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1. 发明申请

US20120184906A1 MICRONEEDLE PATCH APPLICATOR 有权
公开(公告)号：US20120184906A1
公开(公告)日：2012-07-19
申请号：US13332065
申请日：2011-12-20
申请人： Devin V. McAllister
发明人： Devin V. McAllister
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B50/30 , A61M2037/0023 , A61M2209/06
摘要： A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.
摘要翻译：将微针贴片应用于患者皮肤表面的方法和装置包括使用敷贴器。施加器包括壳体，可滑动地设置的施加器板和压缩弹簧。施用板可在缩回位置和展开位置之间移动，并且具有接合表面，其适于与微针贴片相贴合并将其压在皮肤表面上。对接系统将微针补片从支撑件传送到施加器，而不需要用户直接处理微针补丁。一旦安装在施用器中，将微针贴片部署在患者的皮肤表面上，以通过包含在贴片上的微针阵列递送期望的药剂。

2. 发明申请

US20100312191A1 Microneedle Devices and Methods of Manufacture and Use Thereof 有权
标题翻译：微针装置及其制造和使用方法
公开(公告)号：US20100312191A1
公开(公告)日：2010-12-09
申请号：US12853082
申请日：2010-08-09
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M5/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
摘要翻译：提供微针装置用于将组织屏障上的治疗和生物分子转运并用作微火焰保持器。在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。还提供制造这些装置的方法，其可以包括中空和/或多孔微针。用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。在优选的使用方法中，微针装置用于将流体材料输送到生物屏障中，或者与一个或多个腔室中的至少一个微针流体连接。该装置优选地还包括用于控制通过微针的材料流动的装置。这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

3. 发明申请

US20090198185A1 HYDRAULICALLY ACTUATED PUMP FOR LONG DURATION MEDICAMENT ADMINISTRATION 有权
标题翻译：液压驱动泵长期服用药物管理
公开(公告)号：US20090198185A1
公开(公告)日：2009-08-06
申请号：US12336363
申请日：2008-12-16
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M5/145
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.
摘要翻译：目前公开的是液压泵装置及其用途，特别是在流体输送系统中。在一个实施例中，流体输送系统是用于慢剂量药物应用的廉价的一次性装置。流体输送系统可以使用弹簧压缩的波纹管曲柄或根据公知的蠕动原理操作的简单机构的其他组合，以迫使一定体积的超纯生物惰性液压流体穿过孔，从而扩大两个室的一个室液压缸。容纳药物的第二液体储存室响应于泵室的膨胀而通过常规孔排空。然后，药物可以通过任何合适的输注装置流入可移除地附接到其上的患者。

4. 发明授权

US09561042B2 Methods and devices for delivering agents across biological barriers 有权
标题翻译：在跨越生物屏障的情况下递送药剂的方法和装置
公开(公告)号：US09561042B2
公开(公告)日：2017-02-07
申请号：US12617566
申请日：2009-11-12
申请人： Devin V. McAllister , Ciro DiMeglio
发明人： Devin V. McAllister , Ciro DiMeglio
IPC分类号： A61M5/32 , A61B17/20 , A61M37/00
CPC分类号： A61B17/205 , A61M5/322 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , A61M2037/0061 , Y10T29/49826
摘要： The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.
摘要翻译：本发明提供了用于在跨越生物屏障传递物体的微针装置。微针包括集成在微针体中的药剂储存器。

5. 发明授权

US09072828B2 Hydraulically actuated pump for long duration medicament administration 有权
标题翻译：液压驱动泵，用于长时间的药物管理
公开(公告)号：US09072828B2
公开(公告)日：2015-07-07
申请号：US12336395
申请日：2008-12-16
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M37/00 , A61M5/145 , A61M1/10 , A61M5/155 , A61M5/142
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may then flow through any suitable infusion set into a patient removeably attached thereto.
摘要翻译：目前公开的是液压泵装置及其用途，特别是在流体输送系统中。在一个实施例中，流体输送系统是用于慢剂量药物应用的廉价的一次性装置。流体输送系统可以使用弹簧压缩的波纹管曲柄或根据公知的蠕动原理操作的简单机构的其他组合，以迫使一定体积的超纯生物惰性液压流体穿过孔，从而扩大两个室的一个室液压缸。容纳药物的第二液体储存室响应于泵室的膨胀而通过常规孔排空。然后药物可以通过任何合适的输注装置流入可移除地附接到其上的患者。

6. 发明授权

US09011392B2 Methods and devices for delivering agents across biological barriers 有权
标题翻译：在跨越生物屏障的情况下递送药剂的方法和装置
公开(公告)号：US09011392B2
公开(公告)日：2015-04-21
申请号：US12414330
申请日：2009-03-30
申请人： Devin V. McAllister , Ciro DiMeglio
发明人： Devin V. McAllister , Ciro DiMeglio
IPC分类号： A61M5/32 , A61B17/20 , A61M37/00
CPC分类号： A61B17/205 , A61M5/322 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , A61M2037/0061 , Y10T29/49826
摘要： The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.
摘要翻译：本发明提供了用于在跨越生物屏障传递物体的微针装置。微针包括集成在微针体中的药剂储存器。

7. 发明授权

US08708966B2 Microneedle devices and methods of manufacture and use thereof 有权
标题翻译：微针装置及其制造和使用方法
公开(公告)号：US08708966B2
公开(公告)日：2014-04-29
申请号：US12853082
申请日：2010-08-09
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M5/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
摘要翻译：提供微针装置用于跨组织屏障传输分子并用作微火焰保持器。在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。还提供制造这些装置的方法，其可以包括中空和/或多孔微针。用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。在优选的使用方法中，微针装置用于将材料输送到生物屏障中，或者与至少一个微针相连接的室内输送生物屏障。该装置优选地还包括用于控制通过微针的材料流动的装置。这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

8. 发明授权

US08540672B2 Microneedle patch applicator 有权
标题翻译：微针贴片器
公开(公告)号：US08540672B2
公开(公告)日：2013-09-24
申请号：US13332065
申请日：2011-12-20
申请人： Devin V. McAllister
发明人： Devin V. McAllister
IPC分类号： A61M5/20
CPC分类号： A61M37/0015 , A61B17/205 , A61B50/30 , A61M2037/0023 , A61M2209/06
摘要： A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.
摘要翻译：将微针贴片应用于患者皮肤表面的方法和装置包括使用敷贴器。施加器包括壳体，可滑动地设置的施加器板和压缩弹簧。施用板可在缩回位置和展开位置之间移动，并且具有接合表面，其适于与微针贴片相贴合并将其压在皮肤表面上。对接系统将微针补片从支撑件传送到施加器，而不需要用户直接处理微针补丁。一旦安装在施用器中，将微针贴片部署在患者的皮肤表面上，以通过包含在贴片上的微针阵列递送期望的药剂。

9. 发明授权

US08162901B2 Microneedle array patch 失效
标题翻译： Microneedle阵列补丁
公开(公告)号：US08162901B2
公开(公告)日：2012-04-24
申请号：US11975717
申请日：2007-10-19
申请人： Robert R. Gonnelli , Devin V. McAllister
发明人： Robert R. Gonnelli , Devin V. McAllister
IPC分类号： A61M5/315
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices for transport of molecules, including drugs and biological molecules, across tissue, are provided. The microneedle devices permit drug delivery or removal of body fluids at clinically relevant rates across skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. Microneedles can be formed of biodegradable or non-biodegradable polymeric materials or metals. In a preferred embodiment, a microneedle device includes a plugging element comprising a platform including a plurality of microneedle plugs for preventing skin or other tissue barriers from entering the hollow microneedles. In another preferred embodiment, a microneedle device includes a plurality of bioerodible elements for temporarily plugging the hollow microneedles, thereby preventing skin or other tissue barriers from entering the hollow microneedles.
摘要翻译：提供用于跨组织输送分子（包括药物和生物分子）的微针装置。微针装置允许以临床相关的速率在皮肤或其他组织屏障上进行药物输送或去除体液，对组织进行最少或没有损伤，疼痛或刺激。微针可由可生物降解或不可生物降解的聚合物材料或金属形成。在优选实施例中，微针装置包括插入元件，其包括平台，该平台包括用于防止皮肤或其他组织屏障进入中空微针的多个微针塞。在另一优选实施例中，微针装置包括用于暂时堵塞中空微针的多个生物腐蚀元件，从而防止皮肤或其他组织屏障进入中空微针。

10. 发明授权

US08070726B2 Hydraulically actuated pump for long duration medicament administration 有权
标题翻译：液压驱动泵，用于长时间的药物管理
公开(公告)号：US08070726B2
公开(公告)日：2011-12-06
申请号：US12336363
申请日：2008-12-16
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M37/00
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.
摘要翻译：目前公开的是液压泵装置及其用途，特别是在流体输送系统中。在一个实施例中，流体输送系统是用于慢剂量药物应用的廉价的一次性装置。流体输送系统可以使用弹簧压缩的波纹管曲柄或根据公知的蠕动原理操作的简单机构的其他组合，以迫使一定体积的超纯生物惰性液压流体穿过孔，从而扩大两个室的一个室液压缸。容纳药物的第二液体储存室响应于泵室的膨胀而通过常规孔排空。然后，药物可以通过任何合适的输注装置流入可移除地附接到其上的患者。

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