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1. 发明授权

US5401489A Biomodulators as universal imaging agents 失效
公开(公告)号：US5401489A
公开(公告)日：1995-03-28
申请号：US694325
申请日：1991-05-01
申请人： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
发明人： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
IPC分类号： A61K47/48 , A61K49/14 , A61K51/04 , A61K51/08 , A61K49/00 , A61K49/04 , A61K49/02
CPC分类号： A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
摘要： Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.

2. 发明申请

US20130102772A1 SYSTEMS, METHODS AND DEVICES FOR PRODUCING, MANUFACTURING AND CONTROL OF RADIOPHARMACEUTICALS-FULL 审中-公开
标题翻译：用于生产，制造和控制放射线照相的系统，方法和装置
公开(公告)号：US20130102772A1
公开(公告)日：2013-04-25
申请号：US13550425
申请日：2012-07-16
申请人： Dennis ESHIMA , Mehmet Husnu , Jim Stone , Derrick Alcaide , Henry Padgett , Joseph E. Zambanini , Thomas A. Klausing , Chad E. Bouton , Brian C. Kelley , Scott N. Danhof , David A. Holley , Jeffrey T. Stroup , James B. Gleeson , Eric Hassenpflug , James A. Prescott , Herman Benecke , Daniel B. Garbark
发明人： Dennis ESHIMA , Mehmet Husnu , Jim Stone , Derrick Alcaide , Henry Padgett , Joseph E. Zambanini , Thomas A. Klausing , Chad E. Bouton , Brian C. Kelley , Scott N. Danhof , David A. Holley , Jeffrey T. Stroup , James B. Gleeson , Eric Hassenpflug , James A. Prescott , Herman Benecke , Daniel B. Garbark
IPC分类号： B01J19/00 , B65B1/00
CPC分类号： B01J19/0006 , A61J3/002 , A61K51/0491 , B01J19/004 , B01J19/0046 , B01J2219/00049 , B01J2219/00351 , B01J2219/00355 , B01J2219/00585 , B01J2219/00693 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00759 , B65B1/00 , B65B3/003 , G21G1/10 , G21G2001/0015
摘要： Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.
摘要翻译：用于产生用于放射性药物生产的放射性核素的系统，方法和装置; 合成生成的放射性核素并除去任何不需要的产物; 测量合成放射性核素的数量和活度水平; 将放射性核素分配递送到模块化盒式系统中的模块化盒式合成单元，用于同时/并行生产放射性药物输出，并允许重复使用和/或快速，安全和一次性更换子系统的一部分; 将非放射性核素组分作为放射性药物输出生产的一部分提供给模块化盒式合成单元; 测量每个放射性药物输出流量的数量和活动水平; 净化放射性药物输出; 在无菌小瓶中分配单个剂量; 自动生成标签和剂量相关信息; 对提取的放射性药物输出样品进行自动化质量控制; 并为可选的远程数据收集，通信和/或控制提供用于整体和子部分操作的软件和硬件控制。

3. 发明申请

US20130060017A1 METHODS FOR SYNTHESIZING LABELED COMPOUNDS 审中-公开
标题翻译：合成标记化合物的方法
公开(公告)号：US20130060017A1
公开(公告)日：2013-03-07
申请号：US13550055
申请日：2012-07-16
申请人： Dennis ESHIMA , Mehmet HUSNU , Jim STONE , Brian C. KELLEY
发明人： Dennis ESHIMA , Mehmet HUSNU , Jim STONE , Brian C. KELLEY
IPC分类号： C07H1/00
CPC分类号： C07H5/02
摘要： The invention relates to methods for synthesizing compounds on solid supports. The invention also relates to synthesizing labeled compounds, such as those used in the field of radiopharmaceuticals. The invention relates to methods for synthesizing halogenated radiopharmaceuticals such as fludeoxyglucose (also known as fluorodeoxyglucose or FDG).
摘要翻译：本发明涉及在固体支持物上合成化合物的方法。本发明还涉及合成标记的化合物，例如在放射性药物领域中使用的化合物。本发明涉及卤代放射性药物如氟脱氧葡萄糖（也称为氟脱氧葡萄糖或FDG）的合成方法。

4. 发明申请

US20120222774A1 CLOSED VIAL FILL SYSTEM FOR ASEPTIC DISPENSING 有权
标题翻译：封闭式盲管系统用于自由分配
公开(公告)号：US20120222774A1
公开(公告)日：2012-09-06
申请号：US13339226
申请日：2011-12-28
申请人： Mehmet HUSNU , Dennis Eshima , Derrick Alcaide , Scott N. Danhof , Jim Gleeson , Eric Hassenpflug , Jim Prescott
发明人： Mehmet HUSNU , Dennis Eshima , Derrick Alcaide , Scott N. Danhof , Jim Gleeson , Eric Hassenpflug , Jim Prescott
IPC分类号： B65B1/04 , B65D71/06
CPC分类号： A61J1/2006 , A61B50/33 , A61J1/1406 , B65B3/003 , B65B37/06
摘要： A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.
摘要翻译：封闭路径小瓶填充系统包括散装产品小瓶，由步进电动机操作的蠕动泵，分配歧管组件，可连接至少一个最终产品小瓶，可选的质量检查站和可选的废物收集系统。可以将浓度，活性和体积（CAV）传感器并入系统以直接从合成单元接收放射性药物产品。控制系统可以集成到系统中以提供对放射性药物分配过程的各个方面的自动控制。该系统用于将完成的放射性药物无菌分配到接收容器中，例如质量控制小瓶，无菌小瓶和/或最终产品小瓶，同时为用户提供去除和丢弃被污染的一次性组件的有效手段。

5. 发明授权

US5906807A Method of MRI using biomodulators 失效
标题翻译：使用生物调节剂的MRI方法
公开(公告)号：US5906807A
公开(公告)日：1999-05-25
申请号：US405017
申请日：1995-03-16
申请人： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
发明人： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
IPC分类号： A61K47/48 , A61K49/14 , A61K51/04 , A61K51/08 , A61B5/055 , A61K5/00
CPC分类号： A61K51/081 , A61K47/48261 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
摘要： Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
摘要翻译：优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。生物调节剂还可以调节组织以增强非特异性成像剂的吸收。当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。

6. 发明申请

US20130060134A1 CZT SENSOR FOR TUMOR DETECTION AND TREATMENT 审中-公开
标题翻译： CZT传感器用于肿瘤检测和治疗
公开(公告)号：US20130060134A1
公开(公告)日：2013-03-07
申请号：US13606591
申请日：2012-09-07
申请人： Dennis ESHIMA , Mehmet HUSNU , Jim STONE
发明人： Dennis ESHIMA , Mehmet HUSNU , Jim STONE
IPC分类号： G01T1/24 , A61B6/04 , A61N5/10 , G01T1/167
CPC分类号： A61B6/037 , A61B6/12 , A61B6/4241 , A61N5/1049 , A61N2005/1052 , G01T1/1614
摘要： A tumor treatment apparatus may include an array of collimated CZT detectors configured to intersect a known coordinate and measure gamma radiation activity, for example at 511 keV. A radiation delivery system may be configured to direct radiation through the known coordinate on the basis of the gamma radiation activity. A translatable and rotatable table may be configured to support a tumor host, wherein the tumor is positionable relative to the known coordinate on the basis of the gamma radiation activity emitted by the tumor and measured by the array of collimated CZT detectors. Radiation from the radiation delivery system may be delivered to the tumor at the known coordinate, and may be delivered in an intra-operative surgical environment.
摘要翻译：肿瘤治疗装置可以包括被配置为与已知坐标相交并且测量γ辐射活动的准直CZT检测器阵列，例如在511keV。辐射递送系统可以被配置为基于伽马辐射活动来引导辐射通过已知坐标。可翻译和可旋转的桌子可以被配置为支撑肿瘤宿主，其中根据由肿瘤发射的伽马辐射活动并通过准直的CZT检测器阵列测量的肿瘤可相对于已知坐标定位。来自辐射递送系统的辐射可以以已知的坐标递送到肿瘤，并且可以在手术中的手术环境中递送。

7. 发明申请

US20130018618A1 METHOD AND SYSTEM FOR AUTOMATED QUALITY CONTROL PLATFORM 审中-公开
标题翻译：自动质量控制平台的方法与系统
公开(公告)号：US20130018618A1
公开(公告)日：2013-01-17
申请号：US13550030
申请日：2012-07-16
申请人： Dennis Eshima , Mehmet Husnu , Jim Stone
发明人： Dennis Eshima , Mehmet Husnu , Jim Stone
IPC分类号： G06F19/00
CPC分类号： G06Q10/06395 , G06Q10/20 , G21G1/0005
摘要： A method and system for performing automated quality control analysis of a plurality of radiopharmaceuticals are provided. The method includes uniquely identifying each of the plurality of radiopharmaceuticals, and identifying and implementing a tailored quality control program for each of the radiopharmaceuticals. The method further includes automatically performing a plurality of selected quality control tests for each of the radiopharmaceuticals based on the tailored quality control program, and collecting information produced by the plurality of selected quality control tests.
摘要翻译：提供了一种用于执行多种放射性药物的自动化质量控制分析的方法和系统。该方法包括唯一地识别多个放射性药物中的每一个，以及为每个放射性药物识别和实施定制的质量控制程序。该方法还包括基于定制的质量控制程序自动执行针对每个放射性药物的多个选择的质量控制测试，以及收集由多个选择的质量控制测试产生的信息。

8. 发明授权

US06375927B1 Methods of radiotherapy using biomodulators 失效
标题翻译：使用生物调节剂的放射治疗方法
公开(公告)号：US06375927B1
公开(公告)日：2002-04-23
申请号：US09506086
申请日：2000-02-17
申请人： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
发明人： Jerry L. Born , Dennis Eshima , Paul L. Mann , Nicholas A. Matwiyoff
IPC分类号： A61K5100
CPC分类号： A61K51/081 , A61K47/6415 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0497 , A61K51/08 , A61K2121/00 , A61K2123/00
摘要： Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance up-take of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.
摘要翻译：优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。生物调节剂也可以调理组织以增强非特异性成像剂的摄取。当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。

9. 发明授权

US5240693A Image enhancement by coadministration of biomodulators and structurally modified imaging agents 失效
标题翻译：通过共同给予生物调节剂和结构修饰的成像剂的图像增强
公开(公告)号：US5240693A
公开(公告)日：1993-08-31
申请号：US694157
申请日：1991-05-01
申请人： Jerry L. Born , Dennis Eshima , Frank O. Kroh , Paul L. Mann
发明人： Jerry L. Born , Dennis Eshima , Frank O. Kroh , Paul L. Mann
IPC分类号： A61K47/48 , A61K49/14 , A61K51/04 , A61K51/08
CPC分类号： A61K49/085 , A61K49/10 , A61K49/105 , A61K51/0491 , A61K51/0497 , A61K51/081 , A61B6/037 , A61K2121/00 , A61K2123/00
摘要： Biomodulators can be administered together with an agent such as a drug or an imaging agent (specific or non-specific) structurally modified to take advantage of perturbations of cell oligosaccharide displays caused by biomodulators, to enhance images of a host, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity. Biomodulators condition tissue to enhance or otherwise modify up-take of the drug or structurally modified imaging agent.
摘要翻译：生物调节剂可与诸如药物或成像剂（特异性或非特异性）的药剂一起施用，其结构修饰以利用由生物调节剂引起的细胞寡糖显示剂的扰动，以增强宿主的图像，例如NMR-，优选通过增加异常组织信号强度的X射线或放射线图像。生物调节剂调节组织以增强或以其它方式改变药物或结构改性成像剂的摄取。

10. 发明申请

US20110029445A1 PHARMACEUTICAL PRODUCTION MANAGEMENT SYSTEM 审中-公开
标题翻译：医药生产管理系统
公开(公告)号：US20110029445A1
公开(公告)日：2011-02-03
申请号：US12848031
申请日：2010-07-30
申请人： Bretten Whittacre , Dennis Eshima , Arris Robinson , Troy Connelly
发明人： Bretten Whittacre , Dennis Eshima , Arris Robinson , Troy Connelly
IPC分类号： G06Q50/00
CPC分类号： G06Q10/06 , G06Q30/018 , G09B5/00 , G09B7/00 , G09B19/003
摘要： A computer includes a memory and a processor, the memory having instrul. A computer-implemented method, a computer comprising a storage device, a memory and a processor, the storage device having instructions stored therein. The instructions, which when executed by the processor, causes the computer to (1) receive, at the production module, a request for production of a radioactive pharmaceutical; (2) verify, utilizing a training module on the computer, completion by the user of at least a training program corresponding to production of the radioactive pharmaceutical; (3) verify completion by the user of equipment calibration requirements and equipment qualification requirements for the equipment that is used in the production of the radioactive pharmaceutical; and (4) prevent access to further operations of the production module if the training program has not been completed, the equipment calibration requirements have not been completed or the equipment qualification requirements have not been completed.
摘要翻译：计算机包括存储器和处理器，存储器具有通用性。计算机实现的方法，包括存储装置，存储器和处理器的计算机，所述存储装置具有存储在其中的指令。指令在处理器执行时使计算机（1）在生产模块处接收放射性药物生产请求; （2）验证使用计算机上的培训模块，用户至少完成与放射性药物生产相对应的培训计划; （3）验证用户对放射性药物生产所用设备的设备校准要求和设备资质要求; （4）如果培训计划尚未完成，设备校准要求尚未完成或设备资质要求尚未完成，则不得进一步开展生产模块的操作。

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