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1. 发明授权

US6119296A All-sided mouthbrush 有权
标题翻译：全方位的嘴巴
公开(公告)号：US6119296A
公开(公告)日：2000-09-19
申请号：US211124
申请日：1998-12-14
申请人： Dennis Noe , Chris Sold
发明人： Dennis Noe , Chris Sold
IPC分类号： A46B15/00 , A46B7/04 , A46B9/04 , A46B17/06 , A61C17/00
CPC分类号： A46B15/0055 , A46B11/0003 , A46B15/0081 , A46B9/005 , A46B2200/1066 , A46B7/04
摘要： An all-sided mouthbrush for cleaning a mouth of a user. The all-sided mouthbrush includes a handle including a first end having first and second sides, bristles extending from the first side, and an alternate cleaning device connected to the second side, wherein the bristles clean teeth of the user and the alternate cleaning device cleans a tongue and inner side of the mouth of the user. The alternate cleaning device may be in the form of one of a plurality of parallel ridges, a plurality of columns of tuft-shaped bristles, a plurality of spade headed bristles, a scouring pad-like surface or a plurality of off set rows of bristle-like structures made of soluble crystals for scraping the tongue and inner side of the mouth of the user. A plurality of templates each including a respective alternate cleaning surface and a connecting device for connecting one of the plurality of templates to the second side covering said alternate cleaning device may be attached to the all-sided mouthbrush. A resealable packet is provided for each of the templates and for receiving the first end of the handle when not in use for protecting the templates and handle from dirt and germs. A mouth freshening liquid is provided within the pouches for further protecting the templates and handle and provide additional freshening for the mouth of the user.
摘要翻译：用于清洁用户口腔的全方位的嘴唇。全方位的嘴部包括手柄，其包括具有第一和第二侧面的第一端，从第一侧延伸的刷毛和连接到第二侧的备用清洁装置，其中刷毛清洁使用者的牙齿，并且替代清洁装置清洁舌头和使用者口腔的内侧。替代的清洁装置可以是多个平行的脊中的一个，多个簇状刷毛的列，多个铲形的刷毛，擦洗垫状表面或多个排列的刷毛类似结构，由可溶性晶体制成，用于刮擦使用者的舌头和内侧。每个包括相应的替代清洁表面的多个模板和用于将多个模板中的一个模板连接到覆盖所述替代清洁装置的第二侧的连接装置可以附接到全面的口刷。为每个模板提供可重新密封的包，并且在不使用时接收手柄的第一端以保护模板并处理污垢和细菌。在小袋内提供口腔清新液体，用于进一步保护模板和手柄，并为使用者的口腔提供额外的清新。

2. 发明申请

US20050119288A1 Dosing schedule for a novel anticancer agent 审中-公开
标题翻译：一种新型抗癌剂的给药方案
公开(公告)号：US20050119288A1
公开(公告)日：2005-06-02
申请号：US10919831
申请日：2004-08-17
申请人： Samit Bhattacharya , Richard Connell , Jitesh Jani , James Moyer , Dennis Noe , Stefanus Steyn
发明人： Samit Bhattacharya , Richard Connell , Jitesh Jani , James Moyer , Dennis Noe , Stefanus Steyn
IPC分类号： A61K31/00 , A61K31/506 , A61K31/517 , A61P35/00
CPC分类号： A61K31/00 , A61K31/506 , A61K31/517 , A61K2300/00
摘要： The invention is directed to methods for the a method for treating overexpression of the erbB2 in a mammal in need of treatment by administering to the mammal a therapeutically effective amount of a first inhibitor of an erbB2 receptor and then, after an interval of less than 24 hours, administering to the mammal from one to six therapeutically effective amounts of the same or different inhibitor of the erbB2 receptor. The invention is also directed to a slow daily infusion of the erbB2 inhibitor. The overexpression of the erbB2 receptor can result in abnormal cell growth and lead to cancer. By the methods of the invention, the efficacy and safety of the inhibitors is increased. The invention is also directed to kits for facilitating the dose administration method of the invention.
摘要翻译：本发明涉及用于治疗需要治疗的哺乳动物中erbB2的过度表达的方法，其通过向哺乳动物施用治疗有效量的第一种erbB2受体抑制剂，然后在间隔小于24 小时，向哺乳动物施用1至6个治疗有效量的相同或不同的erbB2受体抑制剂。本发明还涉及缓慢的每日输注erbB2抑制剂。 erbB2受体的过度表达可导致细胞生长异常并导致癌症。通过本发明的方法，抑制剂的功效和安全性增加。本发明还涉及用于促进本发明的剂量给药方法的试剂盒。

3. 发明申请

US20050234115A1 Dosage forms and methods of treatment using VEGFR inhibitors 审中-公开
标题翻译：使用VEGFR抑制剂的剂量形式和治疗方法
公开(公告)号：US20050234115A1
公开(公告)日：2005-10-20
申请号：US11109904
申请日：2005-04-20
申请人： Diane Healey , Dennis Noe , James O'Leary
发明人： Diane Healey , Dennis Noe , James O'Leary
IPC分类号： A61K31/425 , A61K31/427
CPC分类号： A61K31/427 , A61K31/425
摘要： The invention provides dosage forms of a compound of formula 1: or pharmaceutically acceptable salts, solvates or prodrugs thereof. The invention further provides methods of treating hyperproliferative diseases, such as cancers, by administering the dosage forms to a mammal.
摘要翻译：本发明提供式1化合物或其药学上可接受的盐，溶剂合物或前药的剂型。本发明还提供了通过向哺乳动物施用剂型来治疗过度增殖性疾病如癌症的方法。

4. 发明申请

US20050226875A1 Uses of anti-CTLA-4 antibodies 审中-公开
标题翻译：使用抗CTLA-4抗体
公开(公告)号：US20050226875A1
公开(公告)日：2005-10-13
申请号：US11085368
申请日：2005-03-21
申请人： Jesus Gomez-Navarro , Dennis Noe , Douglas Hanson , Eileen Mueller
发明人： Jesus Gomez-Navarro , Dennis Noe , Douglas Hanson , Eileen Mueller
IPC分类号： A61K9/00 , A61K39/395 , A61K45/00 , A61K47/26 , C07K16/28
CPC分类号： C07K16/2818 , A61K9/0019 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/73
摘要： The invention relates to treatment of cancer in a mammal who has undergone stem cell transplantation by administering an effective amount of a human anti-CTLA-4 antibody to the mammal. Stem cell transplantation may be allogeneic or autologous stem cell transplantation and may be preceded by a preparatory treatment such as chemotherapy. The methods of the invention may be combined with additional cancer treatments. Further, the invention relates to treatment of cancer using at least 10 mg/kg of a human anti-CTLA-4 antibody, and, more preferably, about 15-20 mg/kg of antibody.
摘要翻译：本发明涉及通过向哺乳动物施用有效量的人抗CTLA-4抗体，已经经历了干细胞移植的哺乳动物的癌症治疗。干细胞移植可以是同种异体或自体干细胞移植，并且之前可以进行诸如化疗的预备治疗。本发明的方法可以与另外的癌症治疗组合。此外，本发明涉及使用至少10mg / kg人抗CTLA-4抗体，更优选约15-20mg / kg抗体治疗癌症。

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