/06 , A61P43/00 , C07D221/22 , C07D223/02 , C07D223/14 , C07D239/06 , C07D453/02 , C07D455/00 , C07D471/08 , C07D471/18 , C07D495/08 , C07D519/00 , C12N9/99
CPC分类号： C07D453/02
摘要： This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.The compounds of this invention are described by the formula ##STR1## where Ar I is phenylene or naphthylene, Ar II is phenyl or naphthyl and A is 1-azabicyclo[2.2.2]octan-3-yl.
摘要翻译：本发明涉及含有两个单环和/或二环的多环化合物和能够在生物pH下形成铵离子的碱性叔氨基，并且能降低体内血清胆固醇水平而不显着降低甲羟戊酸代谢物合成。本发明还涉及使用本发明化合物降低血清胆固醇水平的药物组合物和治疗方法。本发明的化合物由式Ⅰ'描述，其中Ar 1是亚苯基或亚萘基，Ar II是苯基或萘基，A是1-氮杂双环[2.2.2]辛-3-基。

3. 发明申请

US20070101451A1 LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 有权
标题翻译：三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗
公开(公告)号：US20070101451A1
公开(公告)日：2007-05-03
申请号：US11369410
申请日：2006-03-07
申请人： Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South
发明人： Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South
IPC分类号： A01K67/027 , C07H21/02 , C12P21/06 , A61K38/46 , A61K39/395 , C12N9/20
CPC分类号： C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
摘要： Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
摘要翻译：公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。还公开了用于治疗脂质代谢紊乱的方法和组合物。

4. 发明申请

US20060088504A1 Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein Al, very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol 审中-公开
标题翻译：用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白A1，极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法
公开(公告)号：US20060088504A1
公开(公告)日：2006-04-27
申请号：US11254195
申请日：2005-10-19
申请人： Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South , Dawn Marchadier , Cyrille Maugeais , Daniel Rader
发明人： Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South , Dawn Marchadier , Cyrille Maugeais , Daniel Rader
IPC分类号： C12Q1/68 , A61K9/127 , A61K48/00 , C12N15/86 , C12N15/88
CPC分类号： G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
摘要： Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
摘要翻译：用于提高患者中HDL胆固醇和载脂蛋白AI水平以及降低患者中VLDL胆固醇和LDL胆固醇水平的组合物和方法，包括影响基因表达的组合物和方法，LIPG编码脂肪酶其是三酰基甘油脂肪酶家族的成员或其影响酶的酶活性。

5. 发明授权

US5494918A Multicyclic tertiary amine polyaromatic squalene syntase inhibitors 失效
标题翻译：多元叔胺多芳族角鲨烯合成酶抑制剂
公开(公告)号：US5494918A
公开(公告)日：1996-02-27
申请号：US320075
申请日：1994-10-07
申请人： Kent Neuenschwander , Dilip Amin , Anthony C. Scotese , Robert L. Morris
发明人： Kent Neuenschwander , Dilip Amin , Anthony C. Scotese , Robert L. Morris
IPC分类号： A61K31/435 , A61K31/44 , A61K31/505 , A61P3/06 , A61P43/00 , C07D221/22 , C07D223/02 , C07D223/14 , C07D239/06 , C07D453/02 , C07D455/00 , C07D471/08 , C07D471/18 , C07D495/08 , C07D519/00 , C12N9/99
CPC分类号： C07D453/02
摘要： This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
摘要翻译：本发明涉及含有两个单环和/或二环的多环化合物和能够在生物pH下形成铵离子的碱性叔氨基，并且能降低体内血清胆固醇水平而不显着降低甲羟戊酸代谢物合成。本发明还涉及使用本发明化合物降低血清胆固醇水平的药物组合物和治疗方法。

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